GYF_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4Q2_LEIMA

TriTrypDb:

LmjF.32.3700 , LMJLV39_320044900 , LMJSD75_320045000

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Q2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Q2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.623
CLV_NRD_NRD_1	172	174	PF00675	0.553
CLV_NRD_NRD_1	250	252	PF00675	0.536
CLV_NRD_NRD_1	523	525	PF00675	0.498
CLV_NRD_NRD_1	527	529	PF00675	0.429
CLV_NRD_NRD_1	641	643	PF00675	0.582
CLV_NRD_NRD_1	712	714	PF00675	0.632
CLV_NRD_NRD_1	72	74	PF00675	0.713
CLV_PCSK_KEX2_1	172	174	PF00082	0.625
CLV_PCSK_KEX2_1	250	252	PF00082	0.573
CLV_PCSK_KEX2_1	527	529	PF00082	0.455
CLV_PCSK_SKI1_1	124	128	PF00082	0.638
CLV_PCSK_SKI1_1	165	169	PF00082	0.561
CLV_PCSK_SKI1_1	251	255	PF00082	0.466
CLV_PCSK_SKI1_1	290	294	PF00082	0.624
CLV_PCSK_SKI1_1	439	443	PF00082	0.677
CLV_PCSK_SKI1_1	503	507	PF00082	0.498
CLV_PCSK_SKI1_1	519	523	PF00082	0.440
CLV_PCSK_SKI1_1	527	531	PF00082	0.463
CLV_PCSK_SKI1_1	57	61	PF00082	0.628
CLV_PCSK_SKI1_1	599	603	PF00082	0.575
CLV_PCSK_SKI1_1	680	684	PF00082	0.600
CLV_PCSK_SKI1_1	699	703	PF00082	0.348
DEG_APCC_DBOX_1	25	33	PF00400	0.625
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DEG_SCF_FBW7_1	529	536	PF00400	0.620
DEG_SPOP_SBC_1	581	585	PF00917	0.650
DOC_AGCK_PIF_3	724	727	PF00069	0.675
DOC_CYCLIN_RxL_1	602	615	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	659	665	PF00134	0.559
DOC_MAPK_gen_1	38	45	PF00069	0.622
DOC_MAPK_gen_1	524	531	PF00069	0.465
DOC_MAPK_MEF2A_6	38	45	PF00069	0.643
DOC_MAPK_MEF2A_6	562	570	PF00069	0.741
DOC_PP1_RVXF_1	248	255	PF00149	0.465
DOC_PP1_RVXF_1	525	532	PF00149	0.446
DOC_PP1_RVXF_1	641	648	PF00149	0.669
DOC_PP4_FxxP_1	45	48	PF00568	0.691
DOC_USP7_MATH_1	236	240	PF00917	0.590
DOC_USP7_MATH_1	282	286	PF00917	0.663
DOC_USP7_MATH_1	326	330	PF00917	0.763
DOC_USP7_MATH_1	345	349	PF00917	0.797
DOC_USP7_MATH_1	465	469	PF00917	0.697
DOC_USP7_MATH_1	533	537	PF00917	0.669
DOC_USP7_MATH_1	58	62	PF00917	0.721
DOC_USP7_MATH_2	337	343	PF00917	0.726
DOC_USP7_UBL2_3	673	677	PF12436	0.563
DOC_USP7_UBL2_3	680	684	PF12436	0.494
DOC_WW_Pin1_4	27	32	PF00397	0.652
DOC_WW_Pin1_4	415	420	PF00397	0.611
DOC_WW_Pin1_4	44	49	PF00397	0.460
DOC_WW_Pin1_4	529	534	PF00397	0.563
DOC_WW_Pin1_4	577	582	PF00397	0.571
LIG_14-3-3_CanoR_1	16	25	PF00244	0.659
LIG_14-3-3_CanoR_1	688	696	PF00244	0.517
LIG_Actin_WH2_2	390	408	PF00022	0.621
LIG_BRCT_BRCA1_1	131	135	PF00533	0.704
LIG_EVH1_2	41	45	PF00568	0.693
LIG_FHA_1	121	127	PF00498	0.652
LIG_FHA_1	178	184	PF00498	0.444
LIG_FHA_1	535	541	PF00498	0.525
LIG_FHA_1	596	602	PF00498	0.554
LIG_FHA_2	432	438	PF00498	0.649
LIG_FHA_2	81	87	PF00498	0.728
LIG_Integrin_RGD_1	203	205	PF01839	0.659
LIG_LIR_Apic_2	44	48	PF02991	0.668
LIG_LIR_Apic_2	52	56	PF02991	0.748
LIG_LIR_Apic_2	635	641	PF02991	0.570
LIG_LIR_Gen_1	393	398	PF02991	0.519
LIG_LIR_Gen_1	445	455	PF02991	0.737
LIG_LIR_Gen_1	484	493	PF02991	0.543
LIG_LIR_Nem_3	393	397	PF02991	0.502
LIG_LIR_Nem_3	445	450	PF02991	0.736
LIG_LIR_Nem_3	721	727	PF02991	0.550
LIG_MYND_3	283	287	PF01753	0.697
LIG_PCNA_yPIPBox_3	361	370	PF02747	0.543
LIG_PDZ_Class_2	722	727	PF00595	0.661
LIG_Pex14_2	306	310	PF04695	0.713
LIG_SH2_CRK	365	369	PF00017	0.456
LIG_SH2_PTP2	142	145	PF00017	0.356
LIG_SH2_SRC	387	390	PF00017	0.498
LIG_SH2_STAP1	267	271	PF00017	0.547
LIG_SH2_STAP1	708	712	PF00017	0.543
LIG_SH2_STAT3	259	262	PF00017	0.552
LIG_SH2_STAT5	142	145	PF00017	0.557
LIG_SH2_STAT5	387	390	PF00017	0.467
LIG_SH2_STAT5	504	507	PF00017	0.475
LIG_SH2_STAT5	516	519	PF00017	0.514
LIG_SH3_3	116	122	PF00018	0.663
LIG_SH3_3	560	566	PF00018	0.777
LIG_SH3_3	575	581	PF00018	0.524
LIG_SH3_3	642	648	PF00018	0.668
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.610
LIG_SUMO_SIM_par_1	269	276	PF11976	0.609
LIG_SUMO_SIM_par_1	543	548	PF11976	0.546
LIG_SUMO_SIM_par_1	95	101	PF11976	0.502
LIG_TRAF2_1	285	288	PF00917	0.624
LIG_TRAF2_1	337	340	PF00917	0.728
LIG_TYR_ITIM	363	368	PF00017	0.602
MOD_CDK_SPK_2	415	420	PF00069	0.611
MOD_CK1_1	209	215	PF00069	0.741
MOD_CK1_1	329	335	PF00069	0.762
MOD_CK1_1	484	490	PF00069	0.600
MOD_CK1_1	580	586	PF00069	0.548
MOD_CK1_1	650	656	PF00069	0.555
MOD_CK1_1	68	74	PF00069	0.763
MOD_CK1_1	687	693	PF00069	0.636
MOD_CK1_1	75	81	PF00069	0.535
MOD_CK2_1	282	288	PF00069	0.628
MOD_CK2_1	431	437	PF00069	0.648
MOD_CK2_1	483	489	PF00069	0.540
MOD_CK2_1	80	86	PF00069	0.696
MOD_Cter_Amidation	525	528	PF01082	0.483
MOD_GlcNHglycan	110	113	PF01048	0.647
MOD_GlcNHglycan	18	21	PF01048	0.635
MOD_GlcNHglycan	187	190	PF01048	0.507
MOD_GlcNHglycan	192	195	PF01048	0.448
MOD_GlcNHglycan	238	241	PF01048	0.636
MOD_GlcNHglycan	259	262	PF01048	0.620
MOD_GlcNHglycan	320	323	PF01048	0.792
MOD_GlcNHglycan	347	350	PF01048	0.739
MOD_GlcNHglycan	371	374	PF01048	0.501
MOD_GlcNHglycan	389	392	PF01048	0.498
MOD_GlcNHglycan	74	77	PF01048	0.692
MOD_GSK3_1	108	115	PF00069	0.686
MOD_GSK3_1	205	212	PF00069	0.725
MOD_GSK3_1	236	243	PF00069	0.530
MOD_GSK3_1	426	433	PF00069	0.554
MOD_GSK3_1	529	536	PF00069	0.549
MOD_GSK3_1	577	584	PF00069	0.558
MOD_GSK3_1	64	71	PF00069	0.750
MOD_GSK3_1	98	105	PF00069	0.563
MOD_NEK2_1	129	134	PF00069	0.647
MOD_NEK2_1	185	190	PF00069	0.495
MOD_NEK2_1	483	488	PF00069	0.497
MOD_NEK2_1	534	539	PF00069	0.542
MOD_NEK2_1	582	587	PF00069	0.636
MOD_PIKK_1	102	108	PF00454	0.679
MOD_PIKK_1	241	247	PF00454	0.632
MOD_PIKK_1	326	332	PF00454	0.693
MOD_PKA_2	108	114	PF00069	0.683
MOD_PKA_2	129	135	PF00069	0.621
MOD_PKA_2	369	375	PF00069	0.477
MOD_PKA_2	687	693	PF00069	0.543
MOD_PKA_2	72	78	PF00069	0.707
MOD_Plk_1	97	103	PF00069	0.558
MOD_Plk_4	478	484	PF00069	0.544
MOD_Plk_4	582	588	PF00069	0.630
MOD_Plk_4	661	667	PF00069	0.565
MOD_Plk_4	720	726	PF00069	0.683
MOD_ProDKin_1	27	33	PF00069	0.648
MOD_ProDKin_1	415	421	PF00069	0.604
MOD_ProDKin_1	44	50	PF00069	0.459
MOD_ProDKin_1	529	535	PF00069	0.572
MOD_ProDKin_1	577	583	PF00069	0.565
MOD_SUMO_for_1	706	709	PF00179	0.535
MOD_SUMO_rev_2	436	441	PF00179	0.674
MOD_SUMO_rev_2	497	502	PF00179	0.560
MOD_SUMO_rev_2	592	601	PF00179	0.556
MOD_SUMO_rev_2	67	75	PF00179	0.668
TRG_DiLeu_BaEn_2	620	626	PF01217	0.771
TRG_DiLeu_LyEn_5	437	442	PF01217	0.706
TRG_ENDOCYTIC_2	142	145	PF00928	0.557
TRG_ENDOCYTIC_2	365	368	PF00928	0.455
TRG_ER_diArg_1	171	173	PF00400	0.610
TRG_ER_diArg_1	25	28	PF00400	0.584
TRG_ER_diArg_1	250	252	PF00400	0.573
TRG_ER_diArg_1	37	40	PF00400	0.594
TRG_ER_diArg_1	527	529	PF00400	0.455
TRG_NLS_MonoExtC_3	523	528	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P501	Leptomonas seymouri	63%	86%
A0A0S4JJK2	Bodo saltans	34%	89%
A0A1X0NRY5	Trypanosomatidae	41%	99%
A0A3S5H7T3	Leishmania donovani	95%	100%
A4HL07	Leishmania braziliensis	80%	100%
A4I8I8	Leishmania infantum	95%	100%
D0AAM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	98%
E9B3E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BLC8	Trypanosoma cruzi	40%	98%