Centrosomal protein of 104 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L6_LEIMA

TriTrypDb:

LmjF.33.0070 , LMJLV39_330005700 , LMJSD75_330005600

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0097542	ciliary tip	2	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

Q4Q4L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.505
CLV_NRD_NRD_1	123	125	PF00675	0.467
CLV_NRD_NRD_1	185	187	PF00675	0.782
CLV_NRD_NRD_1	274	276	PF00675	0.366
CLV_NRD_NRD_1	309	311	PF00675	0.456
CLV_NRD_NRD_1	600	602	PF00675	0.488
CLV_PCSK_KEX2_1	185	187	PF00082	0.740
CLV_PCSK_KEX2_1	199	201	PF00082	0.627
CLV_PCSK_KEX2_1	274	276	PF00082	0.353
CLV_PCSK_KEX2_1	600	602	PF00082	0.449
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.565
CLV_PCSK_SKI1_1	102	106	PF00082	0.558
CLV_PCSK_SKI1_1	137	141	PF00082	0.378
CLV_PCSK_SKI1_1	301	305	PF00082	0.444
CLV_PCSK_SKI1_1	473	477	PF00082	0.435
CLV_PCSK_SKI1_1	553	557	PF00082	0.344
CLV_PCSK_SKI1_1	601	605	PF00082	0.443
CLV_PCSK_SKI1_1	642	646	PF00082	0.402
CLV_PCSK_SKI1_1	74	78	PF00082	0.449
CLV_PCSK_SKI1_1	82	86	PF00082	0.481
DEG_APCC_DBOX_1	298	306	PF00400	0.448
DEG_APCC_DBOX_1	608	616	PF00400	0.458
DOC_CKS1_1	179	184	PF01111	0.758
DOC_CKS1_1	381	386	PF01111	0.538
DOC_CKS1_1	577	582	PF01111	0.402
DOC_CYCLIN_RxL_1	134	141	PF00134	0.447
DOC_CYCLIN_RxL_1	639	647	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	492	498	PF00134	0.371
DOC_MAPK_gen_1	102	111	PF00069	0.450
DOC_MAPK_gen_1	120	129	PF00069	0.422
DOC_MAPK_gen_1	274	282	PF00069	0.374
DOC_MAPK_gen_1	45	55	PF00069	0.501
DOC_MAPK_gen_1	476	485	PF00069	0.414
DOC_MAPK_gen_1	598	605	PF00069	0.530
DOC_MAPK_MEF2A_6	48	57	PF00069	0.476
DOC_MAPK_MEF2A_6	74	83	PF00069	0.375
DOC_PP1_RVXF_1	135	141	PF00149	0.436
DOC_PP1_RVXF_1	262	269	PF00149	0.517
DOC_PP1_RVXF_1	97	104	PF00149	0.523
DOC_PP2B_LxvP_1	643	646	PF13499	0.481
DOC_PP4_FxxP_1	140	143	PF00568	0.457
DOC_USP7_MATH_1	208	212	PF00917	0.550
DOC_USP7_MATH_1	232	236	PF00917	0.686
DOC_USP7_MATH_1	254	258	PF00917	0.628
DOC_USP7_MATH_1	461	465	PF00917	0.394
DOC_USP7_MATH_1	581	585	PF00917	0.476
DOC_USP7_UBL2_3	677	681	PF12436	0.555
DOC_USP7_UBL2_3	74	78	PF12436	0.452
DOC_WW_Pin1_4	178	183	PF00397	0.747
DOC_WW_Pin1_4	187	192	PF00397	0.793
DOC_WW_Pin1_4	235	240	PF00397	0.651
DOC_WW_Pin1_4	32	37	PF00397	0.704
DOC_WW_Pin1_4	350	355	PF00397	0.547
DOC_WW_Pin1_4	380	385	PF00397	0.604
DOC_WW_Pin1_4	387	392	PF00397	0.609
DOC_WW_Pin1_4	399	404	PF00397	0.484
DOC_WW_Pin1_4	46	51	PF00397	0.464
DOC_WW_Pin1_4	491	496	PF00397	0.438
DOC_WW_Pin1_4	542	547	PF00397	0.381
DOC_WW_Pin1_4	576	581	PF00397	0.442
LIG_14-3-3_CanoR_1	124	128	PF00244	0.478
LIG_14-3-3_CanoR_1	185	192	PF00244	0.777
LIG_14-3-3_CanoR_1	216	223	PF00244	0.512
LIG_14-3-3_CanoR_1	243	247	PF00244	0.562
LIG_14-3-3_CanoR_1	274	282	PF00244	0.522
LIG_14-3-3_CanoR_1	337	342	PF00244	0.451
LIG_14-3-3_CanoR_1	375	381	PF00244	0.545
LIG_14-3-3_CanoR_1	557	565	PF00244	0.437
LIG_14-3-3_CanoR_1	614	618	PF00244	0.488
LIG_14-3-3_CanoR_1	67	75	PF00244	0.361
LIG_Actin_WH2_2	259	276	PF00022	0.530
LIG_Actin_WH2_2	463	480	PF00022	0.442
LIG_AP2alpha_1	268	272	PF02296	0.487
LIG_APCC_ABBAyCdc20_2	624	630	PF00400	0.329
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BRCT_BRCA1_1	107	111	PF00533	0.432
LIG_BRCT_BRCA1_1	256	260	PF00533	0.554
LIG_BRCT_BRCA1_1	471	475	PF00533	0.411
LIG_BRCT_BRCA1_1	630	634	PF00533	0.423
LIG_Clathr_ClatBox_1	209	213	PF01394	0.581
LIG_CtBP_PxDLS_1	384	388	PF00389	0.543
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.539
LIG_eIF4E_1	134	140	PF01652	0.420
LIG_FHA_1	124	130	PF00498	0.416
LIG_FHA_1	50	56	PF00498	0.477
LIG_FHA_1	570	576	PF00498	0.467
LIG_FHA_1	577	583	PF00498	0.476
LIG_FHA_1	587	593	PF00498	0.239
LIG_FHA_2	11	17	PF00498	0.501
LIG_FHA_2	338	344	PF00498	0.366
LIG_FHA_2	594	600	PF00498	0.530
LIG_FHA_2	75	81	PF00498	0.368
LIG_GBD_Chelix_1	658	666	PF00786	0.477
LIG_HP1_1	546	550	PF01393	0.436
LIG_LIR_Apic_2	90	95	PF02991	0.557
LIG_LIR_Gen_1	132	143	PF02991	0.397
LIG_LIR_Gen_1	267	273	PF02991	0.502
LIG_LIR_Gen_1	527	533	PF02991	0.275
LIG_LIR_Gen_1	616	622	PF02991	0.318
LIG_LIR_Nem_3	132	138	PF02991	0.391
LIG_LIR_Nem_3	257	263	PF02991	0.527
LIG_LIR_Nem_3	267	271	PF02991	0.446
LIG_LIR_Nem_3	616	621	PF02991	0.469
LIG_LIR_Nem_3	97	101	PF02991	0.387
LIG_NRBOX	616	622	PF00104	0.304
LIG_NRBOX	639	645	PF00104	0.481
LIG_NRP_CendR_1	694	695	PF00754	0.432
LIG_PCNA_PIPBox_1	321	330	PF02747	0.390
LIG_PCNA_yPIPBox_3	333	346	PF02747	0.374
LIG_Pex14_2	140	144	PF04695	0.334
LIG_Pex14_2	268	272	PF04695	0.487
LIG_Pex14_2	453	457	PF04695	0.500
LIG_Pex14_2	471	475	PF04695	0.271
LIG_PTB_Apo_2	447	454	PF02174	0.390
LIG_PTB_Apo_2	517	524	PF02174	0.442
LIG_PTB_Apo_2	97	104	PF02174	0.439
LIG_Rb_pABgroove_1	134	142	PF01858	0.318
LIG_REV1ctd_RIR_1	269	279	PF16727	0.504
LIG_SH2_CRK	7	11	PF00017	0.474
LIG_SH2_STAP1	7	11	PF00017	0.474
LIG_SH2_STAT3	512	515	PF00017	0.426
LIG_SH2_STAT5	134	137	PF00017	0.339
LIG_SH2_STAT5	164	167	PF00017	0.373
LIG_SH2_STAT5	576	579	PF00017	0.457
LIG_SH3_3	14	20	PF00018	0.514
LIG_SH3_3	176	182	PF00018	0.564
LIG_SH3_3	245	251	PF00018	0.564
LIG_SH3_3	30	36	PF00018	0.674
LIG_SH3_3	378	384	PF00018	0.641
LIG_SH3_3	397	403	PF00018	0.770
LIG_SH3_3	540	546	PF00018	0.355
LIG_SH3_3	574	580	PF00018	0.389
LIG_SH3_3	645	651	PF00018	0.458
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.504
LIG_SUMO_SIM_anti_2	479	487	PF11976	0.389
LIG_SUMO_SIM_par_1	208	213	PF11976	0.550
LIG_SUMO_SIM_par_1	416	422	PF11976	0.464
LIG_SUMO_SIM_par_1	479	487	PF11976	0.437
LIG_SxIP_EBH_1	32	43	PF03271	0.429
LIG_TYR_ITIM	5	10	PF00017	0.463
LIG_UBA3_1	482	488	PF00899	0.318
LIG_UBA3_1	617	624	PF00899	0.244
LIG_WRC_WIRS_1	462	467	PF05994	0.276
MOD_CDK_SPxxK_3	178	185	PF00069	0.591
MOD_CDK_SPxxK_3	187	194	PF00069	0.553
MOD_CK1_1	187	193	PF00069	0.747
MOD_CK1_1	235	241	PF00069	0.623
MOD_CK1_1	249	255	PF00069	0.551
MOD_CK1_1	350	356	PF00069	0.663
MOD_CK1_1	360	366	PF00069	0.698
MOD_CK1_1	379	385	PF00069	0.637
MOD_CK1_1	402	408	PF00069	0.791
MOD_CK1_1	586	592	PF00069	0.350
MOD_CK2_1	337	343	PF00069	0.613
MOD_CK2_1	593	599	PF00069	0.528
MOD_CK2_1	74	80	PF00069	0.327
MOD_GlcNHglycan	160	164	PF01048	0.476
MOD_GlcNHglycan	187	190	PF01048	0.743
MOD_GlcNHglycan	202	205	PF01048	0.753
MOD_GlcNHglycan	218	221	PF01048	0.549
MOD_GlcNHglycan	248	251	PF01048	0.596
MOD_GlcNHglycan	256	259	PF01048	0.607
MOD_GlcNHglycan	359	362	PF01048	0.700
MOD_GlcNHglycan	367	370	PF01048	0.630
MOD_GlcNHglycan	42	45	PF01048	0.419
MOD_GlcNHglycan	479	482	PF01048	0.418
MOD_GlcNHglycan	630	633	PF01048	0.653
MOD_GSK3_1	110	117	PF00069	0.473
MOD_GSK3_1	155	162	PF00069	0.375
MOD_GSK3_1	242	249	PF00069	0.634
MOD_GSK3_1	346	353	PF00069	0.608
MOD_GSK3_1	365	372	PF00069	0.695
MOD_GSK3_1	376	383	PF00069	0.673
MOD_GSK3_1	433	440	PF00069	0.409
MOD_GSK3_1	582	589	PF00069	0.409
MOD_N-GLC_1	376	381	PF02516	0.711
MOD_NEK2_1	159	164	PF00069	0.403
MOD_NEK2_1	346	351	PF00069	0.570
MOD_NEK2_1	471	476	PF00069	0.314
MOD_NEK2_1	477	482	PF00069	0.246
MOD_NEK2_1	533	538	PF00069	0.363
MOD_NEK2_1	603	608	PF00069	0.441
MOD_NEK2_1	658	663	PF00069	0.359
MOD_NEK2_2	613	618	PF00069	0.305
MOD_PK_1	105	111	PF00069	0.502
MOD_PKA_1	185	191	PF00069	0.786
MOD_PKA_1	199	205	PF00069	0.624
MOD_PKA_2	123	129	PF00069	0.450
MOD_PKA_2	184	190	PF00069	0.731
MOD_PKA_2	199	205	PF00069	0.616
MOD_PKA_2	242	248	PF00069	0.592
MOD_PKA_2	273	279	PF00069	0.515
MOD_PKA_2	365	371	PF00069	0.551
MOD_PKA_2	477	483	PF00069	0.396
MOD_PKA_2	556	562	PF00069	0.427
MOD_PKA_2	613	619	PF00069	0.309
MOD_PKA_2	687	693	PF00069	0.598
MOD_PKB_1	216	224	PF00069	0.519
MOD_Plk_1	114	120	PF00069	0.465
MOD_Plk_1	227	233	PF00069	0.628
MOD_Plk_1	346	352	PF00069	0.674
MOD_Plk_1	376	382	PF00069	0.716
MOD_Plk_4	337	343	PF00069	0.613
MOD_Plk_4	49	55	PF00069	0.475
MOD_Plk_4	524	530	PF00069	0.374
MOD_Plk_4	571	577	PF00069	0.351
MOD_Plk_4	583	589	PF00069	0.428
MOD_Plk_4	613	619	PF00069	0.385
MOD_Plk_4	658	664	PF00069	0.345
MOD_ProDKin_1	178	184	PF00069	0.752
MOD_ProDKin_1	187	193	PF00069	0.794
MOD_ProDKin_1	235	241	PF00069	0.651
MOD_ProDKin_1	32	38	PF00069	0.695
MOD_ProDKin_1	350	356	PF00069	0.556
MOD_ProDKin_1	380	386	PF00069	0.608
MOD_ProDKin_1	387	393	PF00069	0.611
MOD_ProDKin_1	399	405	PF00069	0.479
MOD_ProDKin_1	46	52	PF00069	0.455
MOD_ProDKin_1	491	497	PF00069	0.438
MOD_ProDKin_1	542	548	PF00069	0.381
MOD_ProDKin_1	576	582	PF00069	0.435
MOD_SUMO_for_1	129	132	PF00179	0.439
MOD_SUMO_for_1	282	285	PF00179	0.520
MOD_SUMO_rev_2	117	127	PF00179	0.487
MOD_SUMO_rev_2	70	76	PF00179	0.350
TRG_AP2beta_CARGO_1	132	142	PF09066	0.445
TRG_DiLeu_BaEn_1	599	604	PF01217	0.325
TRG_DiLeu_BaEn_4	277	283	PF01217	0.512
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.324
TRG_ENDOCYTIC_2	7	10	PF00928	0.466
TRG_ER_diArg_1	273	275	PF00400	0.393
TRG_NES_CRM1_1	611	623	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U7	Leptomonas seymouri	60%	98%
A0A0N0P8K1	Leptomonas seymouri	25%	79%
A0A0S4ILQ6	Bodo saltans	23%	70%
A0A1X0P6E5	Trypanosomatidae	25%	82%
A0A3R7MW28	Trypanosoma rangeli	25%	81%
A0A3S7X6A2	Leishmania donovani	94%	100%
A4H9Y2	Leishmania braziliensis	25%	100%
A4HL43	Leishmania braziliensis	75%	100%
A4I8M3	Leishmania infantum	94%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	77%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	79%
E9B3I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDJ6	Leishmania major	24%	79%
V5DTJ3	Trypanosoma cruzi	26%	82%