Cyclin-dependent kinases regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-dependent kinase regulatory subunit

Species:

Leishmania major

UniProt:

Q4Q4P3_LEIMA

TriTrypDb:

LmjF.32.3790 , LMJLV39_320045800 , LMJSD75_320045900

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	2
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1902554	serine/threonine protein kinase complex	6	2
GO:1902911	protein kinase complex	5	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q4P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0007049	cell cycle	2	7
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	6
GO:0044237	cellular metabolic process	2	6
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051301	cell division	2	7
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008047	enzyme activator activity	3	2
GO:0016301	kinase activity	4	6
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	7
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0019207	kinase regulator activity	3	7
GO:0019209	kinase activator activity	4	2
GO:0019887	protein kinase regulator activity	4	7
GO:0019899	enzyme binding	3	2
GO:0019900	kinase binding	4	2
GO:0019901	protein kinase binding	5	2
GO:0030234	enzyme regulator activity	2	7
GO:0030295	protein kinase activator activity	5	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0042393	histone binding	3	2
GO:0043130	ubiquitin binding	4	2
GO:0043539	protein serine/threonine kinase activator activity	6	2
GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	6	2
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	95	97	PF00082	0.304
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.363
CLV_PCSK_SKI1_1	18	22	PF00082	0.451
DEG_APCC_DBOX_1	17	25	PF00400	0.445
DOC_MAPK_MEF2A_6	86	93	PF00069	0.363
DOC_PP4_FxxP_1	94	97	PF00568	0.323
DOC_USP7_UBL2_3	26	30	PF12436	0.440
LIG_14-3-3_CanoR_1	61	68	PF00244	0.308
LIG_14-3-3_CterR_2	96	99	PF00244	0.489
LIG_BIR_III_4	13	17	PF00653	0.456
LIG_FHA_1	57	63	PF00498	0.321
LIG_LIR_Gen_1	35	44	PF02991	0.465
LIG_LIR_Nem_3	35	41	PF02991	0.391
LIG_LIR_Nem_3	43	47	PF02991	0.329
LIG_LIR_Nem_3	65	71	PF02991	0.363
LIG_LIR_Nem_3	76	82	PF02991	0.363
LIG_LIR_Nem_3	8	12	PF02991	0.458
LIG_SH2_NCK_1	38	42	PF00017	0.426
LIG_SH2_SRC	38	41	PF00017	0.426
LIG_SH2_STAP1	33	37	PF00017	0.318
LIG_SH2_STAP1	38	42	PF00017	0.325
LIG_SH3_3	44	50	PF00018	0.363
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.442
LIG_UBA3_1	21	26	PF00899	0.451
MOD_CK2_1	61	67	PF00069	0.335
MOD_GSK3_1	57	64	PF00069	0.348
MOD_PIKK_1	73	79	PF00454	0.363
MOD_Plk_2-3	8	14	PF00069	0.464
TRG_DiLeu_BaEn_1	88	93	PF01217	0.329
TRG_ENDOCYTIC_2	38	41	PF00928	0.389
TRG_ENDOCYTIC_2	44	47	PF00928	0.333
TRG_NLS_MonoCore_2	94	99	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV2	Leptomonas seymouri	97%	99%
A0A0S4ISU5	Bodo saltans	67%	97%
A0A0S4J117	Bodo saltans	53%	91%
A0A3Q8IDH6	Leishmania donovani	100%	100%
A2XCH8	Oryza sativa subsp. indica	65%	100%
A4HL16	Leishmania braziliensis	100%	100%
A4I8J7	Leishmania infantum	100%	100%
B0G102	Dictyostelium discoideum	60%	100%
D0AAM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B3F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O23249	Arabidopsis thaliana	65%	100%
P08463	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	88%
P33552	Homo sapiens	69%	100%
P41384	Patella vulgata	67%	100%
P55933	Physarum polycephalum	73%	100%
P56390	Mus musculus	69%	100%
P61024	Homo sapiens	76%	100%
P61025	Mus musculus	76%	100%
Q0P5A5	Bos taurus	76%	100%
Q24152	Drosophila melanogaster	71%	100%
Q25330	Leishmania mexicana	99%	100%
Q2KJI1	Bos taurus	69%	100%
Q6PS57	Oryza sativa subsp. japonica	65%	100%
Q91879	Xenopus laevis	74%	100%
Q9SJJ5	Arabidopsis thaliana	66%	100%
V5BLD6	Trypanosoma cruzi	73%	100%