HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4F9_LEIMA

TriTrypDb:

LmjF.33.0500 , LMJLV39_330011300 , LMJSD75_330011300

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4F9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.376
CLV_NRD_NRD_1	32	34	PF00675	0.476
CLV_PCSK_KEX2_1	151	153	PF00082	0.401
CLV_PCSK_KEX2_1	254	256	PF00082	0.453
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.432
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.453
CLV_PCSK_SKI1_1	148	152	PF00082	0.443
CLV_PCSK_SKI1_1	254	258	PF00082	0.428
CLV_PCSK_SKI1_1	33	37	PF00082	0.475
CLV_PCSK_SKI1_1	62	66	PF00082	0.300
DEG_APCC_DBOX_1	61	69	PF00400	0.298
DEG_Nend_UBRbox_2	1	3	PF02207	0.391
DOC_MAPK_DCC_7	252	261	PF00069	0.394
DOC_MAPK_gen_1	252	261	PF00069	0.344
DOC_MAPK_MEF2A_6	252	261	PF00069	0.394
DOC_MAPK_MEF2A_6	287	294	PF00069	0.303
DOC_PP2B_LxvP_1	269	272	PF13499	0.381
DOC_PP4_FxxP_1	110	113	PF00568	0.574
DOC_USP7_MATH_1	168	172	PF00917	0.647
DOC_USP7_MATH_1	219	223	PF00917	0.666
DOC_WW_Pin1_4	215	220	PF00397	0.618
DOC_WW_Pin1_4	301	306	PF00397	0.543
LIG_14-3-3_CanoR_1	11	16	PF00244	0.419
LIG_14-3-3_CanoR_1	207	214	PF00244	0.518
LIG_14-3-3_CanoR_1	33	42	PF00244	0.410
LIG_14-3-3_CanoR_1	86	91	PF00244	0.408
LIG_Actin_WH2_2	230	245	PF00022	0.512
LIG_BIR_III_4	78	82	PF00653	0.466
LIG_deltaCOP1_diTrp_1	7	15	PF00928	0.374
LIG_FHA_1	11	17	PF00498	0.470
LIG_FHA_2	137	143	PF00498	0.354
LIG_FHA_2	229	235	PF00498	0.526
LIG_GBD_Chelix_1	133	141	PF00786	0.311
LIG_HCF-1_HBM_1	74	77	PF13415	0.359
LIG_LIR_Gen_1	171	181	PF02991	0.335
LIG_LIR_Gen_1	200	206	PF02991	0.372
LIG_LIR_Nem_3	171	177	PF02991	0.350
LIG_LIR_Nem_3	200	204	PF02991	0.365
LIG_Rb_LxCxE_1	192	209	PF01857	0.474
LIG_SH2_CRK	201	205	PF00017	0.464
LIG_SH2_CRK	61	65	PF00017	0.430
LIG_SH2_NCK_1	201	205	PF00017	0.419
LIG_SH2_NCK_1	77	81	PF00017	0.430
LIG_SH2_SRC	199	202	PF00017	0.267
LIG_SH2_STAP1	146	150	PF00017	0.449
LIG_SH2_STAT5	180	183	PF00017	0.445
LIG_SH2_STAT5	43	46	PF00017	0.480
LIG_SH3_3	109	115	PF00018	0.497
LIG_Sin3_3	95	102	PF02671	0.417
LIG_WRC_WIRS_1	87	92	PF05994	0.465
MOD_CDK_SPK_2	215	220	PF00069	0.497
MOD_CK1_1	222	228	PF00069	0.520
MOD_CK2_1	228	234	PF00069	0.537
MOD_GlcNHglycan	123	127	PF01048	0.610
MOD_GlcNHglycan	208	211	PF01048	0.608
MOD_GlcNHglycan	264	267	PF01048	0.452
MOD_GSK3_1	166	173	PF00069	0.613
MOD_GSK3_1	215	222	PF00069	0.552
MOD_GSK3_1	86	93	PF00069	0.347
MOD_LATS_1	31	37	PF00433	0.465
MOD_NEK2_1	136	141	PF00069	0.430
MOD_NEK2_1	260	265	PF00069	0.370
MOD_NEK2_1	44	49	PF00069	0.477
MOD_PKA_1	33	39	PF00069	0.458
MOD_PKA_2	10	16	PF00069	0.468
MOD_PKA_2	206	212	PF00069	0.540
MOD_PKA_2	219	225	PF00069	0.707
MOD_Plk_2-3	179	185	PF00069	0.307
MOD_Plk_4	11	17	PF00069	0.383
MOD_Plk_4	170	176	PF00069	0.515
MOD_Plk_4	290	296	PF00069	0.503
MOD_ProDKin_1	215	221	PF00069	0.617
TRG_DiLeu_BaEn_1	276	281	PF01217	0.494
TRG_DiLeu_BaEn_1	37	42	PF01217	0.347
TRG_DiLeu_BaEn_1	94	99	PF01217	0.424
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.443
TRG_ENDOCYTIC_2	201	204	PF00928	0.457
TRG_ENDOCYTIC_2	61	64	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I587	Leptomonas seymouri	59%	99%
A0A0S4KI40	Bodo saltans	43%	100%
A0A1X0P0R2	Trypanosomatidae	41%	100%
A0A3R7LX07	Trypanosoma rangeli	43%	100%
A0A3S7X6G1	Leishmania donovani	94%	100%
A4HL85	Leishmania braziliensis	80%	100%
A4I8R3	Leishmania infantum	94%	100%
D0A4Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B3M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BKA1	Trypanosoma cruzi	41%	100%