Mpv17/PMP22 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mpv17 / PMP22 family, putative

Species:

Leishmania major

UniProt:

Q4Q4J3_LEIMA

TriTrypDb:

LmjF.33.0270 , LMJLV39_330008800 , LMJSD75_330008500

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q4J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.472
CLV_C14_Caspase3-7	342	346	PF00656	0.596
CLV_NRD_NRD_1	120	122	PF00675	0.327
CLV_NRD_NRD_1	156	158	PF00675	0.629
CLV_NRD_NRD_1	197	199	PF00675	0.696
CLV_NRD_NRD_1	282	284	PF00675	0.641
CLV_PCSK_KEX2_1	120	122	PF00082	0.327
CLV_PCSK_KEX2_1	155	157	PF00082	0.662
CLV_PCSK_KEX2_1	196	198	PF00082	0.661
CLV_PCSK_KEX2_1	282	284	PF00082	0.645
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.664
CLV_PCSK_PC7_1	193	199	PF00082	0.700
CLV_PCSK_SKI1_1	161	165	PF00082	0.567
CLV_PCSK_SKI1_1	2	6	PF00082	0.460
CLV_PCSK_SKI1_1	235	239	PF00082	0.759
CLV_PCSK_SKI1_1	294	298	PF00082	0.666
DEG_Nend_UBRbox_1	1	4	PF02207	0.672
DEG_SPOP_SBC_1	22	26	PF00917	0.607
DOC_AGCK_PIF_1	125	130	PF00069	0.444
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.437
DOC_MAPK_gen_1	193	202	PF00069	0.483
DOC_MAPK_gen_1	209	216	PF00069	0.398
DOC_MAPK_MEF2A_6	196	204	PF00069	0.523
DOC_PP4_FxxP_1	132	135	PF00568	0.444
DOC_USP7_MATH_1	104	108	PF00917	0.724
DOC_USP7_MATH_1	318	322	PF00917	0.373
DOC_USP7_MATH_1	55	59	PF00917	0.683
DOC_WW_Pin1_4	170	175	PF00397	0.340
DOC_WW_Pin1_4	236	241	PF00397	0.498
DOC_WW_Pin1_4	58	63	PF00397	0.640
DOC_WW_Pin1_4	66	71	PF00397	0.584
DOC_WW_Pin1_4	88	93	PF00397	0.698
LIG_14-3-3_CanoR_1	120	124	PF00244	0.477
LIG_14-3-3_CanoR_1	316	326	PF00244	0.347
LIG_APCC_ABBA_1	186	191	PF00400	0.456
LIG_BRCT_BRCA1_1	121	125	PF00533	0.490
LIG_BRCT_BRCA1_1	126	130	PF00533	0.344
LIG_BRCT_BRCA1_1	266	270	PF00533	0.327
LIG_FHA_1	111	117	PF00498	0.634
LIG_FHA_1	170	176	PF00498	0.339
LIG_FHA_2	179	185	PF00498	0.377
LIG_FHA_2	242	248	PF00498	0.509
LIG_FHA_2	35	41	PF00498	0.621
LIG_LIR_Apic_2	129	135	PF02991	0.444
LIG_LIR_Gen_1	122	132	PF02991	0.344
LIG_LIR_Gen_1	272	281	PF02991	0.421
LIG_LIR_Nem_3	122	128	PF02991	0.325
LIG_LIR_Nem_3	173	179	PF02991	0.361
LIG_LIR_Nem_3	184	189	PF02991	0.361
LIG_LIR_Nem_3	231	237	PF02991	0.552
LIG_LIR_Nem_3	267	273	PF02991	0.402
LIG_Pex14_1	304	308	PF04695	0.366
LIG_Pex14_2	128	132	PF04695	0.369
LIG_Pex14_2	234	238	PF04695	0.561
LIG_Pex14_2	270	274	PF04695	0.436
LIG_PTB_Apo_2	262	269	PF02174	0.476
LIG_REV1ctd_RIR_1	184	194	PF16727	0.453
LIG_SH2_NCK_1	287	291	PF00017	0.448
LIG_SH2_NCK_1	295	299	PF00017	0.421
LIG_SH2_SRC	310	313	PF00017	0.414
LIG_SH2_STAP1	295	299	PF00017	0.400
LIG_SH2_STAT5	11	14	PF00017	0.602
LIG_SH2_STAT5	136	139	PF00017	0.423
LIG_SH2_STAT5	166	169	PF00017	0.368
LIG_SH2_STAT5	176	179	PF00017	0.284
LIG_SH2_STAT5	273	276	PF00017	0.466
LIG_SH2_STAT5	310	313	PF00017	0.375
LIG_SH3_3	234	240	PF00018	0.501
LIG_SH3_3	64	70	PF00018	0.603
LIG_SH3_3	86	92	PF00018	0.692
LIG_SUMO_SIM_par_1	113	118	PF11976	0.595
LIG_SUMO_SIM_par_1	63	69	PF11976	0.665
LIG_UBA3_1	285	294	PF00899	0.291
LIG_UBA3_1	330	339	PF00899	0.549
LIG_UBA3_1	4	13	PF00899	0.665
LIG_WRC_WIRS_1	125	130	PF05994	0.344
LIG_WRC_WIRS_1	330	335	PF05994	0.419
MOD_CK1_1	58	64	PF00069	0.633
MOD_CK2_1	241	247	PF00069	0.513
MOD_CK2_1	34	40	PF00069	0.621
MOD_Cter_Amidation	194	197	PF01082	0.665
MOD_GlcNHglycan	106	109	PF01048	0.490
MOD_GlcNHglycan	320	323	PF01048	0.414
MOD_GlcNHglycan	327	330	PF01048	0.380
MOD_GSK3_1	325	332	PF00069	0.399
MOD_GSK3_1	84	91	PF00069	0.698
MOD_GSK3_1	94	101	PF00069	0.668
MOD_N-GLC_1	111	116	PF02516	0.370
MOD_N-GLC_1	264	269	PF02516	0.538
MOD_N-GLC_1	55	60	PF02516	0.515
MOD_N-GLC_1	98	103	PF02516	0.572
MOD_NEK2_1	102	107	PF00069	0.688
MOD_NEK2_1	119	124	PF00069	0.520
MOD_NEK2_1	21	26	PF00069	0.591
MOD_NEK2_1	241	246	PF00069	0.518
MOD_NEK2_1	317	322	PF00069	0.498
MOD_NEK2_1	335	340	PF00069	0.561
MOD_NEK2_1	63	68	PF00069	0.627
MOD_NEK2_2	344	349	PF00069	0.603
MOD_PIKK_1	55	61	PF00454	0.647
MOD_PKA_2	119	125	PF00069	0.490
MOD_PKA_2	84	90	PF00069	0.735
MOD_Plk_1	111	117	PF00069	0.609
MOD_Plk_1	264	270	PF00069	0.411
MOD_Plk_1	344	350	PF00069	0.716
MOD_Plk_1	98	104	PF00069	0.765
MOD_Plk_4	111	117	PF00069	0.588
MOD_Plk_4	162	168	PF00069	0.356
MOD_Plk_4	175	181	PF00069	0.333
MOD_Plk_4	329	335	PF00069	0.402
MOD_Plk_4	34	40	PF00069	0.569
MOD_Plk_4	6	12	PF00069	0.626
MOD_Plk_4	98	104	PF00069	0.722
MOD_ProDKin_1	170	176	PF00069	0.339
MOD_ProDKin_1	236	242	PF00069	0.498
MOD_ProDKin_1	58	64	PF00069	0.633
MOD_ProDKin_1	66	72	PF00069	0.583
MOD_ProDKin_1	88	94	PF00069	0.702
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.424
TRG_ENDOCYTIC_2	141	144	PF00928	0.334
TRG_ENDOCYTIC_2	260	263	PF00928	0.476
TRG_ER_diArg_1	119	121	PF00400	0.533
TRG_ER_diArg_1	196	198	PF00400	0.484
TRG_ER_diArg_1	281	283	PF00400	0.467
TRG_ER_diArg_1	75	78	PF00400	0.647
TRG_ER_FFAT_2	267	278	PF00635	0.403
TRG_Pf-PMV_PEXEL_1	283	288	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA32	Leptomonas seymouri	68%	100%
A0A0S4JM85	Bodo saltans	28%	100%
A0A3Q8IGN8	Leishmania donovani	95%	100%
A0A3S5IR52	Trypanosoma rangeli	30%	100%
A4HL63	Leishmania braziliensis	82%	100%
E9AHM7	Leishmania infantum	95%	100%
E9B3K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BB92	Trypanosoma cruzi	33%	100%