Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4K4_LEIMA

TriTrypDb:

LmjF.33.0190 , LMJLV39_330007500 , LMJSD75_330007300

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q4K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.535
CLV_C14_Caspase3-7	470	474	PF00656	0.650
CLV_NRD_NRD_1	145	147	PF00675	0.513
CLV_NRD_NRD_1	210	212	PF00675	0.583
CLV_NRD_NRD_1	93	95	PF00675	0.506
CLV_PCSK_KEX2_1	145	147	PF00082	0.544
CLV_PCSK_KEX2_1	150	152	PF00082	0.613
CLV_PCSK_KEX2_1	165	167	PF00082	0.410
CLV_PCSK_KEX2_1	210	212	PF00082	0.583
CLV_PCSK_KEX2_1	93	95	PF00082	0.506
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.562
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.368
CLV_PCSK_PC7_1	146	152	PF00082	0.508
CLV_PCSK_SKI1_1	124	128	PF00082	0.419
CLV_PCSK_SKI1_1	151	155	PF00082	0.451
CLV_PCSK_SKI1_1	39	43	PF00082	0.558
CLV_PCSK_SKI1_1	462	466	PF00082	0.540
CLV_PCSK_SKI1_1	94	98	PF00082	0.502
DEG_APCC_DBOX_1	38	46	PF00400	0.421
DEG_SPOP_SBC_1	218	222	PF00917	0.558
DEG_SPOP_SBC_1	464	468	PF00917	0.527
DOC_AGCK_PIF_3	513	516	PF00069	0.590
DOC_CKS1_1	276	281	PF01111	0.699
DOC_CKS1_1	447	452	PF01111	0.678
DOC_CYCLIN_RxL_1	453	463	PF00134	0.609
DOC_MAPK_DCC_7	24	34	PF00069	0.470
DOC_MAPK_MEF2A_6	230	239	PF00069	0.602
DOC_MIT_MIM_1	411	420	PF04212	0.428
DOC_PP1_RVXF_1	478	484	PF00149	0.544
DOC_PP2B_PxIxI_1	393	399	PF00149	0.506
DOC_USP7_MATH_1	15	19	PF00917	0.640
DOC_USP7_MATH_1	218	222	PF00917	0.648
DOC_USP7_MATH_1	228	232	PF00917	0.617
DOC_USP7_MATH_1	342	346	PF00917	0.572
DOC_USP7_MATH_1	439	443	PF00917	0.622
DOC_USP7_MATH_1	464	468	PF00917	0.673
DOC_WW_Pin1_4	220	225	PF00397	0.686
DOC_WW_Pin1_4	247	252	PF00397	0.474
DOC_WW_Pin1_4	275	280	PF00397	0.630
DOC_WW_Pin1_4	302	307	PF00397	0.636
DOC_WW_Pin1_4	363	368	PF00397	0.647
DOC_WW_Pin1_4	446	451	PF00397	0.638
DOC_WW_Pin1_4	475	480	PF00397	0.747
LIG_14-3-3_CanoR_1	190	198	PF00244	0.585
LIG_14-3-3_CanoR_1	324	334	PF00244	0.552
LIG_14-3-3_CanoR_1	340	350	PF00244	0.608
LIG_14-3-3_CanoR_1	416	421	PF00244	0.468
LIG_14-3-3_CanoR_1	462	471	PF00244	0.519
LIG_14-3-3_CanoR_1	480	484	PF00244	0.746
LIG_14-3-3_CanoR_1	486	493	PF00244	0.743
LIG_Actin_WH2_2	290	305	PF00022	0.539
LIG_BRCT_BRCA1_1	326	330	PF00533	0.506
LIG_DLG_GKlike_1	416	424	PF00625	0.512
LIG_eIF4E_1	4	10	PF01652	0.635
LIG_FHA_1	275	281	PF00498	0.670
LIG_FHA_1	303	309	PF00498	0.540
LIG_FHA_1	327	333	PF00498	0.464
LIG_FHA_1	342	348	PF00498	0.476
LIG_FHA_1	393	399	PF00498	0.476
LIG_FHA_1	44	50	PF00498	0.553
LIG_FHA_1	441	447	PF00498	0.650
LIG_FHA_1	450	456	PF00498	0.721
LIG_FHA_1	497	503	PF00498	0.596
LIG_FHA_2	125	131	PF00498	0.527
LIG_FHA_2	468	474	PF00498	0.660
LIG_FHA_2	486	492	PF00498	0.472
LIG_FHA_2	73	79	PF00498	0.587
LIG_HP1_1	38	42	PF01393	0.501
LIG_LIR_Apic_2	444	450	PF02991	0.622
LIG_LIR_Gen_1	327	337	PF02991	0.458
LIG_LIR_Gen_1	411	420	PF02991	0.424
LIG_LIR_Gen_1	510	516	PF02991	0.578
LIG_LIR_Nem_3	292	297	PF02991	0.461
LIG_LIR_Nem_3	327	333	PF02991	0.466
LIG_LIR_Nem_3	411	415	PF02991	0.421
LIG_LIR_Nem_3	418	424	PF02991	0.467
LIG_LIR_Nem_3	510	516	PF02991	0.526
LIG_LIR_Nem_3	68	74	PF02991	0.495
LIG_PDZ_Class_1	511	516	PF00595	0.565
LIG_SH2_CRK	201	205	PF00017	0.593
LIG_SH2_CRK	7	11	PF00017	0.565
LIG_SH2_NCK_1	264	268	PF00017	0.418
LIG_SH2_NCK_1	7	11	PF00017	0.613
LIG_SH2_STAT3	11	14	PF00017	0.648
LIG_SH2_STAT5	312	315	PF00017	0.568
LIG_SH2_STAT5	4	7	PF00017	0.565
LIG_SH2_STAT5	506	509	PF00017	0.338
LIG_SH2_STAT5	512	515	PF00017	0.382
LIG_SH3_3	221	227	PF00018	0.678
LIG_SH3_3	29	35	PF00018	0.683
LIG_SH3_3	431	437	PF00018	0.464
LIG_SUMO_SIM_anti_2	327	335	PF11976	0.582
LIG_TYR_ITIM	5	10	PF00017	0.571
MOD_CDC14_SPxK_1	366	369	PF00782	0.631
MOD_CDK_SPK_2	475	480	PF00069	0.536
MOD_CDK_SPxK_1	363	369	PF00069	0.607
MOD_CK1_1	205	211	PF00069	0.634
MOD_CK1_1	220	226	PF00069	0.641
MOD_CK1_1	287	293	PF00069	0.633
MOD_CK1_1	371	377	PF00069	0.502
MOD_CK1_1	463	469	PF00069	0.572
MOD_CK1_1	484	490	PF00069	0.620
MOD_CK2_1	122	128	PF00069	0.493
MOD_CK2_1	485	491	PF00069	0.544
MOD_CK2_1	72	78	PF00069	0.491
MOD_Cter_Amidation	148	151	PF01082	0.639
MOD_Cter_Amidation	163	166	PF01082	0.451
MOD_GlcNHglycan	214	217	PF01048	0.658
MOD_GlcNHglycan	284	287	PF01048	0.644
MOD_GlcNHglycan	289	292	PF01048	0.557
MOD_GlcNHglycan	462	465	PF01048	0.686
MOD_GlcNHglycan	483	486	PF01048	0.572
MOD_GlcNHglycan	513	516	PF01048	0.519
MOD_GSK3_1	280	287	PF00069	0.634
MOD_GSK3_1	363	370	PF00069	0.652
MOD_GSK3_1	458	465	PF00069	0.616
MOD_GSK3_1	475	482	PF00069	0.746
MOD_N-GLC_1	43	48	PF02516	0.504
MOD_NEK2_1	326	331	PF00069	0.547
MOD_NEK2_1	368	373	PF00069	0.725
MOD_NEK2_1	400	405	PF00069	0.527
MOD_NEK2_1	458	463	PF00069	0.688
MOD_NMyristoyl	1	7	PF02799	0.458
MOD_PIKK_1	15	21	PF00454	0.659
MOD_PIKK_1	280	286	PF00454	0.699
MOD_PIKK_1	485	491	PF00454	0.762
MOD_PKA_2	189	195	PF00069	0.573
MOD_PKA_2	415	421	PF00069	0.397
MOD_PKA_2	479	485	PF00069	0.743
MOD_PKB_1	322	330	PF00069	0.599
MOD_Plk_4	289	295	PF00069	0.702
MOD_Plk_4	304	310	PF00069	0.493
MOD_Plk_4	326	332	PF00069	0.544
MOD_Plk_4	403	409	PF00069	0.446
MOD_Plk_4	416	422	PF00069	0.382
MOD_Plk_4	441	447	PF00069	0.706
MOD_Plk_4	72	78	PF00069	0.501
MOD_ProDKin_1	220	226	PF00069	0.686
MOD_ProDKin_1	247	253	PF00069	0.467
MOD_ProDKin_1	275	281	PF00069	0.632
MOD_ProDKin_1	302	308	PF00069	0.639
MOD_ProDKin_1	363	369	PF00069	0.652
MOD_ProDKin_1	446	452	PF00069	0.635
MOD_ProDKin_1	475	481	PF00069	0.749
MOD_SUMO_rev_2	161	167	PF00179	0.545
MOD_SUMO_rev_2	469	479	PF00179	0.620
TRG_ENDOCYTIC_2	7	10	PF00928	0.571
TRG_ER_diArg_1	144	146	PF00400	0.545
TRG_ER_diArg_1	209	211	PF00400	0.597
TRG_ER_diArg_1	237	240	PF00400	0.644
TRG_ER_diArg_1	36	39	PF00400	0.566
TRG_ER_diArg_1	92	94	PF00400	0.503
TRG_NES_CRM1_1	325	339	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z6	Leptomonas seymouri	38%	93%
A0A1X0P237	Trypanosomatidae	24%	85%
A0A3R7MER9	Trypanosoma rangeli	23%	97%
A0A3S5H7T7	Leishmania donovani	89%	76%
A4HL56	Leishmania braziliensis	70%	93%
A4I8N5	Leishmania infantum	89%	93%
E9B3J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5AVX1	Trypanosoma cruzi	24%	81%