Transmembrane protein 18

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 18, putative

Species:

Leishmania major

UniProt:

Q4Q4P9_LEIMA

TriTrypDb:

LmjF.32.3730 , LMJLV39_320045200 , LMJSD75_320045300

Length:

205

Annotations

LeishMANIAdb annotations

Part of the eukaryotic TMEM18 family, consisting of conserved 3TM nuclear membrane proteins.. Localization: Perinuclear (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	2
GO:0031965	nuclear membrane	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q4P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.476
CLV_NRD_NRD_1	178	180	PF00675	0.299
CLV_NRD_NRD_1	185	187	PF00675	0.414
CLV_PCSK_FUR_1	170	174	PF00082	0.325
CLV_PCSK_KEX2_1	172	174	PF00082	0.285
CLV_PCSK_KEX2_1	177	179	PF00082	0.279
CLV_PCSK_KEX2_1	185	187	PF00082	0.393
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.290
CLV_PCSK_PC7_1	173	179	PF00082	0.331
CLV_PCSK_PC7_1	181	187	PF00082	0.450
CLV_PCSK_SKI1_1	32	36	PF00082	0.595
DOC_MAPK_MEF2A_6	163	171	PF00069	0.531
DOC_PP4_FxxP_1	126	129	PF00568	0.361
DOC_USP7_MATH_1	113	117	PF00917	0.391
DOC_USP7_MATH_1	38	42	PF00917	0.491
LIG_14-3-3_CanoR_1	163	168	PF00244	0.600
LIG_Actin_WH2_2	144	161	PF00022	0.483
LIG_Actin_WH2_2	41	56	PF00022	0.445
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BRCT_BRCA1_1	65	69	PF00533	0.308
LIG_CaM_NSCaTE_8	81	88	PF13499	0.444
LIG_deltaCOP1_diTrp_1	123	126	PF00928	0.308
LIG_EH1_1	161	169	PF00400	0.592
LIG_eIF4E_1	145	151	PF01652	0.447
LIG_eIF4E_1	162	168	PF01652	0.383
LIG_LIR_Apic_2	123	129	PF02991	0.361
LIG_LIR_Nem_3	55	60	PF02991	0.380
LIG_LIR_Nem_3	66	72	PF02991	0.266
LIG_LIR_Nem_3	86	92	PF02991	0.155
LIG_NRBOX	103	109	PF00104	0.371
LIG_Pex14_1	65	69	PF04695	0.290
LIG_REV1ctd_RIR_1	67	75	PF16727	0.361
LIG_SH2_CRK	162	166	PF00017	0.591
LIG_SH2_CRK	60	64	PF00017	0.348
LIG_SH2_NCK_1	60	64	PF00017	0.391
LIG_SH2_PTP2	72	75	PF00017	0.252
LIG_SH2_STAT5	133	136	PF00017	0.331
LIG_SH2_STAT5	145	148	PF00017	0.344
LIG_SH2_STAT5	155	158	PF00017	0.484
LIG_SH2_STAT5	60	63	PF00017	0.320
LIG_SH2_STAT5	72	75	PF00017	0.316
LIG_SUMO_SIM_anti_2	139	145	PF11976	0.252
LIG_SUMO_SIM_par_1	105	110	PF11976	0.485
LIG_TRAF2_1	6	9	PF00917	0.412
LIG_TYR_ITIM	153	158	PF00017	0.408
LIG_UBA3_1	167	172	PF00899	0.517
MOD_CK1_1	41	47	PF00069	0.475
MOD_CK2_1	3	9	PF00069	0.470
MOD_CK2_1	44	50	PF00069	0.438
MOD_GlcNHglycan	109	112	PF01048	0.498
MOD_GlcNHglycan	12	15	PF01048	0.486
MOD_GSK3_1	132	139	PF00069	0.383
MOD_N-GLC_1	63	68	PF02516	0.508
MOD_NEK2_1	107	112	PF00069	0.441
MOD_NEK2_1	26	31	PF00069	0.404
MOD_NEK2_1	3	8	PF00069	0.427
MOD_PKA_1	185	191	PF00069	0.685
MOD_PKA_2	185	191	PF00069	0.707
MOD_Plk_4	136	142	PF00069	0.363
MOD_Plk_4	163	169	PF00069	0.591
MOD_SUMO_rev_2	195	204	PF00179	0.764
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.468
TRG_ENDOCYTIC_2	155	158	PF00928	0.494
TRG_ENDOCYTIC_2	162	165	PF00928	0.473
TRG_ENDOCYTIC_2	60	63	PF00928	0.310
TRG_ENDOCYTIC_2	72	75	PF00928	0.278
TRG_ER_diArg_1	176	179	PF00400	0.532
TRG_ER_diLys_1	202	205	PF00400	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIZ0	Leptomonas seymouri	48%	100%
A0A1X0NRY6	Trypanosomatidae	43%	100%
A0A3R7KYB3	Trypanosoma rangeli	38%	100%
A0A3S7X686	Leishmania donovani	94%	100%
A4HL10	Leishmania braziliensis	77%	100%
A4I8J1	Leishmania infantum	94%	100%
D0AAM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%