SHQ1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SHQ1 protein, putative

Species:

Leishmania major

UniProt:

Q4Q4P1_LEIMA

TriTrypDb:

LmjF.32.3810 , LMJLV39_320046000 , LMJSD75_320046100

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4P1

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	12
GO:0000493	box H/ACA snoRNP assembly	8	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.655
CLV_C14_Caspase3-7	133	137	PF00656	0.680
CLV_C14_Caspase3-7	181	185	PF00656	0.532
CLV_C14_Caspase3-7	87	91	PF00656	0.460
CLV_NRD_NRD_1	195	197	PF00675	0.465
CLV_NRD_NRD_1	313	315	PF00675	0.560
CLV_NRD_NRD_1	440	442	PF00675	0.276
CLV_PCSK_KEX2_1	194	196	PF00082	0.449
CLV_PCSK_KEX2_1	440	442	PF00082	0.276
CLV_PCSK_PC7_1	191	197	PF00082	0.557
CLV_PCSK_SKI1_1	18	22	PF00082	0.500
CLV_PCSK_SKI1_1	286	290	PF00082	0.682
CLV_PCSK_SKI1_1	375	379	PF00082	0.287
CLV_PCSK_SKI1_1	440	444	PF00082	0.276
CLV_PCSK_SKI1_1	464	468	PF00082	0.290
CLV_PCSK_SKI1_1	474	478	PF00082	0.258
CLV_PCSK_SKI1_1	480	484	PF00082	0.237
CLV_PCSK_SKI1_1	489	493	PF00082	0.258
CLV_PCSK_SKI1_1	516	520	PF00082	0.320
CLV_PCSK_SKI1_1	552	556	PF00082	0.432
DEG_APCC_DBOX_1	101	109	PF00400	0.556
DEG_APCC_DBOX_1	17	25	PF00400	0.514
DEG_APCC_DBOX_1	369	377	PF00400	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.432
DEG_SCF_FBW7_2	1	7	PF00400	0.524
DEG_SPOP_SBC_1	111	115	PF00917	0.485
DOC_CDC14_PxL_1	258	266	PF14671	0.535
DOC_CKS1_1	1	6	PF01111	0.428
DOC_CYCLIN_RxL_1	370	381	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.451
DOC_MAPK_DCC_7	370	378	PF00069	0.537
DOC_MAPK_DCC_7	552	561	PF00069	0.431
DOC_MAPK_gen_1	100	108	PF00069	0.524
DOC_MAPK_gen_1	191	199	PF00069	0.518
DOC_MAPK_gen_1	353	360	PF00069	0.516
DOC_MAPK_gen_1	370	378	PF00069	0.517
DOC_MAPK_gen_1	513	521	PF00069	0.485
DOC_MAPK_MEF2A_6	353	360	PF00069	0.568
DOC_MAPK_MEF2A_6	370	378	PF00069	0.424
DOC_MAPK_MEF2A_6	474	483	PF00069	0.572
DOC_MAPK_MEF2A_6	513	521	PF00069	0.485
DOC_PP1_RVXF_1	373	379	PF00149	0.499
DOC_PP1_RVXF_1	47	53	PF00149	0.381
DOC_PP2B_LxvP_1	371	374	PF13499	0.498
DOC_PP2B_LxvP_1	377	380	PF13499	0.458
DOC_PP2B_LxvP_1	564	567	PF13499	0.424
DOC_PP4_FxxP_1	298	301	PF00568	0.564
DOC_USP7_MATH_1	112	116	PF00917	0.711
DOC_USP7_MATH_1	139	143	PF00917	0.738
DOC_USP7_MATH_1	144	148	PF00917	0.750
DOC_USP7_MATH_1	244	248	PF00917	0.729
DOC_USP7_MATH_1	316	320	PF00917	0.750
DOC_USP7_MATH_1	327	331	PF00917	0.623
DOC_USP7_MATH_1	539	543	PF00917	0.599
DOC_USP7_MATH_2	152	158	PF00917	0.518
DOC_WW_Pin1_4	378	383	PF00397	0.535
DOC_WW_Pin1_4	41	46	PF00397	0.508
DOC_WW_Pin1_4	416	421	PF00397	0.476
DOC_WW_Pin1_4	535	540	PF00397	0.642
LIG_14-3-3_CanoR_1	102	106	PF00244	0.622
LIG_14-3-3_CanoR_1	18	28	PF00244	0.502
LIG_14-3-3_CanoR_1	286	291	PF00244	0.704
LIG_14-3-3_CanoR_1	63	67	PF00244	0.468
LIG_BIR_III_2	284	288	PF00653	0.720
LIG_BIR_III_4	217	221	PF00653	0.435
LIG_BRCT_BRCA1_1	156	160	PF00533	0.450
LIG_BRCT_BRCA1_1	164	168	PF00533	0.376
LIG_BRCT_BRCA1_1	254	258	PF00533	0.512
LIG_BRCT_BRCA1_1	28	32	PF00533	0.346
LIG_BRCT_BRCA1_1	329	333	PF00533	0.754
LIG_BRCT_BRCA1_1	356	360	PF00533	0.417
LIG_BRCT_BRCA1_2	164	170	PF00533	0.540
LIG_Clathr_ClatBox_1	212	216	PF01394	0.455
LIG_EH1_1	13	21	PF00400	0.446
LIG_EH1_1	205	213	PF00400	0.562
LIG_EH1_1	470	478	PF00400	0.484
LIG_eIF4E_1	448	454	PF01652	0.553
LIG_eIF4E_1	471	477	PF01652	0.487
LIG_FHA_1	126	132	PF00498	0.614
LIG_FHA_1	275	281	PF00498	0.644
LIG_FHA_1	363	369	PF00498	0.593
LIG_FHA_1	387	393	PF00498	0.480
LIG_FHA_1	461	467	PF00498	0.560
LIG_FHA_1	492	498	PF00498	0.501
LIG_FHA_1	526	532	PF00498	0.493
LIG_FHA_1	72	78	PF00498	0.386
LIG_FHA_2	187	193	PF00498	0.487
LIG_FHA_2	315	321	PF00498	0.763
LIG_FHA_2	359	365	PF00498	0.493
LIG_FHA_2	428	434	PF00498	0.562
LIG_FHA_2	85	91	PF00498	0.450
LIG_IRF3_LxIS_1	345	352	PF10401	0.403
LIG_LIR_Apic_2	297	301	PF02991	0.586
LIG_LIR_Apic_2	40	45	PF02991	0.472
LIG_LIR_Apic_2	423	427	PF02991	0.501
LIG_LIR_Apic_2	493	499	PF02991	0.489
LIG_LIR_Gen_1	11	21	PF02991	0.404
LIG_LIR_Gen_1	165	176	PF02991	0.423
LIG_LIR_Gen_1	255	266	PF02991	0.541
LIG_LIR_Gen_1	395	402	PF02991	0.478
LIG_LIR_Gen_1	44	52	PF02991	0.476
LIG_LIR_Gen_1	84	94	PF02991	0.426
LIG_LIR_Nem_3	11	17	PF02991	0.397
LIG_LIR_Nem_3	165	171	PF02991	0.418
LIG_LIR_Nem_3	255	261	PF02991	0.496
LIG_LIR_Nem_3	36	42	PF02991	0.460
LIG_LIR_Nem_3	395	401	PF02991	0.478
LIG_LIR_Nem_3	44	50	PF02991	0.467
LIG_LIR_Nem_3	84	89	PF02991	0.411
LIG_PCNA_yPIPBox_3	464	477	PF02747	0.553
LIG_Pex14_2	160	164	PF04695	0.411
LIG_PTB_Apo_2	88	95	PF02174	0.452
LIG_PTB_Phospho_1	88	94	PF10480	0.460
LIG_SH2_CRK	42	46	PF00017	0.481
LIG_SH2_SRC	228	231	PF00017	0.518
LIG_SH2_SRC	424	427	PF00017	0.562
LIG_SH2_SRC	496	499	PF00017	0.581
LIG_SH2_SRC	94	97	PF00017	0.412
LIG_SH2_STAP1	398	402	PF00017	0.487
LIG_SH2_STAP1	432	436	PF00017	0.476
LIG_SH2_STAP1	471	475	PF00017	0.562
LIG_SH2_STAP1	66	70	PF00017	0.551
LIG_SH2_STAT5	130	133	PF00017	0.595
LIG_SH2_STAT5	228	231	PF00017	0.399
LIG_SH2_STAT5	42	45	PF00017	0.403
LIG_SH2_STAT5	424	427	PF00017	0.562
LIG_SH2_STAT5	47	50	PF00017	0.336
LIG_SH2_STAT5	471	474	PF00017	0.487
LIG_SH2_STAT5	496	499	PF00017	0.581
LIG_SH2_STAT5	76	79	PF00017	0.381
LIG_SH2_STAT5	94	97	PF00017	0.320
LIG_SH3_3	339	345	PF00018	0.695
LIG_SH3_3	376	382	PF00018	0.510
LIG_SH3_3	72	78	PF00018	0.379
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.522
LIG_SUMO_SIM_par_1	107	116	PF11976	0.652
LIG_SUMO_SIM_par_1	178	184	PF11976	0.557
LIG_SUMO_SIM_par_1	286	292	PF11976	0.708
LIG_SUMO_SIM_par_1	528	534	PF11976	0.539
LIG_TRAF2_1	121	124	PF00917	0.657
LIG_TRAF2_1	190	193	PF00917	0.580
LIG_TRAF2_1	247	250	PF00917	0.703
LIG_TRAF2_1	271	274	PF00917	0.704
LIG_TRAF2_1	361	364	PF00917	0.470
LIG_TRAF2_1	569	572	PF00917	0.586
LIG_UBA3_1	368	372	PF00899	0.538
MOD_CK1_1	110	116	PF00069	0.488
MOD_CK1_1	406	412	PF00069	0.539
MOD_CK1_1	534	540	PF00069	0.650
MOD_CK2_1	186	192	PF00069	0.468
MOD_CK2_1	244	250	PF00069	0.698
MOD_CK2_1	257	263	PF00069	0.526
MOD_CK2_1	314	320	PF00069	0.726
MOD_CK2_1	358	364	PF00069	0.487
MOD_CK2_1	378	384	PF00069	0.562
MOD_CK2_1	481	487	PF00069	0.562
MOD_CK2_1	523	529	PF00069	0.550
MOD_CK2_1	566	572	PF00069	0.601
MOD_GlcNHglycan	141	144	PF01048	0.665
MOD_GlcNHglycan	164	167	PF01048	0.463
MOD_GlcNHglycan	21	24	PF01048	0.425
MOD_GlcNHglycan	246	249	PF01048	0.682
MOD_GlcNHglycan	28	31	PF01048	0.446
MOD_GlcNHglycan	291	294	PF01048	0.703
MOD_GlcNHglycan	404	408	PF01048	0.362
MOD_GlcNHglycan	533	536	PF01048	0.643
MOD_GSK3_1	107	114	PF00069	0.653
MOD_GSK3_1	135	142	PF00069	0.694
MOD_GSK3_1	354	361	PF00069	0.423
MOD_GSK3_1	37	44	PF00069	0.446
MOD_GSK3_1	416	423	PF00069	0.485
MOD_GSK3_1	525	532	PF00069	0.517
MOD_GSK3_1	535	542	PF00069	0.584
MOD_N-GLC_1	413	418	PF02516	0.381
MOD_N-GLC_1	469	474	PF02516	0.353
MOD_NEK2_1	349	354	PF00069	0.541
MOD_NEK2_1	491	496	PF00069	0.537
MOD_NEK2_2	427	432	PF00069	0.581
MOD_PIKK_1	34	40	PF00454	0.535
MOD_PIKK_1	413	419	PF00454	0.579
MOD_PIKK_1	6	12	PF00454	0.462
MOD_PKA_1	314	320	PF00069	0.559
MOD_PKA_1	552	558	PF00069	0.487
MOD_PKA_2	101	107	PF00069	0.627
MOD_PKA_2	354	360	PF00069	0.367
MOD_PKA_2	62	68	PF00069	0.474
MOD_Plk_1	274	280	PF00069	0.702
MOD_Plk_1	413	419	PF00069	0.581
MOD_Plk_1	469	475	PF00069	0.575
MOD_Plk_2-3	178	184	PF00069	0.567
MOD_Plk_2-3	62	68	PF00069	0.544
MOD_Plk_4	101	107	PF00069	0.627
MOD_Plk_4	252	258	PF00069	0.619
MOD_Plk_4	275	281	PF00069	0.711
MOD_Plk_4	286	292	PF00069	0.682
MOD_Plk_4	408	414	PF00069	0.476
MOD_Plk_4	420	426	PF00069	0.476
MOD_Plk_4	427	433	PF00069	0.476
MOD_Plk_4	491	497	PF00069	0.487
MOD_Plk_4	539	545	PF00069	0.587
MOD_Plk_4	552	558	PF00069	0.446
MOD_Plk_4	71	77	PF00069	0.390
MOD_ProDKin_1	378	384	PF00069	0.535
MOD_ProDKin_1	41	47	PF00069	0.508
MOD_ProDKin_1	416	422	PF00069	0.476
MOD_ProDKin_1	535	541	PF00069	0.640
MOD_SUMO_rev_2	292	301	PF00179	0.698
MOD_SUMO_rev_2	311	317	PF00179	0.557
MOD_SUMO_rev_2	484	491	PF00179	0.537
MOD_SUMO_rev_2	546	554	PF00179	0.566
TRG_DiLeu_BaEn_1	275	280	PF01217	0.708
TRG_DiLeu_BaEn_1	364	369	PF01217	0.517
TRG_DiLeu_BaEn_1	487	492	PF01217	0.562
TRG_DiLeu_BaEn_4	192	198	PF01217	0.550
TRG_DiLeu_BaEn_4	249	255	PF01217	0.616
TRG_DiLeu_BaEn_4	275	281	PF01217	0.652
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.605
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.478
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.487
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.476
TRG_ENDOCYTIC_2	398	401	PF00928	0.476
TRG_ENDOCYTIC_2	47	50	PF00928	0.362
TRG_ER_diArg_1	194	196	PF00400	0.554
TRG_ER_diArg_1	345	348	PF00400	0.584
TRG_ER_diArg_1	353	356	PF00400	0.488
TRG_ER_diArg_1	477	480	PF00400	0.487
TRG_ER_diArg_1	48	51	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y0	Leptomonas seymouri	68%	100%
A0A0S4IU29	Bodo saltans	38%	100%
A0A1X0NS82	Trypanosomatidae	46%	100%
A0A3S7X679	Leishmania donovani	93%	100%
A0A422P315	Trypanosoma rangeli	48%	100%
A4HL18	Leishmania braziliensis	81%	100%
A4I8J9	Leishmania infantum	93%	100%
D0AAM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B3F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BR05	Trypanosoma cruzi	49%	100%