Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4G1_LEIMA

TriTrypDb:

LmjF.33.0480 , LMJLV39_330011100 , LMJSD75_330011100

Length:

693

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.703
CLV_C14_Caspase3-7	352	356	PF00656	0.639
CLV_NRD_NRD_1	115	117	PF00675	0.596
CLV_NRD_NRD_1	177	179	PF00675	0.512
CLV_NRD_NRD_1	204	206	PF00675	0.545
CLV_NRD_NRD_1	234	236	PF00675	0.616
CLV_NRD_NRD_1	240	242	PF00675	0.535
CLV_NRD_NRD_1	244	246	PF00675	0.490
CLV_NRD_NRD_1	261	263	PF00675	0.401
CLV_NRD_NRD_1	344	346	PF00675	0.560
CLV_NRD_NRD_1	350	352	PF00675	0.464
CLV_NRD_NRD_1	404	406	PF00675	0.516
CLV_NRD_NRD_1	44	46	PF00675	0.671
CLV_NRD_NRD_1	500	502	PF00675	0.593
CLV_NRD_NRD_1	518	520	PF00675	0.500
CLV_NRD_NRD_1	89	91	PF00675	0.606
CLV_NRD_NRD_1	99	101	PF00675	0.535
CLV_PCSK_FUR_1	168	172	PF00082	0.489
CLV_PCSK_FUR_1	232	236	PF00082	0.499
CLV_PCSK_KEX2_1	170	172	PF00082	0.494
CLV_PCSK_KEX2_1	179	181	PF00082	0.454
CLV_PCSK_KEX2_1	213	215	PF00082	0.521
CLV_PCSK_KEX2_1	234	236	PF00082	0.538
CLV_PCSK_KEX2_1	239	241	PF00082	0.544
CLV_PCSK_KEX2_1	261	263	PF00082	0.532
CLV_PCSK_KEX2_1	339	341	PF00082	0.549
CLV_PCSK_KEX2_1	344	346	PF00082	0.524
CLV_PCSK_KEX2_1	350	352	PF00082	0.427
CLV_PCSK_KEX2_1	365	367	PF00082	0.615
CLV_PCSK_KEX2_1	404	406	PF00082	0.494
CLV_PCSK_KEX2_1	43	45	PF00082	0.662
CLV_PCSK_KEX2_1	500	502	PF00082	0.593
CLV_PCSK_KEX2_1	89	91	PF00082	0.608
CLV_PCSK_KEX2_1	99	101	PF00082	0.533
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.494
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.454
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.534
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.508
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.541
CLV_PCSK_PC7_1	209	215	PF00082	0.552
CLV_PCSK_PC7_1	235	241	PF00082	0.606
CLV_PCSK_PC7_1	340	346	PF00082	0.481
CLV_PCSK_SKI1_1	245	249	PF00082	0.532
CLV_PCSK_SKI1_1	340	344	PF00082	0.480
CLV_PCSK_SKI1_1	412	416	PF00082	0.405
CLV_PCSK_SKI1_1	603	607	PF00082	0.467
DEG_APCC_DBOX_1	339	347	PF00400	0.648
DEG_Nend_UBRbox_4	1	3	PF02207	0.651
DEG_SCF_FBW7_1	104	110	PF00400	0.677
DEG_SCF_FBW7_1	609	615	PF00400	0.709
DEG_SCF_FBW7_1	621	626	PF00400	0.645
DOC_ANK_TNKS_1	500	507	PF00023	0.643
DOC_CKS1_1	104	109	PF01111	0.674
DOC_CKS1_1	606	611	PF01111	0.728
DOC_CKS1_1	632	637	PF01111	0.332
DOC_CYCLIN_RxL_1	600	610	PF00134	0.734
DOC_CYCLIN_yCln2_LP_2	535	538	PF00134	0.613
DOC_MAPK_MEF2A_6	323	330	PF00069	0.722
DOC_MAPK_MEF2A_6	508	515	PF00069	0.671
DOC_MAPK_MEF2A_6	64	73	PF00069	0.717
DOC_PP2B_LxvP_1	534	537	PF13499	0.635
DOC_USP7_MATH_1	105	109	PF00917	0.731
DOC_USP7_MATH_1	125	129	PF00917	0.629
DOC_USP7_MATH_1	143	147	PF00917	0.602
DOC_USP7_MATH_1	307	311	PF00917	0.768
DOC_USP7_MATH_1	349	353	PF00917	0.670
DOC_USP7_MATH_1	356	360	PF00917	0.581
DOC_USP7_MATH_1	455	459	PF00917	0.549
DOC_USP7_MATH_1	563	567	PF00917	0.748
DOC_USP7_MATH_1	591	595	PF00917	0.714
DOC_USP7_MATH_1	612	616	PF00917	0.721
DOC_USP7_MATH_1	623	627	PF00917	0.685
DOC_USP7_UBL2_3	202	206	PF12436	0.750
DOC_USP7_UBL2_3	311	315	PF12436	0.794
DOC_USP7_UBL2_3	87	91	PF12436	0.705
DOC_WW_Pin1_4	103	108	PF00397	0.715
DOC_WW_Pin1_4	111	116	PF00397	0.735
DOC_WW_Pin1_4	310	315	PF00397	0.754
DOC_WW_Pin1_4	322	327	PF00397	0.714
DOC_WW_Pin1_4	376	381	PF00397	0.780
DOC_WW_Pin1_4	577	582	PF00397	0.675
DOC_WW_Pin1_4	605	610	PF00397	0.752
DOC_WW_Pin1_4	619	624	PF00397	0.669
DOC_WW_Pin1_4	628	633	PF00397	0.695
LIG_14-3-3_CanoR_1	109	115	PF00244	0.734
LIG_14-3-3_CanoR_1	123	132	PF00244	0.669
LIG_14-3-3_CanoR_1	239	248	PF00244	0.717
LIG_14-3-3_CanoR_1	256	264	PF00244	0.589
LIG_14-3-3_CanoR_1	350	354	PF00244	0.707
LIG_14-3-3_CanoR_1	412	418	PF00244	0.405
LIG_14-3-3_CanoR_1	45	55	PF00244	0.835
LIG_14-3-3_CanoR_1	576	581	PF00244	0.736
LIG_14-3-3_CanoR_1	99	104	PF00244	0.758
LIG_BIR_III_2	681	685	PF00653	0.477
LIG_BRCT_BRCA1_1	593	597	PF00533	0.705
LIG_CtBP_PxDLS_1	465	469	PF00389	0.405
LIG_eIF4E_1	683	689	PF01652	0.504
LIG_FHA_1	242	248	PF00498	0.722
LIG_FHA_1	323	329	PF00498	0.754
LIG_FHA_1	380	386	PF00498	0.758
LIG_FHA_1	486	492	PF00498	0.659
LIG_FHA_1	528	534	PF00498	0.739
LIG_FHA_1	546	552	PF00498	0.638
LIG_FHA_1	7	13	PF00498	0.659
LIG_FHA_2	16	22	PF00498	0.607
LIG_FHA_2	183	189	PF00498	0.637
LIG_FHA_2	231	237	PF00498	0.710
LIG_FHA_2	376	382	PF00498	0.655
LIG_Integrin_RGD_1	366	368	PF01839	0.528
LIG_Integrin_RGD_1	567	569	PF01839	0.500
LIG_LIR_Gen_1	161	169	PF02991	0.754
LIG_LIR_Gen_1	594	605	PF02991	0.687
LIG_LIR_Nem_3	161	167	PF02991	0.704
LIG_LIR_Nem_3	594	600	PF02991	0.692
LIG_NRBOX	19	25	PF00104	0.713
LIG_NRBOX	530	536	PF00104	0.643
LIG_NRBOX	600	606	PF00104	0.685
LIG_SH2_CRK	265	269	PF00017	0.792
LIG_SH2_STAP1	527	531	PF00017	0.712
LIG_SH2_STAT5	265	268	PF00017	0.733
LIG_SH3_1	214	220	PF00018	0.659
LIG_SH3_2	104	109	PF14604	0.674
LIG_SH3_3	101	107	PF00018	0.718
LIG_SH3_3	137	143	PF00018	0.729
LIG_SH3_3	214	220	PF00018	0.659
LIG_SH3_3	28	34	PF00018	0.707
LIG_SH3_3	380	386	PF00018	0.736
LIG_SH3_3	581	587	PF00018	0.717
LIG_SH3_3	606	612	PF00018	0.699
LIG_SH3_3	629	635	PF00018	0.553
LIG_SUMO_SIM_anti_2	128	135	PF11976	0.680
LIG_SUMO_SIM_par_1	477	483	PF11976	0.356
LIG_WRC_WIRS_1	414	419	PF05994	0.332
MOD_CDC14_SPxK_1	114	117	PF00782	0.686
MOD_CDK_SPK_2	111	116	PF00069	0.693
MOD_CDK_SPK_2	310	315	PF00069	0.594
MOD_CDK_SPxK_1	103	109	PF00069	0.645
MOD_CDK_SPxK_1	111	117	PF00069	0.670
MOD_CK1_1	119	125	PF00069	0.710
MOD_CK1_1	128	134	PF00069	0.617
MOD_CK1_1	200	206	PF00069	0.636
MOD_CK1_1	255	261	PF00069	0.628
MOD_CK1_1	310	316	PF00069	0.676
MOD_CK1_1	400	406	PF00069	0.630
MOD_CK1_1	418	424	PF00069	0.265
MOD_CK1_1	48	54	PF00069	0.768
MOD_CK1_1	579	585	PF00069	0.693
MOD_CK1_1	626	632	PF00069	0.714
MOD_CK1_1	98	104	PF00069	0.665
MOD_CK2_1	182	188	PF00069	0.563
MOD_CK2_1	375	381	PF00069	0.558
MOD_CK2_1	593	599	PF00069	0.644
MOD_GlcNHglycan	125	128	PF01048	0.685
MOD_GlcNHglycan	156	159	PF01048	0.678
MOD_GlcNHglycan	190	193	PF01048	0.713
MOD_GlcNHglycan	199	202	PF01048	0.695
MOD_GlcNHglycan	257	260	PF01048	0.617
MOD_GlcNHglycan	268	271	PF01048	0.554
MOD_GlcNHglycan	292	296	PF01048	0.661
MOD_GlcNHglycan	391	394	PF01048	0.762
MOD_GlcNHglycan	451	454	PF01048	0.690
MOD_GlcNHglycan	50	53	PF01048	0.706
MOD_GlcNHglycan	593	596	PF01048	0.633
MOD_GlcNHglycan	79	82	PF01048	0.699
MOD_GlcNHglycan	92	95	PF01048	0.688
MOD_GSK3_1	103	110	PF00069	0.679
MOD_GSK3_1	111	118	PF00069	0.637
MOD_GSK3_1	119	126	PF00069	0.638
MOD_GSK3_1	128	135	PF00069	0.625
MOD_GSK3_1	154	161	PF00069	0.672
MOD_GSK3_1	178	185	PF00069	0.637
MOD_GSK3_1	224	231	PF00069	0.701
MOD_GSK3_1	310	317	PF00069	0.727
MOD_GSK3_1	322	329	PF00069	0.580
MOD_GSK3_1	356	363	PF00069	0.596
MOD_GSK3_1	375	382	PF00069	0.623
MOD_GSK3_1	445	452	PF00069	0.667
MOD_GSK3_1	607	614	PF00069	0.687
MOD_GSK3_1	619	626	PF00069	0.593
MOD_GSK3_1	95	102	PF00069	0.716
MOD_N-GLC_1	123	128	PF02516	0.701
MOD_N-GLC_1	333	338	PF02516	0.579
MOD_NEK2_1	224	229	PF00069	0.754
MOD_NEK2_1	321	326	PF00069	0.701
MOD_NEK2_1	415	420	PF00069	0.405
MOD_NEK2_1	445	450	PF00069	0.580
MOD_NEK2_1	484	489	PF00069	0.521
MOD_NEK2_1	493	498	PF00069	0.610
MOD_NEK2_1	95	100	PF00069	0.736
MOD_PIKK_1	117	123	PF00454	0.587
MOD_PIKK_1	357	363	PF00454	0.576
MOD_PIKK_1	435	441	PF00454	0.523
MOD_PKA_1	116	122	PF00069	0.699
MOD_PKA_1	178	184	PF00069	0.630
MOD_PKA_1	240	246	PF00069	0.640
MOD_PKA_1	90	96	PF00069	0.656
MOD_PKA_1	99	105	PF00069	0.621
MOD_PKA_2	115	121	PF00069	0.674
MOD_PKA_2	240	246	PF00069	0.640
MOD_PKA_2	255	261	PF00069	0.474
MOD_PKA_2	349	355	PF00069	0.527
MOD_PKA_2	400	406	PF00069	0.618
MOD_PKA_2	493	499	PF00069	0.712
MOD_PKA_2	98	104	PF00069	0.727
MOD_PKB_1	180	188	PF00069	0.631
MOD_PKB_1	239	247	PF00069	0.658
MOD_PKB_1	43	51	PF00069	0.659
MOD_Plk_1	357	363	PF00069	0.504
MOD_Plk_2-3	15	21	PF00069	0.631
MOD_Plk_4	128	134	PF00069	0.719
MOD_Plk_4	15	21	PF00069	0.631
MOD_Plk_4	326	332	PF00069	0.674
MOD_Plk_4	418	424	PF00069	0.377
MOD_Plk_4	579	585	PF00069	0.588
MOD_ProDKin_1	103	109	PF00069	0.645
MOD_ProDKin_1	111	117	PF00069	0.670
MOD_ProDKin_1	310	316	PF00069	0.696
MOD_ProDKin_1	322	328	PF00069	0.633
MOD_ProDKin_1	376	382	PF00069	0.732
MOD_ProDKin_1	577	583	PF00069	0.587
MOD_ProDKin_1	605	611	PF00069	0.703
MOD_ProDKin_1	619	625	PF00069	0.578
MOD_ProDKin_1	628	634	PF00069	0.602
MOD_SUMO_rev_2	174	181	PF00179	0.609
MOD_SUMO_rev_2	368	376	PF00179	0.624
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.544
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.497
TRG_DiLeu_BaLyEn_6	684	689	PF01217	0.623
TRG_DiLeu_LyEn_5	570	575	PF01217	0.535
TRG_ENDOCYTIC_2	164	167	PF00928	0.625
TRG_ENDOCYTIC_2	265	268	PF00928	0.666
TRG_ER_diArg_1	232	235	PF00400	0.735
TRG_ER_diArg_1	238	241	PF00400	0.659
TRG_ER_diArg_1	260	262	PF00400	0.650
TRG_ER_diArg_1	343	345	PF00400	0.705
TRG_ER_diArg_1	404	407	PF00400	0.602
TRG_ER_diArg_1	42	45	PF00400	0.765
TRG_ER_diArg_1	491	494	PF00400	0.710
TRG_ER_diArg_1	500	503	PF00400	0.683
TRG_NES_CRM1_1	432	443	PF08389	0.573
TRG_NLS_MonoExtC_3	178	184	PF00514	0.630
TRG_NLS_MonoExtN_4	176	183	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6F7	Leishmania donovani	88%	89%
A4HL83	Leishmania braziliensis	65%	100%
A4I8R1	Leishmania infantum	88%	89%
E9B3M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%