Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q4H0_LEIMA

TriTrypDb:

LmjF.33.0370 , LMJLV39_330009900 , LMJSD75_330009600

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000152	nuclear ubiquitin ligase complex	3	2
GO:0005680	anaphase-promoting complex	4	2
GO:0005840	ribosome	5	5
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

Q4Q4H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4H0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	8
GO:0009894	regulation of catabolic process	4	2
GO:0009896	positive regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030162	regulation of proteolysis	6	2
GO:0030163	protein catabolic process	4	2
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031331	positive regulation of cellular catabolic process	6	2
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	2
GO:0042176	regulation of protein catabolic process	5	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0045732	positive regulation of protein catabolic process	6	2
GO:0045862	positive regulation of proteolysis	7	2
GO:0048518	positive regulation of biological process	3	8
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051173	positive regulation of nitrogen compound metabolic process	5	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0051247	positive regulation of protein metabolic process	6	8
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0061136	regulation of proteasomal protein catabolic process	6	2
GO:0065007	biological regulation	1	8
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901800	positive regulation of proteasomal protein catabolic process	7	2
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	2
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	2
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	2
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	2
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	2
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	2
GO:0031396	regulation of protein ubiquitination	8	6
GO:0031398	positive regulation of protein ubiquitination	9	6
GO:0031399	regulation of protein modification process	6	6
GO:0031401	positive regulation of protein modification process	7	6
GO:0043085	positive regulation of catalytic activity	4	6
GO:0044093	positive regulation of molecular function	3	6
GO:0050790	regulation of catalytic activity	3	6
GO:0051338	regulation of transferase activity	4	6
GO:0051347	positive regulation of transferase activity	5	6
GO:0051438	regulation of ubiquitin-protein transferase activity	5	6
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	6
GO:0065009	regulation of molecular function	2	6
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	6
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	6
GO:1904666	regulation of ubiquitin protein ligase activity	6	6
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	6

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008047	enzyme activator activity	3	8
GO:0010997	anaphase-promoting complex binding	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0044877	protein-containing complex binding	2	8
GO:0055106	ubiquitin-protein transferase regulator activity	3	8
GO:0097027	ubiquitin-protein transferase activator activity	4	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8
GO:1990757	ubiquitin ligase activator activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	436	440	PF00656	0.557
CLV_MEL_PAP_1	85	91	PF00089	0.716
CLV_NRD_NRD_1	273	275	PF00675	0.808
CLV_NRD_NRD_1	37	39	PF00675	0.742
CLV_NRD_NRD_1	45	47	PF00675	0.750
CLV_NRD_NRD_1	535	537	PF00675	0.503
CLV_NRD_NRD_1	644	646	PF00675	0.506
CLV_NRD_NRD_1	74	76	PF00675	0.760
CLV_PCSK_KEX2_1	273	275	PF00082	0.808
CLV_PCSK_KEX2_1	37	39	PF00082	0.690
CLV_PCSK_KEX2_1	45	47	PF00082	0.700
CLV_PCSK_KEX2_1	535	537	PF00082	0.503
CLV_PCSK_KEX2_1	561	563	PF00082	0.477
CLV_PCSK_KEX2_1	583	585	PF00082	0.645
CLV_PCSK_KEX2_1	74	76	PF00082	0.760
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.477
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.645
CLV_PCSK_SKI1_1	139	143	PF00082	0.800
CLV_PCSK_SKI1_1	247	251	PF00082	0.695
CLV_PCSK_SKI1_1	27	31	PF00082	0.717
CLV_PCSK_SKI1_1	308	312	PF00082	0.733
CLV_PCSK_SKI1_1	49	53	PF00082	0.813
CLV_PCSK_SKI1_1	493	497	PF00082	0.476
CLV_PCSK_SKI1_1	541	545	PF00082	0.487
CLV_PCSK_SKI1_1	564	568	PF00082	0.482
CLV_Separin_Metazoa	279	283	PF03568	0.798
DEG_Kelch_Keap1_1	403	408	PF01344	0.607
DEG_Nend_UBRbox_3	1	3	PF02207	0.742
DEG_SCF_FBW7_1	165	170	PF00400	0.708
DEG_SCF_FBW7_1	227	233	PF00400	0.556
DEG_SPOP_SBC_1	108	112	PF00917	0.670
DOC_ANK_TNKS_1	261	268	PF00023	0.671
DOC_CKS1_1	227	232	PF01111	0.697
DOC_CKS1_1	57	62	PF01111	0.738
DOC_MAPK_gen_1	454	464	PF00069	0.507
DOC_MAPK_gen_1	637	644	PF00069	0.472
DOC_PP1_RVXF_1	420	427	PF00149	0.385
DOC_PP2B_LxvP_1	165	168	PF13499	0.624
DOC_PP2B_LxvP_1	370	373	PF13499	0.492
DOC_PP4_FxxP_1	656	659	PF00568	0.503
DOC_USP7_MATH_1	108	112	PF00917	0.753
DOC_USP7_MATH_1	13	17	PF00917	0.729
DOC_USP7_MATH_1	215	219	PF00917	0.729
DOC_USP7_MATH_1	230	234	PF00917	0.480
DOC_USP7_MATH_1	268	272	PF00917	0.693
DOC_USP7_MATH_1	475	479	PF00917	0.452
DOC_USP7_MATH_2	301	307	PF00917	0.722
DOC_WW_Pin1_4	111	116	PF00397	0.725
DOC_WW_Pin1_4	139	144	PF00397	0.800
DOC_WW_Pin1_4	163	168	PF00397	0.713
DOC_WW_Pin1_4	226	231	PF00397	0.705
DOC_WW_Pin1_4	289	294	PF00397	0.700
DOC_WW_Pin1_4	297	302	PF00397	0.634
DOC_WW_Pin1_4	362	367	PF00397	0.489
DOC_WW_Pin1_4	536	541	PF00397	0.549
DOC_WW_Pin1_4	56	61	PF00397	0.732
DOC_WW_Pin1_4	710	715	PF00397	0.805
DOC_WW_Pin1_4	9	14	PF00397	0.684
LIG_14-3-3_CanoR_1	247	253	PF00244	0.632
LIG_14-3-3_CanoR_1	262	269	PF00244	0.595
LIG_14-3-3_CanoR_1	308	313	PF00244	0.733
LIG_14-3-3_CanoR_1	360	366	PF00244	0.498
LIG_14-3-3_CanoR_1	37	42	PF00244	0.709
LIG_14-3-3_CanoR_1	448	453	PF00244	0.530
LIG_14-3-3_CanoR_1	535	540	PF00244	0.625
LIG_14-3-3_CanoR_1	645	651	PF00244	0.468
LIG_14-3-3_CanoR_1	74	78	PF00244	0.834
LIG_Actin_WH2_2	292	310	PF00022	0.751
LIG_BRCT_BRCA1_1	562	566	PF00533	0.509
LIG_EH1_1	617	625	PF00400	0.501
LIG_FHA_1	160	166	PF00498	0.566
LIG_FHA_1	222	228	PF00498	0.726
LIG_FHA_1	316	322	PF00498	0.718
LIG_FHA_1	378	384	PF00498	0.507
LIG_FHA_1	416	422	PF00498	0.478
LIG_FHA_1	439	445	PF00498	0.476
LIG_FHA_1	52	58	PF00498	0.685
LIG_FHA_1	605	611	PF00498	0.531
LIG_FHA_1	647	653	PF00498	0.523
LIG_FHA_2	362	368	PF00498	0.491
LIG_FHA_2	38	44	PF00498	0.814
LIG_FHA_2	565	571	PF00498	0.486
LIG_FHA_2	588	594	PF00498	0.700
LIG_IBAR_NPY_1	129	131	PF08397	0.776
LIG_LIR_Apic_2	655	659	PF02991	0.502
LIG_LIR_Gen_1	188	199	PF02991	0.621
LIG_LIR_Gen_1	449	459	PF02991	0.586
LIG_LIR_Gen_1	648	658	PF02991	0.469
LIG_LIR_Gen_1	96	105	PF02991	0.715
LIG_LIR_Nem_3	188	194	PF02991	0.619
LIG_LIR_Nem_3	449	455	PF02991	0.530
LIG_LIR_Nem_3	648	653	PF02991	0.483
LIG_LIR_Nem_3	685	691	PF02991	0.444
LIG_MAD2	368	376	PF02301	0.548
LIG_PCNA_yPIPBox_3	612	624	PF02747	0.582
LIG_Pex14_2	688	692	PF04695	0.402
LIG_PTB_Apo_2	506	513	PF02174	0.547
LIG_PTB_Phospho_1	506	512	PF10480	0.547
LIG_RPA_C_Fungi	443	455	PF08784	0.516
LIG_SH2_NCK_1	131	135	PF00017	0.583
LIG_SH2_STAP1	131	135	PF00017	0.583
LIG_SH2_STAP1	159	163	PF00017	0.795
LIG_SH2_STAP1	223	227	PF00017	0.815
LIG_SH2_STAT5	223	226	PF00017	0.655
LIG_SH2_STAT5	347	350	PF00017	0.700
LIG_SH2_STAT5	512	515	PF00017	0.376
LIG_SH2_STAT5	519	522	PF00017	0.376
LIG_SH2_STAT5	609	612	PF00017	0.549
LIG_SH3_2	373	378	PF14604	0.635
LIG_SH3_3	295	301	PF00018	0.712
LIG_SH3_3	370	376	PF00018	0.492
LIG_SH3_3	453	459	PF00018	0.508
LIG_SH3_3	466	472	PF00018	0.492
LIG_SH3_3	50	56	PF00018	0.805
LIG_SUMO_SIM_par_1	410	416	PF11976	0.531
LIG_TRAF2_1	253	256	PF00917	0.605
LIG_TRAF2_1	592	595	PF00917	0.686
LIG_TRAF2_1	672	675	PF00917	0.559
LIG_WRC_WIRS_1	172	177	PF05994	0.728
LIG_WRC_WIRS_1	653	658	PF05994	0.502
LIG_WRC_WIRS_1	95	100	PF05994	0.713
MOD_CDC14_SPxK_1	114	117	PF00782	0.711
MOD_CDK_SPK_2	289	294	PF00069	0.709
MOD_CDK_SPK_2	536	541	PF00069	0.549
MOD_CDK_SPxK_1	111	117	PF00069	0.709
MOD_CDK_SPxK_1	362	368	PF00069	0.491
MOD_CDK_SPxK_1	56	62	PF00069	0.729
MOD_CK1_1	111	117	PF00069	0.794
MOD_CK1_1	12	18	PF00069	0.658
MOD_CK1_1	170	176	PF00069	0.691
MOD_CK1_1	178	184	PF00069	0.686
MOD_CK1_1	185	191	PF00069	0.643
MOD_CK1_1	20	26	PF00069	0.643
MOD_CK1_1	211	217	PF00069	0.722
MOD_CK1_1	218	224	PF00069	0.801
MOD_CK1_1	329	335	PF00069	0.681
MOD_CK1_1	377	383	PF00069	0.499
MOD_CK1_1	398	404	PF00069	0.486
MOD_CK1_1	447	453	PF00069	0.535
MOD_CK1_1	525	531	PF00069	0.472
MOD_CK1_1	666	672	PF00069	0.496
MOD_CK2_1	171	177	PF00069	0.727
MOD_CK2_1	232	238	PF00069	0.809
MOD_CK2_1	250	256	PF00069	0.612
MOD_CK2_1	297	303	PF00069	0.674
MOD_CK2_1	361	367	PF00069	0.498
MOD_CK2_1	37	43	PF00069	0.814
MOD_CK2_1	457	463	PF00069	0.506
MOD_CK2_1	564	570	PF00069	0.487
MOD_CK2_1	588	594	PF00069	0.616
MOD_Cter_Amidation	72	75	PF01082	0.758
MOD_DYRK1A_RPxSP_1	536	540	PF00069	0.550
MOD_GlcNHglycan	14	18	PF01048	0.805
MOD_GlcNHglycan	149	152	PF01048	0.687
MOD_GlcNHglycan	19	22	PF01048	0.812
MOD_GlcNHglycan	210	213	PF01048	0.819
MOD_GlcNHglycan	216	220	PF01048	0.774
MOD_GlcNHglycan	238	242	PF01048	0.710
MOD_GlcNHglycan	258	261	PF01048	0.748
MOD_GlcNHglycan	263	266	PF01048	0.714
MOD_GlcNHglycan	270	273	PF01048	0.677
MOD_GlcNHglycan	312	315	PF01048	0.694
MOD_GlcNHglycan	335	338	PF01048	0.775
MOD_GlcNHglycan	348	351	PF01048	0.771
MOD_GlcNHglycan	402	405	PF01048	0.516
MOD_GlcNHglycan	459	462	PF01048	0.512
MOD_GlcNHglycan	477	480	PF01048	0.226
MOD_GlcNHglycan	693	697	PF01048	0.588
MOD_GlcNHglycan	701	705	PF01048	0.709
MOD_GlcNHglycan	75	78	PF01048	0.763
MOD_GSK3_1	107	114	PF00069	0.686
MOD_GSK3_1	147	154	PF00069	0.665
MOD_GSK3_1	159	166	PF00069	0.684
MOD_GSK3_1	167	174	PF00069	0.661
MOD_GSK3_1	178	185	PF00069	0.567
MOD_GSK3_1	207	214	PF00069	0.747
MOD_GSK3_1	217	224	PF00069	0.597
MOD_GSK3_1	226	233	PF00069	0.534
MOD_GSK3_1	285	292	PF00069	0.721
MOD_GSK3_1	299	306	PF00069	0.784
MOD_GSK3_1	32	39	PF00069	0.777
MOD_GSK3_1	321	328	PF00069	0.721
MOD_GSK3_1	329	336	PF00069	0.711
MOD_GSK3_1	342	349	PF00069	0.704
MOD_GSK3_1	444	451	PF00069	0.514
MOD_GSK3_1	51	58	PF00069	0.593
MOD_GSK3_1	560	567	PF00069	0.478
MOD_GSK3_1	9	16	PF00069	0.658
MOD_N-GLC_1	362	367	PF02516	0.542
MOD_N-GLC_2	388	390	PF02516	0.558
MOD_NEK2_1	100	105	PF00069	0.663
MOD_NEK2_1	147	152	PF00069	0.754
MOD_NEK2_1	175	180	PF00069	0.666
MOD_NEK2_1	207	212	PF00069	0.769
MOD_NEK2_1	283	288	PF00069	0.691
MOD_NEK2_1	395	400	PF00069	0.477
MOD_NEK2_1	415	420	PF00069	0.286
MOD_NEK2_1	462	467	PF00069	0.485
MOD_NEK2_1	482	487	PF00069	0.225
MOD_NEK2_1	576	581	PF00069	0.514
MOD_NEK2_1	652	657	PF00069	0.560
MOD_NEK2_1	692	697	PF00069	0.591
MOD_NEK2_1	93	98	PF00069	0.663
MOD_NEK2_2	186	191	PF00069	0.644
MOD_NEK2_2	682	687	PF00069	0.502
MOD_OFUCOSY	661	667	PF10250	0.511
MOD_PIKK_1	377	383	PF00454	0.466
MOD_PIKK_1	604	610	PF00454	0.577
MOD_PKA_1	37	43	PF00069	0.814
MOD_PKA_1	45	51	PF00069	0.669
MOD_PKA_1	535	541	PF00069	0.623
MOD_PKA_1	645	651	PF00069	0.521
MOD_PKA_2	17	23	PF00069	0.765
MOD_PKA_2	261	267	PF00069	0.781
MOD_PKA_2	33	39	PF00069	0.735
MOD_PKA_2	447	453	PF00069	0.516
MOD_PKA_2	45	51	PF00069	0.730
MOD_PKA_2	535	541	PF00069	0.623
MOD_PKA_2	7	13	PF00069	0.719
MOD_PKA_2	73	79	PF00069	0.737
MOD_PKB_1	340	348	PF00069	0.778
MOD_PKB_1	562	570	PF00069	0.498
MOD_Plk_1	181	187	PF00069	0.641
MOD_Plk_1	302	308	PF00069	0.765
MOD_Plk_1	661	667	PF00069	0.583
MOD_Plk_1	682	688	PF00069	0.498
MOD_Plk_1	91	97	PF00069	0.717
MOD_Plk_2-3	718	724	PF00069	0.562
MOD_Plk_4	167	173	PF00069	0.686
MOD_Plk_4	175	181	PF00069	0.633
MOD_Plk_4	182	188	PF00069	0.585
MOD_Plk_4	37	43	PF00069	0.588
MOD_Plk_4	395	401	PF00069	0.475
MOD_Plk_4	448	454	PF00069	0.543
MOD_Plk_4	718	724	PF00069	0.623
MOD_ProDKin_1	111	117	PF00069	0.727
MOD_ProDKin_1	139	145	PF00069	0.802
MOD_ProDKin_1	163	169	PF00069	0.713
MOD_ProDKin_1	226	232	PF00069	0.700
MOD_ProDKin_1	289	295	PF00069	0.700
MOD_ProDKin_1	297	303	PF00069	0.634
MOD_ProDKin_1	362	368	PF00069	0.491
MOD_ProDKin_1	536	542	PF00069	0.544
MOD_ProDKin_1	56	62	PF00069	0.736
MOD_ProDKin_1	710	716	PF00069	0.804
MOD_ProDKin_1	9	15	PF00069	0.682
MOD_SUMO_for_1	29	32	PF00179	0.708
TRG_ENDOCYTIC_2	191	194	PF00928	0.645
TRG_ER_diArg_1	116	119	PF00400	0.580
TRG_ER_diArg_1	339	342	PF00400	0.711
TRG_ER_diArg_1	419	422	PF00400	0.487
TRG_ER_diArg_1	534	536	PF00400	0.545
TRG_ER_diArg_1	562	565	PF00400	0.518
TRG_NLS_MonoExtN_4	559	565	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N4	Leptomonas seymouri	60%	98%
A0A3Q8ILY5	Leishmania donovani	93%	100%
A4HL72	Leishmania braziliensis	82%	100%
A4I8Q1	Leishmania infantum	93%	100%
D0A4N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B3L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%