Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 2, putative

Species:

Leishmania major

UniProt:

Q4Q4K0_LEIMA

TriTrypDb:

LmjF.33.0230 , LMJLV39_330008100 , LMJSD75_330007800

Length:

572

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic ZDHHC-type palmitoyltransferases (e.g animal ZDHHC20).

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q4K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4K0

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016409	palmitoyltransferase activity	5	9
GO:0016417	S-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	9
GO:0019707	protein-cysteine S-acyltransferase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	449	453	PF00656	0.701
CLV_NRD_NRD_1	320	322	PF00675	0.535
CLV_NRD_NRD_1	384	386	PF00675	0.430
CLV_NRD_NRD_1	423	425	PF00675	0.370
CLV_NRD_NRD_1	458	460	PF00675	0.560
CLV_PCSK_KEX2_1	320	322	PF00082	0.481
CLV_PCSK_KEX2_1	362	364	PF00082	0.282
CLV_PCSK_KEX2_1	384	386	PF00082	0.430
CLV_PCSK_KEX2_1	423	425	PF00082	0.370
CLV_PCSK_KEX2_1	458	460	PF00082	0.560
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.266
CLV_PCSK_PC7_1	419	425	PF00082	0.349
CLV_PCSK_SKI1_1	363	367	PF00082	0.359
CLV_PCSK_SKI1_1	384	388	PF00082	0.397
CLV_PCSK_SKI1_1	433	437	PF00082	0.400
CLV_PCSK_SKI1_1	478	482	PF00082	0.359
DEG_APCC_KENBOX_2	296	300	PF00400	0.212
DEG_MDM2_SWIB_1	475	483	PF02201	0.526
DEG_SCF_FBW7_1	305	310	PF00400	0.242
DOC_MAPK_gen_1	128	137	PF00069	0.623
DOC_MAPK_gen_1	320	326	PF00069	0.194
DOC_MAPK_gen_1	423	431	PF00069	0.598
DOC_MAPK_MEF2A_6	265	272	PF00069	0.445
DOC_MAPK_MEF2A_6	561	568	PF00069	0.711
DOC_PP4_FxxP_1	140	143	PF00568	0.635
DOC_PP4_FxxP_1	205	208	PF00568	0.663
DOC_PP4_FxxP_1	45	48	PF00568	0.364
DOC_USP7_MATH_1	129	133	PF00917	0.646
DOC_USP7_MATH_1	311	315	PF00917	0.308
DOC_USP7_MATH_1	505	509	PF00917	0.671
DOC_USP7_MATH_1	559	563	PF00917	0.655
DOC_USP7_MATH_1	63	67	PF00917	0.494
DOC_WW_Pin1_4	146	151	PF00397	0.652
DOC_WW_Pin1_4	303	308	PF00397	0.248
DOC_WW_Pin1_4	314	319	PF00397	0.312
LIG_14-3-3_CanoR_1	128	137	PF00244	0.571
LIG_14-3-3_CanoR_1	363	368	PF00244	0.449
LIG_14-3-3_CanoR_1	369	379	PF00244	0.411
LIG_14-3-3_CanoR_1	414	419	PF00244	0.592
LIG_14-3-3_CanoR_1	503	511	PF00244	0.689
LIG_14-3-3_CanoR_1	514	520	PF00244	0.672
LIG_14-3-3_CanoR_1	536	543	PF00244	0.635
LIG_14-3-3_CanoR_1	561	565	PF00244	0.595
LIG_14-3-3_CanoR_1	7	15	PF00244	0.555
LIG_APCC_ABBA_1	436	441	PF00400	0.593
LIG_BRCT_BRCA1_1	349	353	PF00533	0.312
LIG_CaM_NSCaTE_8	93	100	PF13499	0.212
LIG_Clathr_ClatBox_1	102	106	PF01394	0.312
LIG_CtBP_PxDLS_1	79	83	PF00389	0.403
LIG_EH1_1	109	117	PF00400	0.491
LIG_eIF4E_1	264	270	PF01652	0.429
LIG_FHA_1	109	115	PF00498	0.369
LIG_FHA_1	14	20	PF00498	0.276
LIG_FHA_1	272	278	PF00498	0.273
LIG_FHA_1	288	294	PF00498	0.223
LIG_FHA_1	355	361	PF00498	0.352
LIG_FHA_1	41	47	PF00498	0.396
LIG_FHA_2	137	143	PF00498	0.657
LIG_FHA_2	371	377	PF00498	0.456
LIG_FHA_2	389	395	PF00498	0.675
LIG_LIR_Apic_2	138	143	PF02991	0.630
LIG_LIR_Apic_2	202	208	PF02991	0.665
LIG_LIR_Apic_2	229	233	PF02991	0.512
LIG_LIR_Apic_2	31	35	PF02991	0.318
LIG_LIR_Apic_2	43	48	PF02991	0.340
LIG_LIR_Gen_1	212	221	PF02991	0.678
LIG_LIR_Gen_1	28	38	PF02991	0.292
LIG_LIR_Gen_1	494	500	PF02991	0.639
LIG_LIR_Gen_1	6	17	PF02991	0.590
LIG_LIR_Gen_1	71	82	PF02991	0.443
LIG_LIR_Gen_1	98	109	PF02991	0.291
LIG_LIR_Nem_3	138	144	PF02991	0.634
LIG_LIR_Nem_3	212	216	PF02991	0.669
LIG_LIR_Nem_3	28	33	PF02991	0.319
LIG_LIR_Nem_3	494	498	PF02991	0.640
LIG_LIR_Nem_3	6	12	PF02991	0.594
LIG_LIR_Nem_3	71	77	PF02991	0.461
LIG_LIR_Nem_3	98	104	PF02991	0.285
LIG_NRBOX	267	273	PF00104	0.358
LIG_PALB2_WD40_1	475	483	PF16756	0.526
LIG_Pex14_2	45	49	PF04695	0.354
LIG_Pex14_2	475	479	PF04695	0.546
LIG_REV1ctd_RIR_1	478	484	PF16727	0.547
LIG_SH2_CRK	213	217	PF00017	0.646
LIG_SH2_CRK	230	234	PF00017	0.512
LIG_SH2_CRK	30	34	PF00017	0.322
LIG_SH2_GRB2like	380	383	PF00017	0.552
LIG_SH2_NCK_1	213	217	PF00017	0.646
LIG_SH2_SRC	248	251	PF00017	0.429
LIG_SH2_STAP1	110	114	PF00017	0.368
LIG_SH2_STAP1	273	277	PF00017	0.283
LIG_SH2_STAP1	30	34	PF00017	0.377
LIG_SH2_STAP1	461	465	PF00017	0.662
LIG_SH2_STAT3	489	492	PF00017	0.528
LIG_SH2_STAT5	110	113	PF00017	0.372
LIG_SH2_STAT5	213	216	PF00017	0.660
LIG_SH2_STAT5	267	270	PF00017	0.260
LIG_SH2_STAT5	273	276	PF00017	0.260
LIG_SH2_STAT5	292	295	PF00017	0.270
LIG_SH2_STAT5	30	33	PF00017	0.315
LIG_SH2_STAT5	359	362	PF00017	0.351
LIG_SH2_STAT5	461	464	PF00017	0.663
LIG_SH3_3	111	117	PF00018	0.408
LIG_SH3_3	190	196	PF00018	0.711
LIG_SH3_3	333	339	PF00018	0.245
LIG_Sin3_3	100	107	PF02671	0.212
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.471
LIG_SUMO_SIM_par_1	10	16	PF11976	0.471
LIG_SUMO_SIM_par_1	268	274	PF11976	0.343
LIG_SUMO_SIM_par_1	292	298	PF11976	0.375
LIG_TRAF2_1	177	180	PF00917	0.593
LIG_TRFH_1	481	485	PF08558	0.520
LIG_TYR_ITIM	271	276	PF00017	0.260
LIG_WRC_WIRS_1	137	142	PF05994	0.621
LIG_WW_3	231	235	PF00397	0.512
LIG_WW_3	317	321	PF00397	0.262
MOD_CDK_SPK_2	303	308	PF00069	0.248
MOD_CDK_SPxK_1	314	320	PF00069	0.194
MOD_CDK_SPxxK_3	314	321	PF00069	0.312
MOD_CK1_1	156	162	PF00069	0.664
MOD_CK1_1	212	218	PF00069	0.646
MOD_CK1_1	25	31	PF00069	0.477
MOD_CK1_1	314	320	PF00069	0.291
MOD_CK1_1	388	394	PF00069	0.697
MOD_CK1_1	501	507	PF00069	0.661
MOD_CK1_1	512	518	PF00069	0.668
MOD_CK1_1	541	547	PF00069	0.645
MOD_CK1_1	68	74	PF00069	0.500
MOD_CK1_1	81	87	PF00069	0.404
MOD_CK2_1	136	142	PF00069	0.646
MOD_CK2_1	392	398	PF00069	0.721
MOD_CK2_1	50	56	PF00069	0.413
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.645
MOD_DYRK1A_RPxSP_1	303	307	PF00069	0.194
MOD_GlcNHglycan	131	134	PF01048	0.331
MOD_GlcNHglycan	184	187	PF01048	0.483
MOD_GlcNHglycan	24	27	PF01048	0.319
MOD_GlcNHglycan	313	316	PF01048	0.512
MOD_GlcNHglycan	503	506	PF01048	0.508
MOD_GlcNHglycan	511	514	PF01048	0.514
MOD_GlcNHglycan	52	55	PF01048	0.583
MOD_GlcNHglycan	67	70	PF01048	0.680
MOD_GlcNHglycan	98	101	PF01048	0.355
MOD_GSK3_1	127	134	PF00069	0.606
MOD_GSK3_1	142	149	PF00069	0.649
MOD_GSK3_1	18	25	PF00069	0.377
MOD_GSK3_1	271	278	PF00069	0.260
MOD_GSK3_1	283	290	PF00069	0.260
MOD_GSK3_1	303	310	PF00069	0.371
MOD_GSK3_1	385	392	PF00069	0.681
MOD_GSK3_1	405	412	PF00069	0.697
MOD_GSK3_1	499	506	PF00069	0.652
MOD_GSK3_1	61	68	PF00069	0.488
MOD_N-GLC_1	370	375	PF02516	0.229
MOD_N-GLC_1	50	55	PF02516	0.643
MOD_N-GLC_1	61	66	PF02516	0.558
MOD_N-GLC_2	222	224	PF02516	0.312
MOD_N-GLC_2	242	244	PF02516	0.239
MOD_NEK2_1	135	140	PF00069	0.591
MOD_NEK2_1	18	23	PF00069	0.314
MOD_NEK2_1	226	231	PF00069	0.512
MOD_NEK2_1	271	276	PF00069	0.295
MOD_NEK2_1	354	359	PF00069	0.283
MOD_NEK2_1	80	85	PF00069	0.425
MOD_NEK2_1	95	100	PF00069	0.316
MOD_NEK2_2	136	141	PF00069	0.610
MOD_NEK2_2	505	510	PF00069	0.748
MOD_PIKK_1	180	186	PF00454	0.622
MOD_PKA_2	127	133	PF00069	0.645
MOD_PKA_2	319	325	PF00069	0.356
MOD_PKA_2	535	541	PF00069	0.716
MOD_PKA_2	560	566	PF00069	0.594
MOD_PKA_2	72	78	PF00069	0.409
MOD_Plk_1	370	376	PF00069	0.446
MOD_Plk_1	5	11	PF00069	0.610
MOD_Plk_1	538	544	PF00069	0.628
MOD_Plk_4	136	142	PF00069	0.632
MOD_Plk_4	19	25	PF00069	0.348
MOD_Plk_4	271	277	PF00069	0.283
MOD_Plk_4	28	34	PF00069	0.329
MOD_Plk_4	280	286	PF00069	0.326
MOD_Plk_4	287	293	PF00069	0.407
MOD_Plk_4	347	353	PF00069	0.308
MOD_Plk_4	355	361	PF00069	0.243
MOD_Plk_4	538	544	PF00069	0.669
MOD_ProDKin_1	146	152	PF00069	0.654
MOD_ProDKin_1	303	309	PF00069	0.248
MOD_ProDKin_1	314	320	PF00069	0.312
TRG_DiLeu_BaEn_1	549	554	PF01217	0.619
TRG_DiLeu_BaEn_4	549	555	PF01217	0.619
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.494
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.336
TRG_ENDOCYTIC_2	141	144	PF00928	0.649
TRG_ENDOCYTIC_2	213	216	PF00928	0.672
TRG_ENDOCYTIC_2	267	270	PF00928	0.260
TRG_ENDOCYTIC_2	273	276	PF00928	0.260
TRG_ENDOCYTIC_2	30	33	PF00928	0.294
TRG_ENDOCYTIC_2	519	522	PF00928	0.654
TRG_ER_diArg_1	125	128	PF00400	0.582
TRG_ER_diArg_1	319	321	PF00400	0.194
TRG_ER_diArg_1	384	386	PF00400	0.630
TRG_ER_diArg_1	413	416	PF00400	0.612
TRG_ER_diArg_1	422	424	PF00400	0.526
TRG_ER_diArg_1	457	459	PF00400	0.767
TRG_ER_diArg_1	470	473	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U1	Leptomonas seymouri	60%	98%
A0A0S4KLP7	Bodo saltans	31%	100%
A0A3R7KZF6	Trypanosoma rangeli	32%	100%
A0A3S7X6D2	Leishmania donovani	94%	100%
A4I8P0	Leishmania infantum	94%	100%
D0A4L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B3K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%