Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4L2_LEIMA

TriTrypDb:

LmjF.33.0110 , LMJLV39_330006200 , LMJSD75_330006100

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.515
CLV_NRD_NRD_1	125	127	PF00675	0.556
CLV_NRD_NRD_1	267	269	PF00675	0.629
CLV_NRD_NRD_1	338	340	PF00675	0.573
CLV_NRD_NRD_1	35	37	PF00675	0.722
CLV_PCSK_FUR_1	140	144	PF00082	0.632
CLV_PCSK_FUR_1	336	340	PF00082	0.613
CLV_PCSK_KEX2_1	125	127	PF00082	0.647
CLV_PCSK_KEX2_1	142	144	PF00082	0.519
CLV_PCSK_KEX2_1	267	269	PF00082	0.669
CLV_PCSK_KEX2_1	338	340	PF00082	0.588
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.519
CLV_PCSK_SKI1_1	220	224	PF00082	0.535
DEG_SPOP_SBC_1	60	64	PF00917	0.533
DOC_ANK_TNKS_1	23	30	PF00023	0.535
DOC_CKS1_1	151	156	PF01111	0.609
DOC_CYCLIN_RxL_1	101	114	PF00134	0.654
DOC_PP1_RVXF_1	105	112	PF00149	0.648
DOC_PP2B_LxvP_1	149	152	PF13499	0.677
DOC_USP7_MATH_1	240	244	PF00917	0.675
DOC_USP7_MATH_1	28	32	PF00917	0.671
DOC_USP7_MATH_1	91	95	PF00917	0.683
DOC_USP7_UBL2_3	172	176	PF12436	0.727
DOC_USP7_UBL2_3	216	220	PF12436	0.660
DOC_WW_Pin1_4	150	155	PF00397	0.662
DOC_WW_Pin1_4	232	237	PF00397	0.585
LIG_14-3-3_CanoR_1	13	17	PF00244	0.645
LIG_14-3-3_CanoR_1	132	138	PF00244	0.590
LIG_FHA_1	198	204	PF00498	0.679
LIG_FHA_1	264	270	PF00498	0.548
LIG_FHA_1	312	318	PF00498	0.579
LIG_FHA_1	79	85	PF00498	0.754
LIG_FHA_2	225	231	PF00498	0.615
LIG_FHA_2	274	280	PF00498	0.571
LIG_FHA_2	38	44	PF00498	0.613
LIG_FHA_2	60	66	PF00498	0.532
LIG_LIR_Gen_1	153	164	PF02991	0.583
LIG_LIR_Gen_1	177	183	PF02991	0.697
LIG_LIR_Nem_3	153	159	PF02991	0.596
LIG_LIR_Nem_3	177	182	PF02991	0.696
LIG_LIR_Nem_3	329	334	PF02991	0.638
LIG_SH2_NCK_1	198	202	PF00017	0.727
LIG_SH2_NCK_1	42	46	PF00017	0.661
LIG_SH2_SRC	179	182	PF00017	0.652
LIG_SH2_STAP1	42	46	PF00017	0.631
LIG_SH2_STAT5	179	182	PF00017	0.631
LIG_SH2_STAT5	238	241	PF00017	0.531
LIG_SH2_STAT5	82	85	PF00017	0.765
LIG_SH3_1	148	154	PF00018	0.697
LIG_SH3_3	148	154	PF00018	0.570
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.721
MOD_CDK_SPK_2	232	237	PF00069	0.611
MOD_CK1_1	15	21	PF00069	0.670
MOD_CK1_1	273	279	PF00069	0.551
MOD_CK1_1	52	58	PF00069	0.705
MOD_CK1_1	59	65	PF00069	0.670
MOD_CK2_1	224	230	PF00069	0.616
MOD_CK2_1	273	279	PF00069	0.571
MOD_CK2_1	59	65	PF00069	0.535
MOD_CK2_1	87	93	PF00069	0.612
MOD_GlcNHglycan	113	116	PF01048	0.606
MOD_GlcNHglycan	30	33	PF01048	0.615
MOD_GlcNHglycan	58	61	PF01048	0.714
MOD_GlcNHglycan	89	92	PF01048	0.689
MOD_GSK3_1	197	204	PF00069	0.695
MOD_GSK3_1	216	223	PF00069	0.576
MOD_GSK3_1	271	278	PF00069	0.705
MOD_GSK3_1	326	333	PF00069	0.596
MOD_GSK3_1	5	12	PF00069	0.609
MOD_GSK3_1	52	59	PF00069	0.683
MOD_GSK3_1	87	94	PF00069	0.636
MOD_LATS_1	35	41	PF00433	0.706
MOD_N-GLC_1	255	260	PF02516	0.626
MOD_N-GLC_1	317	322	PF02516	0.620
MOD_NEK2_1	111	116	PF00069	0.517
MOD_NEK2_1	326	331	PF00069	0.536
MOD_NEK2_1	54	59	PF00069	0.661
MOD_PIKK_1	183	189	PF00454	0.613
MOD_PIKK_1	209	215	PF00454	0.608
MOD_PIKK_1	220	226	PF00454	0.521
MOD_PIKK_1	343	349	PF00454	0.545
MOD_PKA_2	12	18	PF00069	0.662
MOD_Plk_1	183	189	PF00069	0.606
MOD_Plk_1	240	246	PF00069	0.670
MOD_Plk_1	255	261	PF00069	0.573
MOD_Plk_1	317	323	PF00069	0.589
MOD_Plk_1	38	44	PF00069	0.667
MOD_Plk_1	78	84	PF00069	0.680
MOD_Plk_4	242	248	PF00069	0.672
MOD_Plk_4	326	332	PF00069	0.530
MOD_Plk_4	78	84	PF00069	0.676
MOD_ProDKin_1	150	156	PF00069	0.668
MOD_ProDKin_1	232	238	PF00069	0.580
MOD_SUMO_for_1	188	191	PF00179	0.668
MOD_SUMO_rev_2	212	217	PF00179	0.670
TRG_ENDOCYTIC_2	156	159	PF00928	0.606
TRG_ENDOCYTIC_2	179	182	PF00928	0.658
TRG_ENDOCYTIC_2	331	334	PF00928	0.637
TRG_ER_diArg_1	267	269	PF00400	0.669
TRG_ER_diArg_1	295	298	PF00400	0.517
TRG_ER_diArg_1	338	340	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYS1	Leptomonas seymouri	55%	95%
A0A0S4JBY8	Bodo saltans	26%	85%
A0A3Q8IGM9	Leishmania donovani	92%	100%
A0A422NYD6	Trypanosoma rangeli	41%	88%
A4HL47	Leishmania braziliensis	80%	100%
A4I8M6	Leishmania infantum	92%	100%
C9ZPV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
E9B3I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BJG4	Trypanosoma cruzi	39%	88%