Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4F5_LEIMA

TriTrypDb:

LmjF.33.0535 , LMJLV39_330011700 , LMJSD75_330011700

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4F5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.563
CLV_NRD_NRD_1	137	139	PF00675	0.627
CLV_NRD_NRD_1	195	197	PF00675	0.591
CLV_PCSK_KEX2_1	137	139	PF00082	0.627
CLV_PCSK_KEX2_1	195	197	PF00082	0.591
CLV_PCSK_SKI1_1	2	6	PF00082	0.588
CLV_PCSK_SKI1_1	77	81	PF00082	0.503
CLV_Separin_Metazoa	52	56	PF03568	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.694
DOC_ANK_TNKS_1	173	180	PF00023	0.443
DOC_PP2B_LxvP_1	46	49	PF13499	0.533
DOC_PP4_FxxP_1	106	109	PF00568	0.646
DOC_PP4_FxxP_1	149	152	PF00568	0.549
DOC_WW_Pin1_4	61	66	PF00397	0.510
LIG_14-3-3_CanoR_1	188	192	PF00244	0.603
LIG_14-3-3_CanoR_1	24	32	PF00244	0.527
LIG_14-3-3_CanoR_1	39	47	PF00244	0.386
LIG_14-3-3_CanoR_1	77	85	PF00244	0.478
LIG_Actin_WH2_2	25	41	PF00022	0.578
LIG_BRCT_BRCA1_1	145	149	PF00533	0.630
LIG_EH1_1	128	136	PF00400	0.673
LIG_EH1_1	69	77	PF00400	0.509
LIG_eIF4E_1	129	135	PF01652	0.668
LIG_FHA_1	103	109	PF00498	0.593
LIG_FHA_1	146	152	PF00498	0.580
LIG_FHA_1	153	159	PF00498	0.535
LIG_FHA_2	109	115	PF00498	0.638
LIG_FHA_2	24	30	PF00498	0.607
LIG_GBD_Chelix_1	157	165	PF00786	0.571
LIG_LIR_Apic_2	105	109	PF02991	0.647
LIG_LIR_Apic_2	146	152	PF02991	0.584
LIG_LIR_Gen_1	168	178	PF02991	0.399
LIG_LIR_Nem_3	168	173	PF02991	0.408
LIG_PCNA_yPIPBox_3	77	89	PF02747	0.579
LIG_SH2_NCK_1	129	133	PF00017	0.686
LIG_SH2_SRC	45	48	PF00017	0.486
LIG_SH2_STAT5	129	132	PF00017	0.707
LIG_SH2_STAT5	45	48	PF00017	0.420
LIG_SH2_STAT5	88	91	PF00017	0.550
LIG_SH3_3	172	178	PF00018	0.393
LIG_SH3_3	41	47	PF00018	0.496
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.504
MOD_GlcNHglycan	114	118	PF01048	0.680
MOD_GlcNHglycan	140	144	PF01048	0.655
MOD_GlcNHglycan	33	37	PF01048	0.596
MOD_GSK3_1	104	111	PF00069	0.589
MOD_GSK3_1	139	146	PF00069	0.626
MOD_GSK3_1	152	159	PF00069	0.371
MOD_GSK3_1	177	184	PF00069	0.537
MOD_GSK3_1	23	30	PF00069	0.619
MOD_GSK3_1	34	41	PF00069	0.266
MOD_GSK3_1	57	64	PF00069	0.517
MOD_NEK2_1	13	18	PF00069	0.491
MOD_NEK2_1	145	150	PF00069	0.592
MOD_NEK2_1	32	37	PF00069	0.533
MOD_NEK2_1	38	43	PF00069	0.447
MOD_NEK2_2	65	70	PF00069	0.564
MOD_PIKK_1	156	162	PF00454	0.565
MOD_PKA_2	187	193	PF00069	0.616
MOD_PKA_2	23	29	PF00069	0.515
MOD_PKA_2	38	44	PF00069	0.389
MOD_PKA_2	8	14	PF00069	0.521
MOD_Plk_1	28	34	PF00069	0.687
MOD_Plk_4	130	136	PF00069	0.614
MOD_Plk_4	145	151	PF00069	0.483
MOD_Plk_4	177	183	PF00069	0.427
MOD_Plk_4	187	193	PF00069	0.485
MOD_Plk_4	8	14	PF00069	0.579
MOD_ProDKin_1	61	67	PF00069	0.507
TRG_ER_diArg_1	136	138	PF00400	0.602
TRG_NES_CRM1_1	156	168	PF08389	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI4	Leptomonas seymouri	47%	89%
A0A1X0P1T8	Trypanosomatidae	26%	78%
A0A3S5IQJ3	Trypanosoma rangeli	27%	85%
A0A3S7X6D3	Leishmania donovani	95%	100%
A4HL90	Leishmania braziliensis	87%	100%
D0A4Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
E9AHN2	Leishmania infantum	94%	100%
E9B3N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AM33	Trypanosoma cruzi	28%	82%