Tetraspanin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tetraspanin

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q4K7_LEIMA

TriTrypDb:

LmjF.33.0160 , LMJLV39_330007000 , LMJSD75_330006900

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q4K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.745
CLV_NRD_NRD_1	334	336	PF00675	0.575
CLV_NRD_NRD_1	91	93	PF00675	0.437
CLV_PCSK_FUR_1	200	204	PF00082	0.578
CLV_PCSK_KEX2_1	200	202	PF00082	0.725
CLV_PCSK_KEX2_1	336	338	PF00082	0.527
CLV_PCSK_KEX2_1	90	92	PF00082	0.434
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.527
CLV_PCSK_SKI1_1	117	121	PF00082	0.602
CLV_PCSK_SKI1_1	68	72	PF00082	0.338
DOC_MAPK_DCC_7	68	77	PF00069	0.220
DOC_MAPK_MEF2A_6	68	77	PF00069	0.293
DOC_PP1_RVXF_1	115	121	PF00149	0.435
DOC_PP2B_LxvP_1	70	73	PF13499	0.367
DOC_PP4_FxxP_1	22	25	PF00568	0.503
DOC_USP7_MATH_1	245	249	PF00917	0.536
DOC_USP7_MATH_1	300	304	PF00917	0.739
DOC_USP7_MATH_1	311	315	PF00917	0.668
DOC_WW_Pin1_4	249	254	PF00397	0.518
DOC_WW_Pin1_4	303	308	PF00397	0.697
LIG_14-3-3_CanoR_1	299	308	PF00244	0.762
LIG_14-3-3_CterR_2	335	338	PF00244	0.779
LIG_APCC_ABBA_1	132	137	PF00400	0.511
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BRCT_BRCA1_1	186	190	PF00533	0.486
LIG_BRCT_BRCA1_1	301	305	PF00533	0.707
LIG_deltaCOP1_diTrp_1	181	190	PF00928	0.491
LIG_eIF4E_1	100	106	PF01652	0.367
LIG_FHA_1	119	125	PF00498	0.372
LIG_FHA_1	166	172	PF00498	0.506
LIG_FHA_1	206	212	PF00498	0.476
LIG_FHA_1	213	219	PF00498	0.400
LIG_FHA_1	224	230	PF00498	0.443
LIG_FHA_1	26	32	PF00498	0.427
LIG_FHA_1	51	57	PF00498	0.355
LIG_FHA_2	255	261	PF00498	0.523
LIG_FHA_2	31	37	PF00498	0.462
LIG_GBD_Chelix_1	31	39	PF00786	0.714
LIG_LIR_Apic_2	152	156	PF02991	0.468
LIG_LIR_Apic_2	19	25	PF02991	0.626
LIG_LIR_Gen_1	182	191	PF02991	0.373
LIG_LIR_Nem_3	182	188	PF02991	0.424
LIG_LIR_Nem_3	232	238	PF02991	0.495
LIG_LIR_Nem_3	302	308	PF02991	0.690
LIG_NRBOX	111	117	PF00104	0.408
LIG_NRBOX	66	72	PF00104	0.367
LIG_Pex14_1	151	155	PF04695	0.443
LIG_Pex14_1	96	100	PF04695	0.469
LIG_Pex14_2	10	14	PF04695	0.367
LIG_Pex14_2	263	267	PF04695	0.403
LIG_SH2_CRK	100	104	PF00017	0.440
LIG_SH2_CRK	153	157	PF00017	0.459
LIG_SH2_SRC	153	156	PF00017	0.522
LIG_SH2_STAT5	113	116	PF00017	0.440
LIG_SH2_STAT5	262	265	PF00017	0.431
LIG_SUMO_SIM_par_1	289	295	PF11976	0.321
LIG_SUMO_SIM_par_1	68	74	PF11976	0.436
LIG_TRAF2_1	174	177	PF00917	0.459
LIG_TYR_ITIM	111	116	PF00017	0.440
MOD_CK1_1	158	164	PF00069	0.472
MOD_CK1_1	26	32	PF00069	0.434
MOD_CK1_1	303	309	PF00069	0.695
MOD_CK1_1	310	316	PF00069	0.730
MOD_CK2_1	171	177	PF00069	0.532
MOD_CK2_1	254	260	PF00069	0.524
MOD_CK2_1	30	36	PF00069	0.481
MOD_CK2_1	311	317	PF00069	0.758
MOD_CK2_1	41	47	PF00069	0.524
MOD_GlcNHglycan	157	160	PF01048	0.591
MOD_GlcNHglycan	194	197	PF01048	0.672
MOD_GlcNHglycan	313	316	PF01048	0.456
MOD_GSK3_1	155	162	PF00069	0.420
MOD_GSK3_1	163	170	PF00069	0.427
MOD_GSK3_1	23	30	PF00069	0.446
MOD_GSK3_1	245	252	PF00069	0.472
MOD_GSK3_1	299	306	PF00069	0.711
MOD_GSK3_1	307	314	PF00069	0.697
MOD_GSK3_1	43	50	PF00069	0.334
MOD_LATS_1	297	303	PF00433	0.689
MOD_N-GLC_1	128	133	PF02516	0.667
MOD_N-GLC_1	166	171	PF02516	0.619
MOD_N-GLC_1	245	250	PF02516	0.661
MOD_NEK2_1	10	15	PF00069	0.409
MOD_NEK2_1	190	195	PF00069	0.406
MOD_NEK2_1	237	242	PF00069	0.503
MOD_NEK2_1	267	272	PF00069	0.426
MOD_NEK2_1	27	32	PF00069	0.431
MOD_NEK2_1	279	284	PF00069	0.331
MOD_NEK2_2	16	21	PF00069	0.440
MOD_NEK2_2	245	250	PF00069	0.435
MOD_OFUCOSY	157	163	PF10250	0.672
MOD_PIKK_1	190	196	PF00454	0.393
MOD_PKA_2	300	306	PF00069	0.761
MOD_Plk_1	128	134	PF00069	0.468
MOD_Plk_1	166	172	PF00069	0.501
MOD_Plk_1	245	251	PF00069	0.458
MOD_Plk_1	35	41	PF00069	0.467
MOD_Plk_1	46	52	PF00069	0.394
MOD_Plk_4	282	288	PF00069	0.331
MOD_Plk_4	315	321	PF00069	0.687
MOD_Plk_4	51	57	PF00069	0.461
MOD_Plk_4	71	77	PF00069	0.488
MOD_ProDKin_1	249	255	PF00069	0.522
MOD_ProDKin_1	303	309	PF00069	0.697
MOD_SUMO_for_1	322	325	PF00179	0.731
TRG_ENDOCYTIC_2	100	103	PF00928	0.440
TRG_ENDOCYTIC_2	113	116	PF00928	0.503
TRG_ER_diArg_1	199	202	PF00400	0.489
TRG_ER_diArg_1	90	92	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK0	Leptomonas seymouri	36%	81%
A0A3Q8IHA4	Leishmania donovani	88%	100%
A4HL53	Leishmania braziliensis	67%	76%
A4I8N2	Leishmania infantum	88%	100%
E9B3J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%