SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q4F8_LEIMA

TriTrypDb:

LmjF.33.0510 , LMJLV39_330011400 , LMJSD75_330011400

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4F8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.500
CLV_C14_Caspase3-7	485	489	PF00656	0.439
CLV_NRD_NRD_1	316	318	PF00675	0.647
CLV_NRD_NRD_1	341	343	PF00675	0.649
CLV_NRD_NRD_1	429	431	PF00675	0.650
CLV_NRD_NRD_1	469	471	PF00675	0.533
CLV_NRD_NRD_1	536	538	PF00675	0.239
CLV_NRD_NRD_1	647	649	PF00675	0.575
CLV_NRD_NRD_1	821	823	PF00675	0.411
CLV_PCSK_KEX2_1	316	318	PF00082	0.647
CLV_PCSK_KEX2_1	429	431	PF00082	0.650
CLV_PCSK_KEX2_1	469	471	PF00082	0.560
CLV_PCSK_KEX2_1	536	538	PF00082	0.239
CLV_PCSK_KEX2_1	632	634	PF00082	0.574
CLV_PCSK_KEX2_1	646	648	PF00082	0.464
CLV_PCSK_KEX2_1	821	823	PF00082	0.411
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.561
CLV_PCSK_SKI1_1	118	122	PF00082	0.504
CLV_PCSK_SKI1_1	140	144	PF00082	0.444
CLV_PCSK_SKI1_1	160	164	PF00082	0.427
CLV_PCSK_SKI1_1	217	221	PF00082	0.485
CLV_PCSK_SKI1_1	385	389	PF00082	0.578
CLV_PCSK_SKI1_1	403	407	PF00082	0.533
CLV_PCSK_SKI1_1	507	511	PF00082	0.332
CLV_PCSK_SKI1_1	57	61	PF00082	0.608
CLV_PCSK_SKI1_1	586	590	PF00082	0.439
CLV_PCSK_SKI1_1	593	597	PF00082	0.458
CLV_PCSK_SKI1_1	632	636	PF00082	0.603
CLV_PCSK_SKI1_1	676	680	PF00082	0.529
CLV_PCSK_SKI1_1	710	714	PF00082	0.499
CLV_PCSK_SKI1_1	77	81	PF00082	0.421
DEG_APCC_DBOX_1	216	224	PF00400	0.498
DEG_APCC_DBOX_1	56	64	PF00400	0.578
DEG_APCC_DBOX_1	76	84	PF00400	0.389
DEG_SPOP_SBC_1	228	232	PF00917	0.492
DOC_CDC14_PxL_1	443	451	PF14671	0.631
DOC_CYCLIN_RxL_1	583	591	PF00134	0.396
DOC_CYCLIN_RxL_1	707	715	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.402
DOC_MAPK_gen_1	118	126	PF00069	0.517
DOC_MAPK_gen_1	215	223	PF00069	0.501
DOC_MAPK_MEF2A_6	127	134	PF00069	0.467
DOC_MAPK_MEF2A_6	215	223	PF00069	0.501
DOC_MAPK_MEF2A_6	668	677	PF00069	0.412
DOC_MAPK_MEF2A_6	77	85	PF00069	0.553
DOC_USP7_MATH_1	128	132	PF00917	0.612
DOC_USP7_MATH_1	147	151	PF00917	0.318
DOC_USP7_MATH_1	228	232	PF00917	0.554
DOC_USP7_MATH_1	248	252	PF00917	0.537
DOC_USP7_MATH_1	389	393	PF00917	0.624
DOC_USP7_MATH_1	431	435	PF00917	0.584
DOC_USP7_MATH_1	497	501	PF00917	0.523
DOC_USP7_MATH_1	552	556	PF00917	0.454
DOC_USP7_MATH_1	620	624	PF00917	0.584
DOC_USP7_MATH_1	628	632	PF00917	0.448
DOC_USP7_MATH_1	90	94	PF00917	0.600
DOC_WW_Pin1_4	12	17	PF00397	0.646
DOC_WW_Pin1_4	126	131	PF00397	0.556
DOC_WW_Pin1_4	224	229	PF00397	0.483
DOC_WW_Pin1_4	305	310	PF00397	0.633
DOC_WW_Pin1_4	413	418	PF00397	0.635
DOC_WW_Pin1_4	47	52	PF00397	0.493
DOC_WW_Pin1_4	495	500	PF00397	0.439
DOC_WW_Pin1_4	528	533	PF00397	0.532
LIG_14-3-3_CanoR_1	160	168	PF00244	0.569
LIG_14-3-3_CanoR_1	197	207	PF00244	0.555
LIG_14-3-3_CanoR_1	215	220	PF00244	0.330
LIG_14-3-3_CanoR_1	316	326	PF00244	0.600
LIG_14-3-3_CanoR_1	43	48	PF00244	0.606
LIG_14-3-3_CanoR_1	57	66	PF00244	0.493
LIG_14-3-3_CanoR_1	633	637	PF00244	0.562
LIG_14-3-3_CanoR_1	858	862	PF00244	0.442
LIG_Actin_WH2_2	357	375	PF00022	0.572
LIG_Actin_WH2_2	521	538	PF00022	0.439
LIG_APCC_ABBA_1	14	19	PF00400	0.631
LIG_APCC_ABBA_1	143	148	PF00400	0.485
LIG_APCC_ABBA_1	238	243	PF00400	0.429
LIG_BIR_III_4	100	104	PF00653	0.599
LIG_Clathr_ClatBox_1	701	705	PF01394	0.426
LIG_EVH1_1	48	52	PF00568	0.623
LIG_EVH1_2	10	14	PF00568	0.550
LIG_FHA_1	216	222	PF00498	0.482
LIG_FHA_1	292	298	PF00498	0.574
LIG_FHA_1	34	40	PF00498	0.641
LIG_FHA_1	565	571	PF00498	0.489
LIG_FHA_1	573	579	PF00498	0.408
LIG_FHA_1	59	65	PF00498	0.597
LIG_FHA_1	713	719	PF00498	0.446
LIG_FHA_2	114	120	PF00498	0.530
LIG_FHA_2	209	215	PF00498	0.389
LIG_FHA_2	260	266	PF00498	0.434
LIG_FHA_2	483	489	PF00498	0.439
LIG_FHA_2	749	755	PF00498	0.443
LIG_FHA_2	792	798	PF00498	0.406
LIG_FHA_2	867	873	PF00498	0.450
LIG_Integrin_RGD_1	288	290	PF01839	0.491
LIG_Integrin_RGD_1	486	488	PF01839	0.301
LIG_LIR_Gen_1	715	724	PF02991	0.428
LIG_LIR_Gen_1	830	840	PF02991	0.479
LIG_LIR_Nem_3	114	120	PF02991	0.557
LIG_LIR_Nem_3	27	33	PF02991	0.623
LIG_LIR_Nem_3	715	720	PF02991	0.436
LIG_LIR_Nem_3	830	835	PF02991	0.447
LIG_LYPXL_SIV_4	728	736	PF13949	0.456
LIG_NRBOX	219	225	PF00104	0.499
LIG_NRBOX	360	366	PF00104	0.587
LIG_PCNA_yPIPBox_3	667	679	PF02747	0.420
LIG_PDZ_Class_3	882	887	PF00595	0.507
LIG_PTAP_UEV_1	1	6	PF05743	0.628
LIG_PTAP_UEV_1	443	448	PF05743	0.586
LIG_Rb_LxCxE_1	872	887	PF01857	0.505
LIG_SH2_CRK	729	733	PF00017	0.439
LIG_SH2_NCK_1	146	150	PF00017	0.481
LIG_SH2_NCK_1	729	733	PF00017	0.439
LIG_SH2_PTP2	832	835	PF00017	0.462
LIG_SH2_SRC	146	149	PF00017	0.481
LIG_SH2_SRC	237	240	PF00017	0.578
LIG_SH2_SRC	563	566	PF00017	0.484
LIG_SH2_SRC	610	613	PF00017	0.548
LIG_SH2_STAP1	729	733	PF00017	0.439
LIG_SH2_STAP1	859	863	PF00017	0.434
LIG_SH2_STAT5	237	240	PF00017	0.435
LIG_SH2_STAT5	563	566	PF00017	0.484
LIG_SH2_STAT5	772	775	PF00017	0.409
LIG_SH2_STAT5	832	835	PF00017	0.462
LIG_SH3_3	441	447	PF00018	0.656
LIG_SH3_3	46	52	PF00018	0.629
LIG_SH3_3	687	693	PF00018	0.427
LIG_SH3_3	7	13	PF00018	0.632
LIG_SH3_3	812	818	PF00018	0.430
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.440
LIG_SUMO_SIM_par_1	256	262	PF11976	0.411
LIG_SUMO_SIM_par_1	35	41	PF11976	0.643
LIG_SUMO_SIM_par_1	524	529	PF11976	0.532
LIG_SUMO_SIM_par_1	61	67	PF11976	0.572
LIG_SUMO_SIM_par_1	700	705	PF11976	0.430
LIG_TRAF2_1	25	28	PF00917	0.605
LIG_TRAF2_1	555	558	PF00917	0.532
LIG_TRAF2_1	751	754	PF00917	0.444
LIG_TRFH_1	236	240	PF08558	0.432
LIG_WRC_WIRS_1	852	857	PF05994	0.452
LIG_WW_3	463	467	PF00397	0.624
MOD_CDK_SPxxK_3	305	312	PF00069	0.635
MOD_CK1_1	205	211	PF00069	0.516
MOD_CK1_1	227	233	PF00069	0.578
MOD_CK1_1	291	297	PF00069	0.564
MOD_CK1_1	502	508	PF00069	0.287
MOD_CK1_1	58	64	PF00069	0.554
MOD_CK1_1	738	744	PF00069	0.454
MOD_CK2_1	113	119	PF00069	0.434
MOD_CK2_1	259	265	PF00069	0.420
MOD_CK2_1	552	558	PF00069	0.456
MOD_CK2_1	570	576	PF00069	0.585
MOD_CK2_1	747	753	PF00069	0.432
MOD_CK2_1	791	797	PF00069	0.400
MOD_CK2_1	866	872	PF00069	0.445
MOD_CK2_1	875	881	PF00069	0.403
MOD_GlcNHglycan	106	110	PF01048	0.474
MOD_GlcNHglycan	2	5	PF01048	0.667
MOD_GlcNHglycan	294	297	PF01048	0.608
MOD_GlcNHglycan	320	323	PF01048	0.627
MOD_GlcNHglycan	344	347	PF01048	0.746
MOD_GlcNHglycan	354	358	PF01048	0.587
MOD_GlcNHglycan	391	394	PF01048	0.585
MOD_GlcNHglycan	444	447	PF01048	0.580
MOD_GlcNHglycan	499	502	PF01048	0.368
MOD_GlcNHglycan	537	540	PF01048	0.382
MOD_GlcNHglycan	554	557	PF01048	0.407
MOD_GlcNHglycan	57	60	PF01048	0.569
MOD_GlcNHglycan	660	663	PF01048	0.579
MOD_GlcNHglycan	71	74	PF01048	0.462
MOD_GlcNHglycan	740	743	PF01048	0.447
MOD_GSK3_1	128	135	PF00069	0.581
MOD_GSK3_1	198	205	PF00069	0.508
MOD_GSK3_1	224	231	PF00069	0.556
MOD_GSK3_1	242	249	PF00069	0.315
MOD_GSK3_1	274	281	PF00069	0.466
MOD_GSK3_1	284	291	PF00069	0.496
MOD_GSK3_1	413	420	PF00069	0.666
MOD_GSK3_1	43	50	PF00069	0.533
MOD_GSK3_1	495	502	PF00069	0.317
MOD_GSK3_1	564	571	PF00069	0.485
MOD_GSK3_1	628	635	PF00069	0.589
MOD_GSK3_1	653	660	PF00069	0.528
MOD_GSK3_1	708	715	PF00069	0.463
MOD_N-GLC_1	420	425	PF02516	0.650
MOD_NEK2_1	113	118	PF00069	0.499
MOD_NEK2_1	229	234	PF00069	0.533
MOD_NEK2_1	304	309	PF00069	0.545
MOD_NEK2_1	32	37	PF00069	0.612
MOD_NEK2_1	55	60	PF00069	0.558
MOD_NEK2_1	570	575	PF00069	0.499
MOD_NEK2_1	577	582	PF00069	0.407
MOD_NEK2_1	588	593	PF00069	0.317
MOD_NEK2_1	727	732	PF00069	0.435
MOD_NEK2_1	736	741	PF00069	0.371
MOD_NEK2_1	747	752	PF00069	0.238
MOD_NEK2_1	773	778	PF00069	0.414
MOD_PIKK_1	570	576	PF00454	0.487
MOD_PIKK_1	588	594	PF00454	0.437
MOD_PKA_1	342	348	PF00069	0.597
MOD_PKA_1	632	638	PF00069	0.546
MOD_PKA_2	196	202	PF00069	0.484
MOD_PKA_2	42	48	PF00069	0.643
MOD_PKA_2	431	437	PF00069	0.553
MOD_PKA_2	535	541	PF00069	0.254
MOD_PKA_2	632	638	PF00069	0.546
MOD_PKA_2	857	863	PF00069	0.443
MOD_Plk_1	105	111	PF00069	0.537
MOD_Plk_1	147	153	PF00069	0.480
MOD_Plk_1	208	214	PF00069	0.447
MOD_Plk_1	242	248	PF00069	0.484
MOD_Plk_1	26	32	PF00069	0.654
MOD_Plk_1	502	508	PF00069	0.476
MOD_Plk_1	557	563	PF00069	0.385
MOD_Plk_4	208	214	PF00069	0.392
MOD_Plk_4	360	366	PF00069	0.601
MOD_Plk_4	43	49	PF00069	0.641
MOD_Plk_4	543	549	PF00069	0.385
MOD_Plk_4	559	565	PF00069	0.385
MOD_Plk_4	632	638	PF00069	0.609
MOD_Plk_4	848	854	PF00069	0.446
MOD_ProDKin_1	12	18	PF00069	0.648
MOD_ProDKin_1	126	132	PF00069	0.551
MOD_ProDKin_1	224	230	PF00069	0.491
MOD_ProDKin_1	305	311	PF00069	0.635
MOD_ProDKin_1	413	419	PF00069	0.636
MOD_ProDKin_1	47	53	PF00069	0.496
MOD_ProDKin_1	495	501	PF00069	0.254
MOD_ProDKin_1	528	534	PF00069	0.385
MOD_SUMO_for_1	678	681	PF00179	0.557
MOD_SUMO_rev_2	114	122	PF00179	0.520
MOD_SUMO_rev_2	651	661	PF00179	0.546
TRG_DiLeu_BaEn_1	604	609	PF01217	0.491
TRG_DiLeu_BaEn_1	754	759	PF01217	0.482
TRG_DiLeu_BaEn_1	805	810	PF01217	0.480
TRG_DiLeu_BaEn_1	848	853	PF01217	0.423
TRG_DiLeu_BaEn_1	872	877	PF01217	0.465
TRG_DiLeu_BaEn_4	27	33	PF01217	0.544
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.602
TRG_DiLeu_BaLyEn_6	761	766	PF01217	0.457
TRG_ENDOCYTIC_2	729	732	PF00928	0.443
TRG_ENDOCYTIC_2	772	775	PF00928	0.409
TRG_ENDOCYTIC_2	832	835	PF00928	0.462
TRG_ER_diArg_1	315	317	PF00400	0.637
TRG_ER_diArg_1	428	430	PF00400	0.656
TRG_ER_diArg_1	468	470	PF00400	0.512
TRG_ER_diArg_1	535	537	PF00400	0.254
TRG_ER_diArg_1	583	586	PF00400	0.399
TRG_ER_diArg_1	646	648	PF00400	0.564
TRG_ER_diArg_1	718	721	PF00400	0.380
TRG_ER_diArg_1	820	822	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6B7	Leishmania donovani	90%	88%
A4HL86	Leishmania braziliensis	70%	100%
A4I8R4	Leishmania infantum	89%	88%
E9B3M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%