TPR_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4P2_LEIMA

TriTrypDb:

LmjF.32.3800 , LMJLV39_320045900 , LMJSD75_320046000

Length:

224

Annotations

LeishMANIAdb annotations

A conserved kinetoplastid protein with N-terminal signal-anchor and an ankyrin repeat domain. The latter is related to the domain found in eukaryotic peptidyl-prolyl isomerases.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0101031	protein folding chaperone complex	3	2
GO:0140535	intracellular protein-containing complex	2	2
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q4P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.542
CLV_PCSK_KEX2_1	179	181	PF00082	0.542
CLV_PCSK_KEX2_1	93	95	PF00082	0.500
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.500
DEG_Nend_UBRbox_3	1	3	PF02207	0.794
DOC_MAPK_gen_1	82	91	PF00069	0.469
DOC_MAPK_gen_1	93	100	PF00069	0.289
DOC_MAPK_RevD_3	164	180	PF00069	0.456
DOC_USP7_MATH_1	152	156	PF00917	0.278
DOC_WW_Pin1_4	34	39	PF00397	0.506
DOC_WW_Pin1_4	44	49	PF00397	0.531
DOC_WW_Pin1_4	58	63	PF00397	0.623
DOC_WW_Pin1_4	72	77	PF00397	0.422
LIG_14-3-3_CanoR_1	154	160	PF00244	0.332
LIG_14-3-3_CanoR_1	4	11	PF00244	0.555
LIG_FHA_1	10	16	PF00498	0.384
LIG_FHA_1	117	123	PF00498	0.385
LIG_FHA_1	130	136	PF00498	0.441
LIG_FHA_1	156	162	PF00498	0.360
LIG_LIR_Nem_3	23	27	PF02991	0.429
LIG_RPA_C_Fungi	175	187	PF08784	0.472
LIG_SH2_CRK	27	31	PF00017	0.693
LIG_SH3_3	163	169	PF00018	0.478
LIG_SH3_3	42	48	PF00018	0.779
LIG_SH3_3	59	65	PF00018	0.629
LIG_SH3_3	70	76	PF00018	0.649
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.516
LIG_TRAF2_1	99	102	PF00917	0.485
LIG_UBA3_1	88	93	PF00899	0.437
MOD_CDC14_SPxK_1	37	40	PF00782	0.621
MOD_CDK_SPxK_1	34	40	PF00069	0.604
MOD_CK1_1	155	161	PF00069	0.498
MOD_CK1_1	31	37	PF00069	0.662
MOD_GlcNHglycan	33	36	PF01048	0.671
MOD_PIKK_1	28	34	PF00454	0.678
MOD_PIKK_1	3	9	PF00454	0.727
MOD_PKA_2	3	9	PF00069	0.656
MOD_Plk_1	116	122	PF00069	0.516
MOD_Plk_4	117	123	PF00069	0.518
MOD_Plk_4	155	161	PF00069	0.444
MOD_Plk_4	9	15	PF00069	0.453
MOD_ProDKin_1	34	40	PF00069	0.644
MOD_ProDKin_1	44	50	PF00069	0.676
MOD_ProDKin_1	58	64	PF00069	0.801
MOD_ProDKin_1	72	78	PF00069	0.511
MOD_SUMO_rev_2	170	174	PF00179	0.498
TRG_ENDOCYTIC_2	27	30	PF00928	0.692
TRG_ER_diArg_1	178	180	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAP4	Leptomonas seymouri	51%	100%
A0A1X0NTN3	Trypanosomatidae	50%	100%
A0A3S7X657	Leishmania donovani	95%	100%
A4HL17	Leishmania braziliensis	79%	100%
A4I8J8	Leishmania infantum	95%	100%
E9B3F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%