LysM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4M2_LEIMA

TriTrypDb:

LmjF.33.0010 , LMJLV39_330005100 , LMJSD75_330005000

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4M2

PDB structure(s): 7ane_e

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	586	590	PF00656	0.624
CLV_NRD_NRD_1	117	119	PF00675	0.568
CLV_NRD_NRD_1	2	4	PF00675	0.534
CLV_NRD_NRD_1	397	399	PF00675	0.388
CLV_NRD_NRD_1	439	441	PF00675	0.412
CLV_NRD_NRD_1	530	532	PF00675	0.403
CLV_NRD_NRD_1	557	559	PF00675	0.559
CLV_NRD_NRD_1	669	671	PF00675	0.429
CLV_PCSK_FUR_1	223	227	PF00082	0.438
CLV_PCSK_FUR_1	667	671	PF00082	0.540
CLV_PCSK_KEX2_1	2	4	PF00082	0.534
CLV_PCSK_KEX2_1	225	227	PF00082	0.444
CLV_PCSK_KEX2_1	439	441	PF00082	0.505
CLV_PCSK_KEX2_1	497	499	PF00082	0.475
CLV_PCSK_KEX2_1	530	532	PF00082	0.403
CLV_PCSK_KEX2_1	557	559	PF00082	0.487
CLV_PCSK_KEX2_1	669	671	PF00082	0.429
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.480
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.475
CLV_PCSK_SKI1_1	139	143	PF00082	0.526
CLV_PCSK_SKI1_1	226	230	PF00082	0.453
CLV_PCSK_SKI1_1	245	249	PF00082	0.243
CLV_PCSK_SKI1_1	530	534	PF00082	0.445
DEG_APCC_DBOX_1	282	290	PF00400	0.548
DEG_APCC_DBOX_1	326	334	PF00400	0.436
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DEG_SCF_FBW7_1	723	729	PF00400	0.606
DEG_SCF_FBW7_2	772	779	PF00400	0.483
DOC_CDC14_PxL_1	698	706	PF14671	0.525
DOC_CKS1_1	715	720	PF01111	0.489
DOC_CKS1_1	723	728	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	784	790	PF00134	0.486
DOC_MAPK_gen_1	398	406	PF00069	0.353
DOC_MAPK_MEF2A_6	399	408	PF00069	0.434
DOC_PP1_RVXF_1	813	820	PF00149	0.444
DOC_PP2B_LxvP_1	599	602	PF13499	0.416
DOC_PP4_FxxP_1	23	26	PF00568	0.523
DOC_PP4_FxxP_1	43	46	PF00568	0.289
DOC_USP7_MATH_1	125	129	PF00917	0.484
DOC_USP7_MATH_1	200	204	PF00917	0.500
DOC_USP7_MATH_1	349	353	PF00917	0.518
DOC_USP7_MATH_1	357	361	PF00917	0.386
DOC_USP7_MATH_1	409	413	PF00917	0.389
DOC_USP7_MATH_1	552	556	PF00917	0.549
DOC_USP7_MATH_1	584	588	PF00917	0.685
DOC_USP7_MATH_1	610	614	PF00917	0.506
DOC_USP7_MATH_1	651	655	PF00917	0.544
DOC_USP7_MATH_1	657	661	PF00917	0.384
DOC_USP7_UBL2_3	221	225	PF12436	0.463
DOC_USP7_UBL2_3	741	745	PF12436	0.501
DOC_WW_Pin1_4	121	126	PF00397	0.564
DOC_WW_Pin1_4	174	179	PF00397	0.443
DOC_WW_Pin1_4	535	540	PF00397	0.538
DOC_WW_Pin1_4	606	611	PF00397	0.376
DOC_WW_Pin1_4	714	719	PF00397	0.491
DOC_WW_Pin1_4	722	727	PF00397	0.505
DOC_WW_Pin1_4	772	777	PF00397	0.462
LIG_14-3-3_CanoR_1	2	7	PF00244	0.556
LIG_14-3-3_CanoR_1	202	206	PF00244	0.511
LIG_14-3-3_CanoR_1	208	217	PF00244	0.455
LIG_14-3-3_CanoR_1	283	287	PF00244	0.525
LIG_14-3-3_CanoR_1	428	434	PF00244	0.420
LIG_14-3-3_CanoR_1	465	470	PF00244	0.432
LIG_14-3-3_CanoR_1	498	506	PF00244	0.407
LIG_14-3-3_CanoR_1	530	536	PF00244	0.425
LIG_14-3-3_CanoR_1	632	640	PF00244	0.328
LIG_14-3-3_CanoR_1	87	94	PF00244	0.456
LIG_Actin_WH2_2	252	270	PF00022	0.376
LIG_Actin_WH2_2	492	509	PF00022	0.364
LIG_AP_GAE_1	611	617	PF02883	0.537
LIG_APCC_ABBA_1	100	105	PF00400	0.450
LIG_BRCT_BRCA1_1	411	415	PF00533	0.385
LIG_BRCT_BRCA1_1	430	434	PF00533	0.477
LIG_BRCT_BRCA1_1	445	449	PF00533	0.511
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.420
LIG_FHA_1	149	155	PF00498	0.641
LIG_FHA_1	161	167	PF00498	0.538
LIG_FHA_1	241	247	PF00498	0.357
LIG_FHA_1	349	355	PF00498	0.574
LIG_FHA_1	527	533	PF00498	0.505
LIG_FHA_1	536	542	PF00498	0.544
LIG_FHA_1	680	686	PF00498	0.462
LIG_FHA_1	78	84	PF00498	0.453
LIG_FHA_2	384	390	PF00498	0.432
LIG_FHA_2	411	417	PF00498	0.446
LIG_FHA_2	428	434	PF00498	0.297
LIG_FHA_2	449	455	PF00498	0.469
LIG_FHA_2	687	693	PF00498	0.457
LIG_FHA_2	773	779	PF00498	0.467
LIG_GBD_Chelix_1	322	330	PF00786	0.463
LIG_LIR_Apic_2	12	17	PF02991	0.462
LIG_LIR_Apic_2	40	46	PF02991	0.474
LIG_LIR_Apic_2	714	718	PF02991	0.482
LIG_LIR_Apic_2	816	822	PF02991	0.446
LIG_LIR_Gen_1	368	376	PF02991	0.419
LIG_LIR_Gen_1	382	393	PF02991	0.426
LIG_LIR_Gen_1	479	486	PF02991	0.468
LIG_LIR_Gen_1	490	499	PF02991	0.307
LIG_LIR_Gen_1	611	621	PF02991	0.489
LIG_LIR_Gen_1	624	633	PF02991	0.308
LIG_LIR_LC3C_4	598	601	PF02991	0.579
LIG_LIR_Nem_3	211	217	PF02991	0.413
LIG_LIR_Nem_3	241	247	PF02991	0.357
LIG_LIR_Nem_3	360	364	PF02991	0.377
LIG_LIR_Nem_3	382	388	PF02991	0.425
LIG_LIR_Nem_3	396	400	PF02991	0.385
LIG_LIR_Nem_3	479	483	PF02991	0.472
LIG_LIR_Nem_3	490	495	PF02991	0.307
LIG_LIR_Nem_3	611	617	PF02991	0.438
LIG_LIR_Nem_3	624	629	PF02991	0.306
LIG_LIR_Nem_3	732	738	PF02991	0.442
LIG_MYND_1	674	678	PF01753	0.448
LIG_PCNA_yPIPBox_3	507	517	PF02747	0.415
LIG_Pex14_2	138	142	PF04695	0.472
LIG_Pex14_2	205	209	PF04695	0.400
LIG_Pex14_2	397	401	PF04695	0.374
LIG_Pex14_2	469	473	PF04695	0.397
LIG_Pex14_2	617	621	PF04695	0.569
LIG_Rb_LxCxE_1	494	515	PF01857	0.449
LIG_Rb_LxCxE_1	628	649	PF01857	0.385
LIG_SH2_CRK	14	18	PF00017	0.466
LIG_SH2_CRK	244	248	PF00017	0.347
LIG_SH2_CRK	715	719	PF00017	0.434
LIG_SH2_SRC	113	116	PF00017	0.462
LIG_SH2_SRC	69	72	PF00017	0.405
LIG_SH2_STAP1	215	219	PF00017	0.409
LIG_SH2_STAP1	355	359	PF00017	0.496
LIG_SH2_STAP1	738	742	PF00017	0.418
LIG_SH2_STAT3	123	126	PF00017	0.493
LIG_SH2_STAT5	113	116	PF00017	0.432
LIG_SH2_STAT5	123	126	PF00017	0.458
LIG_SH2_STAT5	400	403	PF00017	0.374
LIG_SH2_STAT5	480	483	PF00017	0.564
LIG_SH2_STAT5	69	72	PF00017	0.405
LIG_SH2_STAT5	738	741	PF00017	0.415
LIG_SH2_STAT5	74	77	PF00017	0.450
LIG_SH2_STAT5	742	745	PF00017	0.446
LIG_SH3_3	172	178	PF00018	0.504
LIG_SH3_3	26	32	PF00018	0.526
LIG_SH3_3	343	349	PF00018	0.423
LIG_SH3_3	356	362	PF00018	0.406
LIG_SH3_3	403	409	PF00018	0.434
LIG_SH3_3	519	525	PF00018	0.551
LIG_SH3_3	59	65	PF00018	0.440
LIG_SH3_3	656	662	PF00018	0.397
LIG_SH3_3	699	705	PF00018	0.506
LIG_SH3_3	720	726	PF00018	0.499
LIG_TRAF2_1	512	515	PF00917	0.626
LIG_TRAF2_1	566	569	PF00917	0.461
LIG_TRAF2_1	776	779	PF00917	0.470
LIG_TRAF2_2	543	548	PF00917	0.621
LIG_TYR_ITIM	242	247	PF00017	0.350
LIG_TYR_ITIM	478	483	PF00017	0.560
LIG_WRC_WIRS_1	466	471	PF05994	0.425
LIG_WRC_WIRS_1	532	537	PF05994	0.471
LIG_WRPW_2	100	103	PF00400	0.450
LIG_WRPW_2	86	89	PF00400	0.440
MOD_CDK_SPxxK_3	714	721	PF00069	0.489
MOD_CK1_1	121	127	PF00069	0.494
MOD_CK1_1	240	246	PF00069	0.337
MOD_CK1_1	285	291	PF00069	0.569
MOD_CK1_1	37	43	PF00069	0.504
MOD_CK1_1	380	386	PF00069	0.444
MOD_CK1_1	491	497	PF00069	0.409
MOD_CK1_1	534	540	PF00069	0.541
MOD_CK1_1	609	615	PF00069	0.483
MOD_CK1_1	655	661	PF00069	0.555
MOD_CK1_1	729	735	PF00069	0.533
MOD_CK2_1	174	180	PF00069	0.474
MOD_CK2_1	325	331	PF00069	0.502
MOD_CK2_1	381	387	PF00069	0.439
MOD_CK2_1	410	416	PF00069	0.418
MOD_CK2_1	427	433	PF00069	0.314
MOD_CK2_1	499	505	PF00069	0.435
MOD_CK2_1	563	569	PF00069	0.465
MOD_CK2_1	686	692	PF00069	0.464
MOD_CK2_1	772	778	PF00069	0.467
MOD_DYRK1A_RPxSP_1	174	178	PF00069	0.497
MOD_GlcNHglycan	290	293	PF01048	0.525
MOD_GlcNHglycan	445	448	PF01048	0.536
MOD_GlcNHglycan	474	477	PF01048	0.446
MOD_GlcNHglycan	526	529	PF01048	0.598
MOD_GlcNHglycan	586	589	PF01048	0.660
MOD_GlcNHglycan	663	666	PF01048	0.531
MOD_GlcNHglycan	695	698	PF01048	0.601
MOD_GlcNHglycan	89	92	PF01048	0.463
MOD_GSK3_1	121	128	PF00069	0.555
MOD_GSK3_1	141	148	PF00069	0.456
MOD_GSK3_1	278	285	PF00069	0.556
MOD_GSK3_1	376	383	PF00069	0.435
MOD_GSK3_1	520	527	PF00069	0.462
MOD_GSK3_1	530	537	PF00069	0.412
MOD_GSK3_1	606	613	PF00069	0.518
MOD_GSK3_1	651	658	PF00069	0.554
MOD_GSK3_1	717	724	PF00069	0.571
MOD_GSK3_1	813	820	PF00069	0.460
MOD_LATS_1	116	122	PF00433	0.482
MOD_LATS_1	463	469	PF00433	0.436
MOD_N-GLC_1	303	308	PF02516	0.563
MOD_N-GLC_1	35	40	PF02516	0.515
MOD_N-GLC_1	357	362	PF02516	0.533
MOD_NEK2_1	303	308	PF00069	0.562
MOD_NEK2_1	35	40	PF00069	0.530
MOD_NEK2_1	376	381	PF00069	0.434
MOD_NEK2_1	388	393	PF00069	0.384
MOD_NEK2_1	434	439	PF00069	0.507
MOD_NEK2_1	686	691	PF00069	0.491
MOD_NEK2_1	817	822	PF00069	0.490
MOD_PIKK_1	15	21	PF00454	0.489
MOD_PK_1	278	284	PF00069	0.501
MOD_PKA_1	118	124	PF00069	0.601
MOD_PKA_1	2	8	PF00069	0.636
MOD_PKA_1	530	536	PF00069	0.420
MOD_PKA_2	157	163	PF00069	0.611
MOD_PKA_2	2	8	PF00069	0.537
MOD_PKA_2	201	207	PF00069	0.551
MOD_PKA_2	282	288	PF00069	0.533
MOD_PKA_2	427	433	PF00069	0.404
MOD_PKA_2	530	536	PF00069	0.435
MOD_PKB_1	13	21	PF00069	0.489
MOD_Plk_1	200	206	PF00069	0.449
MOD_Plk_1	240	246	PF00069	0.366
MOD_Plk_1	303	309	PF00069	0.558
MOD_Plk_1	357	363	PF00069	0.519
MOD_Plk_1	381	387	PF00069	0.439
MOD_Plk_1	610	616	PF00069	0.518
MOD_Plk_1	779	785	PF00069	0.476
MOD_Plk_2-3	479	485	PF00069	0.491
MOD_Plk_4	157	163	PF00069	0.487
MOD_Plk_4	537	543	PF00069	0.617
MOD_Plk_4	577	583	PF00069	0.580
MOD_Plk_4	69	75	PF00069	0.427
MOD_Plk_4	752	758	PF00069	0.389
MOD_Plk_4	779	785	PF00069	0.476
MOD_ProDKin_1	121	127	PF00069	0.564
MOD_ProDKin_1	174	180	PF00069	0.438
MOD_ProDKin_1	535	541	PF00069	0.538
MOD_ProDKin_1	606	612	PF00069	0.373
MOD_ProDKin_1	714	720	PF00069	0.489
MOD_ProDKin_1	722	728	PF00069	0.505
MOD_ProDKin_1	772	778	PF00069	0.467
MOD_SUMO_rev_2	42	52	PF00179	0.465
MOD_SUMO_rev_2	452	460	PF00179	0.574
MOD_SUMO_rev_2	502	509	PF00179	0.347
TRG_DiLeu_BaEn_2	320	326	PF01217	0.466
TRG_ENDOCYTIC_2	103	106	PF00928	0.486
TRG_ENDOCYTIC_2	244	247	PF00928	0.349
TRG_ENDOCYTIC_2	400	403	PF00928	0.374
TRG_ENDOCYTIC_2	480	483	PF00928	0.564
TRG_ER_diArg_1	1	3	PF00400	0.550
TRG_ER_diArg_1	438	440	PF00400	0.477
TRG_ER_diArg_1	530	532	PF00400	0.419
TRG_ER_diArg_1	556	558	PF00400	0.558
TRG_ER_diArg_1	667	670	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z7	Leptomonas seymouri	82%	100%
A0A0S4JL67	Bodo saltans	59%	100%
A0A1X0P2Q6	Trypanosomatidae	64%	94%
A0A3Q8IH97	Leishmania donovani	95%	100%
A0A3R7M7H0	Trypanosoma rangeli	68%	100%
A4HL37	Leishmania braziliensis	88%	100%
A4I8L7	Leishmania infantum	94%	100%
C9ZPU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9B3H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BJH2	Trypanosoma cruzi	69%	100%