Endoplasmic reticulum-Golgi intermediate compartment protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania major

UniProt:

Q4Q4N1_LEIMA

TriTrypDb:

LmjF.32.3910 , LMJLV39_320047000 , LMJSD75_320047200

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	7
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q4N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.397
CLV_PCSK_SKI1_1	140	144	PF00082	0.569
CLV_PCSK_SKI1_1	18	22	PF00082	0.334
CLV_PCSK_SKI1_1	185	189	PF00082	0.529
CLV_PCSK_SKI1_1	302	306	PF00082	0.409
DEG_APCC_DBOX_1	259	267	PF00400	0.348
DEG_Nend_UBRbox_1	1	4	PF02207	0.672
DOC_MAPK_MEF2A_6	67	74	PF00069	0.284
DOC_USP7_MATH_1	264	268	PF00917	0.334
DOC_USP7_UBL2_3	184	188	PF12436	0.334
DOC_WW_Pin1_4	235	240	PF00397	0.295
DOC_WW_Pin1_4	252	257	PF00397	0.209
LIG_14-3-3_CanoR_1	121	129	PF00244	0.315
LIG_14-3-3_CanoR_1	260	264	PF00244	0.277
LIG_14-3-3_CanoR_1	265	275	PF00244	0.262
LIG_14-3-3_CanoR_1	291	300	PF00244	0.546
LIG_14-3-3_CanoR_1	53	62	PF00244	0.295
LIG_BIR_III_4	111	115	PF00653	0.439
LIG_BRCT_BRCA1_1	122	126	PF00533	0.385
LIG_EH1_1	282	290	PF00400	0.319
LIG_eIF4E_1	283	289	PF01652	0.408
LIG_FHA_1	178	184	PF00498	0.385
LIG_FHA_1	267	273	PF00498	0.334
LIG_FHA_1	67	73	PF00498	0.319
LIG_FHA_1	85	91	PF00498	0.271
LIG_FHA_2	106	112	PF00498	0.411
LIG_FHA_2	215	221	PF00498	0.334
LIG_LIR_Gen_1	123	130	PF02991	0.363
LIG_LIR_Gen_1	136	145	PF02991	0.299
LIG_LIR_Gen_1	220	231	PF02991	0.325
LIG_LIR_Nem_3	11	16	PF02991	0.495
LIG_LIR_Nem_3	123	129	PF02991	0.363
LIG_LIR_Nem_3	136	141	PF02991	0.299
LIG_LIR_Nem_3	177	181	PF02991	0.327
LIG_LIR_Nem_3	220	226	PF02991	0.325
LIG_LIR_Nem_3	269	274	PF02991	0.338
LIG_PCNA_PIPBox_1	156	165	PF02747	0.385
LIG_PCNA_PIPBox_1	204	213	PF02747	0.218
LIG_PTB_Apo_2	93	100	PF02174	0.334
LIG_REV1ctd_RIR_1	10	16	PF16727	0.534
LIG_SH2_NCK_1	283	287	PF00017	0.479
LIG_SH2_PTP2	138	141	PF00017	0.368
LIG_SH2_PTP2	49	52	PF00017	0.334
LIG_SH2_STAP1	219	223	PF00017	0.364
LIG_SH2_STAP1	227	231	PF00017	0.231
LIG_SH2_STAT3	227	230	PF00017	0.218
LIG_SH2_STAT5	138	141	PF00017	0.368
LIG_SH2_STAT5	210	213	PF00017	0.297
LIG_SH2_STAT5	227	230	PF00017	0.218
LIG_SH2_STAT5	274	277	PF00017	0.319
LIG_SH2_STAT5	283	286	PF00017	0.408
LIG_SH2_STAT5	49	52	PF00017	0.295
LIG_SH3_3	76	82	PF00018	0.385
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.298
LIG_SUMO_SIM_par_1	84	89	PF11976	0.334
LIG_TRFH_1	252	256	PF08558	0.279
MOD_CK1_1	177	183	PF00069	0.295
MOD_CK1_1	221	227	PF00069	0.385
MOD_CK1_1	235	241	PF00069	0.183
MOD_CK1_1	255	261	PF00069	0.149
MOD_CK1_1	28	34	PF00069	0.422
MOD_CK2_1	125	131	PF00069	0.334
MOD_CK2_1	214	220	PF00069	0.334
MOD_GlcNHglycan	295	298	PF01048	0.372
MOD_GSK3_1	115	122	PF00069	0.441
MOD_GSK3_1	18	25	PF00069	0.498
MOD_GSK3_1	214	221	PF00069	0.352
MOD_GSK3_1	225	232	PF00069	0.302
MOD_GSK3_1	255	262	PF00069	0.279
MOD_GSK3_1	266	273	PF00069	0.295
MOD_GSK3_1	66	73	PF00069	0.320
MOD_NEK2_1	148	153	PF00069	0.295
MOD_NEK2_1	20	25	PF00069	0.502
MOD_NEK2_1	231	236	PF00069	0.334
MOD_NEK2_1	292	297	PF00069	0.579
MOD_NEK2_1	74	79	PF00069	0.288
MOD_PKA_2	120	126	PF00069	0.360
MOD_PKA_2	259	265	PF00069	0.303
MOD_PKA_2	66	72	PF00069	0.302
MOD_Plk_1	169	175	PF00069	0.334
MOD_Plk_1	219	225	PF00069	0.361
MOD_Plk_1	74	80	PF00069	0.288
MOD_Plk_2-3	125	131	PF00069	0.329
MOD_Plk_4	214	220	PF00069	0.279
MOD_Plk_4	222	228	PF00069	0.286
MOD_Plk_4	25	31	PF00069	0.486
MOD_Plk_4	270	276	PF00069	0.373
MOD_ProDKin_1	235	241	PF00069	0.295
MOD_ProDKin_1	252	258	PF00069	0.209
MOD_SUMO_rev_2	177	186	PF00179	0.334
TRG_ENDOCYTIC_2	138	141	PF00928	0.368
TRG_ENDOCYTIC_2	208	211	PF00928	0.300
TRG_ER_diArg_1	107	110	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	22%	78%
A0A0N0P4A5	Leptomonas seymouri	26%	76%
A0A0N0P8T7	Leptomonas seymouri	24%	92%
A0A0N1I377	Leptomonas seymouri	74%	100%
A0A0S4J3I3	Bodo saltans	47%	98%
A0A0S4JE72	Bodo saltans	26%	77%
A0A1X0NIB7	Trypanosomatidae	27%	79%
A0A3Q8IGC2	Leishmania donovani	98%	100%
A0A3Q8IGE1	Leishmania donovani	27%	66%
A0A3S5H6H6	Leishmania donovani	23%	84%
A0A3S7X427	Leishmania donovani	26%	91%
A4HJ02	Leishmania braziliensis	26%	91%
A4HL28	Leishmania braziliensis	85%	100%
A4HUR4	Leishmania infantum	23%	84%
A4I6C1	Leishmania infantum	26%	91%
A4I779	Leishmania infantum	27%	66%
A4I8K9	Leishmania infantum	98%	100%
E9B1H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	76%
E9B3G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94283	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	93%
P39727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	74%
Q4Q5Y6	Leishmania major	27%	66%
Q4Q6N5	Leishmania major	26%	91%
Q4R5C3	Macaca fascicularis	24%	82%
Q4R8X1	Macaca fascicularis	27%	81%
Q4V8Y6	Danio rerio	32%	100%
Q54DW2	Dictyostelium discoideum	36%	81%
Q5EAE0	Bos taurus	26%	81%
Q5R8G3	Pongo abelii	26%	81%
Q66KH2	Xenopus laevis	27%	79%
Q6NS19	Xenopus laevis	34%	100%
Q6NVS2	Xenopus tropicalis	28%	80%
Q7T2D4	Danio rerio	25%	82%
Q803I2	Danio rerio	27%	81%
Q969X5	Homo sapiens	33%	100%
Q96RQ1	Homo sapiens	23%	82%
Q9CQE7	Mus musculus	27%	81%
Q9CR89	Mus musculus	23%	82%
Q9DC16	Mus musculus	33%	100%
Q9Y282	Homo sapiens	26%	81%
V5AS26	Trypanosoma cruzi	25%	76%
V5BGJ7	Trypanosoma cruzi	25%	79%