Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4M7_LEIMA

TriTrypDb:

LmjF.32.3950 , LMJLV39_320047400 , LMJSD75_320047600

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4M7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	34	40	PF00089	0.399
CLV_NRD_NRD_1	130	132	PF00675	0.571
CLV_NRD_NRD_1	315	317	PF00675	0.524
CLV_NRD_NRD_1	345	347	PF00675	0.429
CLV_NRD_NRD_1	348	350	PF00675	0.397
CLV_NRD_NRD_1	51	53	PF00675	0.462
CLV_NRD_NRD_1	644	646	PF00675	0.405
CLV_NRD_NRD_1	881	883	PF00675	0.754
CLV_NRD_NRD_1	9	11	PF00675	0.630
CLV_PCSK_KEX2_1	130	132	PF00082	0.537
CLV_PCSK_KEX2_1	190	192	PF00082	0.558
CLV_PCSK_KEX2_1	315	317	PF00082	0.524
CLV_PCSK_KEX2_1	344	346	PF00082	0.431
CLV_PCSK_KEX2_1	36	38	PF00082	0.573
CLV_PCSK_KEX2_1	393	395	PF00082	0.566
CLV_PCSK_KEX2_1	51	53	PF00082	0.435
CLV_PCSK_KEX2_1	881	883	PF00082	0.743
CLV_PCSK_KEX2_1	9	11	PF00082	0.630
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.572
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.380
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.575
CLV_PCSK_PC7_1	311	317	PF00082	0.503
CLV_PCSK_PC7_1	340	346	PF00082	0.559
CLV_PCSK_SKI1_1	111	115	PF00082	0.593
CLV_PCSK_SKI1_1	12	16	PF00082	0.527
CLV_PCSK_SKI1_1	122	126	PF00082	0.520
CLV_PCSK_SKI1_1	350	354	PF00082	0.519
CLV_PCSK_SKI1_1	435	439	PF00082	0.514
CLV_PCSK_SKI1_1	473	477	PF00082	0.541
CLV_PCSK_SKI1_1	567	571	PF00082	0.407
CLV_PCSK_SKI1_1	645	649	PF00082	0.470
CLV_PCSK_SKI1_1	682	686	PF00082	0.533
CLV_PCSK_SKI1_1	696	700	PF00082	0.373
CLV_PCSK_SKI1_1	767	771	PF00082	0.541
CLV_PCSK_SKI1_1	788	792	PF00082	0.616
CLV_PCSK_SKI1_1	811	815	PF00082	0.740
CLV_Separin_Metazoa	674	678	PF03568	0.445
DEG_APCC_DBOX_1	681	689	PF00400	0.538
DEG_APCC_DBOX_1	736	744	PF00400	0.503
DEG_COP1_1	897	906	PF00400	0.603
DEG_MDM2_SWIB_1	666	673	PF02201	0.380
DOC_ANK_TNKS_1	889	896	PF00023	0.568
DOC_CKS1_1	19	24	PF01111	0.731
DOC_CKS1_1	357	362	PF01111	0.305
DOC_CKS1_1	653	658	PF01111	0.554
DOC_CKS1_1	843	848	PF01111	0.796
DOC_CYCLIN_RxL_1	274	284	PF00134	0.388
DOC_CYCLIN_RxL_1	642	650	PF00134	0.539
DOC_CYCLIN_RxL_1	805	819	PF00134	0.739
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.454
DOC_MAPK_FxFP_2	411	414	PF00069	0.548
DOC_MAPK_gen_1	36	46	PF00069	0.556
DOC_MAPK_gen_1	567	576	PF00069	0.502
DOC_MAPK_gen_1	679	688	PF00069	0.517
DOC_MAPK_MEF2A_6	355	364	PF00069	0.498
DOC_MAPK_MEF2A_6	542	551	PF00069	0.510
DOC_MIT_MIM_1	5	14	PF04212	0.658
DOC_PIKK_1	710	717	PF02985	0.519
DOC_PP2B_LxvP_1	176	179	PF13499	0.561
DOC_PP2B_LxvP_1	789	792	PF13499	0.677
DOC_PP2B_LxvP_1	813	816	PF13499	0.641
DOC_PP4_FxxP_1	114	117	PF00568	0.489
DOC_PP4_FxxP_1	411	414	PF00568	0.548
DOC_PP4_FxxP_1	659	662	PF00568	0.519
DOC_PP4_FxxP_1	768	771	PF00568	0.597
DOC_PP4_FxxP_1	804	807	PF00568	0.728
DOC_USP7_MATH_1	181	185	PF00917	0.460
DOC_USP7_MATH_1	213	217	PF00917	0.485
DOC_USP7_MATH_1	419	423	PF00917	0.618
DOC_USP7_MATH_1	442	446	PF00917	0.701
DOC_USP7_MATH_1	728	732	PF00917	0.564
DOC_USP7_MATH_1	884	888	PF00917	0.738
DOC_USP7_MATH_1	906	910	PF00917	0.756
DOC_USP7_MATH_1	912	916	PF00917	0.634
DOC_USP7_UBL2_3	36	40	PF12436	0.377
DOC_WW_Pin1_4	18	23	PF00397	0.700
DOC_WW_Pin1_4	24	29	PF00397	0.699
DOC_WW_Pin1_4	356	361	PF00397	0.297
DOC_WW_Pin1_4	652	657	PF00397	0.457
DOC_WW_Pin1_4	677	682	PF00397	0.385
DOC_WW_Pin1_4	820	825	PF00397	0.765
DOC_WW_Pin1_4	839	844	PF00397	0.766
LIG_14-3-3_CanoR_1	270	276	PF00244	0.453
LIG_14-3-3_CanoR_1	335	340	PF00244	0.542
LIG_14-3-3_CanoR_1	355	360	PF00244	0.197
LIG_14-3-3_CanoR_1	397	405	PF00244	0.509
LIG_14-3-3_CanoR_1	435	440	PF00244	0.554
LIG_14-3-3_CanoR_1	490	496	PF00244	0.411
LIG_14-3-3_CanoR_1	526	531	PF00244	0.505
LIG_14-3-3_CanoR_1	679	688	PF00244	0.547
LIG_14-3-3_CanoR_1	737	741	PF00244	0.451
LIG_14-3-3_CanoR_1	867	872	PF00244	0.706
LIG_14-3-3_CanoR_1	9	15	PF00244	0.669
LIG_Actin_WH2_2	634	651	PF00022	0.539
LIG_Actin_WH2_2	681	698	PF00022	0.473
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	335	339	PF00533	0.547
LIG_BRCT_BRCA1_1	753	757	PF00533	0.539
LIG_Clathr_ClatBox_1	361	365	PF01394	0.511
LIG_deltaCOP1_diTrp_1	347	353	PF00928	0.320
LIG_deltaCOP1_diTrp_1	459	464	PF00928	0.406
LIG_deltaCOP1_diTrp_1	981	984	PF00928	0.555
LIG_FHA_1	105	111	PF00498	0.458
LIG_FHA_1	123	129	PF00498	0.405
LIG_FHA_1	13	19	PF00498	0.647
LIG_FHA_1	180	186	PF00498	0.527
LIG_FHA_1	187	193	PF00498	0.461
LIG_FHA_1	259	265	PF00498	0.507
LIG_FHA_1	357	363	PF00498	0.307
LIG_FHA_1	428	434	PF00498	0.487
LIG_FHA_1	441	447	PF00498	0.526
LIG_FHA_1	778	784	PF00498	0.647
LIG_FHA_1	820	826	PF00498	0.766
LIG_FHA_1	843	849	PF00498	0.717
LIG_FHA_1	978	984	PF00498	0.610
LIG_FHA_2	153	159	PF00498	0.450
LIG_FHA_2	248	254	PF00498	0.522
LIG_FHA_2	398	404	PF00498	0.544
LIG_FHA_2	737	743	PF00498	0.580
LIG_FHA_2	771	777	PF00498	0.707
LIG_FHA_2	830	836	PF00498	0.702
LIG_FHA_2	851	857	PF00498	0.762
LIG_FHA_2	920	926	PF00498	0.669
LIG_FHA_2	936	942	PF00498	0.637
LIG_LIR_Apic_2	145	150	PF02991	0.523
LIG_LIR_Apic_2	297	301	PF02991	0.397
LIG_LIR_Apic_2	801	807	PF02991	0.727
LIG_LIR_Gen_1	194	205	PF02991	0.413
LIG_LIR_Gen_1	286	296	PF02991	0.463
LIG_LIR_Gen_1	369	379	PF02991	0.419
LIG_LIR_Gen_1	462	471	PF02991	0.474
LIG_LIR_Gen_1	505	515	PF02991	0.416
LIG_LIR_Gen_1	525	534	PF02991	0.223
LIG_LIR_Gen_1	635	644	PF02991	0.425
LIG_LIR_Gen_1	754	764	PF02991	0.495
LIG_LIR_Gen_1	979	988	PF02991	0.677
LIG_LIR_Nem_3	199	205	PF02991	0.389
LIG_LIR_Nem_3	274	279	PF02991	0.386
LIG_LIR_Nem_3	286	292	PF02991	0.302
LIG_LIR_Nem_3	325	331	PF02991	0.381
LIG_LIR_Nem_3	369	374	PF02991	0.408
LIG_LIR_Nem_3	462	467	PF02991	0.445
LIG_LIR_Nem_3	505	510	PF02991	0.416
LIG_LIR_Nem_3	525	530	PF02991	0.235
LIG_LIR_Nem_3	563	569	PF02991	0.531
LIG_LIR_Nem_3	635	639	PF02991	0.433
LIG_LIR_Nem_3	754	760	PF02991	0.500
LIG_LIR_Nem_3	91	97	PF02991	0.528
LIG_LIR_Nem_3	979	985	PF02991	0.689
LIG_MYND_1	658	662	PF01753	0.468
LIG_NRBOX	643	649	PF00104	0.546
LIG_Pex14_1	579	583	PF04695	0.499
LIG_Pex14_2	659	663	PF04695	0.409
LIG_Pex14_2	666	670	PF04695	0.337
LIG_PTB_Apo_2	270	277	PF02174	0.356
LIG_PTB_Phospho_1	270	276	PF10480	0.466
LIG_SH2_CRK	226	230	PF00017	0.486
LIG_SH2_CRK	799	803	PF00017	0.685
LIG_SH2_GRB2like	193	196	PF00017	0.535
LIG_SH2_GRB2like	331	334	PF00017	0.525
LIG_SH2_NCK_1	799	803	PF00017	0.685
LIG_SH2_PTP2	238	241	PF00017	0.460
LIG_SH2_PTP2	298	301	PF00017	0.430
LIG_SH2_STAP1	193	197	PF00017	0.502
LIG_SH2_STAP1	371	375	PF00017	0.397
LIG_SH2_STAP1	429	433	PF00017	0.536
LIG_SH2_STAP1	779	783	PF00017	0.555
LIG_SH2_STAT5	17	20	PF00017	0.688
LIG_SH2_STAT5	193	196	PF00017	0.478
LIG_SH2_STAT5	238	241	PF00017	0.340
LIG_SH2_STAT5	289	292	PF00017	0.430
LIG_SH2_STAT5	298	301	PF00017	0.409
LIG_SH2_STAT5	331	334	PF00017	0.435
LIG_SH2_STAT5	410	413	PF00017	0.550
LIG_SH2_STAT5	429	432	PF00017	0.288
LIG_SH2_STAT5	583	586	PF00017	0.413
LIG_SH2_STAT5	759	762	PF00017	0.493
LIG_SH2_STAT5	779	782	PF00017	0.581
LIG_SH2_STAT5	953	956	PF00017	0.628
LIG_SH3_1	844	850	PF00018	0.815
LIG_SH3_1	898	904	PF00018	0.761
LIG_SH3_3	16	22	PF00018	0.628
LIG_SH3_3	422	428	PF00018	0.560
LIG_SH3_3	436	442	PF00018	0.645
LIG_SH3_3	468	474	PF00018	0.545
LIG_SH3_3	650	656	PF00018	0.449
LIG_SH3_3	806	812	PF00018	0.741
LIG_SH3_3	840	846	PF00018	0.807
LIG_SH3_3	898	904	PF00018	0.756
LIG_SH3_3	915	921	PF00018	0.622
LIG_SH3_5	949	953	PF00018	0.492
LIG_Sin3_3	787	794	PF02671	0.589
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.546
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.502
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.488
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.447
LIG_SUMO_SIM_anti_2	909	916	PF11976	0.724
LIG_SUMO_SIM_par_1	152	158	PF11976	0.415
LIG_SUMO_SIM_par_1	435	440	PF11976	0.568
LIG_TRAF2_1	101	104	PF00917	0.475
LIG_TRAF2_1	586	589	PF00917	0.638
LIG_TRAF2_1	592	595	PF00917	0.509
LIG_TRAF2_1	708	711	PF00917	0.515
LIG_UBA3_1	361	368	PF00899	0.432
LIG_UBA3_1	70	79	PF00899	0.564
LIG_WRC_WIRS_1	272	277	PF05994	0.456
LIG_WRC_WIRS_1	291	296	PF05994	0.376
MOD_CDK_SPK_2	677	682	PF00069	0.385
MOD_CDK_SPK_2	839	844	PF00069	0.595
MOD_CK1_1	39	45	PF00069	0.470
MOD_CK1_1	451	457	PF00069	0.567
MOD_CK1_1	462	468	PF00069	0.371
MOD_CK1_1	680	686	PF00069	0.473
MOD_CK2_1	152	158	PF00069	0.446
MOD_CK2_1	247	253	PF00069	0.569
MOD_CK2_1	444	450	PF00069	0.560
MOD_CK2_1	451	457	PF00069	0.447
MOD_CK2_1	519	525	PF00069	0.466
MOD_CK2_1	583	589	PF00069	0.582
MOD_CK2_1	59	65	PF00069	0.431
MOD_CK2_1	705	711	PF00069	0.526
MOD_CK2_1	728	734	PF00069	0.595
MOD_CK2_1	770	776	PF00069	0.692
MOD_CK2_1	829	835	PF00069	0.798
MOD_CK2_1	850	856	PF00069	0.728
MOD_CK2_1	935	941	PF00069	0.710
MOD_CK2_1	960	966	PF00069	0.569
MOD_CMANNOS	461	464	PF00535	0.403
MOD_Cter_Amidation	701	704	PF01082	0.349
MOD_GlcNHglycan	144	147	PF01048	0.589
MOD_GlcNHglycan	302	305	PF01048	0.529
MOD_GlcNHglycan	335	338	PF01048	0.487
MOD_GlcNHglycan	421	424	PF01048	0.601
MOD_GlcNHglycan	649	652	PF01048	0.604
MOD_GlcNHglycan	682	685	PF01048	0.493
MOD_GlcNHglycan	700	703	PF01048	0.277
MOD_GlcNHglycan	862	865	PF01048	0.660
MOD_GlcNHglycan	869	872	PF01048	0.650
MOD_GSK3_1	208	215	PF00069	0.452
MOD_GSK3_1	440	447	PF00069	0.628
MOD_GSK3_1	459	466	PF00069	0.481
MOD_GSK3_1	579	586	PF00069	0.519
MOD_GSK3_1	724	731	PF00069	0.533
MOD_GSK3_1	855	862	PF00069	0.635
MOD_GSK3_1	902	909	PF00069	0.731
MOD_N-GLC_1	179	184	PF02516	0.559
MOD_N-GLC_1	677	682	PF02516	0.385
MOD_N-GLC_1	867	872	PF02516	0.716
MOD_N-GLC_2	544	546	PF02516	0.497
MOD_NEK2_1	186	191	PF00069	0.586
MOD_NEK2_1	271	276	PF00069	0.513
MOD_NEK2_1	290	295	PF00069	0.326
MOD_NEK2_1	309	314	PF00069	0.243
MOD_NEK2_1	448	453	PF00069	0.607
MOD_NEK2_1	46	51	PF00069	0.493
MOD_NEK2_1	463	468	PF00069	0.357
MOD_NEK2_1	484	489	PF00069	0.476
MOD_NEK2_1	59	64	PF00069	0.489
MOD_NEK2_1	637	642	PF00069	0.493
MOD_NEK2_1	647	652	PF00069	0.548
MOD_NEK2_1	826	831	PF00069	0.788
MOD_NEK2_1	859	864	PF00069	0.658
MOD_NEK2_2	213	218	PF00069	0.480
MOD_NEK2_2	926	931	PF00069	0.724
MOD_PIKK_1	751	757	PF00454	0.630
MOD_PIKK_1	829	835	PF00454	0.782
MOD_PKA_1	36	42	PF00069	0.369
MOD_PKA_2	36	42	PF00069	0.369
MOD_PKA_2	736	742	PF00069	0.415
MOD_PKA_2	866	872	PF00069	0.742
MOD_PKB_1	10	18	PF00069	0.535
MOD_PKB_1	120	128	PF00069	0.358
MOD_Plk_1	179	185	PF00069	0.504
MOD_Plk_1	403	409	PF00069	0.518
MOD_Plk_1	826	832	PF00069	0.674
MOD_Plk_1	855	861	PF00069	0.679
MOD_Plk_1	935	941	PF00069	0.773
MOD_Plk_2-3	302	308	PF00069	0.414
MOD_Plk_4	152	158	PF00069	0.475
MOD_Plk_4	181	187	PF00069	0.461
MOD_Plk_4	271	277	PF00069	0.457
MOD_Plk_4	39	45	PF00069	0.505
MOD_Plk_4	427	433	PF00069	0.534
MOD_Plk_4	448	454	PF00069	0.581
MOD_Plk_4	463	469	PF00069	0.305
MOD_Plk_4	491	497	PF00069	0.391
MOD_Plk_4	502	508	PF00069	0.357
MOD_Plk_4	579	585	PF00069	0.513
MOD_Plk_4	855	861	PF00069	0.644
MOD_Plk_4	88	94	PF00069	0.343
MOD_Plk_4	919	925	PF00069	0.633
MOD_Plk_4	960	966	PF00069	0.652
MOD_ProDKin_1	18	24	PF00069	0.700
MOD_ProDKin_1	356	362	PF00069	0.302
MOD_ProDKin_1	652	658	PF00069	0.460
MOD_ProDKin_1	677	683	PF00069	0.381
MOD_ProDKin_1	820	826	PF00069	0.765
MOD_ProDKin_1	839	845	PF00069	0.765
MOD_SUMO_for_1	367	370	PF00179	0.428
MOD_SUMO_for_1	398	401	PF00179	0.519
MOD_SUMO_rev_2	258	264	PF00179	0.419
TRG_DiLeu_BaEn_1	3	8	PF01217	0.589
TRG_DiLeu_BaEn_1	621	626	PF01217	0.545
TRG_DiLeu_BaEn_2	369	375	PF01217	0.517
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.495
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.421
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.511
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.556
TRG_ENDOCYTIC_2	238	241	PF00928	0.470
TRG_ENDOCYTIC_2	276	279	PF00928	0.376
TRG_ENDOCYTIC_2	288	291	PF00928	0.457
TRG_ENDOCYTIC_2	371	374	PF00928	0.425
TRG_ENDOCYTIC_2	610	613	PF00928	0.556
TRG_ENDOCYTIC_2	799	802	PF00928	0.678
TRG_ER_diArg_1	129	131	PF00400	0.568
TRG_ER_diArg_1	314	316	PF00400	0.519
TRG_ER_diArg_1	343	346	PF00400	0.464
TRG_ER_diArg_1	379	382	PF00400	0.468
TRG_ER_diArg_1	50	52	PF00400	0.462
TRG_ER_diArg_1	676	679	PF00400	0.545
TRG_ER_diArg_1	8	10	PF00400	0.513
TRG_ER_diArg_1	874	877	PF00400	0.788
TRG_NLS_MonoExtC_3	247	253	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTN3	Leptomonas seymouri	63%	99%
A0A1X0NSF8	Trypanosomatidae	33%	100%
A0A3Q8ITR9	Leishmania donovani	92%	100%
A0A422NHV7	Trypanosoma rangeli	36%	100%
A4HL32	Leishmania braziliensis	81%	100%
A4I8L3	Leishmania infantum	92%	100%
D0AAK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AXZ4	Trypanosoma cruzi	36%	100%