Cornichon protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cornichon protein

Gene product:

Cornichon protein, putative

Species:

Leishmania major

UniProt:

Q4Q4N8_LEIMA

TriTrypDb:

LmjF.32.3840 , LMJLV39_320046300 , LMJSD75_320046500

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q4N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4N8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0016192	vesicle-mediated transport	4	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.488
CLV_NRD_NRD_1	32	34	PF00675	0.368
CLV_PCSK_KEX2_1	34	36	PF00082	0.348
CLV_PCSK_KEX2_1	5	7	PF00082	0.407
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.388
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.381
CLV_PCSK_SKI1_1	143	147	PF00082	0.486
CLV_PCSK_SKI1_1	35	39	PF00082	0.280
CLV_PCSK_SKI1_1	5	9	PF00082	0.343
CLV_PCSK_SKI1_1	90	94	PF00082	0.193
DEG_APCC_DBOX_1	34	42	PF00400	0.527
DOC_CDC14_PxL_1	15	23	PF14671	0.606
DOC_CYCLIN_RxL_1	138	148	PF00134	0.331
DOC_MAPK_gen_1	31	40	PF00069	0.595
DOC_MAPK_MEF2A_6	33	42	PF00069	0.524
LIG_14-3-3_CanoR_1	110	116	PF00244	0.435
LIG_14-3-3_CanoR_1	164	173	PF00244	0.225
LIG_14-3-3_CanoR_1	6	13	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_deltaCOP1_diTrp_1	9	17	PF00928	0.462
LIG_EH1_1	52	60	PF00400	0.291
LIG_FHA_1	2	8	PF00498	0.545
LIG_FHA_2	27	33	PF00498	0.569
LIG_LIR_Gen_1	120	131	PF02991	0.421
LIG_LIR_Gen_1	167	177	PF02991	0.436
LIG_LIR_Gen_1	45	54	PF02991	0.316
LIG_LIR_Gen_1	9	20	PF02991	0.596
LIG_LIR_Nem_3	120	126	PF02991	0.396
LIG_LIR_Nem_3	151	156	PF02991	0.301
LIG_LIR_Nem_3	16	20	PF02991	0.442
LIG_LIR_Nem_3	167	172	PF02991	0.359
LIG_LIR_Nem_3	45	49	PF02991	0.342
LIG_LIR_Nem_3	9	15	PF02991	0.571
LIG_NRBOX	37	43	PF00104	0.369
LIG_OCRL_FandH_1	38	50	PF00620	0.391
LIG_PDZ_Class_1	183	188	PF00595	0.311
LIG_Pex14_1	61	65	PF04695	0.298
LIG_Pex14_2	11	15	PF04695	0.527
LIG_Pex14_2	181	185	PF04695	0.206
LIG_SH2_CRK	169	173	PF00017	0.332
LIG_SH2_SRC	85	88	PF00017	0.435
LIG_SH2_STAP1	135	139	PF00017	0.293
LIG_SH2_STAP1	85	89	PF00017	0.485
LIG_SH2_STAT5	180	183	PF00017	0.377
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.293
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.416
LIG_SUMO_SIM_par_1	100	106	PF11976	0.467
LIG_SUMO_SIM_par_1	18	24	PF11976	0.571
LIG_WRC_WIRS_1	182	187	PF05994	0.218
MOD_CK1_1	26	32	PF00069	0.595
MOD_GlcNHglycan	68	71	PF01048	0.469
MOD_GSK3_1	1	8	PF00069	0.542
MOD_GSK3_1	137	144	PF00069	0.400
MOD_GSK3_1	53	60	PF00069	0.395
MOD_NEK2_1	1	6	PF00069	0.587
MOD_NEK2_1	119	124	PF00069	0.356
MOD_NEK2_1	137	142	PF00069	0.313
MOD_NEK2_1	181	186	PF00069	0.315
MOD_NEK2_1	42	47	PF00069	0.332
MOD_NEK2_1	74	79	PF00069	0.315
MOD_NEK2_2	85	90	PF00069	0.393
MOD_PIKK_1	137	143	PF00454	0.393
MOD_PKA_1	5	11	PF00069	0.492
MOD_PKA_2	5	11	PF00069	0.524
MOD_Plk_4	119	125	PF00069	0.344
MOD_Plk_4	148	154	PF00069	0.291
MOD_Plk_4	42	48	PF00069	0.390
MOD_Plk_4	53	59	PF00069	0.400
MOD_SUMO_rev_2	26	36	PF00179	0.607
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.523
TRG_ENDOCYTIC_2	169	172	PF00928	0.280
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	68%	99%
A0A0N1HVI2	Leptomonas seymouri	26%	100%
A0A1X0P478	Trypanosomatidae	43%	99%
A0A3Q8IH86	Leishmania donovani	89%	100%
A0A3Q8IHH3	Leishmania donovani	25%	100%
A0A3R7KL43	Trypanosoma rangeli	44%	99%
A4HL20	Leishmania braziliensis	27%	100%
A4HL21	Leishmania braziliensis	68%	100%
A4I8K1	Leishmania infantum	25%	100%
A4I8K2	Leishmania infantum	89%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B3G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4N9	Leishmania major	25%	100%
V5BLE0	Trypanosoma cruzi	23%	100%