Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L5_LEIMA

TriTrypDb:

LmjF.33.0080 , LMJLV39_330005800 , LMJSD75_330005700

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L5

PDB structure(s): 7aih_At , 7am2_At , 7ane_At

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.420
CLV_NRD_NRD_1	132	134	PF00675	0.544
CLV_NRD_NRD_1	174	176	PF00675	0.645
CLV_NRD_NRD_1	60	62	PF00675	0.483
CLV_NRD_NRD_1	86	88	PF00675	0.454
CLV_PCSK_KEX2_1	112	114	PF00082	0.420
CLV_PCSK_KEX2_1	131	133	PF00082	0.615
CLV_PCSK_KEX2_1	16	18	PF00082	0.473
CLV_PCSK_KEX2_1	174	176	PF00082	0.595
CLV_PCSK_KEX2_1	60	62	PF00082	0.483
CLV_PCSK_KEX2_1	86	88	PF00082	0.479
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.473
CLV_PCSK_PC7_1	128	134	PF00082	0.548
CLV_PCSK_PC7_1	82	88	PF00082	0.465
CLV_PCSK_SKI1_1	60	64	PF00082	0.552
CLV_PCSK_SKI1_1	77	81	PF00082	0.322
DEG_SPOP_SBC_1	95	99	PF00917	0.422
DOC_MAPK_JIP1_4	2	8	PF00069	0.453
DOC_USP7_MATH_1	123	127	PF00917	0.517
DOC_USP7_MATH_1	178	182	PF00917	0.499
DOC_USP7_MATH_1	62	66	PF00917	0.503
DOC_WW_Pin1_4	166	171	PF00397	0.530
LIG_14-3-3_CanoR_1	150	156	PF00244	0.434
LIG_14-3-3_CanoR_1	39	43	PF00244	0.426
LIG_14-3-3_CanoR_1	61	67	PF00244	0.494
LIG_FHA_1	158	164	PF00498	0.498
LIG_LIR_Gen_1	157	167	PF02991	0.577
LIG_LIR_Nem_3	157	162	PF02991	0.543
LIG_PDZ_Class_1	178	183	PF00595	0.698
LIG_SH2_CRK	159	163	PF00017	0.480
LIG_SH2_STAP1	159	163	PF00017	0.415
LIG_SH2_STAT5	159	162	PF00017	0.551
LIG_SH2_STAT5	35	38	PF00017	0.402
LIG_SH3_3	143	149	PF00018	0.413
LIG_SH3_3	164	170	PF00018	0.462
MOD_CK1_1	154	160	PF00069	0.463
MOD_CK1_1	169	175	PF00069	0.580
MOD_CK1_1	37	43	PF00069	0.568
MOD_Cter_Amidation	172	175	PF01082	0.448
MOD_GlcNHglycan	3	6	PF01048	0.447
MOD_GlcNHglycan	36	39	PF01048	0.465
MOD_GlcNHglycan	74	77	PF01048	0.431
MOD_GSK3_1	157	164	PF00069	0.512
MOD_GSK3_1	165	172	PF00069	0.547
MOD_GSK3_1	34	41	PF00069	0.433
MOD_N-GLC_1	157	162	PF02516	0.521
MOD_NEK2_1	151	156	PF00069	0.511
MOD_NEK2_1	72	77	PF00069	0.427
MOD_NEK2_1	96	101	PF00069	0.418
MOD_NEK2_2	38	43	PF00069	0.406
MOD_NEK2_2	9	14	PF00069	0.417
MOD_PIKK_1	123	129	PF00454	0.523
MOD_PIKK_1	157	163	PF00454	0.609
MOD_PIKK_1	60	66	PF00454	0.447
MOD_PKA_1	16	22	PF00069	0.385
MOD_PKA_1	60	66	PF00069	0.476
MOD_PKA_2	1	7	PF00069	0.576
MOD_PKA_2	16	22	PF00069	0.479
MOD_PKA_2	38	44	PF00069	0.402
MOD_PKA_2	60	66	PF00069	0.505
MOD_Plk_1	157	163	PF00069	0.530
MOD_ProDKin_1	166	172	PF00069	0.531
TRG_ENDOCYTIC_2	159	162	PF00928	0.489
TRG_ENDOCYTIC_2	45	48	PF00928	0.386
TRG_ER_diArg_1	111	113	PF00400	0.406
TRG_ER_diArg_1	131	133	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I402	Leptomonas seymouri	85%	100%
A0A0S4JQA3	Bodo saltans	58%	100%
A0A1X0P2R8	Trypanosomatidae	66%	100%
A0A3Q8IJU1	Leishmania donovani	94%	100%
A0A422NYD9	Trypanosoma rangeli	70%	96%
A4HL44	Leishmania braziliensis	94%	100%
C9ZPU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	96%
E9AHM6	Leishmania infantum	94%	100%
E9B3I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DB04	Trypanosoma cruzi	71%	84%