FOP_dimer domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L8_LEIMA

TriTrypDb:

LmjF.33.0050 , LMJLV39_330005500 , LMJSD75_330005400

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	114	118	PF00082	0.429
CLV_PCSK_SKI1_1	72	76	PF00082	0.506
DEG_Nend_UBRbox_2	1	3	PF02207	0.602
DEG_SPOP_SBC_1	175	179	PF00917	0.639
DOC_ANK_TNKS_1	122	129	PF00023	0.449
DOC_MIT_MIM_1	127	137	PF04212	0.394
DOC_PP4_FxxP_1	68	71	PF00568	0.467
DOC_USP7_MATH_1	174	178	PF00917	0.489
DOC_USP7_MATH_1	28	32	PF00917	0.499
DOC_USP7_MATH_1	78	82	PF00917	0.435
DOC_WW_Pin1_4	170	175	PF00397	0.601
LIG_14-3-3_CanoR_1	47	54	PF00244	0.531
LIG_14-3-3_CanoR_1	70	75	PF00244	0.466
LIG_14-3-3_CterR_2	229	232	PF00244	0.580
LIG_BRCT_BRCA1_1	207	211	PF00533	0.553
LIG_FHA_1	139	145	PF00498	0.618
LIG_FHA_1	7	13	PF00498	0.601
LIG_FHA_1	95	101	PF00498	0.413
LIG_FHA_2	8	14	PF00498	0.596
LIG_Integrin_RGD_1	55	57	PF01839	0.498
LIG_SH2_SRC	205	208	PF00017	0.498
LIG_SH2_STAP1	200	204	PF00017	0.397
LIG_SH2_STAP1	205	209	PF00017	0.535
LIG_SH2_STAT3	92	95	PF00017	0.401
LIG_SH3_3	160	166	PF00018	0.543
LIG_SH3_3	168	174	PF00018	0.494
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.537
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.419
LIG_SUMO_SIM_par_1	81	87	PF11976	0.400
LIG_SUMO_SIM_par_1	99	106	PF11976	0.485
LIG_TRAF2_1	182	185	PF00917	0.627
MOD_CK1_1	150	156	PF00069	0.658
MOD_CK1_1	159	165	PF00069	0.668
MOD_CK1_1	177	183	PF00069	0.576
MOD_CK1_1	31	37	PF00069	0.487
MOD_CK2_1	126	132	PF00069	0.394
MOD_CK2_1	209	215	PF00069	0.638
MOD_CK2_1	7	13	PF00069	0.601
MOD_GlcNHglycan	149	152	PF01048	0.536
MOD_GlcNHglycan	180	183	PF01048	0.767
MOD_GlcNHglycan	30	33	PF01048	0.445
MOD_GlcNHglycan	35	38	PF01048	0.429
MOD_GSK3_1	150	157	PF00069	0.655
MOD_GSK3_1	170	177	PF00069	0.584
MOD_GSK3_1	180	187	PF00069	0.597
MOD_GSK3_1	205	212	PF00069	0.497
MOD_GSK3_1	31	38	PF00069	0.476
MOD_NEK2_1	33	38	PF00069	0.404
MOD_NEK2_1	46	51	PF00069	0.432
MOD_NEK2_1	94	99	PF00069	0.441
MOD_PIKK_1	156	162	PF00454	0.717
MOD_PIKK_1	180	186	PF00454	0.754
MOD_PIKK_1	7	13	PF00454	0.567
MOD_PKA_2	46	52	PF00069	0.499
MOD_PKB_1	70	78	PF00069	0.327
MOD_Plk_1	103	109	PF00069	0.454
MOD_Plk_1	112	118	PF00069	0.448
MOD_Plk_1	184	190	PF00069	0.604
MOD_Plk_1	205	211	PF00069	0.532
MOD_Plk_1	7	13	PF00069	0.558
MOD_Plk_4	126	132	PF00069	0.476
MOD_Plk_4	78	84	PF00069	0.506
MOD_ProDKin_1	170	176	PF00069	0.603
TRG_DiLeu_BaEn_1	113	118	PF01217	0.435
TRG_ER_diArg_1	69	72	PF00400	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX52	Leptomonas seymouri	54%	100%
A0A0S4JQ70	Bodo saltans	35%	90%
A0A3Q8ILV2	Leishmania donovani	92%	100%
A4HL41	Leishmania braziliensis	72%	100%
A4I8M1	Leishmania infantum	92%	100%
C9ZPU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9B3I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BAE5	Trypanosoma cruzi	34%	100%