ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4Q4K9_LEIMA

TriTrypDb:

LmjF.33.0140 , LMJLV39_330006700 , LMJSD75_330006600

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.646
CLV_C14_Caspase3-7	370	374	PF00656	0.622
CLV_NRD_NRD_1	271	273	PF00675	0.438
CLV_NRD_NRD_1	377	379	PF00675	0.597
CLV_NRD_NRD_1	384	386	PF00675	0.651
CLV_NRD_NRD_1	61	63	PF00675	0.519
CLV_PCSK_KEX2_1	271	273	PF00082	0.438
CLV_PCSK_KEX2_1	376	378	PF00082	0.625
CLV_PCSK_KEX2_1	384	386	PF00082	0.497
CLV_PCSK_KEX2_1	61	63	PF00082	0.549
CLV_PCSK_SKI1_1	209	213	PF00082	0.439
CLV_PCSK_SKI1_1	21	25	PF00082	0.465
CLV_PCSK_SKI1_1	272	276	PF00082	0.572
CLV_PCSK_SKI1_1	393	397	PF00082	0.528
DEG_APCC_DBOX_1	20	28	PF00400	0.459
DOC_ANK_TNKS_1	236	243	PF00023	0.478
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.425
DOC_MAPK_MEF2A_6	225	233	PF00069	0.409
DOC_PP2B_LxvP_1	193	196	PF13499	0.464
DOC_USP7_MATH_1	334	338	PF00917	0.489
DOC_USP7_MATH_1	364	368	PF00917	0.539
DOC_USP7_UBL2_3	389	393	PF12436	0.433
DOC_WW_Pin1_4	128	133	PF00397	0.302
DOC_WW_Pin1_4	398	403	PF00397	0.572
DOC_WW_Pin1_4	45	50	PF00397	0.518
DOC_WW_Pin1_4	8	13	PF00397	0.496
LIG_14-3-3_CanoR_1	176	180	PF00244	0.500
LIG_14-3-3_CanoR_1	207	215	PF00244	0.515
LIG_14-3-3_CanoR_1	306	316	PF00244	0.503
LIG_14-3-3_CanoR_1	376	382	PF00244	0.637
LIG_14-3-3_CanoR_1	384	388	PF00244	0.496
LIG_14-3-3_CanoR_1	55	61	PF00244	0.583
LIG_14-3-3_CterR_2	404	408	PF00244	0.676
LIG_APCC_ABBA_1	195	200	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BIR_III_3	1	5	PF00653	0.604
LIG_BIR_III_4	92	96	PF00653	0.388
LIG_BRCT_BRCA1_1	103	107	PF00533	0.315
LIG_BRCT_BRCA1_1	246	250	PF00533	0.571
LIG_Clathr_ClatBox_1	279	283	PF01394	0.320
LIG_EH_1	42	46	PF12763	0.504
LIG_FHA_1	176	182	PF00498	0.446
LIG_FHA_1	27	33	PF00498	0.453
LIG_FHA_1	292	298	PF00498	0.568
LIG_FHA_1	308	314	PF00498	0.346
LIG_FHA_2	208	214	PF00498	0.515
LIG_FHA_2	300	306	PF00498	0.408
LIG_Integrin_RGD_1	340	342	PF01839	0.579
LIG_Integrin_RGD_1	40	42	PF01839	0.501
LIG_LIR_Gen_1	104	115	PF02991	0.315
LIG_LIR_Gen_1	159	167	PF02991	0.441
LIG_LIR_Gen_1	254	264	PF02991	0.418
LIG_LIR_Nem_3	159	163	PF02991	0.417
LIG_LIR_Nem_3	254	260	PF02991	0.422
LIG_LIR_Nem_3	386	391	PF02991	0.531
LIG_NRBOX	226	232	PF00104	0.374
LIG_PCNA_yPIPBox_3	17	27	PF02747	0.554
LIG_PCNA_yPIPBox_3	185	194	PF02747	0.387
LIG_REV1ctd_RIR_1	278	288	PF16727	0.314
LIG_SH2_CRK	16	20	PF00017	0.616
LIG_SH2_CRK	160	164	PF00017	0.523
LIG_SH2_STAT5	160	163	PF00017	0.513
LIG_SH2_STAT5	290	293	PF00017	0.406
LIG_SH2_STAT5	358	361	PF00017	0.584
LIG_SH2_STAT5	368	371	PF00017	0.516
LIG_SH2_STAT5	73	76	PF00017	0.620
LIG_SH3_3	152	158	PF00018	0.388
LIG_SH3_3	2	8	PF00018	0.642
LIG_SUMO_SIM_anti_2	22	29	PF11976	0.486
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.450
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.406
LIG_SUMO_SIM_par_1	228	235	PF11976	0.408
LIG_SUMO_SIM_par_1	244	249	PF11976	0.399
MOD_CDC14_SPxK_1	401	404	PF00782	0.679
MOD_CDK_SPxK_1	398	404	PF00069	0.664
MOD_CK1_1	128	134	PF00069	0.388
MOD_CK1_1	299	305	PF00069	0.481
MOD_CK1_1	94	100	PF00069	0.388
MOD_CK2_1	207	213	PF00069	0.528
MOD_CK2_1	267	273	PF00069	0.378
MOD_CK2_1	299	305	PF00069	0.452
MOD_CK2_1	341	347	PF00069	0.595
MOD_CK2_1	364	370	PF00069	0.645
MOD_GlcNHglycan	127	130	PF01048	0.388
MOD_GlcNHglycan	2	5	PF01048	0.563
MOD_GlcNHglycan	92	96	PF01048	0.388
MOD_GSK3_1	101	108	PF00069	0.315
MOD_GSK3_1	263	270	PF00069	0.465
MOD_GSK3_1	292	299	PF00069	0.471
MOD_LATS_1	375	381	PF00433	0.545
MOD_N-GLC_1	125	130	PF02516	0.388
MOD_NEK2_1	105	110	PF00069	0.312
MOD_NEK2_1	181	186	PF00069	0.321
MOD_NEK2_1	201	206	PF00069	0.398
MOD_NEK2_2	175	180	PF00069	0.381
MOD_NEK2_2	56	61	PF00069	0.550
MOD_PKA_1	376	382	PF00069	0.631
MOD_PKA_2	175	181	PF00069	0.501
MOD_PKA_2	236	242	PF00069	0.519
MOD_PKA_2	376	382	PF00069	0.632
MOD_PKA_2	383	389	PF00069	0.510
MOD_PKB_1	89	97	PF00069	0.340
MOD_Plk_1	272	278	PF00069	0.367
MOD_Plk_1	291	297	PF00069	0.436
MOD_Plk_4	175	181	PF00069	0.415
MOD_Plk_4	225	231	PF00069	0.381
MOD_Plk_4	236	242	PF00069	0.467
MOD_Plk_4	263	269	PF00069	0.457
MOD_Plk_4	292	298	PF00069	0.466
MOD_Plk_4	299	305	PF00069	0.414
MOD_Plk_4	31	37	PF00069	0.430
MOD_Plk_4	364	370	PF00069	0.460
MOD_Plk_4	377	383	PF00069	0.609
MOD_ProDKin_1	128	134	PF00069	0.302
MOD_ProDKin_1	398	404	PF00069	0.577
MOD_ProDKin_1	45	51	PF00069	0.525
MOD_ProDKin_1	8	14	PF00069	0.496
MOD_SUMO_rev_2	353	357	PF00179	0.547
TRG_DiLeu_BaEn_1	347	352	PF01217	0.441
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.340
TRG_ENDOCYTIC_2	160	163	PF00928	0.441
TRG_ENDOCYTIC_2	198	201	PF00928	0.420
TRG_ER_diArg_1	376	378	PF00400	0.570
TRG_ER_diArg_1	60	62	PF00400	0.553
TRG_ER_diArg_1	88	91	PF00400	0.291
TRG_NES_CRM1_1	278	292	PF08389	0.343
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF8	Leptomonas seymouri	52%	100%
A0A3Q8IHJ7	Leishmania donovani	93%	100%
A4HL51	Leishmania braziliensis	74%	100%
A4I8N0	Leishmania infantum	93%	100%
E9B3J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%