Putative 3-hydroxyisobutyryl-coenzyme A hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyisobutyryl-coenzyme A hydrolase, putative

Species:

Leishmania major

UniProt:

Q4Q4Q4_LEIMA

TriTrypDb:

LmjF.32.3680 , LMJLV39_320044700 , LMJSD75_320044800

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Q4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006573	valine metabolic process	5	2
GO:0006574	valine catabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009063	amino acid catabolic process	4	2
GO:0009081	branched-chain amino acid metabolic process	4	2
GO:0009083	branched-chain amino acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016054	organic acid catabolic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1901606	alpha-amino acid catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	11
GO:0016289	CoA hydrolase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016790	thiolester hydrolase activity	4	11
GO:0016829	lyase activity	2	6
GO:0016853	isomerase activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.276
CLV_C14_Caspase3-7	250	254	PF00656	0.324
CLV_C14_Caspase3-7	344	348	PF00656	0.324
CLV_PCSK_KEX2_1	288	290	PF00082	0.292
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.324
CLV_PCSK_SKI1_1	21	25	PF00082	0.263
CLV_PCSK_SKI1_1	289	293	PF00082	0.294
CLV_PCSK_SKI1_1	321	325	PF00082	0.249
CLV_PCSK_SKI1_1	86	90	PF00082	0.281
DOC_AGCK_PIF_2	88	93	PF00069	0.276
DOC_ANK_TNKS_1	156	163	PF00023	0.312
DOC_CKS1_1	217	222	PF01111	0.324
DOC_CKS1_1	293	298	PF01111	0.324
DOC_CKS1_1	352	357	PF01111	0.408
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.324
DOC_MAPK_DCC_7	157	165	PF00069	0.312
DOC_MAPK_gen_1	173	182	PF00069	0.316
DOC_MAPK_MEF2A_6	157	165	PF00069	0.281
DOC_MAPK_MEF2A_6	175	184	PF00069	0.316
DOC_PP2B_LxvP_1	158	161	PF13499	0.376
DOC_PP4_FxxP_1	136	139	PF00568	0.228
DOC_USP7_MATH_1	200	204	PF00917	0.442
DOC_USP7_MATH_1	339	343	PF00917	0.223
DOC_USP7_MATH_1	6	10	PF00917	0.529
DOC_USP7_UBL2_3	288	292	PF12436	0.406
DOC_WW_Pin1_4	216	221	PF00397	0.397
DOC_WW_Pin1_4	273	278	PF00397	0.249
DOC_WW_Pin1_4	292	297	PF00397	0.285
DOC_WW_Pin1_4	351	356	PF00397	0.469
LIG_14-3-3_CanoR_1	128	136	PF00244	0.266
LIG_14-3-3_CanoR_1	157	161	PF00244	0.386
LIG_14-3-3_CanoR_1	21	26	PF00244	0.129
LIG_14-3-3_CanoR_1	27	32	PF00244	0.249
LIG_14-3-3_CanoR_1	44	50	PF00244	0.421
LIG_14-3-3_CanoR_1	7	13	PF00244	0.477
LIG_14-3-3_CterR_2	369	371	PF00244	0.474
LIG_Actin_WH2_2	160	177	PF00022	0.281
LIG_APCC_ABBA_1	143	148	PF00400	0.267
LIG_DLG_GKlike_1	27	34	PF00625	0.276
LIG_FHA_1	184	190	PF00498	0.253
LIG_FHA_1	219	225	PF00498	0.411
LIG_FHA_1	241	247	PF00498	0.307
LIG_FHA_1	259	265	PF00498	0.275
LIG_FHA_1	279	285	PF00498	0.129
LIG_FHA_1	37	43	PF00498	0.305
LIG_FHA_2	293	299	PF00498	0.384
LIG_FHA_2	335	341	PF00498	0.316
LIG_FHA_2	351	357	PF00498	0.447
LIG_IRF3_LxIS_1	242	249	PF10401	0.204
LIG_LIR_Apic_2	152	156	PF02991	0.249
LIG_LIR_Apic_2	215	220	PF02991	0.324
LIG_LIR_Apic_2	347	352	PF02991	0.292
LIG_LIR_Nem_3	11	17	PF02991	0.287
LIG_LIR_Nem_3	87	93	PF02991	0.263
LIG_SH2_CRK	166	170	PF00017	0.324
LIG_SH2_CRK	217	221	PF00017	0.324
LIG_SH2_NCK_1	217	221	PF00017	0.348
LIG_SH2_STAT5	113	116	PF00017	0.262
LIG_SH2_STAT5	217	220	PF00017	0.276
LIG_SH2_STAT5	304	307	PF00017	0.292
LIG_SH2_STAT5	349	352	PF00017	0.370
LIG_SH2_STAT5	46	49	PF00017	0.303
LIG_SH2_STAT5	57	60	PF00017	0.267
LIG_SH3_1	349	355	PF00018	0.373
LIG_SH3_3	349	355	PF00018	0.371
LIG_SH3_3	356	362	PF00018	0.366
LIG_SH3_3	44	50	PF00018	0.405
LIG_SH3_4	330	337	PF00018	0.276
LIG_SUMO_SIM_par_1	280	285	PF11976	0.382
LIG_SxIP_EBH_1	98	108	PF03271	0.276
LIG_ULM_U2AF65_1	329	334	PF00076	0.276
LIG_WRC_WIRS_1	272	277	PF05994	0.324
MOD_CK1_1	122	128	PF00069	0.361
MOD_CK1_1	232	238	PF00069	0.324
MOD_CK2_1	292	298	PF00069	0.332
MOD_CK2_1	334	340	PF00069	0.330
MOD_DYRK1A_RPxSP_1	351	355	PF00069	0.413
MOD_GlcNHglycan	124	127	PF01048	0.349
MOD_GlcNHglycan	190	193	PF01048	0.324
MOD_GlcNHglycan	340	344	PF01048	0.280
MOD_GlcNHglycan	8	11	PF01048	0.451
MOD_GSK3_1	215	222	PF00069	0.422
MOD_GSK3_1	225	232	PF00069	0.301
MOD_GSK3_1	240	247	PF00069	0.201
MOD_GSK3_1	271	278	PF00069	0.305
MOD_GSK3_1	364	371	PF00069	0.462
MOD_GSK3_1	57	64	PF00069	0.415
MOD_LATS_1	19	25	PF00433	0.380
MOD_NEK2_1	1	6	PF00069	0.523
MOD_NEK2_1	167	172	PF00069	0.278
MOD_NEK2_1	246	251	PF00069	0.301
MOD_PIKK_1	219	225	PF00454	0.288
MOD_PIKK_1	304	310	PF00454	0.407
MOD_PKA_2	156	162	PF00069	0.395
MOD_PKA_2	350	356	PF00069	0.453
MOD_PKA_2	6	12	PF00069	0.454
MOD_Plk_1	244	250	PF00069	0.292
MOD_Plk_4	149	155	PF00069	0.321
MOD_Plk_4	247	253	PF00069	0.435
MOD_Plk_4	52	58	PF00069	0.380
MOD_Plk_4	8	14	PF00069	0.401
MOD_Plk_4	97	103	PF00069	0.362
MOD_ProDKin_1	216	222	PF00069	0.397
MOD_ProDKin_1	273	279	PF00069	0.249
MOD_ProDKin_1	292	298	PF00069	0.285
MOD_ProDKin_1	351	357	PF00069	0.463
MOD_SUMO_rev_2	326	331	PF00179	0.428
MOD_SUMO_rev_2	92	100	PF00179	0.322
TRG_ENDOCYTIC_2	166	169	PF00928	0.267
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P500	Leptomonas seymouri	39%	100%
A0A0N0P5E1	Leptomonas seymouri	67%	100%
A0A1X0NSC5	Trypanosomatidae	46%	100%
A0A1X0NTE8	Trypanosomatidae	47%	100%
A0A1X0NTM5	Trypanosomatidae	48%	100%
A0A381MRJ9	Leishmania infantum	39%	100%
A0A3Q8IDG7	Leishmania donovani	39%	100%
A0A3Q8IHF8	Leishmania donovani	95%	100%
A0A3Q8ITQ0	Leishmania donovani	39%	100%
A2VDC2	Xenopus laevis	42%	96%
A4HHN0	Leishmania braziliensis	28%	100%
A4HL04	Leishmania braziliensis	39%	100%
A4HL05	Leishmania braziliensis	39%	100%
A4HL06	Leishmania braziliensis	85%	99%
A4I8I5	Leishmania infantum	39%	100%
A4I8I6	Leishmania infantum	95%	100%
D0AAN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E8NHQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B3E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	86%
P28817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	74%
Q1PEY5	Arabidopsis thaliana	36%	98%
Q28FR6	Xenopus tropicalis	43%	96%
Q2HJ73	Bos taurus	38%	96%
Q4Q4Q5	Leishmania major	39%	96%
Q4Q4Q6	Leishmania major	38%	100%
Q55GS6	Dictyostelium discoideum	32%	97%
Q58EB4	Danio rerio	38%	97%
Q5XF59	Arabidopsis thaliana	35%	93%
Q5XIE6	Rattus norvegicus	39%	96%
Q5ZJ60	Gallus gallus	39%	96%
Q6NMB0	Arabidopsis thaliana	38%	98%
Q6NVY1	Homo sapiens	39%	96%
Q8QZS1	Mus musculus	39%	96%
Q8RXN4	Arabidopsis thaliana	32%	91%
Q9LK08	Arabidopsis thaliana	30%	89%
Q9LKJ1	Arabidopsis thaliana	37%	98%
Q9SHJ8	Arabidopsis thaliana	33%	96%
Q9T0K7	Arabidopsis thaliana	31%	88%
V5BQZ7	Trypanosoma cruzi	42%	96%