Transmembrane protein 186

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4P8_LEIMA

TriTrypDb:

LmjF.32.3740 , LMJLV39_320045300 , LMJSD75_320045400

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.439
CLV_PCSK_KEX2_1	128	130	PF00082	0.517
DOC_CKS1_1	79	84	PF01111	0.565
DOC_MAPK_gen_1	17	26	PF00069	0.464
DOC_MAPK_gen_1	61	69	PF00069	0.565
DOC_PP2B_LxvP_1	67	70	PF13499	0.678
DOC_WW_Pin1_4	54	59	PF00397	0.585
DOC_WW_Pin1_4	75	80	PF00397	0.581
LIG_14-3-3_CanoR_1	110	118	PF00244	0.644
LIG_14-3-3_CanoR_1	137	142	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BRCT_BRCA1_1	139	143	PF00533	0.570
LIG_CSL_BTD_1	79	82	PF09270	0.558
LIG_DLG_GKlike_1	137	145	PF00625	0.574
LIG_FHA_1	110	116	PF00498	0.557
LIG_Integrin_isoDGR_2	104	106	PF01839	0.623
LIG_LIR_Gen_1	2	11	PF02991	0.509
LIG_LIR_Gen_1	38	46	PF02991	0.623
LIG_LIR_Gen_1	96	107	PF02991	0.510
LIG_LIR_Nem_3	15	21	PF02991	0.424
LIG_LIR_Nem_3	2	7	PF02991	0.518
LIG_LIR_Nem_3	38	44	PF02991	0.593
LIG_LIR_Nem_3	55	59	PF02991	0.585
LIG_LIR_Nem_3	96	102	PF02991	0.515
LIG_Pex14_1	32	36	PF04695	0.413
LIG_PTB_Apo_2	101	108	PF02174	0.600
LIG_PTB_Apo_2	68	75	PF02174	0.607
LIG_PTB_Phospho_1	68	74	PF10480	0.603
LIG_SH2_CRK	21	25	PF00017	0.500
LIG_SH2_GRB2like	74	77	PF00017	0.699
LIG_SH2_STAT5	36	39	PF00017	0.523
LIG_SH2_STAT5	52	55	PF00017	0.382
LIG_SH2_STAT5	74	77	PF00017	0.621
LIG_SH2_STAT5	99	102	PF00017	0.615
LIG_SH3_3	76	82	PF00018	0.567
LIG_SH3_4	61	68	PF00018	0.681
LIG_TRAF2_1	120	123	PF00917	0.556
LIG_WRC_WIRS_1	7	12	PF05994	0.590
MOD_CDK_SPK_2	78	83	PF00069	0.577
MOD_CDK_SPxxK_3	54	61	PF00069	0.584
MOD_CK1_1	3	9	PF00069	0.479
MOD_CK1_1	78	84	PF00069	0.597
MOD_CK2_1	124	130	PF00069	0.579
MOD_GSK3_1	109	116	PF00069	0.657
MOD_GSK3_1	137	144	PF00069	0.615
MOD_GSK3_1	6	13	PF00069	0.549
MOD_N-GLC_1	75	80	PF02516	0.600
MOD_NEK2_1	10	15	PF00069	0.540
MOD_PIKK_1	122	128	PF00454	0.428
MOD_PKA_2	109	115	PF00069	0.572
MOD_PKB_1	135	143	PF00069	0.527
MOD_Plk_4	113	119	PF00069	0.684
MOD_Plk_4	137	143	PF00069	0.567
MOD_Plk_4	6	12	PF00069	0.505
MOD_ProDKin_1	54	60	PF00069	0.584
MOD_ProDKin_1	75	81	PF00069	0.577
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.558
TRG_ENDOCYTIC_2	21	24	PF00928	0.458
TRG_ENDOCYTIC_2	41	44	PF00928	0.549
TRG_ENDOCYTIC_2	99	102	PF00928	0.615
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W3	Leptomonas seymouri	80%	100%
A0A1X0NRY2	Trypanosomatidae	68%	100%
A0A3Q8IGB2	Leishmania donovani	93%	100%
A0A3R7N368	Trypanosoma rangeli	58%	100%
A4HL11	Leishmania braziliensis	83%	100%
A4I8J2	Leishmania infantum	93%	100%
D0AAM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9B3F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DME5	Trypanosoma cruzi	64%	100%