V-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4F0_LEIMA

TriTrypDb:

LmjF.33.0570 , LMJLV39_330012400 , LMJSD75_330012200

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032991	protein-containing complex	1	2
GO:0034708	methyltransferase complex	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0043527	tRNA methyltransferase complex	5	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q4F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4F0

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0030488	tRNA methylation	5	2
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	11
GO:0036265	RNA (guanine-N7)-methylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0106004	tRNA (guanine-N7)-methylation	6	2
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.466
CLV_C14_Caspase3-7	422	426	PF00656	0.418
CLV_C14_Caspase3-7	542	546	PF00656	0.652
CLV_C14_Caspase3-7	73	77	PF00656	0.349
CLV_NRD_NRD_1	122	124	PF00675	0.699
CLV_NRD_NRD_1	238	240	PF00675	0.332
CLV_NRD_NRD_1	538	540	PF00675	0.628
CLV_PCSK_FUR_1	535	539	PF00082	0.638
CLV_PCSK_KEX2_1	122	124	PF00082	0.702
CLV_PCSK_KEX2_1	156	158	PF00082	0.374
CLV_PCSK_KEX2_1	237	239	PF00082	0.349
CLV_PCSK_KEX2_1	443	445	PF00082	0.381
CLV_PCSK_KEX2_1	537	539	PF00082	0.622
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.374
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.414
CLV_PCSK_SKI1_1	156	160	PF00082	0.389
CLV_PCSK_SKI1_1	202	206	PF00082	0.484
CLV_PCSK_SKI1_1	238	242	PF00082	0.332
CLV_PCSK_SKI1_1	386	390	PF00082	0.388
DOC_ANK_TNKS_1	347	354	PF00023	0.410
DOC_CDC14_PxL_1	5	13	PF14671	0.442
DOC_CYCLIN_RxL_1	199	209	PF00134	0.287
DOC_CYCLIN_RxL_1	232	244	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.466
DOC_MAPK_gen_1	443	450	PF00069	0.349
DOC_PP1_RVXF_1	180	186	PF00149	0.480
DOC_PP1_RVXF_1	55	62	PF00149	0.382
DOC_PP2B_LxvP_1	216	219	PF13499	0.442
DOC_PP2B_LxvP_1	307	310	PF13499	0.506
DOC_PP2B_LxvP_1	62	65	PF13499	0.406
DOC_PP4_FxxP_1	399	402	PF00568	0.387
DOC_USP7_MATH_1	249	253	PF00917	0.329
DOC_USP7_MATH_1	333	337	PF00917	0.519
DOC_USP7_MATH_1	415	419	PF00917	0.598
DOC_USP7_MATH_1	44	48	PF00917	0.553
DOC_USP7_UBL2_3	567	571	PF12436	0.673
DOC_WW_Pin1_4	183	188	PF00397	0.464
DOC_WW_Pin1_4	38	43	PF00397	0.663
DOC_WW_Pin1_4	454	459	PF00397	0.501
LIG_14-3-3_CanoR_1	157	162	PF00244	0.420
LIG_14-3-3_CanoR_1	180	186	PF00244	0.431
LIG_14-3-3_CanoR_1	267	271	PF00244	0.506
LIG_14-3-3_CanoR_1	3	11	PF00244	0.456
LIG_14-3-3_CanoR_1	421	425	PF00244	0.469
LIG_14-3-3_CanoR_1	514	521	PF00244	0.441
LIG_AP2alpha_1	171	175	PF02296	0.312
LIG_APCC_ABBA_1	168	173	PF00400	0.229
LIG_BIR_III_2	425	429	PF00653	0.430
LIG_BRCT_BRCA1_1	395	399	PF00533	0.375
LIG_FHA_1	111	117	PF00498	0.641
LIG_FHA_1	153	159	PF00498	0.388
LIG_FHA_1	188	194	PF00498	0.507
LIG_FHA_1	211	217	PF00498	0.334
LIG_FHA_1	255	261	PF00498	0.410
LIG_FHA_1	338	344	PF00498	0.538
LIG_FHA_1	436	442	PF00498	0.429
LIG_FHA_2	161	167	PF00498	0.439
LIG_FHA_2	420	426	PF00498	0.404
LIG_FHA_2	506	512	PF00498	0.647
LIG_LIR_Apic_2	143	147	PF02991	0.560
LIG_LIR_Apic_2	396	402	PF02991	0.394
LIG_LIR_Gen_1	339	349	PF02991	0.403
LIG_LIR_Gen_1	449	458	PF02991	0.495
LIG_LIR_Gen_1	526	534	PF02991	0.532
LIG_LIR_Nem_3	173	178	PF02991	0.320
LIG_LIR_Nem_3	339	344	PF02991	0.386
LIG_LIR_Nem_3	357	362	PF02991	0.565
LIG_LIR_Nem_3	373	378	PF02991	0.342
LIG_LIR_Nem_3	397	403	PF02991	0.307
LIG_LIR_Nem_3	449	453	PF02991	0.455
LIG_LIR_Nem_3	526	532	PF02991	0.521
LIG_MYND_3	485	489	PF01753	0.514
LIG_Pex14_1	145	149	PF04695	0.459
LIG_Pex14_2	171	175	PF04695	0.312
LIG_SH2_CRK	404	408	PF00017	0.573
LIG_SH2_GRB2like	404	407	PF00017	0.461
LIG_SH2_NCK_1	404	408	PF00017	0.404
LIG_SH2_NCK_1	529	533	PF00017	0.494
LIG_SH2_SRC	149	152	PF00017	0.441
LIG_SH2_SRC	404	407	PF00017	0.477
LIG_SH2_STAP1	289	293	PF00017	0.520
LIG_SH2_STAP1	311	315	PF00017	0.419
LIG_SH2_STAT5	258	261	PF00017	0.463
LIG_SH2_STAT5	282	285	PF00017	0.444
LIG_SH2_STAT5	314	317	PF00017	0.337
LIG_SH2_STAT5	487	490	PF00017	0.497
LIG_SH3_3	346	352	PF00018	0.553
LIG_SH3_3	480	486	PF00018	0.539
LIG_SH3_3	528	534	PF00018	0.503
LIG_SH3_3	62	68	PF00018	0.500
LIG_SH3_4	146	153	PF00018	0.526
LIG_SUMO_SIM_par_1	188	194	PF11976	0.542
LIG_TRAF2_1	228	231	PF00917	0.578
LIG_TRAF2_1	501	504	PF00917	0.611
LIG_WRC_WIRS_1	344	349	PF05994	0.509
MOD_CK1_1	110	116	PF00069	0.741
MOD_CK1_1	12	18	PF00069	0.357
MOD_CK1_1	160	166	PF00069	0.492
MOD_CK1_1	209	215	PF00069	0.325
MOD_CK1_1	269	275	PF00069	0.364
MOD_CK1_1	420	426	PF00069	0.477
MOD_CK1_1	550	556	PF00069	0.701
MOD_CK1_1	558	564	PF00069	0.733
MOD_CK2_1	160	166	PF00069	0.492
MOD_CK2_1	278	284	PF00069	0.517
MOD_CK2_1	333	339	PF00069	0.483
MOD_CK2_1	454	460	PF00069	0.557
MOD_CK2_1	505	511	PF00069	0.644
MOD_CK2_1	513	519	PF00069	0.524
MOD_Cter_Amidation	569	572	PF01082	0.621
MOD_GlcNHglycan	230	235	PF01048	0.553
MOD_GlcNHglycan	271	274	PF01048	0.386
MOD_GlcNHglycan	417	420	PF01048	0.578
MOD_GlcNHglycan	552	555	PF01048	0.759
MOD_GlcNHglycan	562	565	PF01048	0.607
MOD_GlcNHglycan	72	75	PF01048	0.351
MOD_GSK3_1	152	159	PF00069	0.391
MOD_GSK3_1	181	188	PF00069	0.432
MOD_GSK3_1	206	213	PF00069	0.341
MOD_GSK3_1	226	233	PF00069	0.363
MOD_GSK3_1	3	10	PF00069	0.544
MOD_GSK3_1	309	316	PF00069	0.394
MOD_GSK3_1	333	340	PF00069	0.484
MOD_GSK3_1	363	370	PF00069	0.490
MOD_GSK3_1	40	47	PF00069	0.587
MOD_GSK3_1	415	422	PF00069	0.430
MOD_GSK3_1	462	469	PF00069	0.599
MOD_LATS_1	154	160	PF00433	0.358
MOD_N-GLC_1	3	8	PF02516	0.627
MOD_N-GLC_1	303	308	PF02516	0.564
MOD_N-GLC_1	337	342	PF02516	0.560
MOD_N-GLC_1	550	555	PF02516	0.748
MOD_N-GLC_1	83	88	PF02516	0.483
MOD_N-GLC_1	97	102	PF02516	0.588
MOD_NEK2_1	214	219	PF00069	0.361
MOD_NEK2_1	263	268	PF00069	0.546
MOD_NEK2_1	343	348	PF00069	0.457
MOD_NEK2_1	523	528	PF00069	0.529
MOD_PKA_1	122	128	PF00069	0.701
MOD_PKA_1	156	162	PF00069	0.349
MOD_PKA_2	122	128	PF00069	0.701
MOD_PKA_2	156	162	PF00069	0.364
MOD_PKA_2	181	187	PF00069	0.451
MOD_PKA_2	249	255	PF00069	0.320
MOD_PKA_2	266	272	PF00069	0.384
MOD_PKA_2	420	426	PF00069	0.465
MOD_PKA_2	513	519	PF00069	0.626
MOD_PKB_1	237	245	PF00069	0.382
MOD_PKB_1	537	545	PF00069	0.572
MOD_Plk_1	278	284	PF00069	0.524
MOD_Plk_1	289	295	PF00069	0.620
MOD_Plk_1	303	309	PF00069	0.690
MOD_Plk_1	337	343	PF00069	0.471
MOD_Plk_1	435	441	PF00069	0.405
MOD_Plk_1	83	89	PF00069	0.511
MOD_Plk_2-3	107	113	PF00069	0.686
MOD_Plk_2-3	513	519	PF00069	0.516
MOD_Plk_4	254	260	PF00069	0.422
MOD_Plk_4	309	315	PF00069	0.425
MOD_Plk_4	363	369	PF00069	0.385
MOD_Plk_4	44	50	PF00069	0.534
MOD_Plk_4	446	452	PF00069	0.404
MOD_ProDKin_1	183	189	PF00069	0.473
MOD_ProDKin_1	38	44	PF00069	0.658
MOD_ProDKin_1	454	460	PF00069	0.511
MOD_SUMO_for_1	140	143	PF00179	0.596
MOD_SUMO_rev_2	73	80	PF00179	0.388
TRG_DiLeu_BaEn_1	339	344	PF01217	0.424
TRG_DiLeu_BaEn_2	435	441	PF01217	0.404
TRG_ENDOCYTIC_2	404	407	PF00928	0.468
TRG_ENDOCYTIC_2	529	532	PF00928	0.492
TRG_ER_diArg_1	179	182	PF00400	0.471
TRG_ER_diArg_1	237	239	PF00400	0.349
TRG_ER_diArg_1	347	350	PF00400	0.503
TRG_ER_diArg_1	534	537	PF00400	0.536
TRG_NES_CRM1_1	54	66	PF08389	0.415
TRG_NLS_MonoExtC_3	570	575	PF00514	0.671
TRG_NLS_MonoExtN_4	122	127	PF00514	0.584
TRG_NLS_MonoExtN_4	571	576	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL73	Leptomonas seymouri	65%	100%
A0A0S4IWR1	Bodo saltans	23%	100%
A0A1X0P0S8	Trypanosomatidae	30%	100%
A0A3Q8IGQ7	Leishmania donovani	94%	100%
A0A422N539	Trypanosoma rangeli	32%	100%
A4HL95	Leishmania braziliensis	79%	100%
A4I8S1	Leishmania infantum	94%	100%
D0A4R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B3N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5D2Q1	Trypanosoma cruzi	33%	100%