Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q4K2_LEIMA

TriTrypDb:

LmjF.33.0210 , LMJLV39_330007900 , LMJSD75_330007600

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q4K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.738
CLV_C14_Caspase3-7	651	655	PF00656	0.615
CLV_C14_Caspase3-7	893	897	PF00656	0.622
CLV_C14_Caspase3-7	906	910	PF00656	0.703
CLV_NRD_NRD_1	688	690	PF00675	0.406
CLV_NRD_NRD_1	751	753	PF00675	0.379
CLV_NRD_NRD_1	758	760	PF00675	0.385
CLV_PCSK_KEX2_1	751	753	PF00082	0.379
CLV_PCSK_KEX2_1	758	760	PF00082	0.385
CLV_PCSK_KEX2_1	76	78	PF00082	0.444
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.465
CLV_PCSK_SKI1_1	278	282	PF00082	0.480
CLV_PCSK_SKI1_1	287	291	PF00082	0.288
CLV_PCSK_SKI1_1	341	345	PF00082	0.507
CLV_PCSK_SKI1_1	427	431	PF00082	0.433
CLV_PCSK_SKI1_1	463	467	PF00082	0.554
CLV_PCSK_SKI1_1	591	595	PF00082	0.356
CLV_PCSK_SKI1_1	690	694	PF00082	0.345
DOC_CDC14_PxL_1	584	592	PF14671	0.629
DOC_CKS1_1	259	264	PF01111	0.726
DOC_CKS1_1	345	350	PF01111	0.602
DOC_CKS1_1	389	394	PF01111	0.458
DOC_CKS1_1	464	469	PF01111	0.754
DOC_CYCLIN_yClb5_NLxxxL_5	421	430	PF00134	0.520
DOC_MAPK_DCC_7	266	274	PF00069	0.667
DOC_MAPK_gen_1	278	288	PF00069	0.655
DOC_MAPK_gen_1	627	635	PF00069	0.635
DOC_MAPK_gen_1	809	818	PF00069	0.755
DOC_MAPK_gen_1	823	832	PF00069	0.564
DOC_MAPK_JIP1_4	215	221	PF00069	0.665
DOC_MAPK_MEF2A_6	281	290	PF00069	0.584
DOC_MAPK_MEF2A_6	364	371	PF00069	0.289
DOC_MAPK_MEF2A_6	477	484	PF00069	0.669
DOC_MAPK_MEF2A_6	629	637	PF00069	0.618
DOC_MAPK_RevD_3	326	342	PF00069	0.391
DOC_PP1_RVXF_1	34	41	PF00149	0.369
DOC_PP1_RVXF_1	731	738	PF00149	0.612
DOC_PP2B_LxvP_1	290	293	PF13499	0.362
DOC_PP2B_LxvP_1	328	331	PF13499	0.381
DOC_PP2B_LxvP_1	541	544	PF13499	0.706
DOC_PP2B_LxvP_1	763	766	PF13499	0.599
DOC_PP4_FxxP_1	155	158	PF00568	0.685
DOC_PP4_FxxP_1	737	740	PF00568	0.609
DOC_PP4_MxPP_1	512	515	PF00568	0.733
DOC_USP7_MATH_1	112	116	PF00917	0.682
DOC_USP7_MATH_1	169	173	PF00917	0.789
DOC_USP7_MATH_1	280	284	PF00917	0.646
DOC_USP7_MATH_1	293	297	PF00917	0.389
DOC_USP7_MATH_1	478	482	PF00917	0.737
DOC_USP7_MATH_1	537	541	PF00917	0.707
DOC_USP7_MATH_1	675	679	PF00917	0.620
DOC_USP7_MATH_1	694	698	PF00917	0.658
DOC_USP7_MATH_1	715	719	PF00917	0.553
DOC_USP7_MATH_1	885	889	PF00917	0.626
DOC_USP7_MATH_2	522	528	PF00917	0.750
DOC_USP7_UBL2_3	241	245	PF12436	0.754
DOC_USP7_UBL2_3	805	809	PF12436	0.733
DOC_WW_Pin1_4	154	159	PF00397	0.847
DOC_WW_Pin1_4	189	194	PF00397	0.732
DOC_WW_Pin1_4	240	245	PF00397	0.734
DOC_WW_Pin1_4	258	263	PF00397	0.627
DOC_WW_Pin1_4	265	270	PF00397	0.683
DOC_WW_Pin1_4	322	327	PF00397	0.449
DOC_WW_Pin1_4	344	349	PF00397	0.567
DOC_WW_Pin1_4	388	393	PF00397	0.447
DOC_WW_Pin1_4	397	402	PF00397	0.386
DOC_WW_Pin1_4	463	468	PF00397	0.769
DOC_WW_Pin1_4	476	481	PF00397	0.661
DOC_WW_Pin1_4	568	573	PF00397	0.724
DOC_WW_Pin1_4	574	579	PF00397	0.690
DOC_WW_Pin1_4	85	90	PF00397	0.697
LIG_14-3-3_CanoR_1	149	155	PF00244	0.805
LIG_14-3-3_CanoR_1	254	260	PF00244	0.743
LIG_14-3-3_CanoR_1	357	362	PF00244	0.565
LIG_14-3-3_CanoR_1	507	515	PF00244	0.707
LIG_14-3-3_CanoR_1	782	792	PF00244	0.591
LIG_Actin_WH2_2	272	289	PF00022	0.674
LIG_Actin_WH2_2	577	593	PF00022	0.604
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BIR_III_2	203	207	PF00653	0.744
LIG_BIR_III_4	646	650	PF00653	0.661
LIG_BRCT_BRCA1_1	633	637	PF00533	0.669
LIG_Clathr_ClatBox_1	682	686	PF01394	0.553
LIG_EH_1	152	156	PF12763	0.689
LIG_EH_1	771	775	PF12763	0.693
LIG_eIF4E_1	316	322	PF01652	0.316
LIG_eIF4E_1	409	415	PF01652	0.449
LIG_EVH1_2	19	23	PF00568	0.362
LIG_EVH1_2	701	705	PF00568	0.718
LIG_FHA_1	138	144	PF00498	0.750
LIG_FHA_1	185	191	PF00498	0.730
LIG_FHA_1	222	228	PF00498	0.713
LIG_FHA_1	298	304	PF00498	0.387
LIG_FHA_1	316	322	PF00498	0.261
LIG_FHA_1	464	470	PF00498	0.742
LIG_FHA_1	47	53	PF00498	0.326
LIG_FHA_1	630	636	PF00498	0.618
LIG_FHA_1	786	792	PF00498	0.538
LIG_FHA_1	96	102	PF00498	0.690
LIG_FHA_2	2	8	PF00498	0.567
LIG_FHA_2	241	247	PF00498	0.692
LIG_FHA_2	259	265	PF00498	0.627
LIG_FHA_2	518	524	PF00498	0.742
LIG_FHA_2	659	665	PF00498	0.667
LIG_FHA_2	839	845	PF00498	0.642
LIG_GBD_Chelix_1	900	908	PF00786	0.442
LIG_HP1_1	293	297	PF01393	0.391
LIG_LIR_Apic_2	386	392	PF02991	0.484
LIG_LIR_Apic_2	573	578	PF02991	0.689
LIG_LIR_Gen_1	296	306	PF02991	0.356
LIG_LIR_Gen_1	363	374	PF02991	0.347
LIG_LIR_Gen_1	634	644	PF02991	0.590
LIG_LIR_Gen_1	843	850	PF02991	0.617
LIG_LIR_Gen_1	858	867	PF02991	0.583
LIG_LIR_LC3C_4	178	181	PF02991	0.774
LIG_LIR_LC3C_4	845	850	PF02991	0.629
LIG_LIR_Nem_3	296	301	PF02991	0.356
LIG_LIR_Nem_3	363	369	PF02991	0.391
LIG_LIR_Nem_3	594	600	PF02991	0.542
LIG_LIR_Nem_3	634	640	PF02991	0.577
LIG_LIR_Nem_3	843	849	PF02991	0.627
LIG_LIR_Nem_3	858	863	PF02991	0.587
LIG_MAD2	463	471	PF02301	0.701
LIG_PALB2_WD40_1	361	369	PF16756	0.391
LIG_PCNA_PIPBox_1	291	300	PF02747	0.391
LIG_PCNA_yPIPBox_3	709	717	PF02747	0.593
LIG_SH2_CRK	298	302	PF00017	0.356
LIG_SH2_CRK	345	349	PF00017	0.607
LIG_SH2_CRK	575	579	PF00017	0.686
LIG_SH2_NCK_1	575	579	PF00017	0.686
LIG_SH2_PTP2	24	27	PF00017	0.319
LIG_SH2_SRC	663	666	PF00017	0.638
LIG_SH2_STAP1	200	204	PF00017	0.745
LIG_SH2_STAP1	372	376	PF00017	0.289
LIG_SH2_STAP1	663	667	PF00017	0.631
LIG_SH2_STAT3	222	225	PF00017	0.736
LIG_SH2_STAT5	200	203	PF00017	0.744
LIG_SH2_STAT5	24	27	PF00017	0.356
LIG_SH2_STAT5	409	412	PF00017	0.356
LIG_SH2_STAT5	597	600	PF00017	0.546
LIG_SH2_STAT5	658	661	PF00017	0.612
LIG_SH3_2	282	287	PF14604	0.627
LIG_SH3_3	177	183	PF00018	0.767
LIG_SH3_3	210	216	PF00018	0.772
LIG_SH3_3	276	282	PF00018	0.712
LIG_SH3_3	461	467	PF00018	0.796
LIG_SH3_3	472	478	PF00018	0.696
LIG_SH3_3	512	518	PF00018	0.789
LIG_SH3_3	696	702	PF00018	0.640
LIG_SH3_3	714	720	PF00018	0.557
LIG_SH3_3	767	773	PF00018	0.665
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.664
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.311
LIG_SUMO_SIM_par_1	270	276	PF11976	0.664
LIG_SUMO_SIM_par_1	299	304	PF11976	0.349
LIG_SUMO_SIM_par_1	357	363	PF11976	0.536
LIG_SUMO_SIM_par_1	413	418	PF11976	0.391
LIG_SUMO_SIM_par_1	681	686	PF11976	0.551
LIG_TRAF2_1	708	711	PF00917	0.629
LIG_TRAF2_1	841	844	PF00917	0.632
LIG_TRAF2_1	910	913	PF00917	0.618
LIG_TYR_ITIM	22	27	PF00017	0.362
LIG_TYR_ITIM	598	603	PF00017	0.409
LIG_UBA3_1	337	342	PF00899	0.464
LIG_UBA3_1	429	433	PF00899	0.475
LIG_UBA3_1	682	690	PF00899	0.414
LIG_WRC_WIRS_1	309	314	PF05994	0.340
LIG_WW_3	173	177	PF00397	0.664
MOD_CDK_SPK_2	240	245	PF00069	0.661
MOD_CK1_1	138	144	PF00069	0.723
MOD_CK1_1	148	154	PF00069	0.643
MOD_CK1_1	191	197	PF00069	0.823
MOD_CK1_1	258	264	PF00069	0.665
MOD_CK1_1	360	366	PF00069	0.414
MOD_CK1_1	43	49	PF00069	0.387
MOD_CK1_1	488	494	PF00069	0.674
MOD_CK1_1	527	533	PF00069	0.763
MOD_CK1_1	60	66	PF00069	0.247
MOD_CK1_1	783	789	PF00069	0.614
MOD_CK1_1	821	827	PF00069	0.626
MOD_CK1_1	858	864	PF00069	0.419
MOD_CK2_1	112	118	PF00069	0.640
MOD_CK2_1	497	503	PF00069	0.661
MOD_CK2_1	517	523	PF00069	0.607
MOD_CK2_1	658	664	PF00069	0.576
MOD_CK2_1	838	844	PF00069	0.520
MOD_CK2_1	907	913	PF00069	0.485
MOD_DYRK1A_RPxSP_1	463	467	PF00069	0.689
MOD_GlcNHglycan	150	153	PF01048	0.601
MOD_GlcNHglycan	171	174	PF01048	0.667
MOD_GlcNHglycan	208	211	PF01048	0.649
MOD_GlcNHglycan	232	236	PF01048	0.819
MOD_GlcNHglycan	275	278	PF01048	0.640
MOD_GlcNHglycan	42	45	PF01048	0.378
MOD_GlcNHglycan	487	490	PF01048	0.654
MOD_GlcNHglycan	499	502	PF01048	0.670
MOD_GlcNHglycan	550	553	PF01048	0.688
MOD_GlcNHglycan	62	65	PF01048	0.220
MOD_GlcNHglycan	651	654	PF01048	0.675
MOD_GlcNHglycan	717	720	PF01048	0.548
MOD_GlcNHglycan	728	731	PF01048	0.537
MOD_GlcNHglycan	798	801	PF01048	0.588
MOD_GlcNHglycan	874	878	PF01048	0.521
MOD_GSK3_1	120	127	PF00069	0.629
MOD_GSK3_1	135	142	PF00069	0.650
MOD_GSK3_1	144	151	PF00069	0.638
MOD_GSK3_1	184	191	PF00069	0.657
MOD_GSK3_1	293	300	PF00069	0.471
MOD_GSK3_1	304	311	PF00069	0.356
MOD_GSK3_1	483	490	PF00069	0.714
MOD_GSK3_1	524	531	PF00069	0.767
MOD_GSK3_1	548	555	PF00069	0.751
MOD_GSK3_1	579	586	PF00069	0.731
MOD_GSK3_1	610	617	PF00069	0.562
MOD_GSK3_1	654	661	PF00069	0.532
MOD_GSK3_1	715	722	PF00069	0.425
MOD_GSK3_1	780	787	PF00069	0.605
MOD_GSK3_1	818	825	PF00069	0.626
MOD_GSK3_1	885	892	PF00069	0.575
MOD_LATS_1	355	361	PF00433	0.454
MOD_LATS_1	505	511	PF00433	0.662
MOD_LATS_1	757	763	PF00433	0.501
MOD_N-GLC_1	497	502	PF02516	0.664
MOD_N-GLC_1	568	573	PF02516	0.676
MOD_N-GLC_1	614	619	PF02516	0.577
MOD_N-GLC_1	784	789	PF02516	0.442
MOD_N-GLC_1	818	823	PF02516	0.752
MOD_N-GLC_1	896	901	PF02516	0.431
MOD_N-GLC_2	71	73	PF02516	0.423
MOD_NEK2_1	125	130	PF00069	0.647
MOD_NEK2_1	135	140	PF00069	0.674
MOD_NEK2_1	184	189	PF00069	0.751
MOD_NEK2_1	297	302	PF00069	0.537
MOD_NEK2_1	308	313	PF00069	0.297
MOD_NEK2_1	350	355	PF00069	0.462
MOD_NEK2_1	40	45	PF00069	0.470
MOD_NEK2_1	554	559	PF00069	0.680
MOD_NEK2_1	561	566	PF00069	0.642
MOD_NEK2_1	583	588	PF00069	0.599
MOD_NEK2_1	623	628	PF00069	0.593
MOD_NEK2_1	67	72	PF00069	0.525
MOD_NEK2_1	726	731	PF00069	0.591
MOD_NEK2_2	293	298	PF00069	0.356
MOD_NEK2_2	489	494	PF00069	0.600
MOD_NEK2_2	537	542	PF00069	0.652
MOD_NEK2_2	728	733	PF00069	0.595
MOD_PIKK_1	221	227	PF00454	0.667
MOD_PIKK_1	507	513	PF00454	0.597
MOD_PIKK_1	786	792	PF00454	0.489
MOD_PK_1	357	363	PF00069	0.368
MOD_PKA_2	148	154	PF00069	0.759
MOD_PKA_2	184	190	PF00069	0.695
MOD_PKA_2	561	567	PF00069	0.600
MOD_Plk_1	896	902	PF00069	0.437
MOD_Plk_4	120	126	PF00069	0.618
MOD_Plk_4	191	197	PF00069	0.688
MOD_Plk_4	270	276	PF00069	0.627
MOD_Plk_4	293	299	PF00069	0.356
MOD_Plk_4	304	310	PF00069	0.356
MOD_Plk_4	357	363	PF00069	0.502
MOD_Plk_4	410	416	PF00069	0.365
MOD_Plk_4	528	534	PF00069	0.609
MOD_Plk_4	537	543	PF00069	0.614
MOD_Plk_4	556	562	PF00069	0.538
MOD_Plk_4	57	63	PF00069	0.413
MOD_Plk_4	579	585	PF00069	0.658
MOD_Plk_4	591	597	PF00069	0.388
MOD_Plk_4	654	660	PF00069	0.531
MOD_Plk_4	719	725	PF00069	0.443
MOD_ProDKin_1	154	160	PF00069	0.823
MOD_ProDKin_1	189	195	PF00069	0.658
MOD_ProDKin_1	240	246	PF00069	0.657
MOD_ProDKin_1	258	264	PF00069	0.513
MOD_ProDKin_1	265	271	PF00069	0.589
MOD_ProDKin_1	322	328	PF00069	0.449
MOD_ProDKin_1	344	350	PF00069	0.423
MOD_ProDKin_1	388	394	PF00069	0.542
MOD_ProDKin_1	397	403	PF00069	0.449
MOD_ProDKin_1	463	469	PF00069	0.711
MOD_ProDKin_1	476	482	PF00069	0.561
MOD_ProDKin_1	568	574	PF00069	0.648
MOD_ProDKin_1	85	91	PF00069	0.610
MOD_SUMO_for_1	432	435	PF00179	0.512
MOD_SUMO_rev_2	2	11	PF00179	0.491
MOD_SUMO_rev_2	80	89	PF00179	0.544
TRG_DiLeu_BaEn_1	844	849	PF01217	0.525
TRG_DiLeu_BaEn_1	865	870	PF01217	0.417
TRG_DiLeu_BaEn_4	607	613	PF01217	0.520
TRG_ENDOCYTIC_2	24	27	PF00928	0.356
TRG_ENDOCYTIC_2	298	301	PF00928	0.356
TRG_ENDOCYTIC_2	600	603	PF00928	0.415
TRG_ENDOCYTIC_2	833	836	PF00928	0.423
TRG_ER_diArg_1	750	752	PF00400	0.446
TRG_ER_diArg_1	758	760	PF00400	0.452
TRG_NES_CRM1_1	589	602	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.798
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYR4	Leptomonas seymouri	44%	99%
A0A3S7X6B9	Leishmania donovani	84%	100%
A4HL58	Leishmania braziliensis	54%	99%
A4I8N8	Leishmania infantum	84%	100%
E9B3J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%