Iwr1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4K8_LEIMA

TriTrypDb:

LmjF.33.0150 , LMJLV39_330006800 , LMJSD75_330006700

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.675
CLV_C14_Caspase3-7	68	72	PF00656	0.699
CLV_NRD_NRD_1	140	142	PF00675	0.640
CLV_NRD_NRD_1	203	205	PF00675	0.317
CLV_NRD_NRD_1	21	23	PF00675	0.630
CLV_NRD_NRD_1	247	249	PF00675	0.700
CLV_PCSK_KEX2_1	121	123	PF00082	0.686
CLV_PCSK_KEX2_1	139	141	PF00082	0.648
CLV_PCSK_KEX2_1	21	23	PF00082	0.630
CLV_PCSK_KEX2_1	247	249	PF00082	0.701
CLV_PCSK_KEX2_1	45	47	PF00082	0.566
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.708
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.566
CLV_PCSK_PC7_1	117	123	PF00082	0.717
CLV_PCSK_SKI1_1	17	21	PF00082	0.612
DOC_PP4_FxxP_1	135	138	PF00568	0.719
DOC_PP4_FxxP_1	51	54	PF00568	0.700
DOC_USP7_MATH_1	158	162	PF00917	0.724
DOC_USP7_MATH_1	253	257	PF00917	0.749
DOC_USP7_MATH_1	28	32	PF00917	0.719
DOC_USP7_MATH_1	87	91	PF00917	0.586
DOC_WW_Pin1_4	156	161	PF00397	0.783
DOC_WW_Pin1_4	50	55	PF00397	0.699
LIG_14-3-3_CanoR_1	115	121	PF00244	0.709
LIG_14-3-3_CanoR_1	140	146	PF00244	0.701
LIG_14-3-3_CanoR_1	251	260	PF00244	0.634
LIG_14-3-3_CanoR_1	269	275	PF00244	0.639
LIG_14-3-3_CanoR_1	57	65	PF00244	0.689
LIG_BIR_III_4	169	173	PF00653	0.666
LIG_Clathr_ClatBox_1	184	188	PF01394	0.660
LIG_Clathr_ClatBox_1	85	89	PF01394	0.744
LIG_FHA_1	14	20	PF00498	0.663
LIG_FHA_1	192	198	PF00498	0.754
LIG_FHA_1	33	39	PF00498	0.644
LIG_FHA_1	78	84	PF00498	0.562
LIG_FHA_2	106	112	PF00498	0.545
LIG_FHA_2	166	172	PF00498	0.684
LIG_FHA_2	91	97	PF00498	0.634
LIG_LIR_Apic_2	195	201	PF02991	0.627
LIG_LIR_Apic_2	48	54	PF02991	0.691
LIG_LIR_Gen_1	180	189	PF02991	0.744
LIG_LIR_Nem_3	100	105	PF02991	0.656
LIG_LIR_Nem_3	161	166	PF02991	0.638
LIG_LIR_Nem_3	180	184	PF02991	0.683
LIG_LIR_Nem_3	256	261	PF02991	0.667
LIG_MYND_1	50	54	PF01753	0.576
LIG_Rb_LxCxE_1	180	202	PF01857	0.670
LIG_SH2_STAP1	181	185	PF00017	0.609
LIG_SH2_STAT5	134	137	PF00017	0.603
LIG_SH2_STAT5	198	201	PF00017	0.627
LIG_SH3_3	34	40	PF00018	0.612
LIG_TRAF2_1	236	239	PF00917	0.654
LIG_TRAF2_1	92	95	PF00917	0.588
LIG_TRFH_1	134	138	PF08558	0.724
LIG_UBA3_1	85	91	PF00899	0.555
MOD_CDC14_SPxK_1	159	162	PF00782	0.786
MOD_CDK_SPxK_1	156	162	PF00069	0.785
MOD_CDK_SPxxK_3	50	57	PF00069	0.697
MOD_CK1_1	13	19	PF00069	0.747
MOD_CK1_1	229	235	PF00069	0.749
MOD_CK1_1	241	247	PF00069	0.473
MOD_CK1_1	254	260	PF00069	0.737
MOD_CK1_1	267	273	PF00069	0.541
MOD_CK1_1	61	67	PF00069	0.542
MOD_CK1_1	90	96	PF00069	0.677
MOD_CK2_1	208	214	PF00069	0.527
MOD_CK2_1	50	56	PF00069	0.698
MOD_GlcNHglycan	149	152	PF01048	0.692
MOD_GlcNHglycan	214	219	PF01048	0.327
MOD_GlcNHglycan	226	231	PF01048	0.566
MOD_GlcNHglycan	237	243	PF01048	0.658
MOD_GlcNHglycan	60	63	PF01048	0.763
MOD_GSK3_1	152	159	PF00069	0.674
MOD_GSK3_1	238	245	PF00069	0.699
MOD_GSK3_1	270	277	PF00069	0.560
MOD_GSK3_1	28	35	PF00069	0.713
MOD_GSK3_1	41	48	PF00069	0.717
MOD_NEK2_1	8	13	PF00069	0.634
MOD_NEK2_2	10	15	PF00069	0.655
MOD_PK_1	141	147	PF00069	0.650
MOD_PKA_1	139	145	PF00069	0.699
MOD_PKA_1	45	51	PF00069	0.563
MOD_PKA_2	116	122	PF00069	0.739
MOD_PKA_2	139	145	PF00069	0.700
MOD_PKA_2	45	51	PF00069	0.754
MOD_PKA_2	56	62	PF00069	0.640
MOD_PKB_1	139	147	PF00069	0.677
MOD_Plk_1	267	273	PF00069	0.641
MOD_Plk_4	152	158	PF00069	0.782
MOD_Plk_4	270	276	PF00069	0.685
MOD_Plk_4	61	67	PF00069	0.560
MOD_ProDKin_1	156	162	PF00069	0.785
MOD_ProDKin_1	50	56	PF00069	0.699
MOD_SUMO_rev_2	84	93	PF00179	0.541
TRG_DiLeu_BaEn_1	180	185	PF01217	0.672
TRG_DiLeu_BaEn_4	126	132	PF01217	0.751
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.662
TRG_ENDOCYTIC_2	181	184	PF00928	0.632
TRG_ENDOCYTIC_2	258	261	PF00928	0.669
TRG_ER_diArg_1	122	125	PF00400	0.670
TRG_ER_diArg_1	138	141	PF00400	0.605
TRG_ER_diArg_1	20	22	PF00400	0.622
TRG_NES_CRM1_1	96	111	PF08389	0.616
TRG_NLS_MonoExtC_3	120	126	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U4	Leptomonas seymouri	44%	82%
A0A3S7X690	Leishmania donovani	88%	100%
A4HL52	Leishmania braziliensis	68%	100%
A4I8N1	Leishmania infantum	88%	100%
D0A4K8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	74%
E9B3J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%