Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4G9_LEIMA

TriTrypDb:

LmjF.33.0380 , LMJLV39_330010000 , LMJSD75_330009700

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4G9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.475
CLV_PCSK_KEX2_1	219	221	PF00082	0.465
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.483
CLV_PCSK_SKI1_1	208	212	PF00082	0.480
CLV_PCSK_SKI1_1	240	244	PF00082	0.508
CLV_PCSK_SKI1_1	248	252	PF00082	0.349
CLV_PCSK_SKI1_1	288	292	PF00082	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.438
DOC_CYCLIN_RxL_1	299	310	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.470
DOC_MAPK_DCC_7	24	34	PF00069	0.513
DOC_MAPK_gen_1	3	12	PF00069	0.496
DOC_MAPK_MEF2A_6	148	156	PF00069	0.456
DOC_PP1_RVXF_1	268	274	PF00149	0.329
DOC_PP2B_LxvP_1	179	182	PF13499	0.369
DOC_PP2B_LxvP_1	32	35	PF13499	0.487
DOC_PP2B_LxvP_1	42	45	PF13499	0.472
DOC_PP4_FxxP_1	273	276	PF00568	0.312
DOC_USP7_MATH_1	147	151	PF00917	0.421
DOC_USP7_UBL2_3	215	219	PF12436	0.429
DOC_WW_Pin1_4	158	163	PF00397	0.553
DOC_WW_Pin1_4	69	74	PF00397	0.655
LIG_14-3-3_CanoR_1	101	108	PF00244	0.591
LIG_14-3-3_CanoR_1	208	217	PF00244	0.440
LIG_14-3-3_CanoR_1	220	228	PF00244	0.346
LIG_14-3-3_CanoR_1	68	73	PF00244	0.630
LIG_14-3-3_CanoR_1	90	95	PF00244	0.564
LIG_BIR_III_2	235	239	PF00653	0.491
LIG_BRCT_BRCA1_1	115	119	PF00533	0.329
LIG_BRCT_BRCA1_1	42	46	PF00533	0.356
LIG_deltaCOP1_diTrp_1	278	286	PF00928	0.412
LIG_eIF4E_1	4	10	PF01652	0.528
LIG_EVH1_1	179	183	PF00568	0.504
LIG_FHA_1	205	211	PF00498	0.570
LIG_FHA_1	257	263	PF00498	0.480
LIG_FHA_1	78	84	PF00498	0.682
LIG_FHA_1	91	97	PF00498	0.515
LIG_FHA_2	183	189	PF00498	0.381
LIG_FHA_2	220	226	PF00498	0.337
LIG_GBD_Chelix_1	300	308	PF00786	0.391
LIG_LIR_Apic_2	175	180	PF02991	0.398
LIG_LIR_Gen_1	188	197	PF02991	0.371
LIG_LIR_Gen_1	222	232	PF02991	0.330
LIG_LIR_Gen_1	295	306	PF02991	0.473
LIG_LIR_Gen_1	49	57	PF02991	0.458
LIG_LIR_Nem_3	188	193	PF02991	0.380
LIG_LIR_Nem_3	222	227	PF02991	0.398
LIG_LIR_Nem_3	278	284	PF02991	0.411
LIG_LIR_Nem_3	295	301	PF02991	0.229
LIG_LIR_Nem_3	315	320	PF02991	0.411
LIG_LIR_Nem_3	36	41	PF02991	0.353
LIG_LIR_Nem_3	49	53	PF02991	0.417
LIG_MLH1_MIPbox_1	115	119	PF16413	0.301
LIG_PDZ_Class_2	321	326	PF00595	0.530
LIG_Pex14_2	227	231	PF04695	0.339
LIG_REV1ctd_RIR_1	228	237	PF16727	0.357
LIG_SH2_CRK	177	181	PF00017	0.388
LIG_SH2_CRK	298	302	PF00017	0.461
LIG_SH2_CRK	92	96	PF00017	0.544
LIG_SH2_GRB2like	50	53	PF00017	0.566
LIG_SH2_NCK_1	317	321	PF00017	0.505
LIG_SH2_PTP2	50	53	PF00017	0.482
LIG_SH2_SRC	50	53	PF00017	0.482
LIG_SH2_STAT3	4	7	PF00017	0.530
LIG_SH2_STAT5	118	121	PF00017	0.393
LIG_SH2_STAT5	171	174	PF00017	0.424
LIG_SH2_STAT5	229	232	PF00017	0.406
LIG_SH2_STAT5	307	310	PF00017	0.427
LIG_SH2_STAT5	50	53	PF00017	0.504
LIG_SH2_STAT5	92	95	PF00017	0.566
LIG_SH3_1	177	183	PF00018	0.511
LIG_SH3_2	238	243	PF14604	0.496
LIG_SH3_3	177	183	PF00018	0.461
LIG_SH3_3	23	29	PF00018	0.480
LIG_SH3_3	235	241	PF00018	0.469
LIG_SH3_3	317	323	PF00018	0.461
LIG_TYR_ITIM	296	301	PF00017	0.481
LIG_WW_1	276	279	PF00397	0.378
MOD_CDK_SPK_2	158	163	PF00069	0.553
MOD_CK1_1	64	70	PF00069	0.602
MOD_CK1_1	72	78	PF00069	0.771
MOD_CK2_1	182	188	PF00069	0.395
MOD_CK2_1	219	225	PF00069	0.350
MOD_GlcNHglycan	248	251	PF01048	0.392
MOD_GlcNHglycan	309	312	PF01048	0.393
MOD_GSK3_1	204	211	PF00069	0.437
MOD_GSK3_1	64	71	PF00069	0.560
MOD_GSK3_1	73	80	PF00069	0.632
MOD_N-GLC_1	204	209	PF02516	0.474
MOD_NEK2_1	112	117	PF00069	0.517
MOD_NEK2_1	119	124	PF00069	0.490
MOD_NEK2_1	306	311	PF00069	0.482
MOD_PIKK_1	219	225	PF00454	0.385
MOD_PKA_1	219	225	PF00069	0.385
MOD_PKA_2	113	119	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.444
MOD_PKA_2	219	225	PF00069	0.398
MOD_Plk_1	204	210	PF00069	0.494
MOD_Plk_4	134	140	PF00069	0.395
MOD_ProDKin_1	158	164	PF00069	0.546
MOD_ProDKin_1	69	75	PF00069	0.658
MOD_SUMO_rev_2	200	207	PF00179	0.476
TRG_AP2beta_CARGO_1	225	234	PF09066	0.320
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.431
TRG_ENDOCYTIC_2	280	283	PF00928	0.427
TRG_ENDOCYTIC_2	298	301	PF00928	0.327
TRG_ENDOCYTIC_2	317	320	PF00928	0.457
TRG_ENDOCYTIC_2	50	53	PF00928	0.504
TRG_ER_diArg_1	152	155	PF00400	0.437
TRG_ER_diArg_1	21	24	PF00400	0.491
TRG_NLS_MonoCore_2	217	222	PF00514	0.528
TRG_NLS_MonoExtN_4	215	222	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I000	Leptomonas seymouri	75%	70%
A0A0S4IZ12	Bodo saltans	42%	89%
A0A1X0P257	Trypanosomatidae	46%	93%
A0A3Q8IGF0	Leishmania donovani	95%	100%
A0A3R7L0A9	Trypanosoma rangeli	46%	93%
A4HL73	Leishmania braziliensis	88%	100%
A4I8Q2	Leishmania infantum	95%	100%
D0A4N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	96%
E9B3L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	75%
V5BFU1	Trypanosoma cruzi	51%	94%