Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RGG-containing protein 2, putative

Species:

Leishmania major

UniProt:

Q4Q4J4_LEIMA

TriTrypDb:

LmjF.33.0260 , LMJLV39_330008600 , LMJSD75_330008300

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098552	side of membrane	2	2
GO:0098562	cytoplasmic side of membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.537
CLV_C14_Caspase3-7	136	140	PF00656	0.668
CLV_C14_Caspase3-7	316	320	PF00656	0.700
CLV_C14_Caspase3-7	32	36	PF00656	0.556
CLV_C14_Caspase3-7	44	48	PF00656	0.527
CLV_C14_Caspase3-7	56	60	PF00656	0.519
CLV_C14_Caspase3-7	68	72	PF00656	0.508
CLV_C14_Caspase3-7	80	84	PF00656	0.501
CLV_C14_Caspase3-7	92	96	PF00656	0.534
CLV_NRD_NRD_1	175	177	PF00675	0.666
CLV_NRD_NRD_1	209	211	PF00675	0.627
CLV_NRD_NRD_1	3	5	PF00675	0.608
CLV_NRD_NRD_1	311	313	PF00675	0.647
CLV_NRD_NRD_1	324	326	PF00675	0.595
CLV_NRD_NRD_1	333	335	PF00675	0.524
CLV_PCSK_KEX2_1	175	177	PF00082	0.666
CLV_PCSK_KEX2_1	209	211	PF00082	0.627
CLV_PCSK_KEX2_1	3	5	PF00082	0.608
CLV_PCSK_KEX2_1	311	313	PF00082	0.655
CLV_PCSK_KEX2_1	333	335	PF00082	0.601
CLV_PCSK_PC7_1	171	177	PF00082	0.672
CLV_PCSK_SKI1_1	281	285	PF00082	0.311
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DOC_MAPK_gen_1	209	216	PF00069	0.617
DOC_MAPK_gen_1	299	308	PF00069	0.530
DOC_PP4_FxxP_1	204	207	PF00568	0.623
DOC_PP4_FxxP_1	273	276	PF00568	0.511
DOC_USP7_MATH_1	105	109	PF00917	0.559
DOC_USP7_MATH_1	134	138	PF00917	0.669
DOC_USP7_MATH_1	170	174	PF00917	0.610
DOC_USP7_MATH_1	317	321	PF00917	0.472
DOC_USP7_MATH_1	329	333	PF00917	0.487
DOC_USP7_MATH_1	33	37	PF00917	0.634
DOC_USP7_MATH_1	45	49	PF00917	0.520
DOC_USP7_MATH_1	57	61	PF00917	0.522
DOC_USP7_MATH_1	69	73	PF00917	0.521
DOC_USP7_MATH_1	81	85	PF00917	0.496
DOC_USP7_MATH_1	93	97	PF00917	0.585
LIG_14-3-3_CanoR_1	12	18	PF00244	0.559
LIG_14-3-3_CanoR_1	3	7	PF00244	0.608
LIG_deltaCOP1_diTrp_1	193	204	PF00928	0.627
LIG_FHA_1	293	299	PF00498	0.511
LIG_FHA_1	303	309	PF00498	0.470
LIG_FHA_2	215	221	PF00498	0.578
LIG_FHA_2	245	251	PF00498	0.511
LIG_LIR_Apic_2	203	207	PF02991	0.622
LIG_LIR_Apic_2	272	276	PF02991	0.511
LIG_LIR_Gen_1	242	252	PF02991	0.511
LIG_LIR_Gen_1	257	264	PF02991	0.427
LIG_LIR_Nem_3	242	248	PF02991	0.511
LIG_LIR_Nem_3	257	263	PF02991	0.440
LIG_LIR_Nem_3	5	9	PF02991	0.600
LIG_Pex14_2	260	264	PF04695	0.511
LIG_SH2_STAT5	297	300	PF00017	0.644
LIG_SUMO_SIM_par_1	212	217	PF11976	0.610
LIG_SUMO_SIM_par_1	303	310	PF11976	0.547
MOD_CK1_1	237	243	PF00069	0.512
MOD_CK2_1	214	220	PF00069	0.590
MOD_CK2_1	286	292	PF00069	0.511
MOD_CK2_1	329	335	PF00069	0.536
MOD_GlcNHglycan	103	106	PF01048	0.533
MOD_GlcNHglycan	109	112	PF01048	0.521
MOD_GlcNHglycan	115	118	PF01048	0.518
MOD_GlcNHglycan	129	132	PF01048	0.533
MOD_GlcNHglycan	13	16	PF01048	0.570
MOD_GlcNHglycan	149	152	PF01048	0.524
MOD_GlcNHglycan	180	183	PF01048	0.660
MOD_GlcNHglycan	236	239	PF01048	0.311
MOD_GlcNHglycan	25	28	PF01048	0.566
MOD_GlcNHglycan	264	267	PF01048	0.311
MOD_GlcNHglycan	31	34	PF01048	0.554
MOD_GlcNHglycan	346	349	PF01048	0.638
MOD_GlcNHglycan	37	40	PF01048	0.564
MOD_GlcNHglycan	43	46	PF01048	0.503
MOD_GlcNHglycan	49	52	PF01048	0.479
MOD_GlcNHglycan	55	58	PF01048	0.466
MOD_GlcNHglycan	61	64	PF01048	0.487
MOD_GlcNHglycan	67	70	PF01048	0.468
MOD_GlcNHglycan	73	76	PF01048	0.489
MOD_GlcNHglycan	79	82	PF01048	0.473
MOD_GlcNHglycan	85	88	PF01048	0.472
MOD_GlcNHglycan	91	94	PF01048	0.569
MOD_GlcNHglycan	97	100	PF01048	0.581
MOD_GSK3_1	101	108	PF00069	0.583
MOD_GSK3_1	123	130	PF00069	0.660
MOD_GSK3_1	21	28	PF00069	0.605
MOD_GSK3_1	237	244	PF00069	0.514
MOD_GSK3_1	29	36	PF00069	0.614
MOD_GSK3_1	41	48	PF00069	0.502
MOD_GSK3_1	53	60	PF00069	0.519
MOD_GSK3_1	65	72	PF00069	0.506
MOD_GSK3_1	77	84	PF00069	0.502
MOD_GSK3_1	89	96	PF00069	0.504
MOD_N-GLC_1	344	349	PF02516	0.610
MOD_NEK2_1	2	7	PF00069	0.610
MOD_NEK2_1	214	219	PF00069	0.592
MOD_NEK2_1	307	312	PF00069	0.564
MOD_NEK2_2	170	175	PF00069	0.609
MOD_PIKK_1	317	323	PF00454	0.448
MOD_PKA_2	11	17	PF00069	0.555
MOD_PKA_2	123	129	PF00069	0.621
MOD_PKA_2	134	140	PF00069	0.555
MOD_PKA_2	170	176	PF00069	0.610
MOD_PKA_2	2	8	PF00069	0.604
MOD_PKA_2	317	323	PF00069	0.448
MOD_PKB_1	176	184	PF00069	0.660
MOD_Plk_1	240	246	PF00069	0.515
MOD_Plk_1	256	262	PF00069	0.428
MOD_Plk_1	302	308	PF00069	0.547
MOD_Plk_4	292	298	PF00069	0.511
MOD_Plk_4	302	308	PF00069	0.470
TRG_DiLeu_BaEn_1	303	308	PF01217	0.545
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.600
TRG_ER_diArg_1	174	176	PF00400	0.678
TRG_ER_diArg_1	2	4	PF00400	0.615
TRG_ER_diArg_1	208	210	PF00400	0.632
TRG_ER_diArg_1	322	325	PF00400	0.705
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6A5	Leishmania donovani	92%	100%
A4I8P4	Leishmania infantum	87%	100%
E9B3K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%