Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4J5_LEIMA

TriTrypDb:

LmjF.33.0250 , LMJLV39_330008500 , LMJSD75_330008200

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.561
CLV_C14_Caspase3-7	295	299	PF00656	0.486
CLV_C14_Caspase3-7	309	313	PF00656	0.468
CLV_MEL_PAP_1	38	44	PF00089	0.419
CLV_NRD_NRD_1	283	285	PF00675	0.548
CLV_NRD_NRD_1	329	331	PF00675	0.548
CLV_NRD_NRD_1	86	88	PF00675	0.632
CLV_NRD_NRD_1	89	91	PF00675	0.581
CLV_PCSK_FUR_1	87	91	PF00082	0.715
CLV_PCSK_KEX2_1	282	284	PF00082	0.547
CLV_PCSK_KEX2_1	329	331	PF00082	0.548
CLV_PCSK_KEX2_1	86	88	PF00082	0.639
CLV_PCSK_KEX2_1	89	91	PF00082	0.606
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.486
CLV_PCSK_SKI1_1	117	121	PF00082	0.377
CLV_PCSK_SKI1_1	128	132	PF00082	0.354
CLV_PCSK_SKI1_1	206	210	PF00082	0.554
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_MAPK_gen_1	13	21	PF00069	0.419
DOC_MAPK_MEF2A_6	15	23	PF00069	0.459
DOC_PP1_RVXF_1	4	10	PF00149	0.480
DOC_PP2B_LxvP_1	193	196	PF13499	0.668
DOC_PP4_FxxP_1	243	246	PF00568	0.396
DOC_SPAK_OSR1_1	242	246	PF12202	0.411
DOC_USP7_MATH_1	180	184	PF00917	0.554
DOC_USP7_MATH_1	246	250	PF00917	0.364
DOC_USP7_MATH_1	31	35	PF00917	0.553
DOC_USP7_MATH_1	52	56	PF00917	0.545
DOC_WW_Pin1_4	184	189	PF00397	0.675
DOC_WW_Pin1_4	269	274	PF00397	0.436
DOC_WW_Pin1_4	50	55	PF00397	0.561
DOC_WW_Pin1_4	95	100	PF00397	0.633
LIG_14-3-3_CanoR_1	147	155	PF00244	0.445
LIG_14-3-3_CanoR_1	284	290	PF00244	0.420
LIG_14-3-3_CanoR_1	41	48	PF00244	0.412
LIG_14-3-3_CanoR_1	6	12	PF00244	0.555
LIG_14-3-3_CanoR_1	89	99	PF00244	0.619
LIG_Actin_WH2_2	12	28	PF00022	0.493
LIG_eIF4E_1	322	328	PF01652	0.399
LIG_FHA_1	188	194	PF00498	0.703
LIG_FHA_1	318	324	PF00498	0.460
LIG_FHA_1	91	97	PF00498	0.677
LIG_FHA_2	198	204	PF00498	0.438
LIG_FHA_2	273	279	PF00498	0.467
LIG_GBD_Chelix_1	323	331	PF00786	0.418
LIG_LIR_Gen_1	164	174	PF02991	0.489
LIG_LIR_Nem_3	109	113	PF02991	0.376
LIG_LIR_Nem_3	164	169	PF02991	0.437
LIG_PDZ_Class_1	333	338	PF00595	0.466
LIG_PTB_Apo_2	300	307	PF02174	0.448
LIG_PTB_Phospho_1	300	306	PF10480	0.443
LIG_RPA_C_Fungi	30	42	PF08784	0.446
LIG_SH2_GRB2like	305	308	PF00017	0.391
LIG_SH2_STAT5	110	113	PF00017	0.395
LIG_SH2_STAT5	265	268	PF00017	0.393
LIG_SH2_STAT5	322	325	PF00017	0.430
LIG_SH3_3	131	137	PF00018	0.379
LIG_SH3_3	54	60	PF00018	0.584
LIG_SUMO_SIM_anti_2	159	164	PF11976	0.456
LIG_SUMO_SIM_par_1	159	164	PF11976	0.440
LIG_TYR_ITIM	108	113	PF00017	0.415
LIG_WRC_WIRS_1	247	252	PF05994	0.315
MOD_CK1_1	187	193	PF00069	0.574
MOD_CK1_1	292	298	PF00069	0.387
MOD_CK1_1	98	104	PF00069	0.587
MOD_CK2_1	161	167	PF00069	0.440
MOD_CK2_1	272	278	PF00069	0.424
MOD_Cter_Amidation	87	90	PF01082	0.510
MOD_GlcNHglycan	156	159	PF01048	0.390
MOD_GlcNHglycan	163	166	PF01048	0.375
MOD_GlcNHglycan	182	185	PF01048	0.469
MOD_GlcNHglycan	298	301	PF01048	0.478
MOD_GSK3_1	180	187	PF00069	0.537
MOD_GSK3_1	221	228	PF00069	0.500
MOD_GSK3_1	265	272	PF00069	0.501
MOD_GSK3_1	285	292	PF00069	0.298
MOD_GSK3_1	313	320	PF00069	0.447
MOD_GSK3_1	98	105	PF00069	0.606
MOD_N-GLC_1	184	189	PF02516	0.666
MOD_N-GLC_1	317	322	PF02516	0.549
MOD_NEK2_1	161	166	PF00069	0.400
MOD_NEK2_1	208	213	PF00069	0.560
MOD_NEK2_1	285	290	PF00069	0.403
MOD_NEK2_1	323	328	PF00069	0.414
MOD_NEK2_1	9	14	PF00069	0.573
MOD_PIKK_1	40	46	PF00454	0.490
MOD_PKA_2	296	302	PF00069	0.411
MOD_PKA_2	31	37	PF00069	0.542
MOD_PKA_2	313	319	PF00069	0.398
MOD_PKA_2	40	46	PF00069	0.515
MOD_PKB_1	90	98	PF00069	0.570
MOD_Plk_1	102	108	PF00069	0.515
MOD_Plk_1	317	323	PF00069	0.555
MOD_Plk_4	246	252	PF00069	0.441
MOD_Plk_4	289	295	PF00069	0.397
MOD_Plk_4	323	329	PF00069	0.423
MOD_ProDKin_1	184	190	PF00069	0.671
MOD_ProDKin_1	269	275	PF00069	0.434
MOD_ProDKin_1	50	56	PF00069	0.559
MOD_ProDKin_1	95	101	PF00069	0.622
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.365
TRG_ENDOCYTIC_2	110	113	PF00928	0.381
TRG_ER_diArg_1	283	285	PF00400	0.544
TRG_ER_diArg_1	328	330	PF00400	0.544
TRG_ER_diArg_1	86	89	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRG0	Leptomonas seymouri	54%	98%
A0A0S4JMI8	Bodo saltans	29%	100%
A0A1X0P0V8	Trypanosomatidae	44%	100%
A0A3Q8IJV7	Leishmania donovani	92%	100%
A0A422NG71	Trypanosoma rangeli	46%	100%
A4HJ17	Leishmania braziliensis	84%	100%
A4I8P3	Leishmania infantum	92%	100%
D0A4L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B3K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BFZ0	Trypanosoma cruzi	44%	100%