Zinc transporter ZIP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ZIP Zinc transporter, putative

Species:

Leishmania major

UniProt:

Q4Q4L3_LEIMA

TriTrypDb:

LmjF.33.0100 , LMJLV39_330006000 , LMJSD75_330005900

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q4L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L3

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006829	zinc ion transport	8	2
GO:0009987	cellular process	1	2
GO:0030001	metal ion transport	6	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071577	zinc ion transmembrane transport	6	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098662	inorganic cation transmembrane transport	5	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0005385	zinc ion transmembrane transporter activity	7	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0046873	metal ion transmembrane transporter activity	5	3
GO:0046915	transition metal ion transmembrane transporter activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.419
CLV_NRD_NRD_1	32	34	PF00675	0.528
CLV_PCSK_FUR_1	30	34	PF00082	0.485
CLV_PCSK_KEX2_1	14	16	PF00082	0.447
CLV_PCSK_KEX2_1	32	34	PF00082	0.537
CLV_PCSK_PC7_1	28	34	PF00082	0.373
CLV_PCSK_SKI1_1	100	104	PF00082	0.419
DEG_SPOP_SBC_1	270	274	PF00917	0.457
DOC_CKS1_1	228	233	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.480
DOC_MAPK_MEF2A_6	171	180	PF00069	0.528
DOC_USP7_MATH_1	121	125	PF00917	0.762
DOC_USP7_MATH_1	207	211	PF00917	0.692
DOC_USP7_MATH_1	250	254	PF00917	0.488
DOC_USP7_MATH_1	261	265	PF00917	0.518
DOC_USP7_MATH_1	270	274	PF00917	0.490
DOC_USP7_MATH_1	284	288	PF00917	0.305
DOC_WW_Pin1_4	227	232	PF00397	0.389
DOC_WW_Pin1_4	75	80	PF00397	0.436
LIG_14-3-3_CanoR_1	32	40	PF00244	0.645
LIG_Actin_WH2_2	288	306	PF00022	0.368
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BRCT_BRCA1_1	210	214	PF00533	0.639
LIG_BRCT_BRCA1_1	252	256	PF00533	0.485
LIG_BRCT_BRCA1_1	286	290	PF00533	0.355
LIG_Clathr_ClatBox_1	150	154	PF01394	0.584
LIG_CSL_BTD_1	6	9	PF09270	0.597
LIG_FHA_1	111	117	PF00498	0.743
LIG_FHA_1	130	136	PF00498	0.620
LIG_FHA_1	144	150	PF00498	0.567
LIG_FHA_1	162	168	PF00498	0.479
LIG_FHA_1	20	26	PF00498	0.699
LIG_FHA_1	246	252	PF00498	0.521
LIG_FHA_1	317	323	PF00498	0.355
LIG_FHA_1	35	41	PF00498	0.656
LIG_FHA_1	58	64	PF00498	0.364
LIG_LIR_Gen_1	185	195	PF02991	0.557
LIG_LIR_Gen_1	233	243	PF02991	0.246
LIG_LIR_Gen_1	287	298	PF02991	0.428
LIG_LIR_Gen_1	43	53	PF02991	0.562
LIG_LIR_Nem_3	211	217	PF02991	0.560
LIG_LIR_Nem_3	233	238	PF02991	0.246
LIG_LIR_Nem_3	287	293	PF02991	0.367
LIG_LIR_Nem_3	43	49	PF02991	0.562
LIG_NRBOX	134	140	PF00104	0.558
LIG_Pex14_1	7	11	PF04695	0.633
LIG_Rb_LxCxE_1	296	314	PF01857	0.285
LIG_REV1ctd_RIR_1	9	19	PF16727	0.619
LIG_SH2_PTP2	292	295	PF00017	0.480
LIG_SH2_STAT5	292	295	PF00017	0.413
LIG_SH2_STAT5	324	327	PF00017	0.523
LIG_SH3_3	3	9	PF00018	0.574
LIG_SH3_3	89	95	PF00018	0.373
LIG_SUMO_SIM_anti_2	131	139	PF11976	0.597
LIG_SUMO_SIM_anti_2	271	280	PF11976	0.476
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.402
LIG_SUMO_SIM_par_1	112	119	PF11976	0.771
MOD_CK1_1	128	134	PF00069	0.659
MOD_CK1_1	265	271	PF00069	0.480
MOD_CK1_1	274	280	PF00069	0.393
MOD_CK1_1	75	81	PF00069	0.486
MOD_CK2_1	185	191	PF00069	0.668
MOD_Cter_Amidation	30	33	PF01082	0.513
MOD_GlcNHglycan	123	126	PF01048	0.587
MOD_GlcNHglycan	128	131	PF01048	0.416
MOD_GlcNHglycan	154	158	PF01048	0.402
MOD_GlcNHglycan	161	164	PF01048	0.396
MOD_GlcNHglycan	167	170	PF01048	0.365
MOD_GlcNHglycan	252	255	PF01048	0.710
MOD_GlcNHglycan	286	289	PF01048	0.379
MOD_GlcNHglycan	53	56	PF01048	0.334
MOD_GlcNHglycan	74	77	PF01048	0.661
MOD_GSK3_1	106	113	PF00069	0.715
MOD_GSK3_1	121	128	PF00069	0.789
MOD_GSK3_1	161	168	PF00069	0.617
MOD_GSK3_1	245	252	PF00069	0.480
MOD_GSK3_1	261	268	PF00069	0.504
MOD_GSK3_1	270	277	PF00069	0.419
MOD_GSK3_1	293	300	PF00069	0.324
MOD_GSK3_1	36	43	PF00069	0.610
MOD_N-GLC_1	207	212	PF02516	0.463
MOD_NEK2_1	153	158	PF00069	0.595
MOD_NEK2_1	161	166	PF00069	0.580
MOD_NEK2_1	269	274	PF00069	0.423
MOD_NEK2_1	322	327	PF00069	0.524
MOD_NEK2_1	40	45	PF00069	0.592
MOD_NEK2_1	57	62	PF00069	0.268
MOD_NEK2_1	98	103	PF00069	0.678
MOD_PKA_2	19	25	PF00069	0.668
MOD_PKA_2	208	214	PF00069	0.659
MOD_Plk_1	98	104	PF00069	0.672
MOD_Plk_2-3	185	191	PF00069	0.675
MOD_Plk_2-3	193	199	PF00069	0.556
MOD_Plk_4	230	236	PF00069	0.461
MOD_Plk_4	274	280	PF00069	0.423
MOD_Plk_4	286	292	PF00069	0.321
MOD_Plk_4	293	299	PF00069	0.212
MOD_ProDKin_1	227	233	PF00069	0.389
MOD_ProDKin_1	75	81	PF00069	0.431
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.610
TRG_ENDOCYTIC_2	187	190	PF00928	0.544
TRG_ENDOCYTIC_2	292	295	PF00928	0.480
TRG_ER_diArg_1	14	17	PF00400	0.626
TRG_ER_diArg_1	30	33	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U6	Leptomonas seymouri	49%	95%
A0A1X0P3V2	Trypanosomatidae	30%	75%
A0A3R7MSD3	Trypanosoma rangeli	33%	100%
A0A3S7X6D4	Leishmania donovani	88%	100%
A4HL46	Leishmania braziliensis	68%	100%
A4I8M5	Leishmania infantum	88%	100%
C9ZPV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9B3I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BAE0	Trypanosoma cruzi	38%	92%