Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4M6_LEIMA

TriTrypDb:

LmjF.32.3960 , LMJLV39_320047500 , LMJSD75_320047700

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4M6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.531
CLV_NRD_NRD_1	134	136	PF00675	0.425
CLV_NRD_NRD_1	164	166	PF00675	0.574
CLV_NRD_NRD_1	38	40	PF00675	0.484
CLV_NRD_NRD_1	46	48	PF00675	0.521
CLV_PCSK_KEX2_1	134	136	PF00082	0.425
CLV_PCSK_KEX2_1	175	177	PF00082	0.548
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.548
CLV_PCSK_PC7_1	171	177	PF00082	0.605
CLV_PCSK_SKI1_1	176	180	PF00082	0.651
CLV_PCSK_SKI1_1	39	43	PF00082	0.506
DEG_APCC_DBOX_1	92	100	PF00400	0.514
DEG_Nend_Nbox_1	1	3	PF02207	0.646
DOC_MAPK_gen_1	165	172	PF00069	0.420
DOC_MAPK_gen_1	39	46	PF00069	0.495
DOC_MAPK_MEF2A_6	39	46	PF00069	0.469
DOC_MAPK_MEF2A_6	8	15	PF00069	0.651
DOC_MAPK_NFAT4_5	39	47	PF00069	0.473
DOC_MAPK_RevD_3	27	40	PF00069	0.530
DOC_PP1_RVXF_1	10	16	PF00149	0.490
DOC_PP4_FxxP_1	15	18	PF00568	0.551
DOC_USP7_MATH_1	18	22	PF00917	0.598
DOC_USP7_UBL2_3	149	153	PF12436	0.442
DOC_USP7_UBL2_3	175	179	PF12436	0.538
DOC_WW_Pin1_4	14	19	PF00397	0.563
LIG_FHA_1	51	57	PF00498	0.598
LIG_FHA_2	157	163	PF00498	0.509
LIG_FHA_2	179	185	PF00498	0.546
LIG_FHA_2	61	67	PF00498	0.495
LIG_LIR_Apic_2	14	18	PF02991	0.505
LIG_LIR_Nem_3	108	112	PF02991	0.489
LIG_LIR_Nem_3	35	41	PF02991	0.494
LIG_Pex14_2	132	136	PF04695	0.554
LIG_SH2_CRK	38	42	PF00017	0.460
LIG_SH2_GRB2like	100	103	PF00017	0.622
LIG_SH2_STAP1	65	69	PF00017	0.550
LIG_SH2_STAT5	45	48	PF00017	0.482
LIG_SH3_3	17	23	PF00018	0.573
LIG_TRAF2_1	128	131	PF00917	0.526
LIG_TRAF2_1	74	77	PF00917	0.605
LIG_TRAF2_2	23	28	PF00917	0.600
LIG_TRFH_1	27	31	PF08558	0.647
LIG_TYR_ITIM	36	41	PF00017	0.461
LIG_UBA3_1	41	48	PF00899	0.473
LIG_UBA3_1	80	84	PF00899	0.570
MOD_CK2_1	125	131	PF00069	0.547
MOD_CK2_1	60	66	PF00069	0.492
MOD_GlcNHglycan	117	120	PF01048	0.651
MOD_GlcNHglycan	127	130	PF01048	0.616
MOD_GSK3_1	14	21	PF00069	0.620
MOD_GSK3_1	48	55	PF00069	0.477
MOD_LATS_1	137	143	PF00433	0.583
MOD_N-GLC_1	105	110	PF02516	0.550
MOD_PKA_2	156	162	PF00069	0.511
MOD_Plk_1	105	111	PF00069	0.525
MOD_Plk_4	105	111	PF00069	0.528
MOD_Plk_4	32	38	PF00069	0.487
MOD_Plk_4	52	58	PF00069	0.511
MOD_ProDKin_1	14	20	PF00069	0.559
MOD_SUMO_for_1	11	14	PF00179	0.563
MOD_SUMO_for_1	74	77	PF00179	0.511
MOD_SUMO_rev_2	141	151	PF00179	0.475
TRG_DiLeu_BaEn_1	76	81	PF01217	0.550
TRG_DiLeu_BaEn_4	76	82	PF01217	0.604
TRG_ENDOCYTIC_2	38	41	PF00928	0.461
TRG_ER_diArg_1	133	135	PF00400	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q7	Leptomonas seymouri	88%	100%
A0A0S4INC1	Bodo saltans	56%	86%
A0A1X0NTH6	Trypanosomatidae	66%	99%
A0A3S7X692	Leishmania donovani	96%	100%
A0A422NHV0	Trypanosoma rangeli	62%	100%
A4HL33	Leishmania braziliensis	91%	100%
A4I8L4	Leishmania infantum	95%	100%
D0AAK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9B3H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%