Tetraspanin family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetraspanin family, putative

Species:

Leishmania major

UniProt:

Q4Q4K6_LEIMA

TriTrypDb:

LmjF.33.0170 , LMJLV39_330007100 , LMJSD75_330007000

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q4K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.716
CLV_PCSK_SKI1_1	8	12	PF00082	0.529
DOC_MAPK_gen_1	266	275	PF00069	0.362
DOC_MAPK_gen_1	57	67	PF00069	0.616
DOC_MAPK_HePTP_8	265	277	PF00069	0.212
DOC_MAPK_MEF2A_6	268	277	PF00069	0.212
DOC_USP7_MATH_1	18	22	PF00917	0.744
LIG_14-3-3_CanoR_1	245	253	PF00244	0.347
LIG_14-3-3_CanoR_1	8	16	PF00244	0.730
LIG_14-3-3_CanoR_1	95	103	PF00244	0.366
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	83	87	PF00533	0.422
LIG_FHA_1	113	119	PF00498	0.338
LIG_FHA_1	224	230	PF00498	0.353
LIG_FHA_1	260	266	PF00498	0.373
LIG_FHA_1	272	278	PF00498	0.353
LIG_FHA_1	98	104	PF00498	0.300
LIG_FHA_2	223	229	PF00498	0.286
LIG_GBD_Chelix_1	178	186	PF00786	0.531
LIG_LIR_Gen_1	141	150	PF02991	0.410
LIG_LIR_Gen_1	154	161	PF02991	0.292
LIG_LIR_Gen_1	280	291	PF02991	0.456
LIG_LIR_Gen_1	52	63	PF02991	0.624
LIG_LIR_Nem_3	141	145	PF02991	0.446
LIG_LIR_Nem_3	151	155	PF02991	0.360
LIG_LIR_Nem_3	267	273	PF02991	0.285
LIG_LIR_Nem_3	280	286	PF02991	0.420
LIG_LIR_Nem_3	38	43	PF02991	0.615
LIG_LIR_Nem_3	52	58	PF02991	0.590
LIG_NRBOX	260	266	PF00104	0.348
LIG_Pex14_2	83	87	PF04695	0.362
LIG_SH2_CRK	142	146	PF00017	0.426
LIG_SH2_CRK	40	44	PF00017	0.642
LIG_SH2_CRK	61	65	PF00017	0.503
LIG_SH2_SRC	218	221	PF00017	0.303
LIG_SH2_STAT5	218	221	PF00017	0.293
LIG_SH2_STAT5	270	273	PF00017	0.336
LIG_SH3_3	208	214	PF00018	0.360
LIG_SH3_3	232	238	PF00018	0.282
LIG_SUMO_SIM_anti_2	100	107	PF11976	0.212
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.427
LIG_SUMO_SIM_par_1	109	115	PF11976	0.362
LIG_SUMO_SIM_par_1	170	175	PF11976	0.260
LIG_TRAF2_1	231	234	PF00917	0.257
LIG_WRC_WIRS_1	91	96	PF05994	0.303
MOD_CK1_1	151	157	PF00069	0.290
MOD_CK1_1	21	27	PF00069	0.670
MOD_CK1_1	244	250	PF00069	0.319
MOD_CK1_1	287	293	PF00069	0.330
MOD_CK1_1	85	91	PF00069	0.335
MOD_CK2_1	228	234	PF00069	0.372
MOD_GlcNHglycan	187	191	PF01048	0.521
MOD_GlcNHglycan	20	23	PF01048	0.572
MOD_GlcNHglycan	246	249	PF01048	0.502
MOD_GlcNHglycan	5	8	PF01048	0.529
MOD_GlcNHglycan	68	71	PF01048	0.419
MOD_GSK3_1	237	244	PF00069	0.288
MOD_GSK3_1	260	267	PF00069	0.397
MOD_GSK3_1	271	278	PF00069	0.373
MOD_GSK3_1	66	73	PF00069	0.388
MOD_GSK3_1	81	88	PF00069	0.307
MOD_GSK3_1	90	97	PF00069	0.350
MOD_N-GLC_1	222	227	PF02516	0.507
MOD_N-GLC_1	49	54	PF02516	0.450
MOD_NEK2_1	138	143	PF00069	0.457
MOD_NEK2_1	186	191	PF00069	0.255
MOD_NEK2_1	241	246	PF00069	0.336
MOD_NEK2_1	264	269	PF00069	0.342
MOD_NEK2_1	271	276	PF00069	0.355
MOD_NEK2_1	277	282	PF00069	0.415
MOD_NEK2_1	284	289	PF00069	0.340
MOD_NEK2_1	49	54	PF00069	0.713
MOD_NEK2_1	87	92	PF00069	0.358
MOD_NEK2_1	94	99	PF00069	0.338
MOD_NEK2_2	70	75	PF00069	0.425
MOD_NEK2_2	82	87	PF00069	0.263
MOD_PKA_2	244	250	PF00069	0.361
MOD_PKA_2	94	100	PF00069	0.375
MOD_Plk_1	49	55	PF00069	0.686
MOD_Plk_4	127	133	PF00069	0.507
MOD_Plk_4	148	154	PF00069	0.363
MOD_Plk_4	260	266	PF00069	0.351
MOD_Plk_4	277	283	PF00069	0.240
MOD_Plk_4	50	56	PF00069	0.701
MOD_Plk_4	70	76	PF00069	0.391
MOD_SUMO_rev_2	181	186	PF00179	0.303
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.722
TRG_ENDOCYTIC_2	142	145	PF00928	0.401
TRG_ENDOCYTIC_2	155	158	PF00928	0.236
TRG_ENDOCYTIC_2	270	273	PF00928	0.303
TRG_ENDOCYTIC_2	40	43	PF00928	0.617
TRG_ENDOCYTIC_2	61	64	PF00928	0.565
TRG_ER_diArg_1	265	268	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P684	Leptomonas seymouri	43%	99%
A0A0S4JPS2	Bodo saltans	25%	100%
A0A3Q8IEM4	Leishmania donovani	91%	100%
A0A422NDS8	Trypanosoma rangeli	26%	100%
A4HL54	Leishmania braziliensis	70%	100%
A4I8N3	Leishmania infantum	91%	100%
E9B3J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BBB3	Trypanosoma cruzi	28%	100%