LeishMANIAdb
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Putative glucose transporter/membrane transporter D2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glucose transporter/membrane transporter D2
Gene product:
glucose transporter/membrane transporter D2, putative
Species:
Leishmania major
UniProt:
Q4Q4J1_LEIMA
TriTrypDb:
LmjF.33.0290 * , LMJLV39_330009100 * , LMJSD75_330008800 *
Length:
594

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

Q4Q4J1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4J1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 17
GO:0008643 carbohydrate transport 5 17
GO:0009987 cellular process 1 2
GO:0015749 monosaccharide transmembrane transport 4 2
GO:0034219 carbohydrate transmembrane transport 3 2
GO:0051179 localization 1 17
GO:0051234 establishment of localization 2 17
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 17
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0015145 monosaccharide transmembrane transporter activity 5 3
GO:0015149 hexose transmembrane transporter activity 6 3
GO:0022857 transmembrane transporter activity 2 40
GO:0051119 sugar transmembrane transporter activity 4 3
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 581 585 PF00656 0.741
CLV_MEL_PAP_1 430 436 PF00089 0.296
CLV_NRD_NRD_1 14 16 PF00675 0.429
CLV_NRD_NRD_1 347 349 PF00675 0.317
CLV_NRD_NRD_1 360 362 PF00675 0.321
CLV_NRD_NRD_1 432 434 PF00675 0.252
CLV_NRD_NRD_1 7 9 PF00675 0.556
CLV_PCSK_KEX2_1 114 116 PF00082 0.350
CLV_PCSK_KEX2_1 210 212 PF00082 0.304
CLV_PCSK_KEX2_1 347 349 PF00082 0.327
CLV_PCSK_KEX2_1 432 434 PF00082 0.238
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.350
CLV_PCSK_PC1ET2_1 210 212 PF00082 0.336
CLV_PCSK_SKI1_1 248 252 PF00082 0.261
CLV_PCSK_SKI1_1 437 441 PF00082 0.253
DEG_SCF_FBW7_1 64 71 PF00400 0.489
DOC_CKS1_1 65 70 PF01111 0.484
DOC_CKS1_1 82 87 PF01111 0.206
DOC_CYCLIN_yClb3_PxF_3 65 73 PF00134 0.469
DOC_MAPK_gen_1 465 475 PF00069 0.282
DOC_MAPK_MEF2A_6 216 223 PF00069 0.332
DOC_MAPK_MEF2A_6 73 81 PF00069 0.544
DOC_PP4_FxxP_1 568 571 PF00568 0.337
DOC_PP4_FxxP_1 94 97 PF00568 0.355
DOC_USP7_MATH_1 113 117 PF00917 0.270
DOC_USP7_MATH_1 132 136 PF00917 0.250
DOC_USP7_MATH_1 4 8 PF00917 0.728
DOC_USP7_MATH_1 507 511 PF00917 0.391
DOC_USP7_MATH_1 531 535 PF00917 0.452
DOC_WW_Pin1_4 31 36 PF00397 0.748
DOC_WW_Pin1_4 57 62 PF00397 0.688
DOC_WW_Pin1_4 64 69 PF00397 0.594
DOC_WW_Pin1_4 81 86 PF00397 0.452
LIG_14-3-3_CanoR_1 148 155 PF00244 0.344
LIG_14-3-3_CanoR_1 15 25 PF00244 0.686
LIG_14-3-3_CanoR_1 432 437 PF00244 0.410
LIG_APCC_ABBA_1 498 503 PF00400 0.525
LIG_BRCT_BRCA1_1 186 190 PF00533 0.271
LIG_BRCT_BRCA1_1 430 434 PF00533 0.407
LIG_DLG_GKlike_1 432 439 PF00625 0.374
LIG_EH1_1 366 374 PF00400 0.374
LIG_EH1_1 69 77 PF00400 0.448
LIG_FHA_1 148 154 PF00498 0.264
LIG_FHA_1 207 213 PF00498 0.264
LIG_FHA_1 368 374 PF00498 0.455
LIG_FHA_1 422 428 PF00498 0.216
LIG_FHA_1 436 442 PF00498 0.365
LIG_FHA_1 511 517 PF00498 0.357
LIG_FHA_1 530 536 PF00498 0.258
LIG_FHA_1 578 584 PF00498 0.737
LIG_FHA_1 82 88 PF00498 0.321
LIG_FHA_2 136 142 PF00498 0.354
LIG_FHA_2 462 468 PF00498 0.295
LIG_FHA_2 48 54 PF00498 0.772
LIG_Integrin_RGD_1 348 350 PF01839 0.165
LIG_LIR_Apic_2 565 571 PF02991 0.277
LIG_LIR_Gen_1 217 226 PF02991 0.328
LIG_LIR_Gen_1 329 338 PF02991 0.372
LIG_LIR_Gen_1 418 427 PF02991 0.269
LIG_LIR_Nem_3 137 142 PF02991 0.248
LIG_LIR_Nem_3 149 155 PF02991 0.232
LIG_LIR_Nem_3 217 221 PF02991 0.329
LIG_LIR_Nem_3 293 299 PF02991 0.297
LIG_LIR_Nem_3 329 334 PF02991 0.355
LIG_LIR_Nem_3 418 422 PF02991 0.311
LIG_LIR_Nem_3 424 428 PF02991 0.321
LIG_LIR_Nem_3 503 508 PF02991 0.467
LIG_LIR_Nem_3 565 569 PF02991 0.281
LIG_LYPXL_S_1 459 463 PF13949 0.316
LIG_LYPXL_yS_3 460 463 PF13949 0.258
LIG_Pex14_2 253 257 PF04695 0.404
LIG_Pex14_2 291 295 PF04695 0.293
LIG_Pex14_2 501 505 PF04695 0.466
LIG_Pex14_2 568 572 PF04695 0.362
LIG_PTB_Apo_2 133 140 PF02174 0.165
LIG_PTB_Apo_2 522 529 PF02174 0.303
LIG_PTB_Apo_2 63 70 PF02174 0.508
LIG_PTB_Phospho_1 133 139 PF10480 0.165
LIG_PTB_Phospho_1 522 528 PF10480 0.347
LIG_REV1ctd_RIR_1 67 77 PF16727 0.605
LIG_SH2_NCK_1 182 186 PF00017 0.190
LIG_SH2_NCK_1 306 310 PF00017 0.159
LIG_SH2_SRC 306 309 PF00017 0.143
LIG_SH2_STAP1 155 159 PF00017 0.343
LIG_SH2_STAP1 265 269 PF00017 0.525
LIG_SH2_STAP1 98 102 PF00017 0.300
LIG_SH2_STAT5 133 136 PF00017 0.319
LIG_SH2_STAT5 207 210 PF00017 0.363
LIG_SH2_STAT5 214 217 PF00017 0.480
LIG_SH2_STAT5 265 268 PF00017 0.435
LIG_SH2_STAT5 367 370 PF00017 0.549
LIG_SH2_STAT5 494 497 PF00017 0.353
LIG_SH2_STAT5 566 569 PF00017 0.236
LIG_SH3_3 20 26 PF00018 0.783
LIG_SH3_3 330 336 PF00018 0.180
LIG_SH3_3 43 49 PF00018 0.729
LIG_SH3_3 455 461 PF00018 0.292
LIG_SH3_3 62 68 PF00018 0.707
LIG_SH3_3 74 80 PF00018 0.361
LIG_SUMO_SIM_par_1 320 326 PF11976 0.335
LIG_SUMO_SIM_par_1 494 499 PF11976 0.404
LIG_SUMO_SIM_par_1 79 84 PF11976 0.192
LIG_TRAF2_1 363 366 PF00917 0.365
LIG_TRAF2_1 571 574 PF00917 0.504
LIG_TRFH_1 567 571 PF08558 0.337
LIG_TYR_ITIM 180 185 PF00017 0.223
LIG_TYR_ITIM 564 569 PF00017 0.290
LIG_TYR_ITSM 135 142 PF00017 0.174
LIG_WRC_WIRS_1 292 297 PF05994 0.261
LIG_WRC_WIRS_1 422 427 PF05994 0.409
MOD_CK1_1 116 122 PF00069 0.238
MOD_CK1_1 135 141 PF00069 0.261
MOD_CK1_1 172 178 PF00069 0.277
MOD_CK1_1 184 190 PF00069 0.279
MOD_CK1_1 259 265 PF00069 0.440
MOD_CK1_1 285 291 PF00069 0.452
MOD_CK1_1 323 329 PF00069 0.379
MOD_CK1_1 34 40 PF00069 0.671
MOD_CK1_1 435 441 PF00069 0.451
MOD_CK1_1 510 516 PF00069 0.231
MOD_CK2_1 135 141 PF00069 0.303
MOD_CK2_1 14 20 PF00069 0.560
MOD_CK2_1 180 186 PF00069 0.271
MOD_CK2_1 4 10 PF00069 0.587
MOD_CK2_1 41 47 PF00069 0.774
MOD_CK2_1 48 54 PF00069 0.771
MOD_GlcNHglycan 130 133 PF01048 0.378
MOD_GlcNHglycan 164 167 PF01048 0.501
MOD_GlcNHglycan 171 174 PF01048 0.491
MOD_GlcNHglycan 186 189 PF01048 0.421
MOD_GlcNHglycan 2 5 PF01048 0.517
MOD_GlcNHglycan 470 473 PF01048 0.433
MOD_GlcNHglycan 535 538 PF01048 0.436
MOD_GlcNHglycan 539 542 PF01048 0.435
MOD_GSK3_1 10 17 PF00069 0.750
MOD_GSK3_1 128 135 PF00069 0.233
MOD_GSK3_1 180 187 PF00069 0.254
MOD_GSK3_1 229 236 PF00069 0.277
MOD_GSK3_1 256 263 PF00069 0.368
MOD_GSK3_1 307 314 PF00069 0.287
MOD_GSK3_1 31 38 PF00069 0.726
MOD_GSK3_1 322 329 PF00069 0.337
MOD_GSK3_1 353 360 PF00069 0.433
MOD_GSK3_1 428 435 PF00069 0.297
MOD_GSK3_1 529 536 PF00069 0.304
MOD_GSK3_1 64 71 PF00069 0.588
MOD_N-GLC_1 128 133 PF02516 0.499
MOD_N-GLC_1 135 140 PF02516 0.489
MOD_N-GLC_1 4 9 PF02516 0.403
MOD_N-GLC_2 174 176 PF02516 0.525
MOD_N-GLC_2 525 527 PF02516 0.367
MOD_NEK2_1 128 133 PF00069 0.354
MOD_NEK2_1 162 167 PF00069 0.266
MOD_NEK2_1 190 195 PF00069 0.309
MOD_NEK2_1 282 287 PF00069 0.311
MOD_NEK2_1 291 296 PF00069 0.301
MOD_NEK2_1 300 305 PF00069 0.261
MOD_NEK2_1 421 426 PF00069 0.332
MOD_NEK2_1 445 450 PF00069 0.300
MOD_NEK2_2 35 40 PF00069 0.575
MOD_NEK2_2 68 73 PF00069 0.474
MOD_NEK2_2 97 102 PF00069 0.325
MOD_PIKK_1 367 373 PF00454 0.555
MOD_PIKK_1 383 389 PF00454 0.191
MOD_PK_1 41 47 PF00069 0.569
MOD_PKA_1 15 21 PF00069 0.561
MOD_PKA_1 40 46 PF00069 0.628
MOD_PKA_1 432 438 PF00069 0.525
MOD_PKA_2 14 20 PF00069 0.692
MOD_PKA_2 147 153 PF00069 0.343
MOD_PKA_2 432 438 PF00069 0.415
MOD_Plk_1 128 134 PF00069 0.271
MOD_Plk_1 135 141 PF00069 0.246
MOD_Plk_1 365 371 PF00069 0.436
MOD_Plk_2-3 353 359 PF00069 0.486
MOD_Plk_4 190 196 PF00069 0.327
MOD_Plk_4 214 220 PF00069 0.449
MOD_Plk_4 222 228 PF00069 0.309
MOD_Plk_4 277 283 PF00069 0.449
MOD_Plk_4 291 297 PF00069 0.356
MOD_Plk_4 323 329 PF00069 0.306
MOD_Plk_4 397 403 PF00069 0.274
MOD_Plk_4 97 103 PF00069 0.261
MOD_ProDKin_1 31 37 PF00069 0.749
MOD_ProDKin_1 57 63 PF00069 0.686
MOD_ProDKin_1 64 70 PF00069 0.591
MOD_ProDKin_1 81 87 PF00069 0.452
TRG_DiLeu_BaLyEn_6 23 28 PF01217 0.570
TRG_DiLeu_BaLyEn_6 333 338 PF01217 0.193
TRG_DiLeu_BaLyEn_6 82 87 PF01217 0.193
TRG_ENDOCYTIC_2 139 142 PF00928 0.318
TRG_ENDOCYTIC_2 182 185 PF00928 0.197
TRG_ENDOCYTIC_2 241 244 PF00928 0.200
TRG_ENDOCYTIC_2 460 463 PF00928 0.258
TRG_ENDOCYTIC_2 566 569 PF00928 0.260
TRG_ENDOCYTIC_2 98 101 PF00928 0.251
TRG_ER_diArg_1 432 434 PF00400 0.448

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 24% 100%
A0A0N0P2E1 Leptomonas seymouri 40% 100%
A0A0N0P3Z7 Leptomonas seymouri 35% 78%
A0A0N0P4D8 Leptomonas seymouri 38% 80%
A0A0N1IG16 Leptomonas seymouri 43% 100%
A0A0N1P9H5 Leptomonas seymouri 63% 100%
A0A0S4J363 Bodo saltans 27% 100%
A0A0S4JDF9 Bodo saltans 38% 100%
A0A0S4JEY7 Bodo saltans 37% 100%
A0A0S4JH90 Bodo saltans 35% 100%
A0A0S4JS00 Bodo saltans 32% 100%
A0A1X0NLE0 Trypanosomatidae 43% 100%
A0A1X0NM05 Trypanosomatidae 42% 100%
A0A1X0NN62 Trypanosomatidae 43% 100%
A0A1X0P9L7 Trypanosomatidae 31% 100%
A0A381N054 Leishmania infantum 43% 100%
A0A3Q8IDK1 Leishmania donovani 95% 100%
A0A3Q8IK60 Leishmania donovani 43% 100%
A0A3Q8IWJ4 Leishmania donovani 43% 91%
A0A3R7KPU3 Trypanosoma rangeli 32% 100%
A0A3R7MGQ7 Trypanosoma rangeli 21% 100%
A0A3S7WY58 Leishmania donovani 22% 100%
A0A3S7XC27 Leishmania donovani 43% 100%
A0A422MNQ4 Trypanosoma rangeli 43% 100%
A4HDC6 Leishmania braziliensis 20% 100%
A4HL65 Leishmania braziliensis 82% 96%
A4HQD6 Leishmania braziliensis 43% 100%
A4HQD7 Leishmania braziliensis 45% 100%
A4HQE7 Leishmania braziliensis 48% 100%
A4I0Q6 Leishmania infantum 22% 100%
A4I8N6 Leishmania infantum 95% 100%
A4IC83 Leishmania infantum 43% 91%
B0WC46 Culex quinquefasciatus 21% 100%
B8MYS7 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) 21% 100%
C0SPB2 Bacillus subtilis (strain 168) 24% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 97%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 95%
O04249 Arabidopsis thaliana 23% 100%
O62787 Sus scrofa 23% 100%
P0AGF4 Escherichia coli (strain K12) 23% 100%
P0AGF5 Escherichia coli O157:H7 23% 100%
P12336 Rattus norvegicus 23% 100%
P13865 Leishmania enriettii 44% 100%
P14246 Mus musculus 23% 100%
P14672 Homo sapiens 23% 100%
P15729 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 100%
P23585 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P40885 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P46333 Bacillus subtilis (strain 168) 22% 100%
P54723 Bacillus subtilis (strain 168) 21% 100%
P54862 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P78831 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 20% 100%
P94493 Bacillus subtilis (strain 168) 23% 100%
Q01441 Leishmania donovani 96% 100%
Q06221 Trypanosoma brucei brucei 37% 100%
Q06222 Trypanosoma brucei brucei 38% 100%
Q09037 Trypanosoma brucei brucei 37% 100%
Q10710 Ricinus communis 24% 100%
Q27115 Trypanosoma vivax 38% 100%
Q4Q0D0 Leishmania major 43% 100%
Q4Q0D1 Leishmania major 44% 100%
Q4Q0D2 Leishmania major 42% 100%
Q4QAR5 Leishmania major 22% 100%
Q8VZ80 Arabidopsis thaliana 22% 100%
Q92253 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 24% 100%
Q94EC4 Oryza sativa subsp. japonica 23% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q9P3U7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 20% 100%
Q9SFG0 Arabidopsis thaliana 23% 100%
Q9SX48 Arabidopsis thaliana 24% 100%
Q9XIH6 Arabidopsis thaliana 24% 100%
Q9XIH7 Arabidopsis thaliana 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS