Adenosine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenosine deaminase-like protein

Species:

Leishmania major

UniProt:

Q4Q4J9_LEIMA

TriTrypDb:

LmjF.33.0235 , LMJLV39_330008300 , LMJSD75_330008000

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0004000	adenosine deaminase activity	4	10
GO:0005488	binding	1	10
GO:0008251	tRNA-specific adenosine deaminase activity	5	2
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	10
GO:0019239	deaminase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.529
CLV_C14_Caspase3-7	582	586	PF00656	0.565
CLV_NRD_NRD_1	114	116	PF00675	0.489
CLV_NRD_NRD_1	143	145	PF00675	0.329
CLV_NRD_NRD_1	158	160	PF00675	0.186
CLV_NRD_NRD_1	187	189	PF00675	0.340
CLV_NRD_NRD_1	325	327	PF00675	0.264
CLV_NRD_NRD_1	368	370	PF00675	0.646
CLV_NRD_NRD_1	430	432	PF00675	0.613
CLV_NRD_NRD_1	483	485	PF00675	0.670
CLV_NRD_NRD_1	57	59	PF00675	0.454
CLV_PCSK_FUR_1	366	370	PF00082	0.494
CLV_PCSK_KEX2_1	114	116	PF00082	0.485
CLV_PCSK_KEX2_1	143	145	PF00082	0.314
CLV_PCSK_KEX2_1	158	160	PF00082	0.186
CLV_PCSK_KEX2_1	186	188	PF00082	0.298
CLV_PCSK_KEX2_1	324	326	PF00082	0.262
CLV_PCSK_KEX2_1	368	370	PF00082	0.662
CLV_PCSK_KEX2_1	432	434	PF00082	0.578
CLV_PCSK_KEX2_1	483	485	PF00082	0.670
CLV_PCSK_KEX2_1	57	59	PF00082	0.454
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.578
CLV_PCSK_PC7_1	479	485	PF00082	0.577
CLV_PCSK_SKI1_1	143	147	PF00082	0.343
CLV_PCSK_SKI1_1	385	389	PF00082	0.480
CLV_PCSK_SKI1_1	474	478	PF00082	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.676
DOC_ANK_TNKS_1	49	56	PF00023	0.416
DOC_CKS1_1	381	386	PF01111	0.406
DOC_CYCLIN_RxL_1	140	150	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.536
DOC_MAPK_DCC_7	324	334	PF00069	0.492
DOC_MAPK_gen_1	114	121	PF00069	0.436
DOC_MAPK_gen_1	141	148	PF00069	0.550
DOC_MAPK_gen_1	158	164	PF00069	0.438
DOC_MAPK_gen_1	312	321	PF00069	0.446
DOC_MAPK_gen_1	483	491	PF00069	0.448
DOC_MAPK_gen_1	76	84	PF00069	0.479
DOC_MAPK_MEF2A_6	114	121	PF00069	0.355
DOC_PP1_RVXF_1	383	389	PF00149	0.475
DOC_PP1_RVXF_1	573	579	PF00149	0.634
DOC_PP2B_LxvP_1	342	345	PF13499	0.471
DOC_PP2B_LxvP_1	489	492	PF13499	0.447
DOC_PP2B_LxvP_1	89	92	PF13499	0.368
DOC_PP4_FxxP_1	330	333	PF00568	0.463
DOC_USP7_MATH_1	169	173	PF00917	0.540
DOC_USP7_MATH_1	230	234	PF00917	0.537
DOC_USP7_MATH_1	408	412	PF00917	0.601
DOC_USP7_MATH_1	427	431	PF00917	0.465
DOC_USP7_MATH_1	443	447	PF00917	0.672
DOC_USP7_MATH_1	579	583	PF00917	0.733
DOC_USP7_MATH_1	59	63	PF00917	0.663
DOC_USP7_MATH_1	66	70	PF00917	0.662
DOC_WW_Pin1_4	200	205	PF00397	0.595
DOC_WW_Pin1_4	24	29	PF00397	0.456
DOC_WW_Pin1_4	279	284	PF00397	0.471
DOC_WW_Pin1_4	380	385	PF00397	0.399
DOC_WW_Pin1_4	395	400	PF00397	0.454
DOC_WW_Pin1_4	5	10	PF00397	0.580
LIG_14-3-3_CanoR_1	174	180	PF00244	0.518
LIG_14-3-3_CanoR_1	274	278	PF00244	0.418
LIG_14-3-3_CanoR_1	302	308	PF00244	0.508
LIG_14-3-3_CanoR_1	335	342	PF00244	0.465
LIG_14-3-3_CanoR_1	483	493	PF00244	0.580
LIG_BIR_III_2	132	136	PF00653	0.471
LIG_BRCT_BRCA1_1	390	394	PF00533	0.589
LIG_deltaCOP1_diTrp_1	311	316	PF00928	0.529
LIG_EVH1_1	380	384	PF00568	0.371
LIG_FHA_1	209	215	PF00498	0.534
LIG_FHA_1	308	314	PF00498	0.529
LIG_FHA_1	381	387	PF00498	0.534
LIG_FHA_1	395	401	PF00498	0.500
LIG_FHA_2	268	274	PF00498	0.583
LIG_FHA_2	485	491	PF00498	0.578
LIG_FHA_2	567	573	PF00498	0.667
LIG_FHA_2	6	12	PF00498	0.631
LIG_LIR_Gen_1	177	185	PF02991	0.570
LIG_LIR_Gen_1	419	429	PF02991	0.587
LIG_LIR_Gen_1	42	52	PF02991	0.331
LIG_LIR_Nem_3	177	183	PF02991	0.578
LIG_LIR_Nem_3	311	317	PF02991	0.431
LIG_LIR_Nem_3	419	424	PF02991	0.625
LIG_LIR_Nem_3	42	47	PF02991	0.343
LIG_LIR_Nem_3	450	454	PF02991	0.588
LIG_SH2_CRK	281	285	PF00017	0.498
LIG_SH2_NCK_1	533	537	PF00017	0.657
LIG_SH2_PTP2	116	119	PF00017	0.399
LIG_SH2_STAP1	180	184	PF00017	0.551
LIG_SH2_STAP1	533	537	PF00017	0.594
LIG_SH2_STAT5	116	119	PF00017	0.456
LIG_SH3_1	325	331	PF00018	0.453
LIG_SH3_3	325	331	PF00018	0.472
LIG_SH3_3	338	344	PF00018	0.425
LIG_SH3_3	375	381	PF00018	0.593
LIG_SUMO_SIM_anti_2	515	521	PF11976	0.523
LIG_SUMO_SIM_par_1	144	150	PF11976	0.471
LIG_TRAF2_1	69	72	PF00917	0.546
LIG_TRAF2_1	8	11	PF00917	0.593
MOD_CDK_SPK_2	380	385	PF00069	0.422
MOD_CDK_SPxxK_3	5	12	PF00069	0.573
MOD_CK1_1	120	126	PF00069	0.492
MOD_CK1_1	233	239	PF00069	0.524
MOD_CK1_1	255	261	PF00069	0.552
MOD_CK1_1	411	417	PF00069	0.542
MOD_CK1_1	532	538	PF00069	0.646
MOD_CK2_1	255	261	PF00069	0.504
MOD_CK2_1	484	490	PF00069	0.629
MOD_CK2_1	5	11	PF00069	0.632
MOD_CK2_1	510	516	PF00069	0.532
MOD_CK2_1	66	72	PF00069	0.572
MOD_Cter_Amidation	322	325	PF01082	0.246
MOD_GlcNHglycan	106	109	PF01048	0.516
MOD_GlcNHglycan	122	125	PF01048	0.283
MOD_GlcNHglycan	170	174	PF01048	0.328
MOD_GlcNHglycan	188	191	PF01048	0.358
MOD_GlcNHglycan	200	203	PF01048	0.271
MOD_GlcNHglycan	232	235	PF01048	0.300
MOD_GlcNHglycan	256	260	PF01048	0.344
MOD_GlcNHglycan	390	393	PF01048	0.528
MOD_GlcNHglycan	425	428	PF01048	0.576
MOD_GlcNHglycan	445	448	PF01048	0.697
MOD_GlcNHglycan	455	458	PF01048	0.747
MOD_GlcNHglycan	520	523	PF01048	0.639
MOD_GlcNHglycan	79	82	PF01048	0.600
MOD_GSK3_1	169	176	PF00069	0.565
MOD_GSK3_1	263	270	PF00069	0.528
MOD_GSK3_1	303	310	PF00069	0.488
MOD_GSK3_1	376	383	PF00069	0.598
MOD_GSK3_1	408	415	PF00069	0.536
MOD_GSK3_1	423	430	PF00069	0.635
MOD_GSK3_1	443	450	PF00069	0.705
MOD_GSK3_1	566	573	PF00069	0.633
MOD_N-GLC_1	303	308	PF02516	0.288
MOD_NEK2_1	208	213	PF00069	0.557
MOD_NEK2_1	216	221	PF00069	0.580
MOD_NEK2_1	222	227	PF00069	0.479
MOD_NEK2_1	305	310	PF00069	0.446
MOD_NEK2_1	334	339	PF00069	0.525
MOD_NEK2_1	394	399	PF00069	0.508
MOD_NEK2_1	510	515	PF00069	0.529
MOD_NEK2_1	553	558	PF00069	0.676
MOD_NEK2_1	577	582	PF00069	0.674
MOD_NEK2_1	87	92	PF00069	0.397
MOD_NEK2_2	570	575	PF00069	0.595
MOD_PIKK_1	553	559	PF00454	0.601
MOD_PK_1	335	341	PF00069	0.448
MOD_PKA_1	186	192	PF00069	0.537
MOD_PKA_1	483	489	PF00069	0.585
MOD_PKA_2	173	179	PF00069	0.533
MOD_PKA_2	186	192	PF00069	0.471
MOD_PKA_2	208	214	PF00069	0.498
MOD_PKA_2	273	279	PF00069	0.418
MOD_PKA_2	334	340	PF00069	0.479
MOD_PKA_2	483	489	PF00069	0.585
MOD_Plk_1	303	309	PF00069	0.488
MOD_Plk_1	376	382	PF00069	0.527
MOD_Plk_1	406	412	PF00069	0.528
MOD_Plk_1	460	466	PF00069	0.577
MOD_Plk_1	551	557	PF00069	0.569
MOD_Plk_1	570	576	PF00069	0.596
MOD_Plk_4	39	45	PF00069	0.425
MOD_Plk_4	460	466	PF00069	0.658
MOD_Plk_4	542	548	PF00069	0.645
MOD_ProDKin_1	200	206	PF00069	0.595
MOD_ProDKin_1	24	30	PF00069	0.456
MOD_ProDKin_1	279	285	PF00069	0.471
MOD_ProDKin_1	380	386	PF00069	0.390
MOD_ProDKin_1	395	401	PF00069	0.462
MOD_ProDKin_1	5	11	PF00069	0.578
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.453
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.471
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.588
TRG_ENDOCYTIC_2	116	119	PF00928	0.438
TRG_ENDOCYTIC_2	180	183	PF00928	0.498
TRG_ENDOCYTIC_2	281	284	PF00928	0.502
TRG_ER_diArg_1	113	115	PF00400	0.471
TRG_ER_diArg_1	142	144	PF00400	0.495
TRG_ER_diArg_1	185	188	PF00400	0.498
TRG_ER_diArg_1	324	326	PF00400	0.464
TRG_ER_diArg_1	365	368	PF00400	0.519
TRG_ER_diArg_1	418	421	PF00400	0.607
TRG_ER_diArg_1	57	59	PF00400	0.557
TRG_NLS_MonoExtC_3	430	435	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P680	Leptomonas seymouri	38%	100%
A0A1X0P1S5	Trypanosomatidae	30%	88%
A0A3Q8IGD9	Leishmania donovani	90%	100%
A0A422NGA7	Trypanosoma rangeli	32%	98%
A4HJ19	Leishmania braziliensis	70%	100%
A4I8P1	Leishmania infantum	90%	100%
D0A4L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9B3K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%