BT1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

BT1 family protein

Gene product:

BT1 family, putative

Species:

Leishmania major

UniProt:

Q4Q4Q0_LEIMA

TriTrypDb:

LmjF.32.3720 , LMJLV39_320045100 , LMJSD75_320045200

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4Q4Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Q0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.674
CLV_NRD_NRD_1	191	193	PF00675	0.340
CLV_NRD_NRD_1	436	438	PF00675	0.242
CLV_NRD_NRD_1	445	447	PF00675	0.442
CLV_NRD_NRD_1	66	68	PF00675	0.306
CLV_PCSK_KEX2_1	191	193	PF00082	0.353
CLV_PCSK_KEX2_1	436	438	PF00082	0.242
CLV_PCSK_KEX2_1	445	447	PF00082	0.442
CLV_PCSK_KEX2_1	65	67	PF00082	0.319
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.313
CLV_PCSK_SKI1_1	169	173	PF00082	0.470
CLV_PCSK_SKI1_1	191	195	PF00082	0.367
CLV_PCSK_SKI1_1	207	211	PF00082	0.340
CLV_PCSK_SKI1_1	354	358	PF00082	0.404
CLV_PCSK_SKI1_1	67	71	PF00082	0.299
CLV_Separin_Metazoa	34	38	PF03568	0.178
DEG_APCC_DBOX_1	300	308	PF00400	0.440
DEG_APCC_DBOX_1	65	73	PF00400	0.499
DOC_CKS1_1	187	192	PF01111	0.427
DOC_CYCLIN_RxL_1	166	175	PF00134	0.191
DOC_CYCLIN_RxL_1	188	199	PF00134	0.438
DOC_CYCLIN_RxL_1	23	34	PF00134	0.240
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.193
DOC_MAPK_DCC_7	26	35	PF00069	0.240
DOC_MAPK_FxFP_2	259	262	PF00069	0.319
DOC_MAPK_gen_1	222	231	PF00069	0.448
DOC_MAPK_gen_1	445	452	PF00069	0.643
DOC_MAPK_gen_1	65	71	PF00069	0.507
DOC_MAPK_HePTP_8	351	363	PF00069	0.304
DOC_MAPK_MEF2A_6	225	233	PF00069	0.405
DOC_MAPK_MEF2A_6	297	306	PF00069	0.520
DOC_MAPK_MEF2A_6	354	363	PF00069	0.367
DOC_MAPK_MEF2A_6	411	420	PF00069	0.178
DOC_MAPK_RevD_3	178	192	PF00069	0.312
DOC_MAPK_RevD_3	422	437	PF00069	0.239
DOC_PP2B_LxvP_1	111	114	PF13499	0.354
DOC_PP2B_LxvP_1	334	337	PF13499	0.193
DOC_PP4_FxxP_1	259	262	PF00568	0.325
DOC_SPAK_OSR1_1	218	222	PF12202	0.479
DOC_USP7_MATH_1	130	134	PF00917	0.499
DOC_USP7_MATH_1	135	139	PF00917	0.486
DOC_USP7_MATH_1	245	249	PF00917	0.252
DOC_USP7_MATH_1	73	77	PF00917	0.255
DOC_USP7_MATH_1	90	94	PF00917	0.195
DOC_WW_Pin1_4	186	191	PF00397	0.430
DOC_WW_Pin1_4	457	462	PF00397	0.603
LIG_14-3-3_CanoR_1	196	204	PF00244	0.653
LIG_14-3-3_CanoR_1	301	305	PF00244	0.499
LIG_Actin_WH2_2	180	198	PF00022	0.416
LIG_APCC_ABBA_1	59	64	PF00400	0.483
LIG_BRCT_BRCA1_1	302	306	PF00533	0.499
LIG_eIF4E_1	319	325	PF01652	0.354
LIG_eIF4E_1	81	87	PF01652	0.304
LIG_FHA_1	1	7	PF00498	0.513
LIG_FHA_1	106	112	PF00498	0.365
LIG_FHA_1	158	164	PF00498	0.322
LIG_FHA_1	173	179	PF00498	0.162
LIG_FHA_1	319	325	PF00498	0.348
LIG_FHA_1	329	335	PF00498	0.282
LIG_FHA_1	347	353	PF00498	0.349
LIG_FHA_1	374	380	PF00498	0.481
LIG_FHA_2	127	133	PF00498	0.499
LIG_FHA_2	373	379	PF00498	0.499
LIG_FHA_2	403	409	PF00498	0.264
LIG_IRF3_LxIS_1	389	396	PF10401	0.304
LIG_LIR_Apic_2	45	50	PF02991	0.276
LIG_LIR_Gen_1	104	114	PF02991	0.346
LIG_LIR_Gen_1	249	259	PF02991	0.365
LIG_LIR_Gen_1	303	314	PF02991	0.464
LIG_LIR_Gen_1	345	356	PF02991	0.299
LIG_LIR_Gen_1	375	385	PF02991	0.499
LIG_LIR_Gen_1	407	417	PF02991	0.302
LIG_LIR_Gen_1	82	90	PF02991	0.368
LIG_LIR_Nem_3	248	254	PF02991	0.367
LIG_LIR_Nem_3	303	308	PF02991	0.517
LIG_LIR_Nem_3	345	351	PF02991	0.284
LIG_LIR_Nem_3	375	380	PF02991	0.508
LIG_LIR_Nem_3	407	412	PF02991	0.330
LIG_LIR_Nem_3	78	84	PF02991	0.360
LIG_LIR_Nem_3	91	97	PF02991	0.299
LIG_MLH1_MIPbox_1	302	306	PF16413	0.499
LIG_Pex14_1	315	319	PF04695	0.304
LIG_Pex14_2	261	265	PF04695	0.285
LIG_PTB_Apo_2	260	267	PF02174	0.362
LIG_PTB_Phospho_1	260	266	PF10480	0.350
LIG_SH2_CRK	252	256	PF00017	0.334
LIG_SH2_PTP2	112	115	PF00017	0.354
LIG_SH2_PTP2	341	344	PF00017	0.299
LIG_SH2_SRC	254	257	PF00017	0.339
LIG_SH2_SRC	341	344	PF00017	0.299
LIG_SH2_STAP1	252	256	PF00017	0.368
LIG_SH2_STAP1	409	413	PF00017	0.264
LIG_SH2_STAT5	112	115	PF00017	0.287
LIG_SH2_STAT5	254	257	PF00017	0.357
LIG_SH2_STAT5	282	285	PF00017	0.434
LIG_SH2_STAT5	319	322	PF00017	0.301
LIG_SH2_STAT5	341	344	PF00017	0.299
LIG_SH2_STAT5	41	44	PF00017	0.304
LIG_SH2_STAT5	81	84	PF00017	0.346
LIG_SH3_3	164	170	PF00018	0.214
LIG_SH3_3	178	184	PF00018	0.338
LIG_SUMO_SIM_par_1	183	189	PF11976	0.346
LIG_SUMO_SIM_par_1	414	419	PF11976	0.359
LIG_TRAF2_1	129	132	PF00917	0.499
LIG_TRAF2_1	292	295	PF00917	0.499
LIG_TRFH_1	84	88	PF08558	0.304
LIG_TYR_ITIM	250	255	PF00017	0.387
LIG_WRC_WIRS_1	344	349	PF05994	0.271
MOD_CDC14_SPxK_1	460	463	PF00782	0.480
MOD_CDK_SPK_2	186	191	PF00069	0.430
MOD_CDK_SPxK_1	186	192	PF00069	0.397
MOD_CDK_SPxK_1	457	463	PF00069	0.474
MOD_CK1_1	101	107	PF00069	0.354
MOD_CK1_1	149	155	PF00069	0.354
MOD_CK1_1	18	24	PF00069	0.397
MOD_CK1_1	381	387	PF00069	0.332
MOD_CK1_1	388	394	PF00069	0.353
MOD_CK2_1	126	132	PF00069	0.367
MOD_CK2_1	372	378	PF00069	0.354
MOD_CK2_1	394	400	PF00069	0.184
MOD_Cter_Amidation	443	446	PF01082	0.526
MOD_GlcNHglycan	137	140	PF01048	0.354
MOD_GlcNHglycan	148	151	PF01048	0.344
MOD_GlcNHglycan	390	393	PF01048	0.423
MOD_GlcNHglycan	437	440	PF01048	0.519
MOD_GSK3_1	101	108	PF00069	0.272
MOD_GSK3_1	126	133	PF00069	0.367
MOD_GSK3_1	135	142	PF00069	0.367
MOD_GSK3_1	14	21	PF00069	0.304
MOD_GSK3_1	196	203	PF00069	0.529
MOD_GSK3_1	246	253	PF00069	0.494
MOD_GSK3_1	324	331	PF00069	0.359
MOD_GSK3_1	343	350	PF00069	0.407
MOD_GSK3_1	381	388	PF00069	0.380
MOD_GSK3_1	75	82	PF00069	0.433
MOD_N-GLC_2	269	271	PF02516	0.354
MOD_NEK2_1	15	20	PF00069	0.324
MOD_NEK2_1	172	177	PF00069	0.258
MOD_NEK2_1	194	199	PF00069	0.515
MOD_NEK2_1	309	314	PF00069	0.299
MOD_NEK2_1	324	329	PF00069	0.427
MOD_NEK2_1	347	352	PF00069	0.392
MOD_NEK2_1	372	377	PF00069	0.415
MOD_NEK2_1	385	390	PF00069	0.366
MOD_NEK2_1	393	398	PF00069	0.342
MOD_NEK2_1	402	407	PF00069	0.361
MOD_NEK2_1	6	11	PF00069	0.319
MOD_NEK2_2	343	348	PF00069	0.337
MOD_PIKK_1	101	107	PF00454	0.354
MOD_PIKK_1	196	202	PF00454	0.424
MOD_PIKK_1	290	296	PF00454	0.271
MOD_PKA_2	135	141	PF00069	0.331
MOD_PKA_2	195	201	PF00069	0.584
MOD_PKA_2	290	296	PF00069	0.401
MOD_PKA_2	300	306	PF00069	0.312
MOD_PKA_2	435	441	PF00069	0.593
MOD_Plk_1	200	206	PF00069	0.420
MOD_Plk_1	245	251	PF00069	0.320
MOD_Plk_1	372	378	PF00069	0.295
MOD_Plk_1	407	413	PF00069	0.304
MOD_Plk_2-3	373	379	PF00069	0.312
MOD_Plk_4	141	147	PF00069	0.388
MOD_Plk_4	15	21	PF00069	0.333
MOD_Plk_4	246	252	PF00069	0.408
MOD_Plk_4	300	306	PF00069	0.365
MOD_Plk_4	343	349	PF00069	0.374
MOD_Plk_4	357	363	PF00069	0.347
MOD_Plk_4	385	391	PF00069	0.305
MOD_Plk_4	416	422	PF00069	0.354
MOD_Plk_4	42	48	PF00069	0.356
MOD_Plk_4	7	13	PF00069	0.313
MOD_Plk_4	75	81	PF00069	0.362
MOD_Plk_4	82	88	PF00069	0.388
MOD_Plk_4	98	104	PF00069	0.307
MOD_ProDKin_1	186	192	PF00069	0.440
MOD_ProDKin_1	457	463	PF00069	0.503
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.418
TRG_ENDOCYTIC_2	112	115	PF00928	0.357
TRG_ENDOCYTIC_2	241	244	PF00928	0.367
TRG_ENDOCYTIC_2	252	255	PF00928	0.421
TRG_ENDOCYTIC_2	256	259	PF00928	0.445
TRG_ENDOCYTIC_2	341	344	PF00928	0.366
TRG_ENDOCYTIC_2	409	412	PF00928	0.354
TRG_ENDOCYTIC_2	84	87	PF00928	0.443
TRG_ER_diArg_1	190	192	PF00400	0.499
TRG_ER_diArg_1	66	68	PF00400	0.362
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	24%	86%
A0A0N1I3H1	Leptomonas seymouri	66%	69%
A0A3Q8IF44	Leishmania donovani	25%	87%
A0A3Q8ILR5	Leishmania donovani	88%	100%
A4HIW8	Leishmania braziliensis	25%	81%
A4HL09	Leishmania braziliensis	77%	100%
A4I8J0	Leishmania infantum	88%	100%
E9AHK6	Leishmania infantum	25%	87%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F4KIL8	Arabidopsis thaliana	21%	97%
Q4Q6R0	Leishmania major	26%	100%
Q55721	Synechocystis sp. (strain PCC 6803 / Kazusa)	21%	96%
Q9SKZ5	Arabidopsis thaliana	23%	85%
Q9SQN2	Arabidopsis thaliana	21%	96%