Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L4_LEIMA

TriTrypDb:

LmjF.33.0090 , LMJLV39_330005900 , LMJSD75_330005800

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.624
CLV_C14_Caspase3-7	541	545	PF00656	0.582
CLV_C14_Caspase3-7	562	566	PF00656	0.577
CLV_NRD_NRD_1	227	229	PF00675	0.470
CLV_NRD_NRD_1	239	241	PF00675	0.337
CLV_NRD_NRD_1	335	337	PF00675	0.536
CLV_NRD_NRD_1	385	387	PF00675	0.532
CLV_PCSK_KEX2_1	227	229	PF00082	0.489
CLV_PCSK_KEX2_1	335	337	PF00082	0.467
CLV_PCSK_KEX2_1	385	387	PF00082	0.532
CLV_PCSK_PC7_1	381	387	PF00082	0.532
CLV_PCSK_SKI1_1	101	105	PF00082	0.495
CLV_PCSK_SKI1_1	283	287	PF00082	0.419
CLV_PCSK_SKI1_1	381	385	PF00082	0.488
CLV_PCSK_SKI1_1	389	393	PF00082	0.482
CLV_PCSK_SKI1_1	538	542	PF00082	0.630
DEG_APCC_DBOX_1	384	392	PF00400	0.417
DEG_APCC_DBOX_1	456	464	PF00400	0.429
DEG_SCF_FBW7_1	539	546	PF00400	0.576
DEG_SPOP_SBC_1	176	180	PF00917	0.475
DEG_SPOP_SBC_1	550	554	PF00917	0.603
DOC_ANK_TNKS_1	187	194	PF00023	0.634
DOC_CDC14_PxL_1	109	117	PF14671	0.479
DOC_CYCLIN_yCln2_LP_2	567	573	PF00134	0.619
DOC_MAPK_gen_1	10	17	PF00069	0.567
DOC_MAPK_gen_1	227	235	PF00069	0.477
DOC_MAPK_MEF2A_6	10	17	PF00069	0.668
DOC_MAPK_MEF2A_6	300	309	PF00069	0.529
DOC_MAPK_MEF2A_6	568	575	PF00069	0.508
DOC_MAPK_MEF2A_6	587	596	PF00069	0.299
DOC_PP2B_LxvP_1	567	570	PF13499	0.641
DOC_PP4_FxxP_1	182	185	PF00568	0.443
DOC_PP4_FxxP_1	284	287	PF00568	0.360
DOC_PP4_FxxP_1	76	79	PF00568	0.499
DOC_USP7_MATH_1	131	135	PF00917	0.418
DOC_USP7_MATH_1	174	178	PF00917	0.563
DOC_USP7_MATH_1	217	221	PF00917	0.420
DOC_USP7_MATH_1	323	327	PF00917	0.500
DOC_USP7_MATH_1	349	353	PF00917	0.609
DOC_USP7_MATH_1	355	359	PF00917	0.627
DOC_USP7_MATH_2	16	22	PF00917	0.632
DOC_WW_Pin1_4	368	373	PF00397	0.579
DOC_WW_Pin1_4	39	44	PF00397	0.454
DOC_WW_Pin1_4	511	516	PF00397	0.674
DOC_WW_Pin1_4	539	544	PF00397	0.642
DOC_WW_Pin1_4	609	614	PF00397	0.512
LIG_14-3-3_CanoR_1	119	125	PF00244	0.515
LIG_14-3-3_CanoR_1	213	222	PF00244	0.515
LIG_14-3-3_CanoR_1	227	233	PF00244	0.344
LIG_14-3-3_CanoR_1	252	257	PF00244	0.428
LIG_14-3-3_CanoR_1	300	307	PF00244	0.535
LIG_14-3-3_CanoR_1	406	413	PF00244	0.366
LIG_14-3-3_CanoR_1	488	498	PF00244	0.569
LIG_14-3-3_CanoR_1	538	543	PF00244	0.532
LIG_Actin_WH2_2	466	484	PF00022	0.468
LIG_APCC_ABBAyCdc20_2	165	171	PF00400	0.436
LIG_BRCT_BRCA1_1	178	182	PF00533	0.411
LIG_BRCT_BRCA1_1	370	374	PF00533	0.466
LIG_deltaCOP1_diTrp_1	136	141	PF00928	0.314
LIG_deltaCOP1_diTrp_1	251	256	PF00928	0.434
LIG_deltaCOP1_diTrp_1	604	609	PF00928	0.524
LIG_eIF4E_1	229	235	PF01652	0.358
LIG_EVH1_1	207	211	PF00568	0.427
LIG_FHA_1	119	125	PF00498	0.404
LIG_FHA_1	12	18	PF00498	0.569
LIG_FHA_1	185	191	PF00498	0.520
LIG_FHA_1	229	235	PF00498	0.358
LIG_FHA_1	300	306	PF00498	0.543
LIG_FHA_1	313	319	PF00498	0.338
LIG_FHA_1	392	398	PF00498	0.421
LIG_FHA_1	511	517	PF00498	0.675
LIG_FHA_1	527	533	PF00498	0.379
LIG_FHA_1	552	558	PF00498	0.663
LIG_FHA_1	593	599	PF00498	0.451
LIG_FHA_2	253	259	PF00498	0.472
LIG_FHA_2	260	266	PF00498	0.487
LIG_FHA_2	539	545	PF00498	0.710
LIG_LIR_Apic_2	179	185	PF02991	0.559
LIG_LIR_Apic_2	281	287	PF02991	0.353
LIG_LIR_Apic_2	74	79	PF02991	0.510
LIG_LIR_Gen_1	136	146	PF02991	0.305
LIG_LIR_Gen_1	432	441	PF02991	0.404
LIG_LIR_Gen_1	445	456	PF02991	0.398
LIG_LIR_Gen_1	489	499	PF02991	0.567
LIG_LIR_Nem_3	136	142	PF02991	0.310
LIG_LIR_Nem_3	251	256	PF02991	0.430
LIG_LIR_Nem_3	373	378	PF02991	0.536
LIG_LIR_Nem_3	432	437	PF02991	0.393
LIG_LIR_Nem_3	445	451	PF02991	0.385
LIG_LIR_Nem_3	489	494	PF02991	0.438
LIG_LIR_Nem_3	52	57	PF02991	0.380
LIG_LIR_Nem_3	92	97	PF02991	0.520
LIG_MAD2	123	131	PF02301	0.548
LIG_NRBOX	465	471	PF00104	0.399
LIG_PCNA_yPIPBox_3	292	304	PF02747	0.464
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.450
LIG_Pex14_1	434	438	PF04695	0.387
LIG_Pex14_2	370	374	PF04695	0.466
LIG_Pex14_2	444	448	PF04695	0.538
LIG_PTB_Apo_2	88	95	PF02174	0.412
LIG_SH2_CRK	229	233	PF00017	0.360
LIG_SH2_NCK_1	438	442	PF00017	0.441
LIG_SH2_STAP1	170	174	PF00017	0.360
LIG_SH2_STAP1	229	233	PF00017	0.475
LIG_SH2_STAP1	301	305	PF00017	0.539
LIG_SH2_STAP1	590	594	PF00017	0.453
LIG_SH2_STAT5	301	304	PF00017	0.550
LIG_SH2_STAT5	438	441	PF00017	0.396
LIG_SH2_STAT5	84	87	PF00017	0.413
LIG_SH3_1	10	16	PF00018	0.637
LIG_SH3_2	208	213	PF14604	0.397
LIG_SH3_3	10	16	PF00018	0.687
LIG_SH3_3	110	116	PF00018	0.453
LIG_SH3_3	180	186	PF00018	0.557
LIG_SH3_3	205	211	PF00018	0.424
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.364
LIG_SUMO_SIM_anti_2	317	322	PF11976	0.346
LIG_SUMO_SIM_anti_2	529	534	PF11976	0.517
LIG_SUMO_SIM_anti_2	595	600	PF11976	0.458
LIG_SUMO_SIM_par_1	230	237	PF11976	0.479
LIG_SUMO_SIM_par_1	465	471	PF11976	0.412
LIG_SUMO_SIM_par_1	513	520	PF11976	0.657
LIG_SUMO_SIM_par_1	528	534	PF11976	0.426
LIG_SUMO_SIM_par_1	593	600	PF11976	0.390
LIG_UBA3_1	50	55	PF00899	0.522
LIG_Vh1_VBS_1	581	599	PF01044	0.442
LIG_WW_2	113	116	PF00397	0.352
MOD_CK1_1	177	183	PF00069	0.436
MOD_CK1_1	21	27	PF00069	0.620
MOD_CK1_1	362	368	PF00069	0.587
MOD_CK1_1	436	442	PF00069	0.503
MOD_CK1_1	489	495	PF00069	0.508
MOD_CK1_1	551	557	PF00069	0.686
MOD_CK1_1	608	614	PF00069	0.477
MOD_CK1_1	72	78	PF00069	0.527
MOD_CK2_1	252	258	PF00069	0.462
MOD_CK2_1	259	265	PF00069	0.372
MOD_CK2_1	411	417	PF00069	0.554
MOD_CK2_1	608	614	PF00069	0.545
MOD_CK2_1	80	86	PF00069	0.507
MOD_CMANNOS	343	346	PF00535	0.470
MOD_GlcNHglycan	127	130	PF01048	0.468
MOD_GlcNHglycan	215	218	PF01048	0.398
MOD_GlcNHglycan	219	222	PF01048	0.404
MOD_GlcNHglycan	267	270	PF01048	0.378
MOD_GlcNHglycan	352	355	PF01048	0.636
MOD_GlcNHglycan	408	411	PF01048	0.444
MOD_GlcNHglycan	413	416	PF01048	0.397
MOD_GlcNHglycan	47	50	PF01048	0.486
MOD_GlcNHglycan	533	536	PF01048	0.531
MOD_GlcNHglycan	57	60	PF01048	0.349
MOD_GlcNHglycan	599	602	PF01048	0.527
MOD_GlcNHglycan	71	74	PF01048	0.476
MOD_GSK3_1	18	25	PF00069	0.613
MOD_GSK3_1	213	220	PF00069	0.413
MOD_GSK3_1	319	326	PF00069	0.498
MOD_GSK3_1	330	337	PF00069	0.596
MOD_GSK3_1	35	42	PF00069	0.553
MOD_GSK3_1	350	357	PF00069	0.389
MOD_GSK3_1	425	432	PF00069	0.402
MOD_GSK3_1	45	52	PF00069	0.585
MOD_GSK3_1	539	546	PF00069	0.733
MOD_GSK3_1	605	612	PF00069	0.632
MOD_GSK3_1	64	71	PF00069	0.299
MOD_N-GLC_1	19	24	PF02516	0.577
MOD_N-GLC_1	90	95	PF02516	0.508
MOD_NEK2_1	125	130	PF00069	0.577
MOD_NEK2_1	215	220	PF00069	0.480
MOD_NEK2_1	234	239	PF00069	0.296
MOD_NEK2_1	451	456	PF00069	0.496
MOD_NEK2_1	486	491	PF00069	0.537
MOD_NEK2_1	516	521	PF00069	0.665
MOD_NEK2_1	68	73	PF00069	0.536
MOD_NEK2_2	433	438	PF00069	0.354
MOD_NEK2_2	49	54	PF00069	0.454
MOD_PIKK_1	288	294	PF00454	0.467
MOD_PIKK_1	489	495	PF00454	0.603
MOD_PKA_1	227	233	PF00069	0.425
MOD_PKA_2	11	17	PF00069	0.631
MOD_PKA_2	118	124	PF00069	0.403
MOD_PKA_2	155	161	PF00069	0.399
MOD_PKA_2	227	233	PF00069	0.367
MOD_PKA_2	299	305	PF00069	0.424
MOD_PKA_2	334	340	PF00069	0.451
MOD_PKA_2	350	356	PF00069	0.480
MOD_PKA_2	487	493	PF00069	0.513
MOD_Plk_1	19	25	PF00069	0.528
MOD_Plk_1	362	368	PF00069	0.554
MOD_Plk_1	400	406	PF00069	0.502
MOD_Plk_1	590	596	PF00069	0.449
MOD_Plk_1	90	96	PF00069	0.534
MOD_Plk_2-3	544	550	PF00069	0.541
MOD_Plk_4	228	234	PF00069	0.378
MOD_Plk_4	294	300	PF00069	0.405
MOD_Plk_4	370	376	PF00069	0.453
MOD_Plk_4	429	435	PF00069	0.363
MOD_Plk_4	49	55	PF00069	0.464
MOD_Plk_4	494	500	PF00069	0.403
MOD_Plk_4	64	70	PF00069	0.309
MOD_Plk_4	80	86	PF00069	0.587
MOD_Plk_4	90	96	PF00069	0.400
MOD_ProDKin_1	368	374	PF00069	0.572
MOD_ProDKin_1	39	45	PF00069	0.449
MOD_ProDKin_1	511	517	PF00069	0.675
MOD_ProDKin_1	539	545	PF00069	0.645
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.510
TRG_ENDOCYTIC_2	197	200	PF00928	0.359
TRG_ENDOCYTIC_2	229	232	PF00928	0.360
TRG_ER_diArg_1	226	228	PF00400	0.449
TRG_ER_diArg_1	384	386	PF00400	0.531
TRG_ER_diArg_1	9	12	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P687	Leptomonas seymouri	42%	67%
A0A3S7X6C3	Leishmania donovani	90%	100%
A4HL45	Leishmania braziliensis	73%	99%
A4I8M4	Leishmania infantum	90%	100%
E9B3I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%