Putative kinetoplast-associated protein p18-2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein p18-2, putative

Species:

Leishmania major

UniProt:

Q4Q4P5_LEIMA

TriTrypDb:

LmjF.32.3770 , LMJLV39_320045600 , LMJSD75_320045700

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.657
CLV_NRD_NRD_1	41	43	PF00675	0.558
CLV_NRD_NRD_1	54	56	PF00675	0.481
CLV_NRD_NRD_1	76	78	PF00675	0.508
CLV_NRD_NRD_1	98	100	PF00675	0.505
CLV_PCSK_KEX2_1	3	5	PF00082	0.657
CLV_PCSK_KEX2_1	54	56	PF00082	0.532
CLV_PCSK_KEX2_1	72	74	PF00082	0.375
CLV_PCSK_KEX2_1	76	78	PF00082	0.518
CLV_PCSK_KEX2_1	85	87	PF00082	0.367
CLV_PCSK_KEX2_1	98	100	PF00082	0.444
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.558
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.380
CLV_PCSK_SKI1_1	125	129	PF00082	0.665
CLV_PCSK_SKI1_1	28	32	PF00082	0.593
CLV_PCSK_SKI1_1	49	53	PF00082	0.613
CLV_PCSK_SKI1_1	54	58	PF00082	0.566
CLV_PCSK_SKI1_1	6	10	PF00082	0.463
CLV_PCSK_SKI1_1	69	73	PF00082	0.293
CLV_Separin_Metazoa	7	11	PF03568	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.739
DOC_CYCLIN_RxL_1	3	12	PF00134	0.411
DOC_MAPK_gen_1	3	11	PF00069	0.544
DOC_MAPK_gen_1	72	83	PF00069	0.546
DOC_USP7_MATH_1	127	131	PF00917	0.529
DOC_USP7_MATH_1	47	51	PF00917	0.509
DOC_USP7_UBL2_3	113	117	PF12436	0.704
DOC_USP7_UBL2_3	121	125	PF12436	0.598
DOC_USP7_UBL2_3	128	132	PF12436	0.591
DOC_USP7_UBL2_3	39	43	PF12436	0.466
DOC_WW_Pin1_4	42	47	PF00397	0.626
DOC_WW_Pin1_4	9	14	PF00397	0.597
LIG_Actin_WH2_2	14	30	PF00022	0.474
LIG_CaM_IQ_9	15	30	PF13499	0.475
LIG_FHA_1	104	110	PF00498	0.643
LIG_FHA_1	58	64	PF00498	0.537
LIG_LIR_Gen_1	12	22	PF02991	0.516
LIG_LIR_Gen_1	65	75	PF02991	0.524
LIG_LIR_Nem_3	12	17	PF02991	0.577
LIG_SH2_CRK	41	45	PF00017	0.517
LIG_TRAF2_1	62	65	PF00917	0.504
MOD_CDK_SPxxK_3	42	49	PF00069	0.626
MOD_CK1_1	100	106	PF00069	0.611
MOD_CK2_1	42	48	PF00069	0.630
MOD_Cter_Amidation	122	125	PF01082	0.626
MOD_GlcNHglycan	110	113	PF01048	0.723
MOD_GlcNHglycan	129	132	PF01048	0.541
MOD_GlcNHglycan	48	52	PF01048	0.496
MOD_GSK3_1	103	110	PF00069	0.566
MOD_GSK3_1	93	100	PF00069	0.589
MOD_N-GLC_2	32	34	PF02516	0.510
MOD_NEK2_1	97	102	PF00069	0.692
MOD_PKA_2	2	8	PF00069	0.645
MOD_PKA_2	97	103	PF00069	0.570
MOD_Plk_1	47	53	PF00069	0.534
MOD_Plk_1	57	63	PF00069	0.495
MOD_ProDKin_1	42	48	PF00069	0.627
MOD_ProDKin_1	9	15	PF00069	0.597
MOD_SUMO_for_1	71	74	PF00179	0.454
TRG_ENDOCYTIC_2	41	44	PF00928	0.615
TRG_ENDOCYTIC_2	67	70	PF00928	0.600
TRG_ER_diArg_1	2	4	PF00400	0.671
TRG_ER_diArg_1	75	77	PF00400	0.529
TRG_ER_diArg_1	97	99	PF00400	0.449
TRG_NES_CRM1_1	74	87	PF08389	0.414
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIB3	Leptomonas seymouri	33%	100%
A0A1X0NSD7	Trypanosomatidae	33%	73%
A0A3Q8IGK7	Leishmania donovani	87%	100%
A0A3Q8ITR1	Leishmania donovani	37%	97%
A0A422P329	Trypanosoma rangeli	35%	69%
A4HL14	Leishmania braziliensis	57%	100%
A4HL15	Leishmania braziliensis	40%	92%
A4I8J5	Leishmania infantum	87%	100%
A4I8J6	Leishmania infantum	37%	97%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4Q4P4	Leishmania major	40%	100%
Q8IS98	Crithidia fasciculata	41%	99%
Q9TY83	Crithidia fasciculata	45%	100%
Q9TY84	Crithidia fasciculata	45%	100%