Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4G4_LEIMA

TriTrypDb:

LmjF.33.0450 , LMJLV39_330010800 , LMJSD75_330010800

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q4G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4G4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.572
CLV_NRD_NRD_1	112	114	PF00675	0.567
CLV_NRD_NRD_1	81	83	PF00675	0.671
CLV_PCSK_KEX2_1	112	114	PF00082	0.475
CLV_PCSK_KEX2_1	81	83	PF00082	0.644
DEG_APCC_DBOX_1	136	144	PF00400	0.445
DEG_Nend_Nbox_1	1	3	PF02207	0.619
DOC_CKS1_1	104	109	PF01111	0.508
DOC_WW_Pin1_4	103	108	PF00397	0.642
DOC_WW_Pin1_4	56	61	PF00397	0.541
LIG_14-3-3_CanoR_1	113	121	PF00244	0.448
LIG_14-3-3_CanoR_1	137	141	PF00244	0.599
LIG_14-3-3_CanoR_1	210	216	PF00244	0.524
LIG_14-3-3_CanoR_1	81	90	PF00244	0.684
LIG_FHA_1	155	161	PF00498	0.523
LIG_FHA_2	104	110	PF00498	0.526
LIG_FHA_2	128	134	PF00498	0.496
LIG_HCF-1_HBM_1	28	31	PF13415	0.396
LIG_LIR_Apic_2	212	216	PF02991	0.669
LIG_LIR_Gen_1	179	188	PF02991	0.495
LIG_LIR_Nem_3	179	185	PF02991	0.513
LIG_LIR_Nem_3	194	200	PF02991	0.505
LIG_LIR_Nem_3	77	83	PF02991	0.585
LIG_Pex14_1	18	22	PF04695	0.323
LIG_Pex14_1	76	80	PF04695	0.595
LIG_SH2_STAP1	47	51	PF00017	0.437
LIG_SH2_STAT3	47	50	PF00017	0.586
LIG_SH2_STAT5	22	25	PF00017	0.397
LIG_SH3_3	165	171	PF00018	0.506
LIG_SH3_3	3	9	PF00018	0.444
LIG_TRAF2_1	106	109	PF00917	0.504
MOD_CK1_1	117	123	PF00069	0.537
MOD_CK1_1	183	189	PF00069	0.597
MOD_CK2_1	103	109	PF00069	0.568
MOD_CK2_1	71	77	PF00069	0.552
MOD_CMANNOS	76	79	PF00535	0.614
MOD_GlcNHglycan	14	18	PF01048	0.434
MOD_GlcNHglycan	162	165	PF01048	0.554
MOD_N-GLC_1	154	159	PF02516	0.534
MOD_N-GLC_1	180	185	PF02516	0.514
MOD_NEK2_1	127	132	PF00069	0.537
MOD_NEK2_1	160	165	PF00069	0.578
MOD_PIKK_1	114	120	PF00454	0.550
MOD_PK_1	180	186	PF00069	0.592
MOD_PKA_1	81	87	PF00069	0.619
MOD_PKA_2	114	120	PF00069	0.452
MOD_PKA_2	136	142	PF00069	0.602
MOD_PKA_2	20	26	PF00069	0.386
MOD_PKA_2	209	215	PF00069	0.518
MOD_PKA_2	81	87	PF00069	0.609
MOD_Plk_1	154	160	PF00069	0.533
MOD_Plk_1	180	186	PF00069	0.538
MOD_Plk_1	71	77	PF00069	0.561
MOD_Plk_2-3	136	142	PF00069	0.512
MOD_Plk_2-3	94	100	PF00069	0.475
MOD_Plk_4	155	161	PF00069	0.648
MOD_Plk_4	41	47	PF00069	0.401
MOD_Plk_4	71	77	PF00069	0.621
MOD_ProDKin_1	103	109	PF00069	0.636
MOD_ProDKin_1	56	62	PF00069	0.541
MOD_SUMO_for_1	90	93	PF00179	0.750
MOD_SUMO_rev_2	84	92	PF00179	0.649
TRG_DiLeu_BaEn_4	93	99	PF01217	0.612
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.493
TRG_ER_diArg_1	112	115	PF00400	0.452
TRG_ER_diArg_1	80	82	PF00400	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYD0	Leptomonas seymouri	75%	99%
A0A0S4KNW6	Bodo saltans	44%	100%
A0A1X0P0X4	Trypanosomatidae	57%	100%
A0A3Q8IHM0	Leishmania donovani	96%	100%
A0A3R7MM31	Trypanosoma rangeli	56%	100%
A4HL80	Leishmania braziliensis	81%	100%
A4I8Q8	Leishmania infantum	96%	100%
D0A4P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BKE3	Trypanosoma cruzi	53%	100%