H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gar1/Naf1 RNA binding region, putative

Species:

Leishmania major

UniProt:

Q4Q4M4_LEIMA

TriTrypDb:

LmjF.32.3980 , LMJLV39_320047700 , LMJSD75_320047900

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	7
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4Q4M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4M4

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	7
GO:0000493	box H/ACA snoRNP assembly	8	7
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0022607	cellular component assembly	4	7
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0022618	ribonucleoprotein complex assembly	6	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0042254	ribosome biogenesis	5	2
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0044085	cellular component biogenesis	3	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071704	organic substance metabolic process	2	7
GO:0071826	ribonucleoprotein complex subunit organization	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.643
CLV_PCSK_FUR_1	147	151	PF00082	0.600
CLV_PCSK_KEX2_1	146	148	PF00082	0.596
CLV_PCSK_KEX2_1	149	151	PF00082	0.603
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.596
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.603
CLV_PCSK_PC7_1	147	153	PF00082	0.628
CLV_PCSK_SKI1_1	67	71	PF00082	0.410
DEG_SPOP_SBC_1	72	76	PF00917	0.233
DOC_PP1_RVXF_1	139	146	PF00149	0.418
DOC_PP2B_LxvP_1	6	9	PF13499	0.603
DOC_USP7_MATH_1	19	23	PF00917	0.507
DOC_USP7_MATH_1	27	31	PF00917	0.344
LIG_14-3-3_CanoR_1	11	20	PF00244	0.581
LIG_AP2alpha_2	107	109	PF02296	0.578
LIG_APCC_ABBA_1	93	98	PF00400	0.508
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BIR_III_2	178	182	PF00653	0.689
LIG_BIR_III_3	1	5	PF00653	0.696
LIG_FHA_1	3	9	PF00498	0.561
LIG_FHA_2	74	80	PF00498	0.508
LIG_Integrin_RGD_1	152	154	PF01839	0.650
LIG_LIR_Apic_2	130	134	PF02991	0.635
LIG_LIR_Gen_1	167	175	PF02991	0.654
LIG_LIR_Nem_3	167	173	PF02991	0.652
LIG_LIR_Nem_3	52	58	PF02991	0.459
LIG_SH2_GRB2like	122	125	PF00017	0.637
LIG_SH2_PTP2	131	134	PF00017	0.628
LIG_SH2_STAT5	122	125	PF00017	0.637
LIG_SH2_STAT5	131	134	PF00017	0.605
LIG_SH2_STAT5	58	61	PF00017	0.477
LIG_SH2_STAT5	71	74	PF00017	0.294
LIG_SH3_3	184	190	PF00018	0.667
LIG_SH3_3	59	65	PF00018	0.410
LIG_SUMO_SIM_par_1	14	22	PF11976	0.573
MOD_CK1_1	158	164	PF00069	0.695
MOD_CK1_1	22	28	PF00069	0.508
MOD_CK2_1	134	140	PF00069	0.590
MOD_CK2_1	157	163	PF00069	0.693
MOD_GlcNHglycan	194	197	PF01048	0.721
MOD_GlcNHglycan	21	24	PF01048	0.489
MOD_N-GLC_1	155	160	PF02516	0.687
MOD_Plk_1	118	124	PF00069	0.635
MOD_Plk_1	155	161	PF00069	0.689
MOD_Plk_1	2	8	PF00069	0.550
MOD_Plk_4	118	124	PF00069	0.635
MOD_Plk_4	2	8	PF00069	0.550
MOD_Plk_4	51	57	PF00069	0.405
MOD_Plk_4	58	64	PF00069	0.402
MOD_SUMO_rev_2	135	143	PF00179	0.587
TRG_ENDOCYTIC_2	106	109	PF00928	0.565
TRG_ER_diArg_1	150	152	PF00400	0.536
TRG_NES_CRM1_1	38	52	PF08389	0.508
TRG_NLS_MonoCore_2	148	153	PF00514	0.630
TRG_NLS_MonoExtC_3	145	150	PF00514	0.590
TRG_NLS_MonoExtN_4	146	153	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P446	Leptomonas seymouri	69%	72%
A0A3S7X6B4	Leishmania donovani	93%	100%
A4HL35	Leishmania braziliensis	83%	100%
A4I8L6	Leishmania infantum	92%	100%
E9B3H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%