Putative serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan SC, Family S9D

Species:

Leishmania major

UniProt:

Q4Q4J7_LEIMA

TriTrypDb:

LmjF.33.0400 , LMJLV39_330010200 , LMJSD75_330009900

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008474	palmitoyl-(protein) hydrolase activity	3	2
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016790	thiolester hydrolase activity	4	2
GO:0098599	palmitoyl hydrolase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.356
CLV_NRD_NRD_1	204	206	PF00675	0.453
CLV_NRD_NRD_1	240	242	PF00675	0.455
CLV_NRD_NRD_1	27	29	PF00675	0.559
CLV_NRD_NRD_1	309	311	PF00675	0.575
CLV_NRD_NRD_1	320	322	PF00675	0.598
CLV_PCSK_KEX2_1	204	206	PF00082	0.453
CLV_PCSK_KEX2_1	240	242	PF00082	0.471
CLV_PCSK_KEX2_1	251	253	PF00082	0.567
CLV_PCSK_KEX2_1	261	263	PF00082	0.429
CLV_PCSK_KEX2_1	29	31	PF00082	0.542
CLV_PCSK_KEX2_1	309	311	PF00082	0.575
CLV_PCSK_KEX2_1	320	322	PF00082	0.598
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.598
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.429
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.520
CLV_PCSK_PC7_1	247	253	PF00082	0.636
CLV_PCSK_SKI1_1	247	251	PF00082	0.575
CLV_PCSK_SKI1_1	377	381	PF00082	0.494
CLV_PCSK_SKI1_1	384	388	PF00082	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.529
DOC_ANK_TNKS_1	319	326	PF00023	0.399
DOC_MAPK_gen_1	164	174	PF00069	0.348
DOC_MAPK_gen_1	28	34	PF00069	0.539
DOC_MAPK_gen_1	62	72	PF00069	0.544
DOC_MAPK_MEF2A_6	65	72	PF00069	0.537
DOC_MAPK_NFAT4_5	65	73	PF00069	0.397
DOC_PP4_FxxP_1	11	14	PF00568	0.488
DOC_USP7_MATH_1	260	264	PF00917	0.607
DOC_USP7_MATH_1	332	336	PF00917	0.517
DOC_USP7_MATH_1	390	394	PF00917	0.750
DOC_USP7_UBL2_3	164	168	PF12436	0.436
LIG_14-3-3_CanoR_1	183	193	PF00244	0.557
LIG_14-3-3_CanoR_1	262	266	PF00244	0.586
LIG_14-3-3_CanoR_1	30	35	PF00244	0.578
LIG_14-3-3_CanoR_1	368	375	PF00244	0.473
LIG_14-3-3_CanoR_1	42	46	PF00244	0.444
LIG_14-3-3_CanoR_1	62	72	PF00244	0.253
LIG_Actin_WH2_2	168	185	PF00022	0.411
LIG_AP2alpha_1	359	363	PF02296	0.434
LIG_BRCT_BRCA1_1	359	363	PF00533	0.550
LIG_BRCT_BRCA1_1	369	373	PF00533	0.371
LIG_BRCT_BRCA1_1	7	11	PF00533	0.496
LIG_FHA_1	177	183	PF00498	0.445
LIG_FHA_1	280	286	PF00498	0.568
LIG_FHA_1	299	305	PF00498	0.420
LIG_FHA_2	328	334	PF00498	0.439
LIG_HCF-1_HBM_1	130	133	PF13415	0.513
LIG_LIR_Apic_2	8	14	PF02991	0.496
LIG_LIR_Gen_1	130	141	PF02991	0.513
LIG_LIR_Gen_1	360	369	PF02991	0.454
LIG_LIR_Nem_3	102	106	PF02991	0.364
LIG_LIR_Nem_3	130	136	PF02991	0.357
LIG_LIR_Nem_3	198	203	PF02991	0.545
LIG_LIR_Nem_3	303	308	PF02991	0.461
LIG_LIR_Nem_3	360	366	PF02991	0.458
LIG_LIR_Nem_3	44	48	PF02991	0.439
LIG_MAD2	183	191	PF02301	0.549
LIG_NRBOX	244	250	PF00104	0.616
LIG_PCNA_yPIPBox_3	240	249	PF02747	0.483
LIG_Pex14_2	339	343	PF04695	0.458
LIG_Pex14_2	359	363	PF04695	0.496
LIG_Pex14_2	369	373	PF04695	0.376
LIG_RPA_C_Fungi	236	248	PF08784	0.591
LIG_SH2_CRK	312	316	PF00017	0.493
LIG_SH2_NCK_1	126	130	PF00017	0.411
LIG_SH2_STAP1	133	137	PF00017	0.513
LIG_SH2_STAP1	86	90	PF00017	0.513
LIG_SH2_STAT5	103	106	PF00017	0.507
LIG_SH2_STAT5	160	163	PF00017	0.402
LIG_SH2_STAT5	192	195	PF00017	0.531
LIG_SH2_STAT5	365	368	PF00017	0.543
LIG_SH2_STAT5	45	48	PF00017	0.474
LIG_SH3_3	7	13	PF00018	0.503
LIG_SUMO_SIM_par_1	171	177	PF11976	0.411
LIG_SUMO_SIM_par_1	280	288	PF11976	0.518
LIG_SUMO_SIM_par_1	300	306	PF11976	0.351
LIG_WRC_WIRS_1	175	180	PF05994	0.411
LIG_WW_3	12	16	PF00397	0.537
MOD_CK1_1	124	130	PF00069	0.454
MOD_CK1_1	176	182	PF00069	0.411
MOD_CK1_1	33	39	PF00069	0.605
MOD_CK1_1	393	399	PF00069	0.632
MOD_CK1_1	82	88	PF00069	0.280
MOD_GlcNHglycan	108	111	PF01048	0.411
MOD_GlcNHglycan	279	282	PF01048	0.699
MOD_GlcNHglycan	38	41	PF01048	0.626
MOD_GlcNHglycan	81	84	PF01048	0.280
MOD_GSK3_1	1	8	PF00069	0.491
MOD_GSK3_1	173	180	PF00069	0.411
MOD_GSK3_1	267	274	PF00069	0.637
MOD_GSK3_1	275	282	PF00069	0.651
MOD_GSK3_1	32	39	PF00069	0.607
MOD_GSK3_1	367	374	PF00069	0.386
MOD_GSK3_1	82	89	PF00069	0.513
MOD_N-GLC_1	274	279	PF02516	0.713
MOD_NEK2_1	1	6	PF00069	0.471
MOD_NEK2_1	174	179	PF00069	0.375
MOD_NEK2_1	32	37	PF00069	0.592
MOD_NEK2_1	327	332	PF00069	0.516
MOD_OFUCOSY	181	188	PF10250	0.627
MOD_PK_1	261	267	PF00069	0.484
MOD_PKA_1	261	267	PF00069	0.601
MOD_PKA_2	261	267	PF00069	0.601
MOD_PKA_2	367	373	PF00069	0.388
MOD_PKA_2	393	399	PF00069	0.723
MOD_PKA_2	41	47	PF00069	0.512
MOD_PKA_2	64	70	PF00069	0.532
MOD_PKB_1	28	36	PF00069	0.497
MOD_Plk_1	121	127	PF00069	0.411
MOD_Plk_1	332	338	PF00069	0.521
MOD_Plk_2-3	300	306	PF00069	0.490
MOD_Plk_4	1	7	PF00069	0.462
MOD_Plk_4	121	127	PF00069	0.411
MOD_Plk_4	261	267	PF00069	0.484
MOD_Plk_4	279	285	PF00069	0.482
MOD_Plk_4	300	306	PF00069	0.522
MOD_Plk_4	64	70	PF00069	0.489
TRG_DiLeu_BaEn_1	211	216	PF01217	0.444
TRG_DiLeu_BaEn_1	376	381	PF01217	0.593
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.608
TRG_ENDOCYTIC_2	133	136	PF00928	0.362
TRG_ENDOCYTIC_2	203	206	PF00928	0.553
TRG_ENDOCYTIC_2	312	315	PF00928	0.486
TRG_ENDOCYTIC_2	45	48	PF00928	0.523
TRG_ER_diArg_1	203	205	PF00400	0.466
TRG_ER_diArg_1	308	310	PF00400	0.575
TRG_ER_diArg_1	319	321	PF00400	0.583
TRG_NES_CRM1_1	88	102	PF08389	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M6	Leptomonas seymouri	54%	100%
A0A3S7X6G6	Leishmania donovani	92%	100%
A4HL75	Leishmania braziliensis	76%	100%
A4I8Q4	Leishmania infantum	92%	100%
E9B3L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%