Centrosomal protein of 19 kDa

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CEP19-like protein, putative

Species:

Leishmania major

UniProt:

Q4Q4L1_LEIMA

TriTrypDb:

LmjF.33.0120 , LMJLV39_330006500 , LMJSD75_330006400

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	2
GO:0005737	cytoplasm	2	12
GO:0005813	centrosome	3	2
GO:0005814	centriole	5	12
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4Q4L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4L1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006903	vesicle targeting	2	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0034453	microtubule anchoring	4	2
GO:0034454	microtubule anchoring at centrosome	6	2
GO:0048199	vesicle targeting, to, from or within Golgi	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072393	microtubule anchoring at microtubule organizing center	5	2
GO:0097712	vesicle targeting, trans-Golgi to periciliary membrane compartment	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.447
CLV_C14_Caspase3-7	312	316	PF00656	0.458
CLV_C14_Caspase3-7	82	86	PF00656	0.434
CLV_NRD_NRD_1	18	20	PF00675	0.414
CLV_NRD_NRD_1	202	204	PF00675	0.319
CLV_NRD_NRD_1	22	24	PF00675	0.418
CLV_NRD_NRD_1	221	223	PF00675	0.264
CLV_NRD_NRD_1	25	27	PF00675	0.397
CLV_PCSK_KEX2_1	129	131	PF00082	0.450
CLV_PCSK_KEX2_1	202	204	PF00082	0.298
CLV_PCSK_KEX2_1	22	24	PF00082	0.404
CLV_PCSK_KEX2_1	221	223	PF00082	0.193
CLV_PCSK_KEX2_1	348	350	PF00082	0.248
CLV_PCSK_KEX2_1	80	82	PF00082	0.486
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.450
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.248
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.580
CLV_PCSK_SKI1_1	158	162	PF00082	0.360
CLV_PCSK_SKI1_1	222	226	PF00082	0.339
CLV_PCSK_SKI1_1	335	339	PF00082	0.287
DEG_SPOP_SBC_1	277	281	PF00917	0.388
DOC_CKS1_1	159	164	PF01111	0.307
DOC_MAPK_gen_1	26	34	PF00069	0.481
DOC_MAPK_gen_1	291	299	PF00069	0.539
DOC_MAPK_RevD_3	115	130	PF00069	0.441
DOC_MAPK_RevD_3	334	349	PF00069	0.491
DOC_USP7_MATH_1	251	255	PF00917	0.521
DOC_USP7_MATH_1	277	281	PF00917	0.499
DOC_USP7_MATH_1	355	359	PF00917	0.541
DOC_WW_Pin1_4	158	163	PF00397	0.330
DOC_WW_Pin1_4	247	252	PF00397	0.557
DOC_WW_Pin1_4	278	283	PF00397	0.552
DOC_WW_Pin1_4	55	60	PF00397	0.528
LIG_14-3-3_CanoR_1	108	115	PF00244	0.400
LIG_14-3-3_CanoR_1	168	174	PF00244	0.584
LIG_14-3-3_CanoR_1	222	231	PF00244	0.448
LIG_14-3-3_CanoR_1	67	72	PF00244	0.496
LIG_deltaCOP1_diTrp_1	9	18	PF00928	0.469
LIG_FHA_1	185	191	PF00498	0.548
LIG_FHA_1	214	220	PF00498	0.449
LIG_FHA_1	259	265	PF00498	0.535
LIG_FHA_1	48	54	PF00498	0.464
LIG_FHA_2	318	324	PF00498	0.465
LIG_FHA_2	34	40	PF00498	0.507
LIG_LIR_Apic_2	191	195	PF02991	0.539
LIG_LIR_Gen_1	233	241	PF02991	0.557
LIG_LIR_Gen_1	58	69	PF02991	0.462
LIG_LIR_Gen_1	9	18	PF02991	0.360
LIG_LIR_Nem_3	187	192	PF02991	0.539
LIG_LIR_Nem_3	233	239	PF02991	0.490
LIG_LIR_Nem_3	323	327	PF02991	0.539
LIG_LIR_Nem_3	9	14	PF02991	0.357
LIG_MYND_1	115	119	PF01753	0.438
LIG_PCNA_PIPBox_1	87	96	PF02747	0.396
LIG_PCNA_yPIPBox_3	80	94	PF02747	0.395
LIG_PTB_Apo_2	326	333	PF02174	0.539
LIG_SH2_NCK_1	192	196	PF00017	0.539
LIG_SH2_SRC	103	106	PF00017	0.344
LIG_SH2_STAP1	103	107	PF00017	0.341
LIG_SH2_STAP1	346	350	PF00017	0.448
LIG_SH2_STAT5	189	192	PF00017	0.497
LIG_SH2_STAT5	344	347	PF00017	0.480
LIG_SH3_3	156	162	PF00018	0.408
LIG_SH3_3	209	215	PF00018	0.469
LIG_SH3_3	279	285	PF00018	0.457
LIG_SH3_3	333	339	PF00018	0.456
LIG_SH3_3	349	355	PF00018	0.476
LIG_SH3_3	41	47	PF00018	0.582
LIG_SUMO_SIM_par_1	49	54	PF11976	0.327
LIG_TRAF2_1	28	31	PF00917	0.381
LIG_TRAF2_1	320	323	PF00917	0.462
LIG_UBA3_1	71	80	PF00899	0.398
MOD_CDK_SPK_2	158	163	PF00069	0.354
MOD_CK1_1	254	260	PF00069	0.463
MOD_CK1_1	353	359	PF00069	0.582
MOD_CK2_1	140	146	PF00069	0.408
MOD_CK2_1	317	323	PF00069	0.447
MOD_CK2_1	33	39	PF00069	0.504
MOD_CK2_1	67	73	PF00069	0.521
MOD_DYRK1A_RPxSP_1	158	162	PF00069	0.271
MOD_GlcNHglycan	109	112	PF01048	0.398
MOD_GlcNHglycan	288	291	PF01048	0.301
MOD_GlcNHglycan	358	361	PF01048	0.304
MOD_GSK3_1	176	183	PF00069	0.473
MOD_GSK3_1	247	254	PF00069	0.501
MOD_GSK3_1	260	267	PF00069	0.430
MOD_GSK3_1	272	279	PF00069	0.473
MOD_GSK3_1	63	70	PF00069	0.461
MOD_N-GLC_1	277	282	PF02516	0.275
MOD_N-GLC_1	98	103	PF02516	0.463
MOD_NEK2_1	107	112	PF00069	0.348
MOD_NEK2_1	89	94	PF00069	0.436
MOD_PIKK_1	353	359	PF00454	0.457
MOD_PKA_2	107	113	PF00069	0.414
MOD_PKA_2	174	180	PF00069	0.490
MOD_Plk_1	317	323	PF00069	0.437
MOD_Plk_2-3	317	323	PF00069	0.447
MOD_Plk_4	184	190	PF00069	0.539
MOD_Plk_4	235	241	PF00069	0.490
MOD_Plk_4	67	73	PF00069	0.552
MOD_Plk_4	89	95	PF00069	0.434
MOD_ProDKin_1	158	164	PF00069	0.333
MOD_ProDKin_1	247	253	PF00069	0.557
MOD_ProDKin_1	278	284	PF00069	0.552
MOD_ProDKin_1	55	61	PF00069	0.525
MOD_SUMO_rev_2	317	327	PF00179	0.448
TRG_DiLeu_BaEn_1	9	14	PF01217	0.370
TRG_ENDOCYTIC_2	61	64	PF00928	0.372
TRG_ER_diArg_1	201	203	PF00400	0.482
TRG_ER_diArg_1	21	23	PF00400	0.396
TRG_ER_diArg_1	221	223	PF00400	0.419
TRG_NLS_MonoExtC_3	18	23	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z2	Leptomonas seymouri	57%	95%
A0A0S4JKX9	Bodo saltans	35%	100%
A0A1X0P0L9	Trypanosomatidae	39%	94%
A0A3R7KC81	Trypanosoma rangeli	40%	96%
A0A3S7X6D1	Leishmania donovani	94%	100%
A4HL49	Leishmania braziliensis	79%	100%
A4I8M8	Leishmania infantum	94%	100%
D0A4K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E9B3J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BKD3	Trypanosoma cruzi	41%	96%