LeishMANIAdb
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Cyclic nucleotide-binding protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cyclic nucleotide-binding protein-like protein
Gene product:
cAMP response protein 1, putative
Species:
Leishmania major
UniProt:
Q4Q4M5_LEIMA
TriTrypDb:
LmjF.32.3970 , LMJLV39_320047600 * , LMJSD75_320047800 *
Length:
699

Annotations

LeishMANIAdb annotations

A protein related to animal PKA regulatory subunits. Likely binds cAMP.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4M5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4M5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 2
GO:0005488 binding 1 2
GO:0017076 purine nucleotide binding 4 2
GO:0030551 cyclic nucleotide binding 4 2
GO:0030552 cAMP binding 4 2
GO:0030554 adenyl nucleotide binding 5 2
GO:0032553 ribonucleotide binding 3 2
GO:0032555 purine ribonucleotide binding 4 2
GO:0032559 adenyl ribonucleotide binding 5 2
GO:0036094 small molecule binding 2 2
GO:0043167 ion binding 2 2
GO:0043168 anion binding 3 2
GO:0097159 organic cyclic compound binding 2 2
GO:0097367 carbohydrate derivative binding 2 2
GO:1901265 nucleoside phosphate binding 3 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.355
CLV_NRD_NRD_1 136 138 PF00675 0.489
CLV_NRD_NRD_1 152 154 PF00675 0.447
CLV_NRD_NRD_1 160 162 PF00675 0.450
CLV_NRD_NRD_1 180 182 PF00675 0.456
CLV_NRD_NRD_1 198 200 PF00675 0.470
CLV_NRD_NRD_1 207 209 PF00675 0.482
CLV_NRD_NRD_1 215 217 PF00675 0.463
CLV_NRD_NRD_1 285 287 PF00675 0.405
CLV_NRD_NRD_1 293 295 PF00675 0.300
CLV_NRD_NRD_1 3 5 PF00675 0.695
CLV_NRD_NRD_1 365 367 PF00675 0.440
CLV_NRD_NRD_1 439 441 PF00675 0.398
CLV_NRD_NRD_1 517 519 PF00675 0.422
CLV_NRD_NRD_1 697 699 PF00675 0.734
CLV_PCSK_FUR_1 204 208 PF00082 0.552
CLV_PCSK_FUR_1 290 294 PF00082 0.363
CLV_PCSK_KEX2_1 136 138 PF00082 0.489
CLV_PCSK_KEX2_1 151 153 PF00082 0.480
CLV_PCSK_KEX2_1 180 182 PF00082 0.454
CLV_PCSK_KEX2_1 198 200 PF00082 0.366
CLV_PCSK_KEX2_1 206 208 PF00082 0.478
CLV_PCSK_KEX2_1 215 217 PF00082 0.454
CLV_PCSK_KEX2_1 292 294 PF00082 0.350
CLV_PCSK_KEX2_1 3 5 PF00082 0.651
CLV_PCSK_KEX2_1 364 366 PF00082 0.439
CLV_PCSK_KEX2_1 370 372 PF00082 0.443
CLV_PCSK_KEX2_1 461 463 PF00082 0.332
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.610
CLV_PCSK_PC1ET2_1 292 294 PF00082 0.350
CLV_PCSK_PC1ET2_1 370 372 PF00082 0.515
CLV_PCSK_PC1ET2_1 461 463 PF00082 0.332
CLV_PCSK_PC7_1 132 138 PF00082 0.508
CLV_PCSK_PC7_1 366 372 PF00082 0.588
CLV_PCSK_SKI1_1 198 202 PF00082 0.574
CLV_PCSK_SKI1_1 271 275 PF00082 0.407
CLV_PCSK_SKI1_1 358 362 PF00082 0.460
CLV_PCSK_SKI1_1 370 374 PF00082 0.437
CLV_PCSK_SKI1_1 392 396 PF00082 0.468
CLV_PCSK_SKI1_1 440 444 PF00082 0.480
CLV_PCSK_SKI1_1 478 482 PF00082 0.297
CLV_PCSK_SKI1_1 511 515 PF00082 0.546
CLV_PCSK_SKI1_1 549 553 PF00082 0.512
CLV_PCSK_SKI1_1 67 71 PF00082 0.589
DEG_APCC_DBOX_1 214 222 PF00400 0.460
DEG_APCC_DBOX_1 477 485 PF00400 0.340
DEG_APCC_DBOX_1 528 536 PF00400 0.458
DEG_APCC_KENBOX_2 295 299 PF00400 0.434
DEG_Nend_UBRbox_2 1 3 PF02207 0.735
DEG_SPOP_SBC_1 60 64 PF00917 0.498
DOC_CYCLIN_RxL_1 64 73 PF00134 0.598
DOC_MAPK_FxFP_2 223 226 PF00069 0.552
DOC_MAPK_gen_1 159 168 PF00069 0.468
DOC_MAPK_gen_1 215 223 PF00069 0.543
DOC_MAPK_gen_1 3 11 PF00069 0.719
DOC_MAPK_gen_1 370 377 PF00069 0.488
DOC_MAPK_gen_1 440 450 PF00069 0.482
DOC_MAPK_gen_1 461 468 PF00069 0.402
DOC_MAPK_gen_1 475 484 PF00069 0.249
DOC_MAPK_gen_1 518 525 PF00069 0.403
DOC_MAPK_HePTP_8 552 564 PF00069 0.537
DOC_MAPK_MEF2A_6 370 379 PF00069 0.439
DOC_MAPK_MEF2A_6 475 484 PF00069 0.347
DOC_MAPK_MEF2A_6 555 564 PF00069 0.532
DOC_MAPK_RevD_3 191 207 PF00069 0.497
DOC_MAPK_RevD_3 274 288 PF00069 0.402
DOC_PP1_RVXF_1 269 275 PF00149 0.428
DOC_PP2B_LxvP_1 192 195 PF13499 0.538
DOC_PP4_FxxP_1 223 226 PF00568 0.407
DOC_PP4_FxxP_1 38 41 PF00568 0.578
DOC_PP4_FxxP_1 525 528 PF00568 0.479
DOC_USP7_MATH_1 352 356 PF00917 0.571
DOC_USP7_MATH_1 46 50 PF00917 0.642
DOC_USP7_MATH_1 521 525 PF00917 0.519
DOC_USP7_MATH_1 58 62 PF00917 0.625
DOC_USP7_UBL2_3 247 251 PF12436 0.507
DOC_USP7_UBL2_3 288 292 PF12436 0.403
DOC_WW_Pin1_4 335 340 PF00397 0.378
DOC_WW_Pin1_4 347 352 PF00397 0.509
DOC_WW_Pin1_4 537 542 PF00397 0.519
LIG_14-3-3_CanoR_1 3 11 PF00244 0.683
LIG_14-3-3_CanoR_1 51 56 PF00244 0.643
LIG_14-3-3_CanoR_1 529 533 PF00244 0.504
LIG_14-3-3_CanoR_1 582 590 PF00244 0.504
LIG_14-3-3_CanoR_1 596 601 PF00244 0.670
LIG_Actin_WH2_2 242 260 PF00022 0.479
LIG_APCC_ABBA_1 505 510 PF00400 0.527
LIG_BRCT_BRCA1_1 420 424 PF00533 0.334
LIG_BRCT_BRCA1_1 598 602 PF00533 0.647
LIG_BRCT_BRCA1_1 6 10 PF00533 0.717
LIG_eIF4E_1 142 148 PF01652 0.592
LIG_FHA_1 278 284 PF00498 0.319
LIG_FHA_1 393 399 PF00498 0.503
LIG_FHA_1 420 426 PF00498 0.480
LIG_FHA_1 538 544 PF00498 0.450
LIG_FHA_1 578 584 PF00498 0.517
LIG_FHA_2 117 123 PF00498 0.340
LIG_FHA_2 233 239 PF00498 0.500
LIG_FHA_2 99 105 PF00498 0.534
LIG_LIR_Apic_2 220 226 PF02991 0.526
LIG_LIR_Apic_2 37 41 PF02991 0.514
LIG_LIR_Apic_2 524 528 PF02991 0.518
LIG_LIR_Gen_1 187 197 PF02991 0.428
LIG_LIR_Gen_1 313 321 PF02991 0.335
LIG_LIR_Gen_1 340 349 PF02991 0.355
LIG_LIR_Gen_1 467 476 PF02991 0.322
LIG_LIR_Gen_1 49 60 PF02991 0.615
LIG_LIR_Gen_1 520 528 PF02991 0.372
LIG_LIR_Gen_1 682 690 PF02991 0.497
LIG_LIR_Nem_3 187 192 PF02991 0.453
LIG_LIR_Nem_3 313 317 PF02991 0.335
LIG_LIR_Nem_3 331 337 PF02991 0.335
LIG_LIR_Nem_3 340 345 PF02991 0.292
LIG_LIR_Nem_3 467 473 PF02991 0.322
LIG_LIR_Nem_3 49 55 PF02991 0.691
LIG_LIR_Nem_3 520 525 PF02991 0.363
LIG_LIR_Nem_3 599 605 PF02991 0.514
LIG_LIR_Nem_3 682 686 PF02991 0.477
LIG_MLH1_MIPbox_1 420 424 PF16413 0.335
LIG_Pex14_2 236 240 PF04695 0.409
LIG_Pex14_2 379 383 PF04695 0.431
LIG_PTB_Apo_2 379 386 PF02174 0.528
LIG_PTB_Phospho_1 379 385 PF10480 0.533
LIG_Rb_LxCxE_1 313 331 PF01857 0.335
LIG_SH2_NCK_1 342 346 PF00017 0.331
LIG_SH2_PTP2 52 55 PF00017 0.732
LIG_SH2_SRC 342 345 PF00017 0.355
LIG_SH2_STAP1 342 346 PF00017 0.355
LIG_SH2_STAP1 621 625 PF00017 0.409
LIG_SH2_STAT3 107 110 PF00017 0.577
LIG_SH2_STAT3 142 145 PF00017 0.482
LIG_SH2_STAT3 385 388 PF00017 0.491
LIG_SH2_STAT3 423 426 PF00017 0.335
LIG_SH2_STAT5 107 110 PF00017 0.440
LIG_SH2_STAT5 256 259 PF00017 0.378
LIG_SH2_STAT5 262 265 PF00017 0.378
LIG_SH2_STAT5 348 351 PF00017 0.585
LIG_SH2_STAT5 385 388 PF00017 0.386
LIG_SH2_STAT5 411 414 PF00017 0.408
LIG_SH2_STAT5 423 426 PF00017 0.258
LIG_SH2_STAT5 470 473 PF00017 0.355
LIG_SH2_STAT5 52 55 PF00017 0.663
LIG_SH3_3 38 44 PF00018 0.563
LIG_SUMO_SIM_anti_2 164 169 PF11976 0.488
LIG_SUMO_SIM_anti_2 280 285 PF11976 0.331
LIG_SUMO_SIM_anti_2 548 554 PF11976 0.516
LIG_SUMO_SIM_par_1 274 280 PF11976 0.402
LIG_SUMO_SIM_par_1 402 408 PF11976 0.378
LIG_SUMO_SIM_par_1 565 571 PF11976 0.510
LIG_TRAF2_1 25 28 PF00917 0.638
LIG_TRAF2_1 338 341 PF00917 0.363
LIG_TRFH_1 191 195 PF08558 0.530
LIG_TYR_ITIM 332 337 PF00017 0.447
LIG_TYR_ITIM 468 473 PF00017 0.447
LIG_UBA3_1 244 253 PF00899 0.397
LIG_UBA3_1 77 83 PF00899 0.571
LIG_WRC_WIRS_1 186 191 PF05994 0.544
LIG_WRC_WIRS_1 35 40 PF05994 0.666
LIG_WRC_WIRS_1 522 527 PF05994 0.454
MOD_CK1_1 390 396 PF00069 0.561
MOD_CK1_1 460 466 PF00069 0.384
MOD_CK1_1 530 536 PF00069 0.483
MOD_CK1_1 539 545 PF00069 0.489
MOD_CK1_1 588 594 PF00069 0.673
MOD_CK1_1 61 67 PF00069 0.675
MOD_CK1_1 616 622 PF00069 0.409
MOD_CK1_1 656 662 PF00069 0.578
MOD_CK2_1 116 122 PF00069 0.533
MOD_CK2_1 22 28 PF00069 0.695
MOD_CK2_1 232 238 PF00069 0.538
MOD_CK2_1 335 341 PF00069 0.363
MOD_CK2_1 570 576 PF00069 0.545
MOD_GlcNHglycan 258 261 PF01048 0.368
MOD_GlcNHglycan 299 302 PF01048 0.434
MOD_GlcNHglycan 322 325 PF01048 0.335
MOD_GlcNHglycan 564 567 PF01048 0.441
MOD_GlcNHglycan 598 601 PF01048 0.631
MOD_GSK3_1 228 235 PF00069 0.458
MOD_GSK3_1 292 299 PF00069 0.355
MOD_GSK3_1 457 464 PF00069 0.450
MOD_GSK3_1 5 12 PF00069 0.737
MOD_GSK3_1 558 565 PF00069 0.485
MOD_GSK3_1 588 595 PF00069 0.520
MOD_GSK3_1 59 66 PF00069 0.698
MOD_GSK3_1 624 631 PF00069 0.405
MOD_GSK3_1 94 101 PF00069 0.538
MOD_N-GLC_1 14 19 PF02516 0.731
MOD_N-GLC_1 297 302 PF02516 0.434
MOD_N-GLC_1 457 462 PF02516 0.443
MOD_N-GLC_1 5 10 PF02516 0.725
MOD_N-GLC_1 596 601 PF02516 0.639
MOD_N-GLC_2 469 471 PF02516 0.317
MOD_NEK2_1 232 237 PF00069 0.422
MOD_NEK2_1 274 279 PF00069 0.335
MOD_NEK2_1 443 448 PF00069 0.480
MOD_NEK2_1 451 456 PF00069 0.348
MOD_NEK2_1 536 541 PF00069 0.482
MOD_NEK2_1 553 558 PF00069 0.406
MOD_NEK2_1 568 573 PF00069 0.316
MOD_NEK2_1 59 64 PF00069 0.552
MOD_NEK2_1 614 619 PF00069 0.500
MOD_NEK2_1 653 658 PF00069 0.503
MOD_NEK2_1 681 686 PF00069 0.474
MOD_NEK2_1 76 81 PF00069 0.602
MOD_PIKK_1 116 122 PF00454 0.462
MOD_PIKK_1 392 398 PF00454 0.534
MOD_PIKK_1 616 622 PF00454 0.445
MOD_PK_1 136 142 PF00069 0.555
MOD_PK_1 161 167 PF00069 0.496
MOD_PK_1 322 328 PF00069 0.335
MOD_PK_1 461 467 PF00069 0.408
MOD_PK_1 5 11 PF00069 0.721
MOD_PKA_1 136 142 PF00069 0.355
MOD_PKA_1 161 167 PF00069 0.496
MOD_PKA_1 292 298 PF00069 0.355
MOD_PKA_1 4 10 PF00069 0.603
MOD_PKA_1 461 467 PF00069 0.335
MOD_PKA_2 136 142 PF00069 0.601
MOD_PKA_2 292 298 PF00069 0.447
MOD_PKA_2 461 467 PF00069 0.356
MOD_PKA_2 474 480 PF00069 0.309
MOD_PKA_2 528 534 PF00069 0.466
MOD_PKA_2 94 100 PF00069 0.524
MOD_PKB_1 159 167 PF00069 0.497
MOD_Plk_1 153 159 PF00069 0.578
MOD_Plk_1 390 396 PF00069 0.564
MOD_Plk_1 418 424 PF00069 0.343
MOD_Plk_1 5 11 PF00069 0.727
MOD_Plk_1 568 574 PF00069 0.423
MOD_Plk_2-3 689 695 PF00069 0.535
MOD_Plk_4 136 142 PF00069 0.477
MOD_Plk_4 232 238 PF00069 0.467
MOD_Plk_4 279 285 PF00069 0.355
MOD_Plk_4 322 328 PF00069 0.408
MOD_Plk_4 419 425 PF00069 0.480
MOD_Plk_4 461 467 PF00069 0.335
MOD_Plk_4 5 11 PF00069 0.721
MOD_Plk_4 539 545 PF00069 0.460
MOD_Plk_4 558 564 PF00069 0.244
MOD_ProDKin_1 335 341 PF00069 0.378
MOD_ProDKin_1 347 353 PF00069 0.503
MOD_ProDKin_1 537 543 PF00069 0.514
MOD_SUMO_rev_2 434 443 PF00179 0.402
MOD_SUMO_rev_2 454 463 PF00179 0.227
TRG_DiLeu_BaEn_1 488 493 PF01217 0.482
TRG_DiLeu_BaEn_1 548 553 PF01217 0.512
TRG_DiLeu_BaEn_1 670 675 PF01217 0.576
TRG_ENDOCYTIC_2 334 337 PF00928 0.384
TRG_ENDOCYTIC_2 342 345 PF00928 0.319
TRG_ENDOCYTIC_2 470 473 PF00928 0.342
TRG_ENDOCYTIC_2 52 55 PF00928 0.620
TRG_ENDOCYTIC_2 522 525 PF00928 0.390
TRG_ENDOCYTIC_2 687 690 PF00928 0.550
TRG_ER_diArg_1 180 182 PF00400 0.479
TRG_ER_diArg_1 197 199 PF00400 0.397
TRG_ER_diArg_1 203 206 PF00400 0.514
TRG_ER_diArg_1 363 366 PF00400 0.446
TRG_ER_diArg_1 657 660 PF00400 0.505
TRG_NES_CRM1_1 472 483 PF08389 0.356
TRG_NLS_MonoExtC_3 285 290 PF00514 0.385
TRG_Pf-PMV_PEXEL_1 216 220 PF00026 0.579
TRG_Pf-PMV_PEXEL_1 650 655 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 691 696 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAZ4 Leptomonas seymouri 65% 100%
A0A1X0NTP9 Trypanosomatidae 47% 98%
A0A3Q8IDJ1 Leishmania donovani 96% 100%
A0A422NHV4 Trypanosoma rangeli 47% 99%
A4HL34 Leishmania braziliensis 80% 100%
A4I8L5 Leishmania infantum 96% 100%
D0AAJ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 99%
E9B3H5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BDD3 Trypanosoma cruzi 48% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS