Putative kinetoplast DNA-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein 3, putative

Species:

Leishmania major

UniProt:

Q4Q4P4_LEIMA

TriTrypDb:

LmjF.32.3780 , LMJLV39_320045700 , LMJSD75_320045800

Length:

136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.720
CLV_NRD_NRD_1	113	115	PF00675	0.714
CLV_NRD_NRD_1	3	5	PF00675	0.577
CLV_NRD_NRD_1	48	50	PF00675	0.501
CLV_NRD_NRD_1	57	59	PF00675	0.458
CLV_NRD_NRD_1	87	89	PF00675	0.500
CLV_NRD_NRD_1	9	11	PF00675	0.408
CLV_PCSK_FUR_1	55	59	PF00082	0.470
CLV_PCSK_KEX2_1	110	112	PF00082	0.672
CLV_PCSK_KEX2_1	3	5	PF00082	0.577
CLV_PCSK_KEX2_1	57	59	PF00082	0.447
CLV_PCSK_KEX2_1	9	11	PF00082	0.408
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.600
CLV_PCSK_SKI1_1	107	111	PF00082	0.626
CLV_PCSK_SKI1_1	115	119	PF00082	0.580
CLV_PCSK_SKI1_1	128	132	PF00082	0.525
CLV_PCSK_SKI1_1	28	32	PF00082	0.534
CLV_PCSK_SKI1_1	4	8	PF00082	0.552
CLV_PCSK_SKI1_1	49	53	PF00082	0.489
CLV_PCSK_SKI1_1	57	61	PF00082	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.607
DOC_CKS1_1	44	49	PF01111	0.505
DOC_MAPK_gen_1	98	105	PF00069	0.503
DOC_MAPK_MEF2A_6	118	126	PF00069	0.513
DOC_PP2B_LxvP_1	79	82	PF13499	0.460
DOC_USP7_MATH_1	122	126	PF00917	0.611
DOC_USP7_MATH_1	34	38	PF00917	0.375
DOC_USP7_UBL2_3	115	119	PF12436	0.606
DOC_USP7_UBL2_3	128	132	PF12436	0.527
DOC_USP7_UBL2_3	31	35	PF12436	0.413
DOC_WW_Pin1_4	43	48	PF00397	0.572
DOC_WW_Pin1_4	9	14	PF00397	0.461
LIG_14-3-3_CanoR_1	123	127	PF00244	0.650
LIG_14-3-3_CanoR_1	3	9	PF00244	0.661
LIG_14-3-3_CanoR_1	57	62	PF00244	0.490
LIG_Actin_WH2_2	14	30	PF00022	0.408
LIG_FHA_1	100	106	PF00498	0.574
LIG_FHA_1	22	28	PF00498	0.603
LIG_HP1_1	122	126	PF01393	0.515
LIG_LIR_Gen_1	12	21	PF02991	0.454
LIG_LIR_Gen_1	65	75	PF02991	0.470
LIG_LIR_Nem_3	12	17	PF02991	0.449
LIG_LIR_Nem_3	60	64	PF02991	0.512
LIG_LIR_Nem_3	65	70	PF02991	0.468
LIG_LYPXL_yS_3	61	64	PF13949	0.510
LIG_PCNA_PIPBox_1	87	96	PF02747	0.440
LIG_PCNA_yPIPBox_3	84	94	PF02747	0.484
LIG_SH2_CRK	41	45	PF00017	0.624
LIG_SH3_3	100	106	PF00018	0.574
LIG_SH3_3	56	62	PF00018	0.611
LIG_TYR_ITIM	59	64	PF00017	0.506
MOD_CDK_SPxK_1	43	49	PF00069	0.556
MOD_CDK_SPxxK_3	43	50	PF00069	0.521
MOD_CK1_1	12	18	PF00069	0.450
MOD_CK1_1	42	48	PF00069	0.534
MOD_CK2_1	42	48	PF00069	0.514
MOD_GlcNHglycan	133	136	PF01048	0.603
MOD_GlcNHglycan	36	39	PF01048	0.495
MOD_GSK3_1	122	129	PF00069	0.610
MOD_GSK3_1	39	46	PF00069	0.435
MOD_N-GLC_1	99	104	PF02516	0.505
MOD_NEK2_1	126	131	PF00069	0.524
MOD_NEK2_1	2	7	PF00069	0.567
MOD_NEK2_1	21	26	PF00069	0.288
MOD_PKA_1	57	63	PF00069	0.451
MOD_PKA_2	122	128	PF00069	0.614
MOD_PKA_2	2	8	PF00069	0.680
MOD_PKA_2	57	63	PF00069	0.451
MOD_PKB_1	55	63	PF00069	0.503
MOD_ProDKin_1	43	49	PF00069	0.571
MOD_ProDKin_1	9	15	PF00069	0.463
MOD_SUMO_rev_2	42	52	PF00179	0.543
TRG_ENDOCYTIC_2	41	44	PF00928	0.625
TRG_ENDOCYTIC_2	61	64	PF00928	0.510
TRG_ENDOCYTIC_2	67	70	PF00928	0.461
TRG_ER_diArg_1	2	4	PF00400	0.589
TRG_ER_diArg_1	55	58	PF00400	0.440
TRG_ER_diArg_1	8	10	PF00400	0.449
TRG_NLS_Bipartite_1	98	115	PF00514	0.568
TRG_NLS_MonoExtC_3	109	114	PF00514	0.598
TRG_NLS_MonoExtC_3	117	122	PF00514	0.545
TRG_NLS_MonoExtN_4	107	114	PF00514	0.609
TRG_NLS_MonoExtN_4	115	122	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIB3	Leptomonas seymouri	65%	100%
A0A1X0NSD7	Trypanosomatidae	44%	75%
A0A3Q8IGK7	Leishmania donovani	42%	100%
A0A3Q8ITR1	Leishmania donovani	94%	100%
A0A422P329	Trypanosoma rangeli	48%	71%
A4HL14	Leishmania braziliensis	35%	100%
A4HL15	Leishmania braziliensis	85%	95%
A4I8J5	Leishmania infantum	42%	100%
A4I8J6	Leishmania infantum	94%	100%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4P5	Leishmania major	40%	100%
Q8IS98	Crithidia fasciculata	66%	100%
Q9TY83	Crithidia fasciculata	35%	100%
Q9TY84	Crithidia fasciculata	35%	100%