Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4G3_LEIMA

TriTrypDb:

LmjF.33.0460 , LMJLV39_330010900 , LMJSD75_330010900

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.618
CLV_NRD_NRD_1	133	135	PF00675	0.537
CLV_NRD_NRD_1	138	140	PF00675	0.516
CLV_NRD_NRD_1	248	250	PF00675	0.623
CLV_NRD_NRD_1	53	55	PF00675	0.777
CLV_PCSK_KEX2_1	133	135	PF00082	0.546
CLV_PCSK_KEX2_1	138	140	PF00082	0.507
CLV_PCSK_KEX2_1	148	150	PF00082	0.421
CLV_PCSK_KEX2_1	225	227	PF00082	0.523
CLV_PCSK_KEX2_1	248	250	PF00082	0.623
CLV_PCSK_KEX2_1	53	55	PF00082	0.726
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.533
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.463
CLV_PCSK_PC7_1	134	140	PF00082	0.545
CLV_PCSK_SKI1_1	134	138	PF00082	0.402
DEG_APCC_DBOX_1	133	141	PF00400	0.404
DEG_SPOP_SBC_1	177	181	PF00917	0.554
DEG_SPOP_SBC_1	185	189	PF00917	0.551
DOC_CYCLIN_RxL_1	130	141	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.626
DOC_MAPK_gen_1	225	231	PF00069	0.478
DOC_PP1_RVXF_1	265	272	PF00149	0.483
DOC_PP2B_LxvP_1	80	83	PF13499	0.623
DOC_USP7_MATH_1	177	181	PF00917	0.596
DOC_USP7_MATH_1	197	201	PF00917	0.562
DOC_WW_Pin1_4	117	122	PF00397	0.640
DOC_WW_Pin1_4	203	208	PF00397	0.652
LIG_14-3-3_CanoR_1	274	283	PF00244	0.522
LIG_14-3-3_CanoR_1	53	62	PF00244	0.784
LIG_Actin_WH2_2	124	140	PF00022	0.412
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.495
LIG_FAT_LD_1	150	158	PF03623	0.454
LIG_FHA_1	186	192	PF00498	0.696
LIG_FHA_1	39	45	PF00498	0.620
LIG_FHA_1	69	75	PF00498	0.654
LIG_FHA_2	185	191	PF00498	0.646
LIG_FHA_2	53	59	PF00498	0.552
LIG_LIR_Apic_2	155	159	PF02991	0.442
LIG_LIR_Gen_1	179	186	PF02991	0.538
LIG_LIR_Gen_1	6	14	PF02991	0.608
LIG_LIR_Nem_3	179	185	PF02991	0.526
LIG_LIR_Nem_3	6	10	PF02991	0.662
LIG_PCNA_yPIPBox_3	145	154	PF02747	0.460
LIG_PCNA_yPIPBox_3	234	245	PF02747	0.515
LIG_PDZ_Class_3	283	288	PF00595	0.634
LIG_SH2_NCK_1	182	186	PF00017	0.527
LIG_SH2_STAT5	156	159	PF00017	0.462
LIG_SH2_STAT5	222	225	PF00017	0.453
LIG_SH2_STAT5	9	12	PF00017	0.661
LIG_SH3_1	29	35	PF00018	0.652
LIG_SH3_3	204	210	PF00018	0.683
LIG_SH3_3	29	35	PF00018	0.772
LIG_SUMO_SIM_par_1	69	75	PF11976	0.606
LIG_TRAF2_1	230	233	PF00917	0.523
LIG_WRC_WIRS_1	4	9	PF05994	0.657
MOD_CDC14_SPxK_1	120	123	PF00782	0.632
MOD_CDK_SPK_2	208	213	PF00069	0.603
MOD_CDK_SPxK_1	117	123	PF00069	0.638
MOD_CDK_SPxxK_3	208	215	PF00069	0.594
MOD_CK1_1	200	206	PF00069	0.708
MOD_CK1_1	208	214	PF00069	0.517
MOD_CK1_1	52	58	PF00069	0.642
MOD_GlcNHglycan	193	196	PF01048	0.671
MOD_GlcNHglycan	198	202	PF01048	0.615
MOD_GSK3_1	256	263	PF00069	0.512
MOD_GSK3_1	49	56	PF00069	0.679
MOD_GSK3_1	68	75	PF00069	0.462
MOD_N-GLC_1	38	43	PF02516	0.567
MOD_NEK2_1	178	183	PF00069	0.535
MOD_PKA_1	53	59	PF00069	0.697
MOD_PKA_2	260	266	PF00069	0.526
MOD_PKA_2	279	285	PF00069	0.457
MOD_PKA_2	52	58	PF00069	0.643
MOD_PKB_1	272	280	PF00069	0.505
MOD_Plk_1	256	262	PF00069	0.484
MOD_Plk_1	58	64	PF00069	0.677
MOD_Plk_1	68	74	PF00069	0.568
MOD_Plk_1	76	82	PF00069	0.465
MOD_Plk_4	152	158	PF00069	0.454
MOD_Plk_4	68	74	PF00069	0.514
MOD_ProDKin_1	117	123	PF00069	0.638
MOD_ProDKin_1	203	209	PF00069	0.645
MOD_SUMO_rev_2	186	194	PF00179	0.602
TRG_ENDOCYTIC_2	182	185	PF00928	0.540
TRG_ER_diArg_1	133	135	PF00400	0.536
TRG_ER_diArg_1	137	139	PF00400	0.531
TRG_ER_diArg_1	212	215	PF00400	0.630
TRG_ER_diArg_1	248	250	PF00400	0.615
TRG_NES_CRM1_1	126	141	PF08389	0.407
TRG_NES_CRM1_1	78	93	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHC5	Leishmania donovani	93%	100%
A4HL81	Leishmania braziliensis	67%	100%
A4I8Q9	Leishmania infantum	91%	100%
E9B3M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%