Putative enolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative enolase

Gene product:

enolase, putative

Species:

Leishmania major

UniProt:

Q4Q4P6_LEIMA

TriTrypDb:

LmjF.32.3760 , LMJLV39_320045500 , LMJSD75_320045600

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0000015	phosphopyruvate hydratase complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

Q4Q4P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0006082	organic acid metabolic process	3	3
GO:0006090	pyruvate metabolic process	7	3
GO:0006091	generation of precursor metabolites and energy	3	3
GO:0006096	glycolytic process	5	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006753	nucleoside phosphate metabolic process	4	3
GO:0006757	obsolete ATP generation from ADP	4	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009117	nucleotide metabolic process	5	3
GO:0009132	nucleoside diphosphate metabolic process	5	3
GO:0009135	purine nucleoside diphosphate metabolic process	6	3
GO:0009141	nucleoside triphosphate metabolic process	5	3
GO:0009144	purine nucleoside triphosphate metabolic process	6	3
GO:0009150	purine ribonucleotide metabolic process	6	3
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	3
GO:0009185	ribonucleoside diphosphate metabolic process	6	3
GO:0009199	ribonucleoside triphosphate metabolic process	6	3
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	3
GO:0009259	ribonucleotide metabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0016310	phosphorylation	5	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019693	ribose phosphate metabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0046031	ADP metabolic process	7	3
GO:0046034	ATP metabolic process	7	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046939	obsolete nucleotide phosphorylation	6	3
GO:0055086	nucleobase-containing small molecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0072521	purine-containing compound metabolic process	4	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004634	phosphopyruvate hydratase activity	5	8
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0000287	magnesium ion binding	5	3
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.661
CLV_NRD_NRD_1	195	197	PF00675	0.529
CLV_NRD_NRD_1	297	299	PF00675	0.382
CLV_NRD_NRD_1	501	503	PF00675	0.529
CLV_NRD_NRD_1	590	592	PF00675	0.530
CLV_NRD_NRD_1	606	608	PF00675	0.654
CLV_PCSK_KEX2_1	195	197	PF00082	0.606
CLV_PCSK_KEX2_1	297	299	PF00082	0.420
CLV_PCSK_KEX2_1	501	503	PF00082	0.512
CLV_PCSK_KEX2_1	590	592	PF00082	0.510
CLV_PCSK_KEX2_1	606	608	PF00082	0.617
CLV_PCSK_SKI1_1	149	153	PF00082	0.363
CLV_PCSK_SKI1_1	332	336	PF00082	0.440
CLV_PCSK_SKI1_1	36	40	PF00082	0.497
CLV_PCSK_SKI1_1	502	506	PF00082	0.538
CLV_PCSK_SKI1_1	550	554	PF00082	0.355
DEG_SIAH_1	581	589	PF03145	0.496
DEG_SPOP_SBC_1	151	155	PF00917	0.418
DEG_SPOP_SBC_1	267	271	PF00917	0.394
DEG_SPOP_SBC_1	308	312	PF00917	0.511
DOC_CYCLIN_RxL_1	128	139	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.525
DOC_MAPK_DCC_7	229	238	PF00069	0.482
DOC_MAPK_gen_1	430	437	PF00069	0.478
DOC_MAPK_gen_1	501	508	PF00069	0.467
DOC_MAPK_MEF2A_6	229	238	PF00069	0.482
DOC_MAPK_MEF2A_6	257	265	PF00069	0.470
DOC_MAPK_MEF2A_6	501	508	PF00069	0.467
DOC_USP7_MATH_1	100	104	PF00917	0.620
DOC_USP7_MATH_1	127	131	PF00917	0.489
DOC_USP7_MATH_1	244	248	PF00917	0.628
DOC_USP7_MATH_1	252	256	PF00917	0.452
DOC_USP7_MATH_1	26	30	PF00917	0.494
DOC_USP7_MATH_1	308	312	PF00917	0.506
DOC_USP7_MATH_1	546	550	PF00917	0.475
DOC_USP7_MATH_1	566	570	PF00917	0.478
DOC_USP7_MATH_1	79	83	PF00917	0.452
DOC_USP7_UBL2_3	404	408	PF12436	0.426
DOC_USP7_UBL2_3	592	596	PF12436	0.579
DOC_USP7_UBL2_3	598	602	PF12436	0.603
DOC_WW_Pin1_4	152	157	PF00397	0.502
DOC_WW_Pin1_4	205	210	PF00397	0.566
DOC_WW_Pin1_4	459	464	PF00397	0.548
DOC_WW_Pin1_4	476	481	PF00397	0.237
LIG_14-3-3_CanoR_1	101	105	PF00244	0.560
LIG_14-3-3_CanoR_1	149	157	PF00244	0.503
LIG_14-3-3_CanoR_1	203	209	PF00244	0.718
LIG_14-3-3_CanoR_1	229	234	PF00244	0.390
LIG_14-3-3_CanoR_1	243	253	PF00244	0.404
LIG_14-3-3_CanoR_1	25	35	PF00244	0.520
LIG_14-3-3_CanoR_1	257	265	PF00244	0.403
LIG_14-3-3_CanoR_1	302	308	PF00244	0.469
LIG_14-3-3_CanoR_1	381	387	PF00244	0.386
LIG_14-3-3_CanoR_1	501	507	PF00244	0.459
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_4	112	116	PF00653	0.514
LIG_BIR_III_4	274	278	PF00653	0.572
LIG_BIR_III_4	375	379	PF00653	0.496
LIG_BRCT_BRCA1_1	254	258	PF00533	0.320
LIG_BRCT_BRCA1_1	39	43	PF00533	0.453
LIG_CaM_NSCaTE_8	144	151	PF13499	0.430
LIG_eIF4E_1	231	237	PF01652	0.434
LIG_EVH1_1	578	582	PF00568	0.531
LIG_FHA_1	152	158	PF00498	0.516
LIG_FHA_1	159	165	PF00498	0.459
LIG_FHA_1	237	243	PF00498	0.403
LIG_FHA_1	267	273	PF00498	0.527
LIG_FHA_1	326	332	PF00498	0.403
LIG_FHA_1	333	339	PF00498	0.423
LIG_FHA_1	357	363	PF00498	0.501
LIG_FHA_1	503	509	PF00498	0.383
LIG_FHA_1	553	559	PF00498	0.538
LIG_FHA_1	581	587	PF00498	0.538
LIG_FHA_1	70	76	PF00498	0.406
LIG_FHA_1	83	89	PF00498	0.435
LIG_FHA_2	109	115	PF00498	0.588
LIG_FHA_2	483	489	PF00498	0.355
LIG_FHA_2	494	500	PF00498	0.464
LIG_FHA_2	551	557	PF00498	0.299
LIG_FHA_2	82	88	PF00498	0.509
LIG_LIR_Apic_2	230	234	PF02991	0.324
LIG_LIR_Gen_1	117	126	PF02991	0.391
LIG_LIR_Gen_1	255	265	PF02991	0.382
LIG_LIR_Gen_1	531	540	PF02991	0.425
LIG_LIR_LC3C_4	173	176	PF02991	0.238
LIG_LIR_Nem_3	117	121	PF02991	0.501
LIG_LIR_Nem_3	255	261	PF02991	0.464
LIG_LIR_Nem_3	37	42	PF02991	0.540
LIG_LIR_Nem_3	4	10	PF02991	0.453
LIG_LIR_Nem_3	531	535	PF02991	0.501
LIG_LIR_Nem_3	577	581	PF02991	0.549
LIG_MLH1_MIPbox_1	39	43	PF16413	0.453
LIG_Pex14_2	39	43	PF04695	0.541
LIG_REV1ctd_RIR_1	36	45	PF16727	0.509
LIG_SH2_CRK	118	122	PF00017	0.483
LIG_SH2_CRK	231	235	PF00017	0.399
LIG_SH2_NCK_1	118	122	PF00017	0.483
LIG_SH2_NCK_1	137	141	PF00017	0.242
LIG_SH2_NCK_1	231	235	PF00017	0.336
LIG_SH2_PTP2	262	265	PF00017	0.426
LIG_SH2_PTP2	532	535	PF00017	0.339
LIG_SH2_SRC	137	140	PF00017	0.371
LIG_SH2_STAP1	10	14	PF00017	0.563
LIG_SH2_STAT5	187	190	PF00017	0.363
LIG_SH2_STAT5	262	265	PF00017	0.426
LIG_SH2_STAT5	402	405	PF00017	0.394
LIG_SH2_STAT5	42	45	PF00017	0.452
LIG_SH2_STAT5	492	495	PF00017	0.331
LIG_SH2_STAT5	532	535	PF00017	0.424
LIG_SH3_1	576	582	PF00018	0.578
LIG_SH3_3	474	480	PF00018	0.438
LIG_SH3_3	576	582	PF00018	0.494
LIG_SUMO_SIM_par_1	504	510	PF11976	0.453
LIG_TRAF2_2	465	470	PF00917	0.456
LIG_UBA3_1	170	178	PF00899	0.432
LIG_WRC_WIRS_1	237	242	PF05994	0.476
LIG_WW_2	579	582	PF00397	0.594
MOD_CDK_SPxK_1	205	211	PF00069	0.565
MOD_CK1_1	215	221	PF00069	0.649
MOD_CK1_1	224	230	PF00069	0.477
MOD_CK1_1	3	9	PF00069	0.557
MOD_CK1_1	306	312	PF00069	0.541
MOD_CK1_1	455	461	PF00069	0.682
MOD_CK1_1	476	482	PF00069	0.304
MOD_CK1_1	541	547	PF00069	0.425
MOD_CK1_1	82	88	PF00069	0.443
MOD_CK2_1	108	114	PF00069	0.671
MOD_CK2_1	273	279	PF00069	0.553
MOD_GlcNHglycan	118	121	PF01048	0.344
MOD_GlcNHglycan	145	148	PF01048	0.511
MOD_GlcNHglycan	16	19	PF01048	0.420
MOD_GlcNHglycan	161	164	PF01048	0.337
MOD_GlcNHglycan	196	199	PF01048	0.544
MOD_GlcNHglycan	214	217	PF01048	0.651
MOD_GlcNHglycan	225	229	PF01048	0.462
MOD_GlcNHglycan	274	278	PF01048	0.475
MOD_GlcNHglycan	28	31	PF01048	0.492
MOD_GlcNHglycan	284	287	PF01048	0.468
MOD_GlcNHglycan	338	341	PF01048	0.541
MOD_GlcNHglycan	454	457	PF01048	0.607
MOD_GlcNHglycan	535	538	PF01048	0.491
MOD_GlcNHglycan	540	543	PF01048	0.423
MOD_GlcNHglycan	568	571	PF01048	0.505
MOD_GlcNHglycan	61	64	PF01048	0.539
MOD_GlcNHglycan	90	93	PF01048	0.485
MOD_GSK3_1	100	107	PF00069	0.651
MOD_GSK3_1	116	123	PF00069	0.519
MOD_GSK3_1	14	21	PF00069	0.427
MOD_GSK3_1	166	173	PF00069	0.337
MOD_GSK3_1	205	212	PF00069	0.761
MOD_GSK3_1	223	230	PF00069	0.456
MOD_GSK3_1	252	259	PF00069	0.506
MOD_GSK3_1	26	33	PF00069	0.450
MOD_GSK3_1	278	285	PF00069	0.405
MOD_GSK3_1	303	310	PF00069	0.482
MOD_GSK3_1	332	339	PF00069	0.557
MOD_GSK3_1	351	358	PF00069	0.276
MOD_GSK3_1	437	444	PF00069	0.459
MOD_GSK3_1	455	462	PF00069	0.629
MOD_GSK3_1	493	500	PF00069	0.525
MOD_GSK3_1	502	509	PF00069	0.429
MOD_GSK3_1	546	553	PF00069	0.466
MOD_N-GLC_1	158	163	PF02516	0.468
MOD_N-GLC_1	325	330	PF02516	0.394
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	14	19	PF00069	0.371
MOD_NEK2_1	236	241	PF00069	0.335
MOD_NEK2_1	268	273	PF00069	0.467
MOD_NEK2_1	303	308	PF00069	0.528
MOD_NEK2_1	351	356	PF00069	0.520
MOD_NEK2_1	418	423	PF00069	0.450
MOD_NEK2_1	437	442	PF00069	0.289
MOD_NEK2_1	507	512	PF00069	0.564
MOD_NEK2_2	252	257	PF00069	0.357
MOD_NEK2_2	48	53	PF00069	0.485
MOD_PK_1	229	235	PF00069	0.380
MOD_PKA_2	100	106	PF00069	0.554
MOD_PKA_2	194	200	PF00069	0.582
MOD_PKA_2	256	262	PF00069	0.522
MOD_PKA_2	566	572	PF00069	0.522
MOD_Plk_1	278	284	PF00069	0.411
MOD_Plk_1	418	424	PF00069	0.408
MOD_Plk_1	556	562	PF00069	0.539
MOD_Plk_1	79	85	PF00069	0.481
MOD_Plk_2-3	108	114	PF00069	0.659
MOD_Plk_2-3	482	488	PF00069	0.447
MOD_Plk_4	166	172	PF00069	0.345
MOD_Plk_4	236	242	PF00069	0.534
MOD_Plk_4	382	388	PF00069	0.482
MOD_Plk_4	437	443	PF00069	0.516
MOD_Plk_4	473	479	PF00069	0.432
MOD_Plk_4	502	508	PF00069	0.495
MOD_Plk_4	528	534	PF00069	0.446
MOD_ProDKin_1	152	158	PF00069	0.510
MOD_ProDKin_1	205	211	PF00069	0.565
MOD_ProDKin_1	459	465	PF00069	0.541
MOD_ProDKin_1	476	482	PF00069	0.244
MOD_SUMO_rev_2	29	38	PF00179	0.511
TRG_ENDOCYTIC_2	118	121	PF00928	0.573
TRG_ENDOCYTIC_2	262	265	PF00928	0.426
TRG_ENDOCYTIC_2	384	387	PF00928	0.365
TRG_ENDOCYTIC_2	532	535	PF00928	0.524
TRG_ER_diArg_1	289	292	PF00400	0.441
TRG_ER_diArg_1	296	298	PF00400	0.448
TRG_ER_diArg_1	430	433	PF00400	0.386
TRG_ER_diArg_1	589	591	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A1	Leptomonas seymouri	39%	94%
A0A1X0NS02	Trypanosomatidae	26%	100%
A0A3Q8IJR5	Leishmania donovani	88%	100%
A4HL13	Leishmania braziliensis	71%	100%
A4I8J4	Leishmania infantum	89%	100%
D0AAM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B3F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DME2	Trypanosoma cruzi	26%	100%