Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4G8_LEIMA

TriTrypDb:

LmjF.33.0390 , LMJLV39_330010100 , LMJSD75_330009800

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.640
CLV_NRD_NRD_1	196	198	PF00675	0.578
CLV_NRD_NRD_1	229	231	PF00675	0.448
CLV_NRD_NRD_1	301	303	PF00675	0.328
CLV_NRD_NRD_1	40	42	PF00675	0.453
CLV_PCSK_KEX2_1	166	168	PF00082	0.640
CLV_PCSK_KEX2_1	196	198	PF00082	0.578
CLV_PCSK_KEX2_1	229	231	PF00082	0.516
CLV_PCSK_KEX2_1	239	241	PF00082	0.502
CLV_PCSK_KEX2_1	354	356	PF00082	0.426
CLV_PCSK_KEX2_1	39	41	PF00082	0.450
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.502
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.426
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.440
CLV_PCSK_SKI1_1	258	262	PF00082	0.391
CLV_PCSK_SKI1_1	303	307	PF00082	0.394
CLV_PCSK_SKI1_1	354	358	PF00082	0.451
DEG_APCC_DBOX_1	130	138	PF00400	0.456
DEG_ODPH_VHL_1	272	284	PF01847	0.424
DEG_SPOP_SBC_1	62	66	PF00917	0.607
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.531
DOC_MAPK_gen_1	39	48	PF00069	0.506
DOC_MAPK_MEF2A_6	29	37	PF00069	0.498
DOC_PP2B_LxvP_1	253	256	PF13499	0.445
DOC_PP2B_LxvP_1	54	57	PF13499	0.545
DOC_PP4_FxxP_1	347	350	PF00568	0.337
DOC_USP7_MATH_1	160	164	PF00917	0.620
DOC_USP7_MATH_1	169	173	PF00917	0.711
DOC_USP7_MATH_1	247	251	PF00917	0.511
DOC_USP7_MATH_1	62	66	PF00917	0.607
DOC_USP7_UBL2_3	239	243	PF12436	0.500
DOC_USP7_UBL2_3	299	303	PF12436	0.400
DOC_WW_Pin1_4	167	172	PF00397	0.551
DOC_WW_Pin1_4	180	185	PF00397	0.626
DOC_WW_Pin1_4	214	219	PF00397	0.553
DOC_WW_Pin1_4	360	365	PF00397	0.589
DOC_WW_Pin1_4	86	91	PF00397	0.622
DOC_WW_Pin1_4	92	97	PF00397	0.632
LIG_14-3-3_CanoR_1	102	108	PF00244	0.590
LIG_14-3-3_CanoR_1	129	138	PF00244	0.507
LIG_14-3-3_CanoR_1	141	149	PF00244	0.604
LIG_14-3-3_CanoR_1	204	209	PF00244	0.517
LIG_14-3-3_CanoR_1	233	241	PF00244	0.489
LIG_14-3-3_CanoR_1	302	312	PF00244	0.338
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_eIF4E_1	21	27	PF01652	0.465
LIG_FHA_1	211	217	PF00498	0.472
LIG_FHA_1	304	310	PF00498	0.362
LIG_FHA_1	49	55	PF00498	0.469
LIG_FHA_1	62	68	PF00498	0.586
LIG_FHA_2	10	16	PF00498	0.548
LIG_FHA_2	130	136	PF00498	0.530
LIG_FHA_2	215	221	PF00498	0.536
LIG_FHA_2	284	290	PF00498	0.365
LIG_IRF3_LxIS_1	185	192	PF10401	0.581
LIG_LIR_Apic_2	346	350	PF02991	0.341
LIG_LIR_Gen_1	28	37	PF02991	0.433
LIG_LIR_Gen_1	331	340	PF02991	0.385
LIG_LIR_Nem_3	28	33	PF02991	0.489
LIG_LIR_Nem_3	331	337	PF02991	0.378
LIG_LIR_Nem_3	42	48	PF02991	0.445
LIG_Pex14_2	347	351	PF04695	0.338
LIG_REV1ctd_RIR_1	293	303	PF16727	0.273
LIG_SH2_CRK	269	273	PF00017	0.353
LIG_SH2_CRK	30	34	PF00017	0.419
LIG_SH2_CRK	58	62	PF00017	0.544
LIG_SH2_GRB2like	311	314	PF00017	0.356
LIG_SH2_NCK_1	222	226	PF00017	0.536
LIG_SH2_SRC	21	24	PF00017	0.497
LIG_SH2_STAP1	17	21	PF00017	0.499
LIG_SH2_STAP1	222	226	PF00017	0.536
LIG_SH2_STAP1	58	62	PF00017	0.566
LIG_SH2_STAT5	21	24	PF00017	0.476
LIG_SH2_STAT5	294	297	PF00017	0.342
LIG_SH2_STAT5	345	348	PF00017	0.330
LIG_SH3_3	215	221	PF00018	0.539
LIG_SH3_3	241	247	PF00018	0.499
LIG_SH3_3	275	281	PF00018	0.429
LIG_SH3_3	353	359	PF00018	0.477
LIG_SUMO_SIM_par_1	280	286	PF11976	0.426
LIG_TYR_ITIM	56	61	PF00017	0.559
LIG_UBA3_1	308	317	PF00899	0.423
LIG_WRC_WIRS_1	344	349	PF05994	0.323
MOD_CDC14_SPxK_1	95	98	PF00782	0.595
MOD_CDK_SPK_2	86	91	PF00069	0.607
MOD_CDK_SPxK_1	92	98	PF00069	0.602
MOD_CK1_1	103	109	PF00069	0.579
MOD_CK1_1	172	178	PF00069	0.664
MOD_CK1_1	49	55	PF00069	0.553
MOD_CK1_1	75	81	PF00069	0.615
MOD_CK1_1	89	95	PF00069	0.563
MOD_CK2_1	129	135	PF00069	0.551
MOD_CK2_1	282	288	PF00069	0.372
MOD_CK2_1	325	331	PF00069	0.385
MOD_GlcNHglycan	1	4	PF01048	0.571
MOD_GlcNHglycan	102	105	PF01048	0.628
MOD_GlcNHglycan	109	112	PF01048	0.622
MOD_GlcNHglycan	121	124	PF01048	0.514
MOD_GlcNHglycan	163	166	PF01048	0.650
MOD_GlcNHglycan	171	174	PF01048	0.727
MOD_GlcNHglycan	191	194	PF01048	0.598
MOD_GlcNHglycan	247	250	PF01048	0.517
MOD_GlcNHglycan	51	54	PF01048	0.516
MOD_GSK3_1	103	110	PF00069	0.640
MOD_GSK3_1	115	122	PF00069	0.548
MOD_GSK3_1	161	168	PF00069	0.661
MOD_GSK3_1	169	176	PF00069	0.580
MOD_GSK3_1	210	217	PF00069	0.590
MOD_GSK3_1	44	51	PF00069	0.446
MOD_N-GLC_1	72	77	PF02516	0.509
MOD_N-GLC_2	124	126	PF02516	0.586
MOD_N-GLC_2	313	315	PF02516	0.378
MOD_NEK2_1	107	112	PF00069	0.656
MOD_NEK2_1	155	160	PF00069	0.574
MOD_NEK2_1	235	240	PF00069	0.465
MOD_NEK2_1	268	273	PF00069	0.392
MOD_NEK2_1	325	330	PF00069	0.432
MOD_NEK2_1	48	53	PF00069	0.486
MOD_NEK2_1	61	66	PF00069	0.530
MOD_NEK2_2	9	14	PF00069	0.540
MOD_PIKK_1	46	52	PF00454	0.500
MOD_PKA_2	160	166	PF00069	0.623
MOD_PKA_2	195	201	PF00069	0.533
MOD_PKB_1	202	210	PF00069	0.496
MOD_Plk_1	323	329	PF00069	0.427
MOD_Plk_2-3	335	341	PF00069	0.402
MOD_Plk_4	103	109	PF00069	0.524
MOD_Plk_4	150	156	PF00069	0.506
MOD_ProDKin_1	167	173	PF00069	0.551
MOD_ProDKin_1	180	186	PF00069	0.627
MOD_ProDKin_1	214	220	PF00069	0.546
MOD_ProDKin_1	360	366	PF00069	0.590
MOD_ProDKin_1	86	92	PF00069	0.622
MOD_SUMO_rev_2	232	241	PF00179	0.466
TRG_ENDOCYTIC_2	10	13	PF00928	0.597
TRG_ENDOCYTIC_2	269	272	PF00928	0.358
TRG_ENDOCYTIC_2	294	297	PF00928	0.342
TRG_ENDOCYTIC_2	30	33	PF00928	0.317
TRG_ENDOCYTIC_2	58	61	PF00928	0.566
TRG_ER_diArg_1	128	131	PF00400	0.520
TRG_ER_diArg_1	140	143	PF00400	0.550
TRG_ER_diArg_1	196	199	PF00400	0.695
TRG_NLS_MonoExtN_4	350	357	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P717	Leptomonas seymouri	50%	100%
A0A3Q8IJX1	Leishmania donovani	90%	100%
A4HL74	Leishmania braziliensis	65%	100%
A4I8Q3	Leishmania infantum	90%	100%
E9B3L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%