Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L9_LEIMA

TriTrypDb:

LmjF.33.0040 , LMJLV39_330005400 , LMJSD75_330005300

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.387
CLV_C14_Caspase3-7	516	520	PF00656	0.572
CLV_C14_Caspase3-7	68	72	PF00656	0.518
CLV_NRD_NRD_1	339	341	PF00675	0.643
CLV_NRD_NRD_1	412	414	PF00675	0.710
CLV_NRD_NRD_1	88	90	PF00675	0.553
CLV_PCSK_KEX2_1	338	340	PF00082	0.655
CLV_PCSK_KEX2_1	412	414	PF00082	0.663
CLV_PCSK_KEX2_1	88	90	PF00082	0.553
CLV_PCSK_SKI1_1	18	22	PF00082	0.434
CLV_PCSK_SKI1_1	217	221	PF00082	0.506
CLV_PCSK_SKI1_1	307	311	PF00082	0.636
CLV_PCSK_SKI1_1	451	455	PF00082	0.504
CLV_PCSK_SKI1_1	89	93	PF00082	0.483
DEG_APCC_DBOX_1	17	25	PF00400	0.475
DEG_APCC_DBOX_1	216	224	PF00400	0.474
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SPOP_SBC_1	319	323	PF00917	0.521
DEG_SPOP_SBC_1	359	363	PF00917	0.607
DEG_SPOP_SBC_1	36	40	PF00917	0.375
DOC_CKS1_1	452	457	PF01111	0.405
DOC_CYCLIN_RxL_1	112	121	PF00134	0.382
DOC_CYCLIN_RxL_1	213	224	PF00134	0.509
DOC_PP1_RVXF_1	114	121	PF00149	0.358
DOC_PP4_FxxP_1	452	455	PF00568	0.486
DOC_USP7_MATH_1	132	136	PF00917	0.484
DOC_USP7_MATH_1	139	143	PF00917	0.606
DOC_USP7_MATH_1	159	163	PF00917	0.483
DOC_USP7_MATH_1	253	257	PF00917	0.706
DOC_USP7_MATH_1	268	272	PF00917	0.695
DOC_USP7_MATH_1	319	323	PF00917	0.588
DOC_USP7_MATH_1	359	363	PF00917	0.607
DOC_USP7_MATH_1	486	490	PF00917	0.392
DOC_WW_Pin1_4	147	152	PF00397	0.606
DOC_WW_Pin1_4	297	302	PF00397	0.593
DOC_WW_Pin1_4	315	320	PF00397	0.699
DOC_WW_Pin1_4	390	395	PF00397	0.653
DOC_WW_Pin1_4	451	456	PF00397	0.407
DOC_WW_Pin1_4	49	54	PF00397	0.383
LIG_14-3-3_CanoR_1	11	20	PF00244	0.457
LIG_14-3-3_CanoR_1	338	345	PF00244	0.626
LIG_14-3-3_CanoR_1	375	379	PF00244	0.545
LIG_14-3-3_CanoR_1	76	85	PF00244	0.469
LIG_14-3-3_CanoR_1	88	94	PF00244	0.572
LIG_Actin_WH2_2	457	475	PF00022	0.452
LIG_BIR_III_4	121	125	PF00653	0.411
LIG_BIR_III_4	510	514	PF00653	0.480
LIG_BRCT_BRCA1_1	141	145	PF00533	0.623
LIG_BRCT_BRCA1_1	51	55	PF00533	0.434
LIG_FHA_1	148	154	PF00498	0.573
LIG_FHA_1	194	200	PF00498	0.395
LIG_FHA_1	339	345	PF00498	0.693
LIG_FHA_1	444	450	PF00498	0.558
LIG_FHA_2	124	130	PF00498	0.613
LIG_FHA_2	438	444	PF00498	0.601
LIG_FHA_2	483	489	PF00498	0.536
LIG_FHA_2	514	520	PF00498	0.651
LIG_FHA_2	55	61	PF00498	0.610
LIG_FHA_2	66	72	PF00498	0.357
LIG_HCF-1_HBM_1	200	203	PF13415	0.498
LIG_LIR_Apic_2	450	455	PF02991	0.487
LIG_LIR_Gen_1	117	125	PF02991	0.397
LIG_LIR_Gen_1	393	400	PF02991	0.491
LIG_LIR_Nem_3	14	20	PF02991	0.424
LIG_LIR_Nem_3	393	399	PF02991	0.484
LIG_Pex14_2	295	299	PF04695	0.529
LIG_Pex14_2	51	55	PF04695	0.344
LIG_SH2_SRC	31	34	PF00017	0.436
LIG_SH2_STAT5	245	248	PF00017	0.536
LIG_SH2_STAT5	448	451	PF00017	0.472
LIG_SH2_STAT5	483	486	PF00017	0.419
LIG_SH2_STAT5	77	80	PF00017	0.428
LIG_SH2_STAT5	85	88	PF00017	0.461
LIG_SH3_3	206	212	PF00018	0.440
LIG_SH3_3	30	36	PF00018	0.532
LIG_SH3_3	417	423	PF00018	0.575
LIG_TRAF2_1	126	129	PF00917	0.554
LIG_TRAF2_1	371	374	PF00917	0.657
MOD_CDK_SPxxK_3	147	154	PF00069	0.547
MOD_CDK_SPxxK_3	451	458	PF00069	0.401
MOD_CK1_1	135	141	PF00069	0.691
MOD_CK1_1	256	262	PF00069	0.665
MOD_CK1_1	318	324	PF00069	0.703
MOD_CK1_1	392	398	PF00069	0.605
MOD_CK1_1	44	50	PF00069	0.517
MOD_CK2_1	123	129	PF00069	0.610
MOD_CK2_1	281	287	PF00069	0.572
MOD_CK2_1	368	374	PF00069	0.664
MOD_CK2_1	400	406	PF00069	0.581
MOD_CK2_1	437	443	PF00069	0.516
MOD_CK2_1	482	488	PF00069	0.493
MOD_GlcNHglycan	13	16	PF01048	0.351
MOD_GlcNHglycan	136	140	PF01048	0.592
MOD_GlcNHglycan	172	175	PF01048	0.429
MOD_GlcNHglycan	257	261	PF01048	0.707
MOD_GlcNHglycan	325	328	PF01048	0.638
MOD_GlcNHglycan	370	373	PF01048	0.620
MOD_GlcNHglycan	46	49	PF01048	0.482
MOD_GlcNHglycan	488	491	PF01048	0.396
MOD_GlcNHglycan	79	82	PF01048	0.512
MOD_GSK3_1	131	138	PF00069	0.683
MOD_GSK3_1	239	246	PF00069	0.519
MOD_GSK3_1	256	263	PF00069	0.531
MOD_GSK3_1	297	304	PF00069	0.630
MOD_GSK3_1	315	322	PF00069	0.618
MOD_GSK3_1	35	42	PF00069	0.563
MOD_GSK3_1	359	366	PF00069	0.729
MOD_GSK3_1	477	484	PF00069	0.455
MOD_GSK3_1	486	493	PF00069	0.414
MOD_GSK3_1	49	56	PF00069	0.326
MOD_GSK3_1	7	14	PF00069	0.450
MOD_GSK3_1	92	99	PF00069	0.472
MOD_NEK2_1	320	325	PF00069	0.559
MOD_NEK2_1	43	48	PF00069	0.550
MOD_NEK2_1	460	465	PF00069	0.438
MOD_NEK2_1	54	59	PF00069	0.435
MOD_NEK2_1	7	12	PF00069	0.572
MOD_NEK2_2	139	144	PF00069	0.459
MOD_PIKK_1	152	158	PF00454	0.523
MOD_PIKK_1	338	344	PF00454	0.673
MOD_PIKK_1	400	406	PF00454	0.557
MOD_PIKK_1	54	60	PF00454	0.606
MOD_PKA_1	338	344	PF00069	0.587
MOD_PKA_2	338	344	PF00069	0.642
MOD_PKA_2	374	380	PF00069	0.612
MOD_PKA_2	411	417	PF00069	0.656
MOD_PKA_2	481	487	PF00069	0.420
MOD_PKA_2	7	13	PF00069	0.576
MOD_Plk_1	307	313	PF00069	0.609
MOD_Plk_1	460	466	PF00069	0.436
MOD_ProDKin_1	147	153	PF00069	0.602
MOD_ProDKin_1	297	303	PF00069	0.596
MOD_ProDKin_1	315	321	PF00069	0.703
MOD_ProDKin_1	390	396	PF00069	0.645
MOD_ProDKin_1	451	457	PF00069	0.405
MOD_ProDKin_1	49	55	PF00069	0.379
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.551
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.460
TRG_ENDOCYTIC_2	17	20	PF00928	0.470
TRG_ENDOCYTIC_2	426	429	PF00928	0.627
TRG_ER_diArg_1	248	251	PF00400	0.555
TRG_ER_diArg_1	337	340	PF00400	0.601
TRG_ER_diArg_1	411	413	PF00400	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK4	Leptomonas seymouri	59%	99%
A0A0S4JPU3	Bodo saltans	33%	95%
A0A3S7X6B5	Leishmania donovani	92%	100%
A0A422NYF9	Trypanosoma rangeli	43%	100%
A4HL40	Leishmania braziliensis	77%	100%
A4I8M0	Leishmania infantum	92%	100%
C9ZPU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9B3I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5AUZ3	Trypanosoma cruzi	45%	100%