WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4N4_LEIMA

TriTrypDb:

LmjF.32.3880 , LMJLV39_320046700 , LMJSD75_320046900

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.515
CLV_C14_Caspase3-7	200	204	PF00656	0.586
CLV_NRD_NRD_1	42	44	PF00675	0.478
CLV_NRD_NRD_1	84	86	PF00675	0.499
CLV_PCSK_KEX2_1	42	44	PF00082	0.480
CLV_PCSK_SKI1_1	182	186	PF00082	0.529
CLV_PCSK_SKI1_1	206	210	PF00082	0.595
CLV_PCSK_SKI1_1	340	344	PF00082	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.434
DEG_ODPH_VHL_1	172	185	PF01847	0.522
DEG_SPOP_SBC_1	110	114	PF00917	0.564
DEG_SPOP_SBC_1	19	23	PF00917	0.457
DOC_MAPK_gen_1	39	48	PF00069	0.516
DOC_PP1_RVXF_1	180	186	PF00149	0.551
DOC_PP1_RVXF_1	204	210	PF00149	0.599
DOC_PP4_FxxP_1	48	51	PF00568	0.599
DOC_USP7_MATH_1	15	19	PF00917	0.437
DOC_USP7_MATH_1	152	156	PF00917	0.608
DOC_USP7_MATH_1	302	306	PF00917	0.588
DOC_USP7_MATH_1	57	61	PF00917	0.518
DOC_WW_Pin1_4	212	217	PF00397	0.643
DOC_WW_Pin1_4	261	266	PF00397	0.523
DOC_WW_Pin1_4	276	281	PF00397	0.384
LIG_14-3-3_CanoR_1	85	94	PF00244	0.490
LIG_FHA_1	111	117	PF00498	0.456
LIG_FHA_1	179	185	PF00498	0.567
LIG_FHA_1	283	289	PF00498	0.359
LIG_FHA_1	30	36	PF00498	0.444
LIG_FHA_1	76	82	PF00498	0.461
LIG_LIR_Apic_2	276	280	PF02991	0.489
LIG_LIR_Nem_3	155	160	PF02991	0.426
LIG_LIR_Nem_3	21	27	PF02991	0.387
LIG_LIR_Nem_3	245	251	PF02991	0.433
LIG_PDZ_Class_2	352	357	PF00595	0.503
LIG_SH2_NCK_1	127	131	PF00017	0.478
LIG_SH2_SRC	127	130	PF00017	0.491
LIG_SH2_SRC	137	140	PF00017	0.432
LIG_SH2_STAT5	137	140	PF00017	0.436
LIG_SH2_STAT5	141	144	PF00017	0.409
LIG_SH2_STAT5	163	166	PF00017	0.388
LIG_SH2_STAT5	274	277	PF00017	0.434
LIG_SH2_STAT5	341	344	PF00017	0.436
LIG_SH2_STAT5	45	48	PF00017	0.360
LIG_SH2_STAT5	64	67	PF00017	0.498
LIG_SH3_3	221	227	PF00018	0.504
LIG_SH3_3	35	41	PF00018	0.544
LIG_SUMO_SIM_par_1	111	121	PF11976	0.453
LIG_SUMO_SIM_par_1	281	287	PF11976	0.489
LIG_SUMO_SIM_par_1	31	37	PF11976	0.469
MOD_CK1_1	112	118	PF00069	0.564
MOD_CK1_1	17	23	PF00069	0.442
MOD_CK1_1	199	205	PF00069	0.611
MOD_CK1_1	29	35	PF00069	0.386
MOD_CK1_1	89	95	PF00069	0.502
MOD_CK2_1	246	252	PF00069	0.497
MOD_CK2_1	301	307	PF00069	0.621
MOD_CK2_1	93	99	PF00069	0.528
MOD_GlcNHglycan	164	167	PF01048	0.466
MOD_GlcNHglycan	17	20	PF01048	0.510
MOD_GlcNHglycan	196	199	PF01048	0.563
MOD_GlcNHglycan	203	206	PF01048	0.630
MOD_GlcNHglycan	304	307	PF01048	0.675
MOD_GlcNHglycan	52	55	PF01048	0.546
MOD_GSK3_1	10	17	PF00069	0.408
MOD_GSK3_1	158	165	PF00069	0.540
MOD_GSK3_1	19	26	PF00069	0.410
MOD_GSK3_1	89	96	PF00069	0.519
MOD_N-GLC_1	229	234	PF02516	0.481
MOD_N-GLC_2	162	164	PF02516	0.386
MOD_NEK2_1	284	289	PF00069	0.379
MOD_NEK2_1	301	306	PF00069	0.440
MOD_NEK2_1	81	86	PF00069	0.470
MOD_NEK2_2	246	251	PF00069	0.520
MOD_Plk_1	229	235	PF00069	0.483
MOD_Plk_2-3	93	99	PF00069	0.551
MOD_Plk_4	112	118	PF00069	0.462
MOD_Plk_4	246	252	PF00069	0.457
MOD_Plk_4	31	37	PF00069	0.390
MOD_ProDKin_1	212	218	PF00069	0.653
MOD_ProDKin_1	261	267	PF00069	0.519
MOD_ProDKin_1	276	282	PF00069	0.380
TRG_DiLeu_BaEn_2	98	104	PF01217	0.395
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.540
TRG_ENDOCYTIC_2	45	48	PF00928	0.420
TRG_ER_diArg_1	41	43	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G5	Leptomonas seymouri	61%	98%
A0A1X0NS90	Trypanosomatidae	34%	97%
A0A3S5IR82	Trypanosoma rangeli	32%	100%
A0A3S7X6A3	Leishmania donovani	92%	99%
A4HL25	Leishmania braziliensis	83%	99%
A4I8K6	Leishmania infantum	92%	99%
D0AAK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B3G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5DE80	Trypanosoma cruzi	31%	100%